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Inaugurated in 2004, the Orthomolecular Medicine Hall of Fame recognizes the achieve-
ments of pioneers and leaders in the advancement of Orthomolecular Medicine. On Saturday,
April 25, during the Orthomolecular Medicine Today Conference, four new members were
inducted, bringing the total number in the Hall of Fame to sixty-four Pictured above from
left to right: Aileen Burford-Mason, L. John Hoffer and Hyla Cass.
Irwin Kahan 1919-2015 create, with very few resources and in a hos-
tile psychiatric community, a new organiza-
Irwin Kahan was born on a Saskatch- tion dedicated to improving the lives of peo-
ewan farm in 1919. After serving with the ple with schizophrenia. In this endeavour, he
Royal Canadian Air Force during World worked closely with his wife Fannie Kahan,
War II, he graduated from McGill Univer- Abram Hoffer, other CSF board members,
sity with a social work degree. and a large crew of volunteers from branches
In the 1950s, Irwin was an integral which he had established across Canada. In
member of the research team, headed by Dr. 1975, the Academy of Orthomolecular Psy-
Abram Hoffer, that provided the foundation chiatry elected Irwin as an honorary member
for the orthomolecular medicine approach. in recognition of meritorious contributions
Later, as Executive Director of the Saskatch- to Orthomolecular Psychiatry.
ewan Division, Canadian Mental Health Irwins approach was multi-pronged, fo-
Association, for over a decade he advocated cusing on: assisting people at the grassroots
fiercely for the adoption of orthomolecular level; policy and advocacy at the government
treatment. level; media communications to promote
In 1968, Irwin became the founding di- widespread public understanding of schizo-
rector of the Schizophrenia Foundation of phrenia and the orthomolecular approach;
Saskatchewan, and shortly afterwards the and raising professionals knowledge regard-
founding executive director of the Canadian ing orthomolecular practice.
Schizophrenia Foundation (now the Inter- Irwin is the author of the memoir Tend-
national Schizophrenia Foundation). With ing the Tree of Life (Wild Sage Press, 2015),
passion and dedication, Irwin worked hard to which includes some of his orthomolecular
52 Journal of Orthomolecular Medicine Vol 30, No 1, 2015
and the public. Aileen serves on the editorial and hormones, weight management, and
board of the Journal of Orthomolecular Medi- natural treatments for addiction, anxiety dis-
cine and is a member of the core faculty of orders, and depression. Audiences include
the Orthomolecular Medicine Today Con- the American College for Advancement in
ference. She is currently working on a new Medicine, the International Society for Or-
book to be published by Harper Collins in thomolecular Medicine, and The American
spring 2017. Academy of Anti-Aging Medicine (A4M).
Born in Toronto, Canada, Hyla obtained
her pre-medical and medical education from
the University of Toronto School of Medi-
Hyla Cass cine, interned at LAC-USC Medical Cen-
Hyla Cass MD is an internationally ac- ter, then completed her residency training at
claimed psychiatrist and one of the our fore- Cedars-Sinai Medical Center, Los Angeles,
most experts and pioneers in integrative med- where she then served as an attending staff
icine. Combining the best of natural medicine physician for 10 years.
with modern science in her clinical practice An Assistant Clinical Professor of Psy-
for over 30 years, and in writings, lectures, chiatry at UCLA School of Medicine for 20
and media appearances, shes certified by the years, Board Member and Chair of Vitamin
American Board of Psychiatry and Neurol- Relief USA, providing at-risk children, teens,
ogy (ABPN), as well the American Board of seniors and adults with daily multiple vitamins
Holistic Integrative Medicine (ABIHM). across the U.S, she also is a Board Member of
She is the author of a number of popu- the American College for Advancement in
lar books including St. Johns Wort: Natures Medicine (ACAM), Advisory Board member
Blues Buster; Kava: Natures Answer to Stress, at Taste for Life Magazine and Medical Edi-
Anxiety and Insomnia; Natural Highs; Sup- tor at Total Health Magazine.
plement Your Prescription; 8 Weeks to Vibrant Most recently she serves on the Board of
Health; and The Addicted Brain and How to Governors of the Placencia Health Group,
Break Free. which is creating a Medical Free Zone in
Dr. Cass also speaks to professional Belize, while maintaining the highest scien-
and lay audiences on topics ranging from tific, professional and ethical standards, with
complementary medicine and psychiatry, an innovative World Center for Anti-Aging
longevity enhancement, womens health Medicine and Clinical Therapies.
54 Journal of Orthomolecular Medicine Vol 30, No 1, 2015
Key points from the lecture: Dr Levy presented on the causes of, and neg-
-MSCs live on vascular beds throughout the ative effects of excess calcium in the body.
body.
