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ISOM News

2015 Orthomolecular Medicine Hall of Fame

Inaugurated in 2004, the Orthomolecular Medicine Hall of Fame recognizes the achieve-
ments of pioneers and leaders in the advancement of Orthomolecular Medicine. On Saturday,
April 25, during the Orthomolecular Medicine Today Conference, four new members were
inducted, bringing the total number in the Hall of Fame to sixty-four Pictured above from
left to right: Aileen Burford-Mason, L. John Hoffer and Hyla Cass.

Irwin Kahan 1919-2015 create, with very few resources and in a hos-
tile psychiatric community, a new organiza-
Irwin Kahan was born on a Saskatch- tion dedicated to improving the lives of peo-
ewan farm in 1919. After serving with the ple with schizophrenia. In this endeavour, he
Royal Canadian Air Force during World worked closely with his wife Fannie Kahan,
War II, he graduated from McGill Univer- Abram Hoffer, other CSF board members,
sity with a social work degree. and a large crew of volunteers from branches
In the 1950s, Irwin was an integral which he had established across Canada. In
member of the research team, headed by Dr. 1975, the Academy of Orthomolecular Psy-
Abram Hoffer, that provided the foundation chiatry elected Irwin as an honorary member
for the orthomolecular medicine approach. in recognition of meritorious contributions
Later, as Executive Director of the Saskatch- to Orthomolecular Psychiatry.
ewan Division, Canadian Mental Health Irwins approach was multi-pronged, fo-
Association, for over a decade he advocated cusing on: assisting people at the grassroots
fiercely for the adoption of orthomolecular level; policy and advocacy at the government
treatment. level; media communications to promote
In 1968, Irwin became the founding di- widespread public understanding of schizo-
rector of the Schizophrenia Foundation of phrenia and the orthomolecular approach;
Saskatchewan, and shortly afterwards the and raising professionals knowledge regard-
founding executive director of the Canadian ing orthomolecular practice.
Schizophrenia Foundation (now the Inter- Irwin is the author of the memoir Tend-
national Schizophrenia Foundation). With ing the Tree of Life (Wild Sage Press, 2015),
passion and dedication, Irwin worked hard to which includes some of his orthomolecular
52 Journal of Orthomolecular Medicine Vol 30, No 1, 2015

Irwin Kahan Aileen Burford-Mason

medicine experiences. Irwins three decades afraid of horses.)


of putting his heart and soul into advocat- While living in Newmarket Aileen
ing for better treatment and conditions for met and married the love of her life, Roger
schizophrenics resulted in many lives saved Burford-Mason (d. 1998). They moved to
from years of suffering and an increase in the Hitchin, Hertfordshire, where their son Oli-
quality of those lives. ver was born. After some years in teaching,
she returned to research, this time in immu-
nology. In 1983 she completed her PhD in
immunology and continued research in that
Aileen Burford-Mason field until 1988 when she emigrated with
Born Aileen Philomena Reilly in Bir- her family from the UK to Canada.
mingham England, Aileen returned with Once in Toronto she moved into cancer
her parents to their native Ireland when she research, holding positions as Research As-
was three years old. Her earliest education sociate and later Assistant Professor in the
was at the Dominican Convent, Santa Sa- University of Torontos Department of Pa-
bina, Dublin, where her favourite activities thology. However, a nutritional thread had
were writing, drawing and performing in run through her research career, and she
school productions. From there she went to gradually became convinced that all disease
boarding school at Loreto Convent, County had its roots in inadequate nutrition. So in
Meath, where she learned little science but 1996 she made the transition from conven-
developed a lasting love of music. tional research to orthomolecular medicine.
Aileens scientific education began in Today Aileen divides her time between
earnest at University College Dublin where her private practice, writing, and lecturing to
she obtained her Bachelor of Science degree. medical and allied health professionals on
After graduation she moved to England to the evidence based use of diet and supple-
pursue a research career as a forensic bio- ments in health maintenance and disease
chemist in the horse-racing town of New- prevention. Since 2008, Nutrition for Docs,
market, Suffolk. Her most enduring mem- the course on diet and supplements she de-
ory of that time was her futile attempts to signed and teaches has been presented across
appear calm and unruffled when collecting Canada to 1,700 doctors. Eat Well, Age Bet-
blood and urine samples from horses. (The ter, her best-selling book based on the course,
horses were not fooled and to this day she is has been enthusiastically received by doctors
53
ISOM News

