Enzymes available from Sigma Enzymes available from Sigma Enzymes available from Sigma

OXIDOREDUCTASES CONH 2 COO 2.7.1.15 Ribokinase

1.1.1.1 Alcohol dehydrogenase
HYALURONIC ACID DERMATAN BLOOD GROUP ALGINATES O-ANTIGENS STARCH GLYCOGEN + O O COO 2.7.1.16 Ribulokinase
P GLYCOPROTEINS + O O
N
1.1.1.3 Homoserine dehydrogenase
SUBSTANCES CH2COO OH N
Ribose -O - P - O - P - O- Adenosine(P) Ribose - O - P - O - P - O -Adenosine + NICOTINATE COO COO 2.7.1.17 Xylulokinase
1.1.1.8 Glycerol-3-phosphate dehydrogenase
O GANGLIOSIDES PEPTIDO- CH2OH CH2OH N
.11
+ COO
2.7.1.19 Phosphoribulokinase

GLYCAN CH OHCHITIN CHONDROITIN PECTIN INULIN CELLULOSE 2.4.2

1.1.1.9 D-Xylulose reductase NH O O N RP 2.7.1.24 Dephospho-CoA kinase
MUCINS O O
Indoleacetate
NH O O
6.3.5.1
Ribose- P N
L 2.7.7.18 2.7.1.25 Adenylylsulfate kinase
1.1.1.10 l-Xylulose reductase
2
O
HO Indoxyl NAD(P) +
Desamino-NAD Nicotinate- Quinolinate- A 2.7.1.28 Triokinase
1.1.1.14 l-Iditol dehydrogenase O O (Auxin) 6.3.1.5 2.4.2.19
Y O O 1.1.1.132
1.1.1.19 Glucuronate reductase CHOH COO - 2.4.1.68 HO CH3
OH OH OH nucleotide nucleotide R
2.7.1.30 Glycerol kinase
1.1.1.21 Aldehyde reductase AcNH COO - 6.3.2.7-10 2.4.1.69 1.2.3.7 2.4.2.19 2.7.1.31 Glycerate kinase
S
CHOH O
1.1.1.22 UDPglucose dehydrogenase CH2OH
OPC
2.4.99.7 6.3.2.13 HO O OPPU
2.4.1.17
HO OH OPPU CH3
OPPT
2.4.1.29
OH
LACTOSE
OH
HO
+
CH2CH(NH3)COO HO CH 2CH2NH 2 HO CH2CH2NHCOCH 3 CH3O CH 2CH2NHCOCH 3 COO O 2.7.1.32
2.7.1.33
Choline kinase
Pantothenate kinase
A
1.1.1.23 Histidinol dehydrogenase CH3CH OH OH CH2CHO
1.1.1.25 Shikimate dehydrogenase
NHAC
UDP-
OH
HO HO OPPG
GDP- TDP-Rhamnose CH2OH NH NH NH NH N
COO
M 2.7.1.34 Pantetheine kinase

C 2.4.1.21
5-Hydroxytryptamine 2.3.1.5 N-Acetyl-serotonin
1.1.1.27 Lactate dehydrogenase COO- O 4.1.1.28 2.1.1.4 2.7.1.36 Mevalonate kinase
HO
UDP-N-Ac-Muramate Iduronate OH 2.4.1.1 2.4.1.11 HO
NH NH
5-Hydroxy- N-Acetyl-5-O-methyl-serotonin Quinolinate A
1.1.1.29 Glycerate dehydrogenase
Mannuronate CH3 etc. 3.2.1.23 Indole- Indole tryptophan (SEROTONIN) (MELATONIN)
2.7.1.39 Homoserine kinase
1.1.1.30
1.1.1.31
3-Hydroxybutyrate dehydrogenase
3-Hydroxyisobutyrate dehydrogenase
C CMP-N-Acetyl GDP-Fucose O 2.4.1.21
OH OH 2.7.1.38 acetaldehyde 1.14.16.4 T
2.7.1.40
2.7 1.47
Pyruvate kinase
D-Ribulokinase
1.1.1.32
1.1.1.34
Mevaldate reductase
Hydroxymethylglutaryl-CoA reductase (NADPH)
H neuraminate
HO
CH2OH
O COO 5.1.3.12
CH2OH
O
5.1.3.13 O
OH OPPT OH 4.1.1.43 +
+
COO I 2.7.1.53
2.7.1.60
l-Xylulokinase
N-Acylmannosamine kinase
A 4.2.1.47 + COCH2CH(NH 3)COO COO
1.1.1.35 3-Hydroxyacyl-CoA dehydrogenase CHOH
O 2.4.1.33 GALACTOSE CO CH2CH(NH 3)COO CO CH2CH(NH 3)COO
C 2.7.1.71 Shikimate kinase
CHOH COO
2.4.1.16
COO -
OH ADP- CH2OH CH 2COCOO CHO NH2 NH2 OCH OCH NH2 2.7.1.80 Pyrophosphateserine phosphotransferase
R AcNH NH2
1.1.1.37
1.1.1.39
Malate dehydrogenase
Malate dehydrogenase (decarboxylating) CH2OH OH OPPU O
HO OH HO OPPG CH2OH
O
TDP-4-Oxo- Glucose
O
CH2OH 4.1.99.1 NH
3.5.1.9
NH2 OH OH COO COO 2.7.1.82 Ethanolamine kinase
Kynurenine 1.14.13.9 3-Hydroxy 3-Hydroxy 1.13.11.6 2-Amino-3-carboxy 4.1.1.45
OH 3.7.1.3
HO 6-deoxyglucose NH
Formylkynurenine 2-Aminomuconate-
I OH 2.7.7.43 2.7.1.6 2.7.1.107 Diacylglycerol kinase
1.1.1.41 Isocitrate dehydrogenase (NAD+) 1.1.1.158 CH2OH NHCOCH 3 GDP-Mannose HO
O
Indolepyruvate A
1.1.1.44 Phosphogluconate dehydrogenase 3.1.3.29 O HO OH OPPU kynurenine anthranilate muconate semialdehyde 6-semialdehyde 2.7.2.3 Phosphoglycerate kinase
(decarboxylating)
D HO UDP-N-Ac-
OH OPPU
CH2OH
HO OH HO OH
GDP-Glucose HO 1.13.11.11 COO H H Catechol M
2.7.2.4
2.7.2.6
Aspartate kinase
Formate kinase
1.1.1.45 l-Gulonate dehydrogenase
N-Ac-Neuraminate Galactosamine OH
UDP-Glucose
OH OP 2.4.1.22
E MANNOSE I