-Decreased capillary beds due to decreased Key points from the lecture:
nutrients and other factors house less -The majority of people in the developed
MSCs. parts of the world experience body-wide ex-
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ISOM News
Key points from the lecture. Dr Hunninghake discussed the roles of oxi-
Key ways to support healthy brain mitochondria: dative factors and antioxidants in the out-
-Follow a natural-food-based diet high in comes of cancer patients, as well as the causes
phytonutrients. Phytonutrients support and effects of decreased oxygen utilization
neuroprotection, neurogenesis, and are as- and thyroid hormone dysregulation.
sociated with optimism, cognitive resilience,
and vigor. Key points from the lecture.
-Challenge the brain with calorie restriction. The low oxygen cycle.
Rodent models show restriction preserves -Low cellular oxygen decreases ATP gener-
mitochondrial energy production and neu- ated by the Krebs cycle. This results in de-
ronal activity4 creased production of antioxidant enzymes
The brain functions best when the individual which leads to increased mitochondrial
is hungry and physically active.5 injury. Mitochondrial injury causes cells to
-Following a ketogenic diet improves mito- shift from aerobic to anaerobic energy pro-
chondrial function, decreases apoptosis and duction and results in less CO2 output by
inflammation. Adding supplemental ketone cells. Decreased CO2 results in less displac-
bodies to a healthy diet may help achieve the ing of oxygen off hemoglobin and therefore
same effects. 6 decreased oxygen transport to cells.
-Include nutrients that support mitochon- -Increasing oxygen in the body therapeuti-
drial health, including acetyl-l-carnitine, cally helps reverse the cycle.
creatine, CoQ10, and fish oils. -Low oxygen is a factor in the development
and function of cancer cells.
Garry Vickar, MD Free T3 to reverse T3 ratio.
The Abram Hoffer I Knew -Free T3 (fT3) is a metabolic activator while
reverse T3 (rT3) is a metabolic retardant. fT3
Dr Vickar discussed his experiences growing and rT3 are made from T4 by different deio-
up with, and the influences Dr Abram Hoffer dinase enzymes. 5 deiodinase makes fT3 but
had on his decision to enter the field of psychi- is inhibited by stress, infection, starvation,
atry, and also outlined Dr Hoffers trials with inflammation and toxins (especially mer-
the conventional psychiatry establishment. cury, plastics, pesticides). -As fT3 decreases,
rT3 increases along with its retardant effects.
Key points from the lecture: The ideal target ratio of fT3:rT3 is 1821/1
-From early on in his career Dr Hoffer was as calculated using the formula: fT3 x 100 /
scrupulously honest and ethical, never add- rT3. The quickest way to address a low ratio
ing his name to a paper he had not materi- is to use small amounts of T3 along with nu-
ally contributed. trient support and detoxification.
Dr Hoffers thoughts on treating people:
-a diagnoses enables, not disables people, it Burt Berkson, MD, PhD
allows them to move forward Alpha-Lipoic Acids Effects on the Mitochon-
-the first step is decency, be respectful, hon- drion and Human Disease Modification
est, courteous, and ethical
- be non-judgemental, empathetic, convey a Dr Berkson presented on the many roles of
feeling of safety alpha-lipoic acid (ALA) in the body and
-do no harm some of its clinical applications including
-no one can treat a patient if theres not a liver disease and cancer. He also presented
sense of hope, expectation and trust documentations of dramatic successes with
cancer using non-standard cancer protocols.
Ron Hunninghake, MD
Thyroid Dysregulation and the Metabolic Roots Key points from the lecture.
of Cancer -Key actions of ALA include scavenging free
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ISOM News
Dr Brown presented key dietary measures be deduced when patients dont respond to
that have been shown to reverse coronary iodine supplementation, have adverse effects
heart disease. from supplementation, or have very high io-
dide excretion on iodine loading test.
Key points from the lecture -Defects can be addressed by countering
Lifestyle changes for cardiovascular health: oxidative damage with antioxidants, detoxi-
-Follow a Mediterranean Diet. The benefit fication, and the inclusion of iodine and salt
of the diet does not seem to come from the to competitively inhibit goitrogen uptake.
specific foods, but rather from the synergistic -Delta-Iodolactone is created from iodine
effect of the whole diet.17 A Mediterranean and arachidonic acid and is a key regulator
diet supplemented with walnuts or olive oil of apoptosis and cellular proliferation in the
decreased cardiovascular events by 30%.18 thyroid. It is only present with iodine ad-
-Reduce Advanced Glycation Endproducts ministration at 100 times the RDA (RDA is
(AGEs). AGEs are formed by high-temper- 150 micrograms for adults).25
ature cooking, especially frying, baking and
roasting. AGEs in the blood after a meal can James Greenblatt, MD
impair macro and microvascular function. A Lithium in the Treatment of Mood and Mem-
low-AGE diet decreases inflammation and ory Disorders
oxidative stress.19
-Address Diet-Induced Acidosis. Diet- Dr Greenblatt discussed the use of pharma-
induced acidosis has clinical relevance.20 ceutical lithium and its health risks, the roles
A higher dietary acid load increases blood of lithium in the brain, and benefits of nutri-
pressure and LDL-cholesterol.21 tional lithium.