Hyla Cass Leonard John Hoffer

and the public. Aileen serves on the editorial and hormones, weight management, and
board of the Journal of Orthomolecular Medi- natural treatments for addiction, anxiety dis-
cine and is a member of the core faculty of orders, and depression. Audiences include
the Orthomolecular Medicine Today Con- the American College for Advancement in
ference. She is currently working on a new Medicine, the International Society for Or-
book to be published by Harper Collins in thomolecular Medicine, and The American
spring 2017. Academy of Anti-Aging Medicine (A4M).
Born in Toronto, Canada, Hyla obtained
her pre-medical and medical education from
the University of Toronto School of Medi-
Hyla Cass cine, interned at LAC-USC Medical Cen-
Hyla Cass MD is an internationally ac- ter, then completed her residency training at
claimed psychiatrist and one of the our fore- Cedars-Sinai Medical Center, Los Angeles,
most experts and pioneers in integrative med- where she then served as an attending staff
icine. Combining the best of natural medicine physician for 10 years.
with modern science in her clinical practice An Assistant Clinical Professor of Psy-
for over 30 years, and in writings, lectures, chiatry at UCLA School of Medicine for 20
and media appearances, shes certified by the years, Board Member and Chair of Vitamin
American Board of Psychiatry and Neurol- Relief USA, providing at-risk children, teens,
ogy (ABPN), as well the American Board of seniors and adults with daily multiple vitamins
Holistic Integrative Medicine (ABIHM). across the U.S, she also is a Board Member of
She is the author of a number of popu- the American College for Advancement in
lar books including St. Johns Wort: Natures Medicine (ACAM), Advisory Board member
Blues Buster; Kava: Natures Answer to Stress, at Taste for Life Magazine and Medical Edi-
Anxiety and Insomnia; Natural Highs; Sup- tor at Total Health Magazine.
plement Your Prescription; 8 Weeks to Vibrant Most recently she serves on the Board of
Health; and The Addicted Brain and How to Governors of the Placencia Health Group,
Break Free. which is creating a Medical Free Zone in
Dr. Cass also speaks to professional Belize, while maintaining the highest scien-
and lay audiences on topics ranging from tific, professional and ethical standards, with
complementary medicine and psychiatry, an innovative World Center for Anti-Aging
longevity enhancement, womens health Medicine and Clinical Therapies.
54 Journal of Orthomolecular Medicine Vol 30, No 1, 2015

to starvation, and micronutrient metabolism


Leonard John Hoffer in disease. He authored the chapter on the
Leonard John Hoffer is a Professor of metabolic features of human starvation in the
Medicine at McGill University and Associ- last several editions of the clinical nutrition
ate Professor in McGills School of Dietet- textbook, Modern Nutrition in Health and
ics and Human Nutrition. He is a full-time Disease, and co-authored the chapter entitled
investigator in the Lady Davis Institute for Enteral and parenteral nutrition therapy in
Medical Research, Jewish General Hospi- the 2015 edition of Harrisons Principles of In-
tal, Montreal, and a Senior Physician in the ternal Medicine, the worlds most prestigious
Divisions of General Internal Medicine and medical textbook. In 2012 he was recipient of
Endocrinology in the JGH, where he serves the Kursheed Jeejeebhoy Award and Plenary
on the nutritional support team. Lecture, Canadian Nutrition Society.
Dr. Hoffer obtained his medical and Influenced throughout his career by the
subspecialty training in internal medicine at ideas of his father, Abram, John Hoffer has
McGill, then a PhD in Human Nutrition at spent much of his career thinking about and
the Massachusetts Institute of Technology, studying the therapeutic potential of nutri-
Cambridge MA, a clinical fellowship in nu- tion in the treatment of important diseases,
tritional support at Harvard Medical School, including cancer. He has served on the edi-
and a post-doctoral fellowship in biochem- torial board of the Journal of Orthomolecular
istry at Brandeis University, returning to Medicine for decades, and since 2009 as as-
McGill in 1984 as an assistant professor. sociate editor. With funding from the Hecht
Dr. Hoffers research and clinical interests Foundation, he was able to contribute to in-
focus on the relationship between disease terest in and study of the use of high-dose
and malnutrition, the metabolic adaptation vitamin C in cancer therapy.