1.
HO O O + COO 2.7.2.11 Glutamate 5-kinase
1.1.1.49 Glucose-6-phosphate dehydrogenase OPPU UDP- 1.2.1.32

4.
(Sialate) 2.7.7.13 4.2.1.46 OH CH2CH(NH 3)COO C-CH(OH)CH(OH)CH 2OP NH C C CH CH2OP
Galactose-P

1.
CH2 C CH2CH 2NH2 HOC-CH(OH)CH(OH)CH 2OP 2.7.3.2 Creatine kinase
1.1.1.56 Ribitol dehydrogenase COO 2
S
COO
Galacturonate 1.1.1.2
N

19
CH2OP NHAC CH
1.1.1.79 Glyoxylate reductase (NADP+)
COO O 2.7.1.7 2.7.7.27 NH CH OH OH 1.14.12.1 2.7.4.2 Phosphomevalonate kinase
O HO OH HO O P CH 2OH N N NH2
1.1.1.81 Hydroxypyruvate reductase NH 4.2.1.20 H H O NH 2 2.7.4.3 Adenylate kinase
1.1.1.82 Malate dehydrogenase (NADP+) UDP-N-Ac-
3.1.3.29 5.1.3.7 Mannose-1-P
TDP-Glucose
2.7.7.34 2.7.7.9 5.1.3.2 HO
O
Tryptamine
4.1.1.28
TRYPTOPHAN Indole-3-glycerol-P 1-(o-Carboxy phenylamino)
4.1.1.48
N-(5-P-Ribosyl)
2.4.2.18
Anthranilate
OOC
OOC
2-Amino
O 2.7.4.4 Nucleoside-phosphate kinase
1.1.1.85 3-Isopropylmalate dehydrogenase ACNH
HO OH Glucosamine
OH
4.1.3.20 HO OH OPPU 5.1.3.6 CH 2OP
O 2.7.7.10 COO 1-deoxyribulose-5-P anthranilate
2.7.4.6 Nucleoside-diphosphate kinase
1.1.1.86 Ketol-acid reductoisomerase
pyruvate OH 2.7.7.12 OH OPPU OC muconate 2.7.4.8 Guanylate kinase

A
1.1.1.95 Phosphoglycerate dehydrogenase HO COO COO COO OOC 2.7.4.9 dtmp kinase
1.1.1.100 3-Oxoacyl-[acyl-carrier-protein] reductase N-Ac-Mannosamine-6-P UDP-Glucuronate 5.4.2.8 2.7.7.24 CH 2OH
O OH P OCH 2 CH2 COO COO
COO
4.1.3.27
CH 2COCOO
2.7.4.14 Cytidylate kinase
HO OH HO OH
1.1.1.102 3-Dehydrosphinganine reductase
1.1.1.105 Retinol dehydrogenase
CH2OH
O
CH2OH
O 4.1.3.20
CH2OH
O
CH2OP
O
HOCH HCOH
C OH OH HO
CH2 CH2
C 2.7.6.1
2.7.7.3
Ribose-phosphate pyrophosphokinase
Pantetheine-phosphate adenylyltransferase
I
OH P O OH P O O-C-COO
Mannose-6-P HO OH OP UDP-Galactose O O OC-COO 2.7.7.4 Sulfate adenylyl transferase
H OH
1.1.1.130 3-Dehydro-L-gulonate 2-dehydrogenase 2.7.1.60 CH 2OP H OH OH OH OH OH OH OH
2.4.1.13 4.6.1.3 4.2.1.10 1.1.1.25 2.7.1.71 2.5.1.19 5.4.99.5
Shikimate-5 4.6.1.4
ACNH
1.1.1.157 3-Hydroxybutyryl-CoA dehydrogenase
HO OH HO OH OPPU HO OH OP O HO 3-Deoxy-D-arabino- Dehydro- Dehydro- Shikimate Shikimate-3-P Chorismate Prephenate D
2.7.7.6 RNA nucleotidyltransferase (DNA-directed)

E
1.1.1.158 UDP-N-acetylmuramate dehydrogenase OH HO OH OH 2.4.1.9 2.7.7.7 DNA nucleotidyltransferase (DNA-directed)
heptulosonate-7-P quinate shikimate enolpyruvate 3-P
Glucose-1-P PEP 2.7.7.9 UTPglucose-1-phosphate uridylyltransferase
S
1.1.1.169 2-Dehydropantoate 2-reductase NHAC NHCOCH 3 5.4.2.3 +
NHCOCH 3 +
X O O CH2COCOO 2.7.7.10 UTPhexose-1-phosphate uridylyltransferase
CH2CH(NH3) COO
1.1.1.204 Xanthine dehydrogenase
1.1.1.205 IMP-dehydrogenase N-Ac-Mannosamine UDP-N-Ac-Glucosamine N-Ac-Glucosamine-1-P N-Ac-Glucosamine-6-P HO OH OH CH2OH
O
OH
CH2COO
CH2CH(NH3) COO CH2COCOO
4.2.1.51 2.7.7.12 UDP glucosehexose-1-phosphate
1.1.3.8
1.1.3.22
l-Gulonolactone oxidase
Xanthine oxidase
O 5.1.3.14 2.7.7.23
H H OH
2.3.1
.4 NH2
-OOC
O
CH2COO
O
CH2COO
1.3.1.13 2.7.7.13
uridylyltransferase
Mannose-1-phosphate guanylyltransferase
1.1.99.1 Choline dehydrogenase S
COO OH OH OH OH
5.3.1.8 Glucosamine-6-P HO OH OH
COO OH OH OH 2.7.7.14 Ethanolamine-phosphate cytidylyltransferase
Fumaryl 5.2.1.2 Maleyl 1.13.11.5 Homogentisate 1.14.16.1 2.6.1.5
O 1.13.11.27 2.6.1.5
OH
HOCH 2 C C C CO CH2OH
Hydroxyphenyl TYROSINE PHENYLALANINE Phenylpyruvate 2.7.7.15 Choline-phosphate cytidylyltransferase
E OP
1.1.99.5 Glycerol-3-phosphate dehydrogenase
OH H OH OH 4.3.1
1.2.1.3 Aldehyde dehydrogenase (NAD+)
COO -
OH OH H OH
acetoacetate acetoacetate 1.3.1.13 pyruvate 1.3.1.13
.5 2.7.7.18 Nicotinate-nucleotide adenylyltransferase

