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  • HIV-1 &amp AIDS

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    AyioKun
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    This document discusses HIV-1 and AIDS. It begins by describing retroviruses and their life cycle. HIV-1 is classified as a lentivirus. The document then covers the history of HIV/AIDS, describing its initial appearances, recognition as a new syndrome, and identification as caused by a virus. It also discusses treatments and vaccine efforts. The molecular biology of HIV-1 is explained through its retroviral life cycle. Finally, the document covers HIV-1 pathology, transmission routes, and the structure and proteins of the HIV-1 genome.

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    HIV-1 & AIDS

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    This document discusses HIV-1 and AIDS. It begins by describing retroviruses and their life cycle. HIV-1 is classified as a lentivirus. The document then covers the history of HIV/AIDS, describing its initial appearances, recognition as a new syndrome, and identification as caused by a virus. It also discusses treatments and vaccine efforts. The molecular biology of HIV-1 is explained through its retroviral life cycle. Finally, the document covers HIV-1 pathology, transmission routes, and the structure and proteins of the HIV-1 genome.

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    Attribution Non-Commercial (BY-NC)
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    15 Ansichten2 Seiten

    HIV-1 &amp AIDS

    Hochgeladen von

    AyioKun
    This document discusses HIV-1 and AIDS. It begins by describing retroviruses and their life cycle. HIV-1 is classified as a lentivirus. The document then covers the history of HIV/AIDS, describing its initial appearances, recognition as a new syndrome, and identification as caused by a virus. It also discusses treatments and vaccine efforts. The molecular biology of HIV-1 is explained through its retroviral life cycle. Finally, the document covers HIV-1 pathology, transmission routes, and the structure and proteins of the HIV-1 genome.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Als PDF, TXT herunterladen oder online auf Scribd lesen
    Markieren Sie unangemessene Inhalte
    von 2

    HIV-1 AND AIDS

    I. RETROVIRUSES--RETROVIRIDAE
    A. MORPHOLOGY
    B. LIFE CYCLE
    1. GENOMIC RNA --> dsDNA
    2. dsDNA --> HOST GENOME
    3. HOST GENOME --> mRNA (GENOMIC RNA)
    C. CLASSIFICATION BY GENERA
    1. Alpharetrovirus (ALV,RSV) ONCORNAVIRUSES
    2. Betaretovirus (MMTV, MPMV) |
    3. Gammaretovirus (MLV, FeLV) |
    4. Deltaretrovirus (BLV, PTLV) |
    5. Epsilonretrovir (WDSV) ↓

    6. SPUMAVIRUS (HUMAN, SIMIAN, FELINE FOAMY V)


    7. LENTIVIRUS
    a. PRIMATE (SIV, HIV-1, HIV-2)
    b. VISNA
    c. EIAV, FIV, BIV
    II. HISTORY
    A. FIRST APPEARANCES
    B. FIRST RECOGNIZED - A NEW SYNDROME
    C. VIRAL ETIOLOGY
    1. ANTIGENS PRODUCED--TESTS-ELISA & WESTERN BLOT
    2. SEQUENCED
    3. MOLECULAR BIOLOGY
    D TREATMENTS--AZT, ddI, ddC & PROTEASE INHIITORS (11 DRUGS)
    E. VACCINES--MANY TRIALS UNDERWAY (OR COMPLETED)
    III. MOLECULAR BIOLOGY OF HIV-1
    A. RETROVIRUS LIFE CYCLE
    1. INFECTION
    2. UNCOATING
    3. REVERSE TRANSCRIPTION
    4. INTEGRATION
    5. LATENCY
    6. TRANSCRIPTION
    7. GENE EXPRESSION--SPLICING
    8. tat & rev GENES, ETC.
    9. ASSEMBLY
    10. EXIT
    IV. PATHOLOGY
    A. INITIAL INFECTION
    B. LATENCY
    C. ARC
    D. AIDS
    E. STAGING--WALTER REED & CDC
    V. TRANSMISSION
    A. SEXUAL
    B. INTRAVENOUS DRUG USE
    C. BIRTH--PERINATAL

    THE HIV-1 GENOME**


    Cap TAR pA PBS(181-200) DIS(~260) SD(~290) ϕ(~315) AUG(336)
    R(1-97) U5(98-181)
    RRE
    R U5 | U3 R
    5’cap-----------------------------------------------------------An 3’
    gag pol env
    |MA-CA-NC-p6-p1-p2|PR-RT-IN| | gp120-gp41 |
    vif nef
    vpr
    vpu
    tat: -- -
    rev: - ---

    **TAR-Tat binding, PBS-primer binding, DIS-dimer init. site


    ,SD-splice donor, ϕ−packing, AUG-start of gag, RRE-Rev binding

    HIV-1 PROTEINS
    PROTEIN MAP(N) SIZE(KD) FUNCTION
    MA 336 18 Matrix protein

    CA 732 24 Capsid or Core protein

    P2 1425 2 ??

    NC 1467 17 Nucleocapsid, binds ϕ & primer tRNA

    P1 1632 1 ??

    P6 1680 6 Interacts with Vpr

    PR 1799 10 Proteinase

    RT 2096 66/51 Reverse transcriptase-RNAse H

    IN 3776 31 Integrase

    Gp120 5855 120 Spike or Surface protein (SU)


    Gp41 7304 41 Transmembrane protein (TM)

    Tat 5377 16 Binds to TAR, Promotes transcription


    of unspliced mRNAs.

    Rev 5516 19 Binds to RRE, Transport of mRNAs

    Vif 5487 23 Viral infectivity factor; a late


    function, maturation ?

    Vpr 5105 14 Nuclear protein, function unclear,


    Blocks cell cycle in S or G2

    Vpu 5608 16 Late function, viral release ?

    Nef 8343 27 (3’-orf) Down regulation of CD4

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