Other beneficial actions:
-Decrease calorie intake enough to decrease Key points from the lecture:
weight without causing malnutrition. Calo- -Examination of tap water lithium content
rie restriction protects against endothelial shows suicide rate and mortality are inverse-
dysfunction and stiffness.22 ly associated with lithium levels.
-Increase dietary polyphenols. Polyphenols -Lithium reduces brain inflammation, pos-
protect against arterial inflammation.23 sibly by increasing formation of the anti-in-
-Consume nitrate from plant-based foods. flammatory resolvin 17-hydroxy-DHA.26
Dietary nitrate lowers diastolic blood pres- -Lithium decreases dopamine sythesis, re-
sure.24 lease, and effects at the postsynaptic recep-
tor.
David Brownstein, MD -Lithium decreases the activity of glutamate,
A Holistic Approach to Iodine Deficiency which is excitatory in the brain.
-Lithium stimulates GABA production and
Dr Brownstein discussed the key functions release and upregulates GABA receptors
and therapeutic actions of iodine, along with -Lithium may reduce risk and progression of
reasons for deficiencies and the impact defi- Alzheimers Disease. Tau and beta amyloid
ciencies have on health. production is a factor in neurotoxicity and
cell damage. The enzyme glycogen synthase
Key points from the lecture: kinase-3 (GSK-3) stimulates tau and beta
-Defects with the sodium/iodide symporter amyloid production. Lithium inhibits the
decrease iodine uptake by the thyroid. action of GSK-3.
-The main causes of the defects include oxi- -Lithium may help restore neurogenisis in
dative damage from fluoride and perchlo- cancer patients with neurocognitive impair-
rate, and inhibition of iodide by competition ment due to chemotherapy 27
with bromine. -A common form of nutritional lithium is
-Defective function of the symporters can lithium orotate.
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ISOM News
16. Rosanoff A, Seelig MS: Comparison of mecha- Br J Nutr, 2008; 100: 642-651.
nism and functional effects of magnesium and 22. Weiss EP, Fontana L: Caloric restriction: powerful
statin pharmaceuticals. J Am Coll Nutr, 2004; 5: protection for the aging heart and vasculature. Am
501S-505S J Physiol Heart Circ Physiol, 2011; 301: 1205-1219
17. Corella D, Carrasco P, Sorli JV, et al: Mediter- 23. Tangney C, Raumussen H: Polyphenols, Inflam-
ranean diet reduces the adverse effect of the TC- mation, and Cardiovascular Disease. Curr Athero-
F7L2rs7903145 polymorphism on the cardiovas- scler Rep, 2013; 15: 324.
cular risk factors and stroke incidence. Diabetes 24. Sobko T1, Marcus C, Govoni M, et al: Dietary ni-
Care, 2013; 36: 3803-3811 trate in Japanese traditional foods lowers diastolic
18. Estruch R, Ros E, Salas-Salvad J, et al: Primary blood pressure in healthy volunteers. Nitric Oxide.
prevention of cardiovascular disease with a Medi- 2010; 22: 136-140.
terranean diet. N Engl J Med, 2013; 368: 1279- 25. Dugrillon A, Uedelhoven WM, Pisarev MA, et
1290. al: Identification of delta-iodolactone in iodide
19. Luvano-Contreras C, Garay-Sevilla ME, Wrobel treated human goiter and its inhibitory effect on
K, et al: Dietary advanced glycation end products proliferation of human thyroid follicles. Horm
restriction diminishes inflammation markers and Metab Res, 1994; 26: 465-469
oxidative stress in patients with type 2 diabetes 26. Basselin M, Kim HW, Chen M, et al: Lithium
mellitus. J Clin Biochem Nutr, 2013; 52: 22-26 modifies brain arachidonic and docosahexaenoic
20. Omodei D, Fontana L: Calorie restriction and metabolism in rat lipopolysaccharide model of
prevention of age-associated chronic disease. neuroinflammation. J Lipid Res, 2010; 51: 1049
FEBS Lett, 2011; 585: 1537-1542. 1056.
21. Murakami K, Sasaki S, Takahahi Y, et al: Asso- 27. Khasraw M, Ashley D, Wheeler G, et al: Using
ciation between dietary acid-base load and cardio- lithium as a neuroprotective agent in patients with
metabolic risk factors in young Japanese women. cancer. BMC Medicine, 2012; 10: 131.