S 3.2.1.26 2.7.7.23 UDP-N-acetylglucosamine pyrophosphorylase

SUCROSE GLUCOSE
HO OH HO OH
Fructose
1.2.1.7 Benzaldehyde dehydrogenase (NADP+) HOCH 2 C C C C HO OH OH 3.2.1.48 + 2.7.7.24 Glucose-1-phosphate thymidylyltransferase
1.2.1.8 Betaine-aldehyde dehydrogenase CHOHCH 2NHCH 3 CHOHCH 2NH2 CH2CH(NH3) COO-
H OH H H OH OH OH CH2CH2NH2 4.1
C
1.2.1.11 Aspartate-semialdehyde dehydrogenase 1.1.1.19 1.13.99.1 3.1.3.25 .1.2 CH2CH2NH2 CH=CHCOO
2.7.7.27 Glucose-1-phosphate adenylyltransferase
1.2.1.12 Glyceraldehyde-3-phosphate dehydrogenase Gulonate Glucuronate Inositol Inositol-P 5.5.1.4 5 2.7.7.34 Glucose-1-phosphate guanylyltransferase
5.4.2.2 OH OH OH OH Ubiquinone Cinnamate A 2.7.7.41 Phosphatidate cytidylyltransferase
ATP
1.2.1.13 Glyceraldehyde-3-phosphate dehydrogenase OH H OH OH OH H OH 1 1.14.16.2
1.2.1.16 Succinate-semialdehyde dehydrogenase (NAD(P)+) OH H OH OH 1.1.1.2 OH OH OH OH Menaquinone 2.7.7.43 N-Acylneuraminate cytidylyltransferase
1.2.1.18 Malonate semialdehyde dehydrogenase
(acetylating)
3.1.1.18 HOCH 2 C
H
C C
H
C
H
CO HOCH 2 C
H
C C
H
CO CO
HOCH 2 C C C C CO 1.1.1.14 H H OH H CH2OP
O
3.1.3.9 2.7.1.2 Epinephrine 2.1.1.28
Norepinephrine 1.14.17.1
Dopamine 4.1.1.28
Dopa
+
CH2CH(NH3) COO
OH
Tyramine 1.14.13.11 T 2.7.8.1
2.7.8.2
Ethanolamine phosphotransferase
Diacylglycerol cholinephosphotransferase
1.2.1.21 Glycolaldehyde dehydrogenase O O H O HOCH 2 C C C C CH2OH
2.6.1.16
2.7.1.1
ADP
(Adrenaline)
CHOHCH 2NH2
(Noradrenaline)
HN O E 2.7.8.3 Ceramide cholinephosphotransferase
Gulonolactone 1.1.3.8 2-Oxogulonolactone ASCORBATE OH OH H OH 6
C
2.7.8.5 CDPdiacylglycerolglycerol-3-
.1.
1.2.1.23 2-Oxoaldehyde dehydrogenase (NAD+) O 1.14.18.1 H2 I I CH=CHCOO
1.10.2.1 2.7
1.2.1.24 Succinate-semialdehyde dehydrogenase OH H OH Sorbitol HO OH CH2 OP 2.1 C Coumarate
phosphate 3-phosphatidyltransferase
1.1.1.45
OH H OH H
1.10.3.3 .1. -Tocopherol O
1.2.1.25 2-Oxoisovalerate dehydrogenase (acylating)
C COO- CO COO -
4 OH
1.1.1.49 O
OH
OCH 3
CH-COO O O
H 2.7.8.8 CDPdiacylglycerolserine O-phosphatidyltransferase

Glucose-6-P
1.2.1.27 Methylmalonate-semialdehyde HOCH 2 C C CO HOCH 2 C C CO HOCH2 C C CO CO CO CH(OH)COO CHOHCH 2OH (Vitamin E) + 2.7.8.11 CDPdiacylglycerolinositol
P-Glucono Normetepinephrine O
dehydrogenase (acylating) H OH H 1.1.1.130 H OH H O 2.7.1.3 O NH3 OH
O 3-phosphatidyltransferase
1.2.1.31
1.2.1.32
l-Aminoadipate-semialdehyde dehydrogenase
Aminomuconate-semialdehyde dehydrogenase
P 3-Dehydrogulonate 2, 3-Dioxogulonate Dehydroascorbate H H OH H 3 .1.1
.17 lactone HO OH OH
OH
OCH 3
.3.
4
(Normetadrenaline) OCH 3 Dopaquinone
O NH
I
OH
I
L
2.8.3.5
2.8.3.6
3-Oxoacid CoA-transferase
3-Oxoadipate CoA-transferase
1.2.1.36 Retinal dehydrogenase E C C C C COO - NADP + OH 1.4 OH
1.14.18.1
A
POCH2
OH H OH H H OH H H 5.3.1.9 4-OH-3-Methoxy- 4-OH-3-Methoxy- Plastoquinone MELANIN THYROXINE LIGNIN Tannins Plant Pigments HYDROLASES
N
1.2.1.41 Glutamate-5-semialdehyde dehydrogenase 5.3.1.8
6-P-Gluconate NADPH
OH OH H OH
1.2.1.52 Oxoglutarate dehydrogenase HOCH 2 C C C CHO HOCH 2 C C C CHO HOCH 2 C C CO CH 2OH
H H OH
D-mandelate phenylglycol M
3.1.1.3 Triacylglycerol lipase

T
1.2.3.5 Glyoxylate oxidase 3.1.1.4 Phospholipase A2
H OH H OH OH H OH OH
1.2.3.7
1.2.4.1
Indole-3-acetaldehyde oxidase
Pyruvate dehydrogenase (lipoamide)
O L-Xylose 4.1.1.34 D-Arabinose 5.3.1.3 D-Ribulose 2.7.1.47 HOCH 2 C C C CO CH2OP NADP +
H H HO
CH2OP
O NHCOCH 2NH2 NH N
OOC-CH-CH 2COO
O
I 3.1.1.5
3.1.1.7
Lysophospholipase
Acetylcholinesterase

N
OH OH H 1.1.1.44 NH N OOC N
1.2.4.2 Oxoglutarate dehydrogenase (lipoamide) HNCO C N C 3.1.1.17 Gluconolactonase
S 2.2.1.1 H 2C HC C
1.2.7.1 Pyruvate synthase OH H H OH H OH H
Fructose-1-P POCH2 C C C CO CH2OH H 2C CHO CHO CH CH CH H 2N C CH 3.1.1.21 Retinyl-palmitate esterase
1.2.7.2 2-Oxobutyrate synthase
E
HOCH 2 C C C CH2OH HOCH 2 C C CO CH 2OH POCH2 C C CO CH2OH
H H H NADPH
OH OH H
OH OH
OC
NH
RP
HN C
NH
RP
H 2N C
N
RP H2 N
C
N
RP
H 2N C
N
RP H 2N
C N RP E 3.1.1.28 Acylcarnitine hydrolase

