Autoimmune Diseases and Conditions - Guillain-

Barre Syndrome; Studies from Vanderbilt

University in the Area of Guillain-Barre
Syndrome Described (Ipilimumab-induced
Guillain-Barre Syndrome Presenting as
Dysautonomia: An Unusual Presentation of a
Rare Complication of Immunotherapy)
Publication info: Immunotherapy Weekly ; Atlanta (Jun 7, 2017): 1370.

ProQuest document link

ABSTRACT (ENGLISH)
According to news originating from Nashville, Tennessee, by NewsRx correspondents, research stated, "Immune-
related adverse events are common and welldocumented in patients treated with ipilimumab, a cytotoxic T-
lymphocyte antigen-4 monoclonal antibody approved for the treatment of metastatic and stage III melanoma.
According to the news editors, the research concluded: "Given the...

FULL TEXT
2017 JUN 7 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Current study results
on Autoimmune Diseases and Conditions - Guillain-Barre Syndrome have been published. According to news
originating from Nashville, Tennessee, by NewsRx correspondents, research stated, "Immune-related adverse
events are common and welldocumented in patients treated with ipilimumab, a cytotoxic T-lymphocyte antigen-4
monoclonal antibody approved for the treatment of metastatic and stage III melanoma. Neurological
complications are rare, but widely variable and potentially devastating."

Our news journalists obtained a quote from the research from Vanderbilt University, "Here, we discuss a case of a
patient who was treated with a single dose of ipilimumab for resected stage III melanoma. She subsequently
developed pandysautonomia that manifested as a tonically dilated pupil, gastrointestinal dysmotility, urinary
retention, and profound orthostatic hypotension. Guillain-Barre syndrome was diagnosed on electromyography.
She was treated with intravenous immunoglobulin, droxidopa, and supportive care, with prolonged but eventual
recovery."

According to the news editors, the research concluded: "Given the broadening use of ipilimumab in the treatment
of advanced and metastatic melanoma, awareness and recognition of its profound immune-mediated adverse
effects are essential."

For more information on this research see: Ipilimumab-induced Guillain-Barre Syndrome Presenting as
Dysautonomia: An Unusual Presentation of a Rare Complication of Immunotherapy. Journal of Immunotherapy,
2017;40(5):196-199. Journal of Immunotherapy can be contacted at: Lippincott Williams &Wilkins, Two Commerce
Sq, 2001 Market St, Philadelphia, PA 19103, USA. (Lippincott Williams and Wilkins - www.lww.com; Journal of
Immunotherapy - journals.lww.com/immunotherapy-journal/pages/default.aspx)

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The news correspondents report that additional information may be obtained from W.K. Wu, Vanderbilt University,
Sch Med, Nashville, TN 37232, United States. Additional authors for this research include K.K. Broman, E.R.
Brownie and R.M. Kauffmann.

Keywords for this news article include: Nashville, Tennessee, United States, North and Central America, Autonomic
Nervous System Diseases and Conditions, Immunology, Autoimmune Diseases and Conditions of the Nervous
System, Peripheral Nervous System Diseases and Conditions, Neuromuscular Diseases and Conditions,
Demyelinating Diseases and Conditions, Guillain-Barre Syndrome, Guillain-Barre Syndrome,
Polyradiculoneuropathy, Drugs and Therapies, Polyneuropathies, Immunotherapy, Oncology, Melanoma, Vanderbilt
University.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx
LLC

DETAILS

Subject: Metastasis; Immunotherapy; Neurological disorders; Autoimmune diseases; Guillain-

Barre syndrome; Nervous system; Melanoma; Neuromuscular diseases;
Dysautonomia

Location: United States--US Nashville Tennessee Tennessee Central America

Company / organization: Name: Lippincott Williams &Wilkins; NAICS: 511120; Name: Vanderbilt University;
NAICS: 611310

Identifier / keyword: City:Nashville State:Tennessee Country:United States Region:North and Central

America Autonomic Nervous System Diseases and Conditions Immunology
Autoimmune Diseases and Conditions of the Nervous System Peripheral Nervous
System Diseases and Conditions Neuromuscular Diseases and Conditions
Demyelinating Diseases and Conditions Guillain-Barre Syndrome Guillain-Barre
Syndrome Polyradiculoneuropathy Drugs and Therapies Polyneuropathies
Immunotherapy Oncology Melanoma

Publication title: Immunotherapy Weekly; Atlanta

First page: 1370

Publication year: 2017

Publication date: Jun 7, 2017

Publisher: NewsRx

Place of publication: Atlanta

Country of publication: United States

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 Publication subject: Medical Sciences--Allergology And Immunology

ISSN: 10908625

Source type: Trade Journals

Language of publication: English

Document type: Expanded Reporting

ProQuest document ID: 1904602534

Document URL: https://search.proquest.com/docview/1904602534?accountid=33171

Copyright: Copyright 2017, NewsRx LLC

Last updated: 2017-06-01

Database: Biological Science Database

Copyright 2017 ProQuest LLC. All rights reserved.

Terms and Conditions Contact ProQuest

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