Highlights from the 44th Orthomolecular


Medicine Today Conference by Paul Demeda, CNP
Neil Riordan, PhD -MSCs secrete compounds that stimulate
Secretions of Mesenchymal Stem Cells: The Next resprouting of neural fibres and repair spinal
Generation in Orthomolecular Medicine cord.
-Bone marrow MSCs are a safe and feasible
Dr Riordan presented on the benefits and treatment for spinal cord injury.1
uses of Mesenchymal Stem Cells (MSCs) -The MSC-secreted protein IGFBP-4 con-
for addressing a variety of chronic and criti- sistently inhibits several cancer cells in vivo
cal health issues.MSCs and their secretions and in vitro.2
are an important repair system in the body -Human MSC cells did not provoke an au-
and control aspects of immunity, inflamma- toimmune response when injected into rats.
tion, and stimulate regeneration of cells and
tissue. The number and function of MSCs Tom Levy, MD, JD
dramatically decrease as people age. Calcium: The Toxic Nutrient

Key points from the lecture: Dr Levy presented on the causes of, and neg-
-MSCs live on vascular beds throughout the ative effects of excess calcium in the body.
body.
-Decreased capillary beds due to decreased Key points from the lecture:
nutrients and other factors house less -The majority of people in the developed
MSCs. parts of the world experience body-wide ex-
55
ISOM News

cess of calcium, NOT deficiencies. Sulfate, which is implicated in various in-


-Excess calcium is toxic to the body and a flammatory neurological and autoimmune
factor in ALL chronic diseases. Causes of disorders.
calcium excess include intake from diet or -Treatment options that have proven effec-
supplements, and antioxidant deficiencies, tive at addressing adverse effects from the
especially vitamin C. vaccine include IV vitamin C, glutathione,
-Osteoporosis is focal scurvy of the bones. EDTA, and oral nutrients including EPA,
Vitamin C is required for the formation DHA, GLA, turmeric, and lipoic acid.
of collagen in the bones, stimulates bone-
building cells and inhibits bone-destroying Hyla Cass, MD
cells. Vitamin C is depleted by chronic in- The Addicted Brain and How to Break Free
flammation and body infections. Low levels
of antioxidants, especially vitamin C, favour Dr Cass discussed the imbalances and other
bone destruction. factors that can lead to addictions, as well as
-Chronic calcium loss from bone feeds a natural approaches for addressing them. She
corresponding excess of calcium elsewhere also reported on appropriate supplements
in the body. and nutrients and included dosing informa-
-Excess calcium promotes arterial calcifica- tion.
tion Calcifications are commonly seen in pa-
tients with cancer. Key points from the lecture
-Death from all causes is increased by elevated Steps for addressing mood and addiction is-
calcium intake from diet or supplements. sues:
-Rule out conditions that affect brain func-
Atsuo Yanagisawa, MD tion, including: food allergies, blood sugar is-
Orthomolecular Treatment for Girls with sues, adrenal and thyroid issues, sex hormone
Adverse Effects of Human Papilloma Virus imbalances, and stress.
(HPV) Vaccine -Incorporate lifestyle changes, for example
mind-body techniques, guided imagery and
Dr Yanagisawas presentation addressed the meditation.
negative effects of HPV vaccine and or- -Supplement with vitamins, minerals, amino
thomolecular steps to address them. The acids and herbs that help balance mood and
Japanese government suspended their rec- stop cravings. Natural mood elevators and
ommendation for inclusion in the vaccina- energizers include tyrosine and D,L-pheny-
tion schedule after just two months due to lalanine to support dopamine; and 5-HTP
the high amount of adverse events. and L-tryptophan to support serotonin.
-N-acetylcysteine has shown benefit in the
Key points from the lecture treatment of food, gambling, nicotine, co-
-Delayed onset symptoms can appear many caine and cannabis addiction at doses of
months after vaccination and may be due to 2,400 mg daily. 3
movement of vaccine particles to different
tissues over time. Symptoms include head- Benjamin Brown, ND
ache, muscle weakness and pain, dizziness, Brain Mitochondrial Metabolism and Psychi-
joint pain, hypersomnia, and memory loss. atric Illness
-Lab findings show, normal blood chemistry,
absence of inflammatory markers in blood, Dr Brown presented that brain mitochon-
increased proinflammatory cytokines in spi- dria are crucial forimportant aspects of brain
nal fluid, reduced brain blood flow, and high function and dysfunction of mitochondria
leukocyte sensitivity against aluminum. can contribute to neurodegenerative and
-The HPV vaccine contains the adjuvant psychiatric disorders. He also discussed nat-
Amorphous Aluminum Hydroxyphosphate ural ways to support mitochondria health.
56 Journal of Orthomolecular Medicine Vol 30, No 1, 2015