Fructose-6-P
1.3.1.1 Dihydrouracil dehydrogenase (NAD+) 3.1.1.31 6-Phosphogluconolactonase
1.3.1.2 Dihydropyrimidine dehydrogenase (NADP+)
S
H OH OH H OH
2.7.1.53
H OH
HOCH 2 C C C CH2OH
5.1.3.1
Glycinamide- 2.1.2.2 Formyl Formyl 6.3.5.3 6.3.3.1 5-Amino 4.1.1.21 5-Amino-4-imidazole 6.3.2.6 5-Amino-4-imidazole 4.3.2.2 5-Aminoimidazole O S 3.1.1.32 Phospholipase A1
1.3.1.8 Acyl-CoA dehydrogenase (NADP+) L-Arabitol L-Xylulose L-Xylulose-5-P H H
ribosyl-P glycinamide-R P glycinamidine-R P imidazole-R P carboxylate-R P (N-succinylcarboxamide)-R P carboxamide-R P C C N 3.1.2.1 Acetyl-CoA hydrolase
1.3.1.9
1.3.1.10
Enoyl-[acyl-carrier-protein] reductase (NADH)
Enoyl-[acyl-carrier-protein]
OH OH H H OH H H OH H OH OH OH
Ribitol
POCH2 C C CO CH2OH ATP H2 N
HCO C
CH 3.1.2.3
3.1.2.4
Succinyl-CoA hydrolase
3-Hydroxyisobutyryl-CoA hydrolase
HOCH 2 C C C CHO HOCH 2 C C C CH 2OH HOCH 2 C C C CHO OH OH H H 2.7.1.11 NH
O
NH O
2.1.2.3 NH N RP
3.1.2.11 Acetoacetyl-CoA hydrolase
reductase (NADPH, B-specific) NH2 H2 N C N O
1.3.1.13 Prephenate dehydrogenase (NADP+) H H OH 1.1.1.10 OH H OH OH H OH D-Ribulose-5-P POCH 2 C C CHO 3.1.3.11 H2NCONH 2 H 2N COO OC
CO HN C CO C
C C N
Inosine Formylamido- 3.1.2.20 Acyl-CoA hydrolase
1.3.1.14 Orotate reductase (NADH) 2.7.1.47 ADP 6.3.4.13 Urea OC C
CO
OC C OC C
HN CH HN C CH 3.2.2.2
3.1.3
.5 imidazole- 3.1.3.2 Acid phosphatase
L-Arabinose 5.3 Xylitol D-Xylose H H H OH OH
N H NH N H NH N NH OC C HC C 3.1.3.3 Phosphoserine phosphatase
1.3.1.26
1.3.1.35
Dihydrodipicolinate reductase
Phosphatidylcholine desaturase OH H H
.1.
4 OH OH OH OH HOCH 2 C C C CHO 5.1.3.1
Erythrose-4-P 3.5.3.4 H
3.5.2.5
H
1.7.3.3
H
1.1.1.204
NH NH
1.1.3.22
N NH
2.4.2.1 carboxamide-R P 3.1.3.4 Phosphatidate phosphatase
1.3.3.3 Coproporphyrinogen oxidase
OH OH OH
H H HO
+ Allantoate Allantoin URATE 1.1.3.22 Xanthine Hypoxanthine 3.5.4.10 O
3.1.3.5 5-Nucleotidase
HOCH 2 C C C CHO HOCH 2 C C CO CH2OH POCH2 C C CO CH OH C C C CO CH2OP CH2(NH3)COO NH2 N 3.1.3.9 Glucose-6-phosphatase
1.3.3.4 Protoporphyrinogen oxidase POCH 2 C
2
D-Ribose .1.
4 NH2 N
N
HN C
GLYCINE
1.3.5.1 Succinate dehydrogenase (ubiquinone) H OH OH H H H H N CH 3.1.3.11 Fructose-bisphosphatase
1.3.99.1 Succinate dehydrogenase
L-Lyxose L-Ribulose 2.7.1.16
L-Ribulose-5-P 5.1.3.4 5.3.1.6
H OH OH OH H
2.6 .10
.1
N CH O O O HC N
CH
N
NH2 N
C
OOC-CH-CH 2COO
HC C
N RP
P 3.1.3.15 Histidinol-phosphatase

