Beruflich Dokumente
Kultur Dokumente
BRACHYTHERAPY
Sergey Akulinichev and Vasily Derzhiev
Institute for nuclear research of RAS (INR),
Moscow and Troitsk, Russia
Preliminary schedule of the talk:
3. Conclusions
Medical applications of ytterbium
sources
In HDR Brachytherapy only 1 source of 6-20 Ci is short-
time inserted via several (or one) catheters .
Usual isotopes: Co-60, Ir-192 or Yb-169.
Main localizations: prostate, breast, lung (possibly-
vascular system).
Why ytterbium?
Soft spectrum compared to Co-60 and Ir-192 ( ~ 92 KeV ),
Reduced dose to normal tissue and easier shielding,
High radioactivity - up to 6 Ci / mg for pure Yb-169
(only 0.6 Ci/ mg for Ir-192),
Half-life 32 days.
easy shielding:
2. Source production using laser technology
3 steps:
1) Enrichment of initial isotope Yb-168
(AVLIS : Atomic Vapor Laser Isotope Separation),
ais
Design of AVLIS facility:
= 582.79 nm
|3> = 4f13(2F7/2)6s26p(7/2,3/2)2
copper vapor lasers
120W
= 581.067 nm
3 Dye laser
|2> = 4f136s6p3P1
system
ms
= 555.648 nm
Vacuum
Chamber Control |1> = 4f136s2 1S0
With system
extractor cooling
system
3-step cascade of photo-ionization of
Yb-168 (ais-auto ionization state)
The vacuum chamber with evaporator and extractor
(the unique and most complicated part of the facility)
Symmetry
x axis
Zone of collector
selective
ionization
gap
a
Vapor
source diaphragm
y
Some methods of isotope enrichment
laser photo-ionization
centrifuges
IA VIII B
1 2
H He
II A III A IV A V A VI A VII A
3 4 5 6 7 8 9 10
Li Be B C N O F Ne
11 12 13 14 15 16 17 18
Na Mg Al Si P S Cl Ar
III B IV B V B VI B VII B VIII I B II B
19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36
K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr
37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54
Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe
55 56 57 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86
Cs Ba La Hf Ta W Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn
Lanthanide 58 59 60 61 62 63 64 65 66 67 68 69 70 71
Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu
series
90 91 92 93 94 95 96 97 98 99 100 101 102 103
Actinide series Th Pa U Np Pu Am Cm Bk Cf Es Fm Md No Lr
Parameters of 3- Channel Dye - Laser System for AVLIS of Ytterbium
Nano-granules of ytterbium
inner capsule
The inner capsule irradiation by secondary neutrons
on INR proton linac
Measured Ytterbium Spectrum
450000
400000
350000
Number of Photons
300000
250000
200000
150000
100000
50000
0
10 47 85 122 160 197 234 272 309 347 384
Ene rgy, ke V