Key points from the lecture. Dr Hunninghake discussed the roles of oxi-
Key ways to support healthy brain mitochondria: dative factors and antioxidants in the out-
-Follow a natural-food-based diet high in comes of cancer patients, as well as the causes
phytonutrients. Phytonutrients support and effects of decreased oxygen utilization
neuroprotection, neurogenesis, and are as- and thyroid hormone dysregulation.
sociated with optimism, cognitive resilience,
and vigor. Key points from the lecture.
-Challenge the brain with calorie restriction. The low oxygen cycle.
Rodent models show restriction preserves -Low cellular oxygen decreases ATP gener-
mitochondrial energy production and neu- ated by the Krebs cycle. This results in de-
ronal activity4 creased production of antioxidant enzymes
The brain functions best when the individual which leads to increased mitochondrial
is hungry and physically active.5 injury. Mitochondrial injury causes cells to
-Following a ketogenic diet improves mito- shift from aerobic to anaerobic energy pro-
chondrial function, decreases apoptosis and duction and results in less CO2 output by
inflammation. Adding supplemental ketone cells. Decreased CO2 results in less displac-
bodies to a healthy diet may help achieve the ing of oxygen off hemoglobin and therefore
same effects. 6 decreased oxygen transport to cells.
-Include nutrients that support mitochon- -Increasing oxygen in the body therapeuti-
drial health, including acetyl-l-carnitine, cally helps reverse the cycle.
creatine, CoQ10, and fish oils. -Low oxygen is a factor in the development
and function of cancer cells.
Garry Vickar, MD Free T3 to reverse T3 ratio.
The Abram Hoffer I Knew -Free T3 (fT3) is a metabolic activator while
reverse T3 (rT3) is a metabolic retardant. fT3
Dr Vickar discussed his experiences growing and rT3 are made from T4 by different deio-
up with, and the influences Dr Abram Hoffer dinase enzymes. 5 deiodinase makes fT3 but
had on his decision to enter the field of psychi- is inhibited by stress, infection, starvation,
atry, and also outlined Dr Hoffers trials with inflammation and toxins (especially mer-
the conventional psychiatry establishment. cury, plastics, pesticides). -As fT3 decreases,
rT3 increases along with its retardant effects.
Key points from the lecture: The ideal target ratio of fT3:rT3 is 1821/1
-From early on in his career Dr Hoffer was as calculated using the formula: fT3 x 100 /
scrupulously honest and ethical, never add- rT3. The quickest way to address a low ratio
ing his name to a paper he had not materi- is to use small amounts of T3 along with nu-
ally contributed. trient support and detoxification.
Dr Hoffers thoughts on treating people:
-a diagnoses enables, not disables people, it Burt Berkson, MD, PhD
allows them to move forward Alpha-Lipoic Acids Effects on the Mitochon-
-the first step is decency, be respectful, hon- drion and Human Disease Modification
est, courteous, and ethical
- be non-judgemental, empathetic, convey a Dr Berkson presented on the many roles of
feeling of safety alpha-lipoic acid (ALA) in the body and
-do no harm some of its clinical applications including
-no one can treat a patient if theres not a liver disease and cancer. He also presented
sense of hope, expectation and trust documentations of dramatic successes with
cancer using non-standard cancer protocols.
Ron Hunninghake, MD
Thyroid Dysregulation and the Metabolic Roots Key points from the lecture.
of Cancer -Key actions of ALA include scavenging free
57
ISOM News