Fructose-
N N
POCH 2 C C CO CH 2OH CH2OP 20 O C NH 3.1.3.25 myo-Inositol-1(or 4)-monophosphatase
4 HC
U
1.3.99.2 Butyryl-CoA dehydrogenase 4.1.2.- . N CH
O NH2 1 1. N -O P~O P~O P O CH
1.3.99.3 Acyl-CoA dehydrogenase H OH 2.2.1.2 1. 2 O HC C C N
INOSINE-P 3.1.3.27 Phosphatidylglycerophosphatase
1.1.1 OH H
1:6-bis-P 2. O P O CH2 O N N RP(P) Fumarate Aspartate
R
1.3.99.7 Glutaryl-CoA dehydrogenase O O O N C 3.1.3.29 N-Acylneuraminate-9-phosphatase
.9 HOCH 2 C C CO CH2OH D-Xylulose-5-P OOCCH 2NHCH3
CH (IMP)
1.3.99.10 Isovaleryl-CoA dehydrogenase HC C 3.1.3.31 Nucleotidase
Sarcosine 2.7.4.3
1.4.1.1 Alanine dehydrogenase OH H
D-Xylulose
2.7.1.17
2.7
OH OH
Glyoxylate
O
OH
4.6.1.1 ATP
OH OH
2.7.4.6
ADP
2.7.4.4 4.3.2.2
N NH RP
Adenylo- 6.3.4.4 O
N
I 3.1.4.2
3.1.4.3
Glycerophosphocholine phosphodiesterase
Phospholipase C
1.4.1.2 Glutamate dehydrogenase
ADENOSINE-P C
1.4.1.7 Serine dehydrogenase .1.
15
P-Ribosyl 1.5.99.2 Cyclic AMP (AMP) succinate 3.1.4.6
HN C CH N 3.1.4.4 Phospholipase D
1.4.1.8 Valine dehydrogenase (NADP+)
amine 1.17.4.1 1.1.1.205 OC C 3.1.4.10 1-Phosphatidylinositol phosphodieterase
1.4.1.9 Leucine dehydrogenase H H H
H H H OH
OOCCH 2N(CH3)2
1.4.4.2
d-ADP Adenine 2.4.2.1
N
H
N RP E 3.1.4.12 Sphingomyelin phosphodiesterase
3.2.1.21 -Glucosidase
S
1.4.1.10 Glycine dehydrogenase POCH 2 C C C CHO
1.4.1.14 Glutamate synthase (NADH) POCH2 C C C C CO CH2OP 4.1.2.13 Dimethylglycine 2.7.4.6 3.5.4
XANTHOSINE-P 3.2.1.23 -Galactosidase
Chloroplast Stroma 2.7.7.7 2.4.2.15
1.4.1.19
1.4.3.1
Tryptophan dehydrogenase
d-Aspartate oxidase PHOTO- PHOTO-
OH OH OH
D-Ribose-5-P Sedoheptulose-PP
OH OH OH H
2.1.1.5 2.7.7
.7 DNA 2.7.7.7
d-GTP d-GDP .3 (XMP)
O
3.2.1.26 -Fructofuranosidase
3.2.1.45 Glucosylceramidase
1.1 Guanine 6.3.4.1 C N
1.4.3.2
1.4.3.4
l-Amino-acid oxidase
Amine oxidase (flavin-containing) P SYSTEM II
Chlorophyll 2H +
SYSTEM I
ATP 2.2.1.1 OOCCH2N(CH3)3
+
d-ATP 2.7 d-CTP
7.4
.1 2.4.2
.1 6.3.5.2
HN
H2 N C
C CH
3.2.1.46 Galactosylceramidase
3.2.1.48 Sucrose a-glucosidase
.7
H 3.6.1.34 .7 C
1.4.3.8 Ethanolamine oxidase Pheophytin Ferredoxin ADP+Pi
4.1.2.13
Betaine 2.7.4.6 2.7.4.8
N N RP 3.2.2.2 Inosine nucleosidase
1.4.4.2 Glycine dehydrogenase (decarboxylating)
O 2e*- 3H+
POCH 2CHOHCHO FOLIC ATP 2.7.7.6
RNA 2.7.7.6
GTP GDP
GUANOSINE-P
3.3.1.1
3.5.1.1
Adenosylhomocysteinase
Asparaginase
3-P-Glyceraldehyde ACID
1.5.1.2 Pyrroline-5-carboxylate reductase
1.2.1.8 2.1.2.1 2.7
2e* .7.6 TTP 2.7. 1.17.4 3.5.1.2 Glutaminase
T
1.5.1.3 Dihydrofolate reductase 2.2.1.1
PQ C1 .1 (GMP)
2e*
1.5.1.5 Methylenetetrahydrofolate reductase (NADP+) Cyt. HOCH2CO CH2OP + 4.6 3.5.1.6 -Ureidopropionase
.1.1 OHCCH 2N(CH3)3
1.5.1.6
1.5.1.7
Formyltetrahydrofolate dehydrogenase
Saccharopine dehydrogenase (NAD+, O b 3.6.1.3 Dihydroxy- 5.3
Pi Pi
2.4.2.14
6.3.4.7 Betaine POOL
0 O 2.7 O
NH2
C P
3.5.1.9 Arylformamidase
3.5.1.18 Succinyl-diaminopimelate desuccinylase

S acetone-P .1 aldehyde 4.2.1.2 O TDP O CH

Y
4.1.2.5 C .7 . C N 3.5.1.22 Pantothenase
5.3.1
l-lysine-forming) C
1.5.1.8 Saccharopine dehydrogenase (NADP+, PQH2
NAD+ CH3
HN CH-CH3
HN
C
C CH3 6 2.7
.4.9 HN C-CH3
HN CH
OC CH 3.5.1.23 Ceramidase
(Glycerone-P)
l-lysine-forming) Y e- Thylakoid 2H
+

+
2.7.1.28
+
1.1.99.1
CH3
H2NCH 2 CHCOO H2NCONHCH 2CHCOO
OC
NH
CH 2
OC CH
OC
N
CH
DP
2.1.1.45 OC CH
N DP
N
DP R 3.5.2.2
3.5.2.3
Dihydropyrimidinase
Dihydroorotase
1.5.1.9 Saccharopine dehydrogenase (NAD+, 3.5.4.12 2.7.4.14
l-glutamate-forming) N Mn Membrane f
PC
NADP
1.2.1.12
HOCH2CH2N (CH3) 3
CHOLINE 3-Amino- 3.5.1.6
-Ureido 3.5.2.2
Dihydro
NH
1.3.1.2 Thymine
2.4.2.4
THYMIDINE-P d-UMP d-CMP d-CDP I 3.5.2.5 Allantoinase

T
3.5.2.7 Imidazolonepropionase
1.5.1.10 Saccharopine dehydrogenase (NADP+,
P680 2H+ Tr
PC 3H +
H
+
HOCH 2CH(OH)CHO 1.2.1.13 + isobutyrate isobutyrate thymine O O 2.4.2 NH 2 M 3.5.2.10 Creatininase
l-glutamate-forming)
ans P700 ns H Glyceraldehyde HOCH2CH(NH3)COO 2. C C
NADH 4.2.1.22 1. CH2 .4 C
H located proto H H H
+
2H+ HN HN CH
I
+
1.5.1.12 1-Pyrroline-5-carboxylate dehydrogenase 1. N CH 3.5.3.1 Arginase
2H2O SERINE 1.17.4.1
+
H
NADPH+H + 13
+ +
1.5.3.1 Sarcosine oxidase H
+
OC CH2 OC CH 3.5.3.4 Allantoicase
OC CH
E 2.6.1.51
+
H + H2NCONHCH 2CH 2COO
1.5.99.1
1.5.99.2
Sarcosine dehydrogenase
Dimethylglycine dehydrogenase
O2 H
+
H H+
H H
CH2OP
O 1.4.1.7
4.1.1.11 H2NCH 2CH2COO
3.5.1.6 Carbamoyl 3.5.2.2 Dihydro-
NH
1.3.1.2
N H
3.5.4.1 NH
CDP D 3.5.3.6
3.5.4.1
Arginine deiminase
Cytosine deaminase
S Thylakoid Lumen POCH 2CHOHCOOP
-Alanine Uracil Cytosine
1.5.99.8 Proline dehydrogenase
++ POCH 2 C C CO CH 2OP 2.7.6.1 1:3-bis-P-Glycerate HOCH2COCOO -OOC
-alanine uracil O O
NH 2
C I 3.5.4.3 Guanine deaminase
CH 2.7.4.6
1.6.4.1 Cystine reductase (NADH) O 3.5.4.6 AMP deaminase
I Thylakoid Membrane Mg OP O P O O C
1.6.5.3 NADH dehydrogenase (ubiquinone) OH OH Hydroxy- 3.1.3.3
NH2 CH2 C
CH2
C HN
C
CH HN CH
C HN CH N
N 3.5.4.10 IMP cyclohydrolase

Ribulose-1:5-bis-P OH OH HN HN CH 2.4.2.9 OC CH
1.6.6.1
1.6.6.2
Nitrate reductase (NADH)
Nitrate reductase [NAD(P)H] S P-Ribosyl-PP pyruvate OC
N
CH-COO
OC CH-COO OC C-COO OC C-COO OC N CH
OC
N
CH N
E
3.5.4.12 dCMP deaminase
3.5.4.19 Phosphoribosyl-AMP cyclohydrolase
+ N RPPP
Chloroplast Stroma RPPP
1.6.6.3
1.6.6.4
Nitrate reductase (NADPH)
Nitrite reductase [NAD(P)H]
Fixation CO2 ADP P OCH2CH(NH3)COO
Phospho-
H
Carbamoyl
NH
Dihydro Orotate Orotidine-P
NH
Uridine-P UDP
RP
URIDINE-
RP 6.3.4.2
CYTIDINE- S
3.6.1.3 Adenosinetriphosphatase
3.6.1.15 Nucleoside-triphosphatase
3.5.2.3 4.1.1.23 (UMP) 2.7.4.4
1.6.6.8 GMP reductase 2.7.2.3 serine aspartate orotate 1.3.1.14 2.4.2.10 2.7.4.6 triphosphate triphosphate 3.6.1.31 Phosphoribosyl-ATP pyrophosphatase
1.7.3.3
1.7.7.1
Urate oxidase
Ferredoxinnitrate reductase O2 4.1.1.39
1.1.1.29 (UTP) (CTP)
3.6.1.34 H+-transporting ATP synthase
3.7.1.2 Fumarylacetoacetase
1.7.99.4 Nitrate reductase COO
HO HO
COO ATP 2.6.1.52
2.6.1.22
NH2 NH2
3.7.1.3
3.9.1.1
Kynureninase
Phosphoamidase
1.8.1.3 Hypotaurine dehydrogenase COO H H H H H H H H H H CONH 2
+ C N OC N N H H
1.8.1.4 Dihydrolipoamide dehydrogenase
C C NH C
-Linolenate
1.14.99.25 P OCH2 C C C C N P OCH 2 C C C C NH P OCH 2 C C CO CH2
1.8.2.1 Sulfite dehydrogenase Linoleate Arachidonate 1.13.11.34 Leukotriene B4 OH
POCH2CHOH COO
1.1.1.95
P OCH2COCOO CH CH CH
P OCH 2 C C C CH
LYSASES
1.8.3.1 Sulfite oxidase
COO 5. O
3-P-Glycerate P-Hydroxy- OH OH HC
N
C
N OH OH HC
N
C
N OH OH HC
N
C
N
4.1.1.1 Pyruvate decarboxylase
1.1 3.99 COO O O RP OH OH HN N 4.1.1.3 Oxaloacetate decarboxylase
1.8.7.1 Sulfite reductase (ferredoxin)
1.3.1.35 COO pyruvate 3.6.1.31
RP(PP)
3.5.4.19
RP
C
1.8.99.1 Sulfite reductase 4.9 .3
9 .1 O 2.4.2.17
P-Ribosyl-ATP P-Ribosyl-AMP P-Ribosylformimino P-Ribulosylformimino Imidazole H
4.1.1.4
4.1.1.9
Acetoacetate decarboxylase
Malonyl-CoA decarboxylase
L
1.8.99.2 Adenylsulphate reductase COSCoA
1.9.3.1 Cytochrome-c oxidase
CO-S-ACP
HO OH 5.3.99.5
HO
OH 2.7.1.31 5-aminoimidazole- 5.3.1.16 5-aminoimidazole- glycerol-P 4.1.1.11 Aspartate 1-decarboxylase
1.10.2.1 l-Ascorbatecytochrome-b5 reductase
I Oleoyl-CoA Palmitoleoyl-ACP Prostaglandin PGE 2 Thromboxane B2 POCH2CH(O P) COO
HC C CH 2CHCOO
+ carboxamide-R P +
carboxamide-R P+ 4.1.1.12 Aspartate 4-decarboxylase
HOCH2CH(OH) COO + HC C CH2COCH 2OP 4.1.1.15 Glutamate decarboxylase
1.10.2.2 Ubiquinolcytochrome-c reductase 1.14.99.5 2, 3-Diphospho- 5.4.2.1 N NH NHCOCH 2CH2NH2 HC C CH2CH(NH 3)COO HC C CH2CH(NH 3)CHO HC C CH 2CH(NH 3)CH2OH HC C CH2CH(NH 3)CH2OP
1.10.3.3 l-Ascorbate oxidase
1.10.99.1 Plastoquinolplastocyanin reductase P COSCoA CH3(CH2)14CH=CHCOS-CoA CH3(CH2)14CH(OH)CH 2COS
COS-CoA CH3(CH2)14COCH 2COS-CoA
glycerate Glycerate C
H Carnosine N NH
N NH N NH N NH
N
C
NH
4.2.1.19 4.1.1.17
4.1.1.20
Ornithine decarboxylase
Diaminopimelate decarboxylase
1.13.11.1 Catechol 1,2-dioxygenase
I Stearoyl-CoA Dehydrostearoyl-CoA OH-Stearoyl-CoA Oxostearoyl-CoA CH 3COO
CH
CH CH CH H 4 1.1.21 Phosphoribosylaminoimidazole carboxylase
1.13.11.2 Catechol 2,3-dioxygenase CH3(CH2)14COCH 2COS-CoA
HISTIDINE Histidinal Histidinol Histidinol-P Imidazole 4.1.1.22 Histidine decarboxylase
1.13.11.5 Homogentisate 1,2-dioxygenase
1.13.11.6 3-Hydroxyanthranilate 3,4-dioxygenase
D Endoplasmic Reticulum ACETATE 4.1.1.22 1.1.1.23 1.1.1.23 3.1.3.15 2.6.1.9
acetol-P 4.1.1.23
4.1.1.25
Orotidine-5-phosphate decarboxylase
Tyrosine decarboxylase
CH3(CH2)14COS-ACP CH 3(CH2)14COSCoA HOCH2CH(O P)COO HC C CH2CH2NH2