radicals, recycling antioxidants, enhancing nalism is a steady stream of irresponsible


insulin sensitivity, chelating heavy metals, distortions that most people find refresh-
stimulating organ regeneration and generat- ing.
ing glutathione. Three steps of EBM:
-ALA production by the body dramatically -obtain and analyze the most reliable, bias-
decreases as people age. free scientific evidence
-ALA pushes anaerobic cell metabolism -determine the relevance of the evidence to
into aerobic cell metabolism by inhibiting the situation of the patient
the enzyme pyruvate dehydrogenase kinase -coordinate treatment with regards to the
(PDK). Inhibiiting PDK results in pyruvate patients preferences
being directed into the Krebs Cycle over
conversion to lactate. Aileen Burford Mason, PhD
-Therapeutic doses of IV ALA promote liver Orthomolecular Cardiology: Unmasking the
regeneration.7 Magnesium Link to Multiple Cardiovascular
-ALA disrupts tumour metabolism, which Risk Factors
induces cell death by apoptosis and necrosis,8
and stimulates apoptosis in human breast Dr Burford Mason discussed several important
cancer cells,9 and lung cancer cells,10 and he- roles of magnesium in cardiovascular health
patocellular carcinoma cells. 11 and the dangers of magnesium deficiency.

John Hoffer, MD, PhD Key points from the lecture:


Principles and Practice of Evidence-based Or- -Cardiovascular symptoms of magnesium
thomolecular Medicine deficiency include arrhythmias and atrial fi-
brillation, palpitations, and increased blood
Dr Hoffer discussed the the merits of Evi- pressure.
dence Based Medicine (EBM) and steps for -As the ratio of calcium to magnesium in-
using it in practice. He also addressed the creases the death rate from heart disease in-
important limitation of EBM bias. creases.13
-Calcium supplementation can be danger-
Key points from the lecture ous. A study on older women supplementing
Some types of bias in clinical investigation 1000 mg of calcium showed increased risk
include: of myocardial infarction, stroke, and sudden
-Technically avoidable bias such as poor death.14
quality trial design, flawed execution, and -Magnesium intake decreases coronary ar-
biased reporting of results tery calcification.15
-Cheating -Magnesium helps regulate cholesterol.
-Reporting bias, for example only publishing Magnesium deficiency results in insufficient
postitive trial results. An article in JAMA Mg-ATP available to deactivate HMG-
Psychiatry 2015 reported that the vast ma- CoA reductase (the rate-limiting enzyme
jority of positive trials were publshed while in cholesterol production), which results in
the majority of not-postive trials not pub- sustained cholesterol production.16
lished.12 -The daily adult requirement (DRI) for mag-
-Fundamentalist/fanatical bias, for example nesium is 300-450 mg. The average intake in
stating theres no evidence when evidence North America is around 200 mg.
exists -Magnesium deficiency is best detected by
-Flight-of-fancy bias drawing conclu- examining functional signs and symptoms.
sions based on relevant but insufficient evi-
dence someone reported it in a test tube Benjamin Brown, ND
and 3 mice, so its got to work for all people Healing the Heart with Food and Food Bioac-
-Thoughts on Media based medicine: Jour- tives
58 Journal of Orthomolecular Medicine Vol 30, No 1, 2015