4.3.1.3
1.13.11.11 Tryptophan 2,3-dioxygenase Chain elongation Mitochondrial 4.1.1.28 Aromatic-L-amino-acid decarboxylase
Palmitoyl-ACP Palmitoyl-CoA 2-P-Glycerate OOC CHCH 2CH2COO OC CHCH 2CH2COO CH C CH CHCOO
B
1.13.11.20 Cysteine dioxygenase N NH 4.1.1.29 Sulfoalanine decarboxylase
1.13.11.21 -Carotene 15,15-dioxygenase CH3(CH2)n CH=CHCOS-CoA CH 3(CH2)n CH(OH)CH 2COSACP CH 3(CH2)n COCH 2COSACP
1.2.1.4 C HN NH N NH N NH 4.3.1.3 4.1.1.32 Phosphoenolpyruvate carboxykinase (GTP)
1.13.11.27 4-Hydroxyphenylpyruvate dioxygenase
I 1.3.1.9 4.2.1.60 1.1.1.100
H HISTAMINE CH
3.5.2.7 CH
4.2.1.49 CH 4.1.1.33 Diphosphomevalonate decarboxylase
1.13.11.34 Arachidonate 5-lipoxygenase ACYL-ACP 2, 3-Enoyl-ACP 4.2.1.61
3-OH-Acyl-ACP 3-Oxoacyl-ACP Formimino Imidazolone Urocanate 4.1.1.34 Dehydro-l-gulonate decarboxylase
O 1.3.1.10 2.3.1.41 CH3CH 2OH
1.13.99.1 myo-lnositol oxygenase
1.14.11.1 g-Butyrobetaine dioxygenase 4.2.1.11 ETHANOL glutamate propionate 4.1.1.36
4.1.1.37
Phosphopantothenoylcysteine decarboxylase
Uroporphyrinogen decarboxylase
2.1.3.2 2.3
1.14.11.2 Procollagen-proline dioxygenase S CH3(CH2)5CH=CHCH 2COSACP
4.2.1.6 CH (CH ) CH(OH)CH COSACP
.1.3
0
4.1.1.39 Ribulose-bisphosphate carboxylase
CH3(CH2)6CH2CH 2COSACP 3, 4-Decenoyl-ACP CH 3(CH2)6COCH 2COSACP + 4.1.1.41 Methylmalonyl-CoA decarboxylase
Y 0
1.14.11.8 Trimethyllysine dioxygenase 3 2 6 2
Decanoyl-ACP
1.1.1.100
3-OH-Decanoyl-ACP 3-Oxo-Decanoyl-ACP
CH2CO-OCH2CH(NH 3)COO 2-
HSO3- Phosphoadenylyl- Adenylylsulphate
1.3.1 1.1.1.1 4.1.1.43 Phenylpyruvate decarboxylase
1.14.12.1 Anthranilate 1,2-dioxygenase
.9 CH3(CH2)6CH=CHCOSACP Acetylserine HS SO 4 1.2.1.32
N
(deaminating, decarboxylating) 2.7.7.4 4.1.1.45 Aminocarboxymuconate-
0 1.8.99.1 1.8.99.2 2.7.1.25 (APS)
1.14.13.5 Imidazoleacetate 4-monooxygenase 2, 3-Decenoyl-ACP 4 .2.1.6 2.3.1.41 CH2=C(OP ) COO +
sulphate semialdehyde decarboxylase
CH3CHO
1.14.13.9 Kynurenine 3-monooxygenase
1.14.13.11 trans-Cinnamate 4-monooxygenase T CH 3(CH2)2CH 2CH2COSACP CH3(CH2)2CH=CHCO-S-ACP CH3(CH2)2CH(OH)CH 2COSACP
1.1.1.100
CH3(CH2)2COCH 2COSACP P-enolpyruvate Acetaldehyde
S-CH 2CH(NH 3)COO
+
4.2
.99 +
+
CH2CH(NH 3)COO
(PAPS)
+
4.1.1.48
4.1.1.49
Indole-3-glycerol-phosphate synthase
Phosphoenolpyruvate carboxykinase (ATP)
.8 HSCH 2CH(NH
1.14.13.12 Benzoate 4-monooxygenase
1.14.13.39 Nitric oxide synthase
H Hexanoyl-ACP
1.3.1.9
2, 3-Hexenoyl-ACP
4.2.1.59
3-OH-Hexanoyl-ACP 3-Oxo-Hexanoyl-ACP
HS
S-CH 2CH(NH 3)COO 3)COO
4.4.1.1
+
SCH 2CH2CH(NH 3)COO 4.2.1.22
+
HSCH 2CH2CH(NH 3)COO
2.1.1.13
CH 3 - SCH 2CH2CH(NH 3)COO 4.1.1.50
4.1.1.65
Adenosylmethionine decarboxylase
Phosphatidylserine decarboxylase
2.3.1.41
1.14.16.1 Phenylalanine 4-monooxygenase E CH3CH=CHCO.S-ACP CYSTINE 1.6.4.1 CYSTEINE
4.2.99.9
Cystathionine 4.4.1.8
Homocysteine 2.1.1.14
METHIONINE 4.1.1.71
4.1.2.5
2-Oxoglutarate decarboxylase
Threonine aldolase
S
1.14.16.2 Tyrosine 3-monooxygenase
1.14.16.4 Tryptophan 5-monooxygenase CH3CH2CH2COSACP CH3CH=CHCO-S-ACP CH3CH(OH)CH 2COS-ACP CH3COCH 2COSACP ADP .1.
1
1.13.11.20 Adenosyl 4.1.2.12 Ketopantoaldolase
1.3.1.9 4.2.1.58 1.1.1.100 4.1 4.4.1.15 3.3.1.1 Adenosyl 2.5.1.6
I Butanoyl-ACP Crotonoyl-ACP 3-OH-Butanoyl-ACP Acetoacetyl-ACP
1.14.17.1 Dopamine -monooxygenase + 4.1.2.13 Fructose-bisphosphate aldolase
HOOCCH 2CO-S-ACP +
SCH 2CH2CH(NH 3)COO
1.14.18.1 Monophenol monooxygenase
R-CH2COO CH2OH CH2OH Malonyl-ACP 2.7.1.40 Glutamate CH 3 - SCH 2CH 2CH(NH 3)COO
4.1.2.14 2-Dehydro-3-deoxyphosphogluconate aldolase