Dr Brown presented key dietary measures be deduced when patients dont respond to
that have been shown to reverse coronary iodine supplementation, have adverse effects
heart disease. from supplementation, or have very high io-
dide excretion on iodine loading test.
Key points from the lecture -Defects can be addressed by countering
Lifestyle changes for cardiovascular health: oxidative damage with antioxidants, detoxi-
-Follow a Mediterranean Diet. The benefit fication, and the inclusion of iodine and salt
of the diet does not seem to come from the to competitively inhibit goitrogen uptake.
specific foods, but rather from the synergistic -Delta-Iodolactone is created from iodine
effect of the whole diet.17 A Mediterranean and arachidonic acid and is a key regulator
diet supplemented with walnuts or olive oil of apoptosis and cellular proliferation in the
decreased cardiovascular events by 30%.18 thyroid. It is only present with iodine ad-
-Reduce Advanced Glycation Endproducts ministration at 100 times the RDA (RDA is
(AGEs). AGEs are formed by high-temper- 150 micrograms for adults).25
ature cooking, especially frying, baking and
roasting. AGEs in the blood after a meal can James Greenblatt, MD
impair macro and microvascular function. A Lithium in the Treatment of Mood and Mem-
low-AGE diet decreases inflammation and ory Disorders
oxidative stress.19
-Address Diet-Induced Acidosis. Diet- Dr Greenblatt discussed the use of pharma-
induced acidosis has clinical relevance.20 ceutical lithium and its health risks, the roles
A higher dietary acid load increases blood of lithium in the brain, and benefits of nutri-
pressure and LDL-cholesterol.21 tional lithium.
Other beneficial actions:
-Decrease calorie intake enough to decrease Key points from the lecture:
weight without causing malnutrition. Calo- -Examination of tap water lithium content
rie restriction protects against endothelial shows suicide rate and mortality are inverse-
dysfunction and stiffness.22 ly associated with lithium levels.
-Increase dietary polyphenols. Polyphenols -Lithium reduces brain inflammation, pos-
protect against arterial inflammation.23 sibly by increasing formation of the anti-in-
-Consume nitrate from plant-based foods. flammatory resolvin 17-hydroxy-DHA.26
Dietary nitrate lowers diastolic blood pres- -Lithium decreases dopamine sythesis, re-
sure.24 lease, and effects at the postsynaptic recep-
tor.
David Brownstein, MD -Lithium decreases the activity of glutamate,
A Holistic Approach to Iodine Deficiency which is excitatory in the brain.
-Lithium stimulates GABA production and
Dr Brownstein discussed the key functions release and upregulates GABA receptors
and therapeutic actions of iodine, along with -Lithium may reduce risk and progression of
reasons for deficiencies and the impact defi- Alzheimers Disease. Tau and beta amyloid
ciencies have on health. production is a factor in neurotoxicity and
cell damage. The enzyme glycogen synthase
Key points from the lecture: kinase-3 (GSK-3) stimulates tau and beta
-Defects with the sodium/iodide symporter amyloid production. Lithium inhibits the
decrease iodine uptake by the thyroid. action of GSK-3.
-The main causes of the defects include oxi- -Lithium may help restore neurogenisis in
dative damage from fluoride and perchlo- cancer patients with neurocognitive impair-
rate, and inhibition of iodide by competition ment due to chemotherapy 27
with bromine. -A common form of nutritional lithium is
-Defective function of the symporters can lithium orotate.
59
ISOM News

Jonathan Prousky, ND, MSc References


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