S
+ +
1 14.99.1 Prostaglandin synthase
1.1.1.8 HO 2SCH 2CH(NH 3 )COO S-Adenosyl + 4.1.3.1 Isocitrate lyase
1 14.99.5 Stearoyl-CoA desaturase
CH3(CH2)n+2COS-CoA 6.2.1.3 3.1.2.20 FATTY ACID
HOCH
CH2 OH
HOCH
CH2O P
2.3.1.41 ATP 4.4.1.15 HSO3- Cysteine
HO3SCH 2CH(NH 3)COO
Cysteate homocysteine 2.1.1.10
4.1.3.2
4.1.3.4
Malate synthase
Hydroxymethylglutaryl-CoA lyase
1.14.99.7 Squalene monooxygenase
1.14.99.25 Linoleoyl-CoA desaturase 4.1 4.1.1.50 4.1.3.5 Hydroxymethylglutaryl-CoA synthase
1.17.4.1 Ribonucleoside-diphosphate reductase ACYL-CoA Glycerol
2.7.1.30
3-P-Glycerol 2.3.1.39 .1.
2 HO2SCH 2COCOO sulphinate .1. 6.3.2
.2 +
CH2SH 2.1.1.20 4.1.3.7 Citrate (si)-synthase
1.18.6.1 Nitrogenase (Cytosol)
KETONE BODIES 3.7
3-Sulphinyl
29
OOCCH(NH 3)CH2CH2CONHCHCOO 4.1.3.8 ATP citrate (pro-S)-lyase
2.3.1.15 CH3CO COO
2.3.1.51 CH3COCH 3 CH3CH(OH)CH 2COO
pyruvate HO2SCH 2CH2NH2 HO3SCH 2CH2NH2 -Glutamylcysteine 4.1.3.16 4-Hydroxy-2-oxoglutarate aldolase
TRANSFERASES
2.1.1.1 Nicotinamide N-methyltransferase
2.3.1.7 Acetone 3-OH-Butyrate
HOOCCH 2CO-SCoA
Malonyl-Co-A PYRUVATE 1.4.1.1
2.6.1.2
+
CH3CH(NH3)COO
ALANINE 4.1.1.29
Hypotaurine 1.8.1.3
Taurine Glycine
CH2SH
4.1.3.18
4.1.3.20
Acetolactate synthase
N-Acylneuraminate-9-phosphate synthase
2.1.1.2 Guanidinoacetate N-methyltransferase Carnitine 3.1.1.3
CH2O-CO-R
CH2O-CO-R CH2O-CO-R 2.7.8.5 1.2.4.1 4.1.2.5 + 6.3.2
.3
+ 4.1.3.21 Homocitrate synthase
2.1.1.3
2.1.1.4
Thetinhomocysteine S-methyltransferase
Acetylserotonin N-methyltransferase
L O-Acyl-carnitine
R-CO-OCH R-CO-OCH R-CO-OCH
4.1.1.4 1.1.1.30
CH 3CO-S-ACP 4.1.1.9
2.3.1.12
1.8.1.4
4.1.3
.18
OOCCH2CH2COOCH2CH2CH(NH 3)COO
Succinylhomoserine
OOCCH(NH 3)CH2CH2CONHCHCONHCH 2COO
Glutathione
4.1.3.22
4.1.3.27
Citramalate lyase
Anthranilate synthase
2.1.1.5 Betainehomocysteine S-methyltransferase I CH2O-CO-R"
CH2OH CH2O P
CH3COCH 2COO Acetyl-ACP 4.1.1.12
+ Bile Acids 4.1.99.1 Tryptophanase
Triacylglycerol Acetoacetate 1.1 CH3CH(OH)CH(NH 3)COO + + 4.2.1.2 Fumarate hydratase
2.1.1.6 Catechol O-methyl transferase
P O-Acyl-carnitine Diacyl .1.2 2.6.1.18 POCH 2CH2CH(NH 3)COO HOCH 2CH2CH(NH 3)COO
3.1.3.4 2.7.1.107 Phosphatidate
7 4.2.1.3 Aconitate hydratase
2.1.1.10 Homocysteine S-methyltransferase
FAT 2.3.1.20
glycerol THREONINE O-Phospho- 2.7.1.39Homoserine HOCH 2 C(CH 3)2COCOO
I
2.1.1.13 5-Methyltetrahydrofolatehomocysteine 3.1.1.28 3.1.2.11 4.2.1.4 Citrate dehydratase
CH3CH(OH)COO 2.3.1.46 4.1.2.12
S-methyl transferase 2.3.1.38
LACTATE
4.2.99.2
homoserine HCHO Oxopantoate 4.2.1.9 Dihydroxy-acid dehydratase
2.1.1.14 5-Methyltetrahydropteroyltriglutamate
D ATP OHCCH 2COO
4.1.3
.18 CH3 CH3
CH3
+
4.2.1.10 3-Dehydroxyquinate dehydratase
CH3(CH2)n CH2CH2COSCoA 1.1.1.3 CHCH(NH 3)COO 1.1.1.169 4.2.1.11 Phosphopyruvate hydratase (enolase)
homocysteine S-methyltransferase CH3(CH2)n CH=CHCOSCoA
4.2.1.17
CH3(CH n CH(OH)CH 2COSCoA CH3(CH2)n COCH 2COSCoA
GTP Malonic COO C (OH)CH(OH)COO
2.1.1.17 Phosphatidylethanolamine N-methyltransferase
ACYL-CoA 1.3.99.3
2, 3-Enoyl-CoA 3-OH-Acyl-CoA 1.1.1.35
3-Oxoacyl-CoA
2.3.1.16 4.2
.1. 4.2.1.16
CHCOCOO CH3
4.2.1.13 l-Serine dehydratase
2.1.1.20
2.1.1.28
Glycine N-methyltransferase
Phenylethanolamine N-methyltransferase D (Mitochondria) CH 3 COSCoA
5 2 semi- CH3COC(OH)CH 3
2-Acetolactate
1.1.1.86
CH3
2-3-Dihydroxy 4.2.1.9
CH3
2-Oxo- 1.4.1.8 VALINE
2.6.1.32
HOCH 2 C(CH 3)2CH(OH)COO
4.2.1.16
4.2.1.17
Threonine dehydratase
Enoyl-CoA hydratase
2.1.1.45 Thymidylate synthase
E 1.2.1.18 aldehyde Pantoate 4.2.1.18 Methylglutaconyl-CoA hydratase
2.1.1.71 Phosphatidyl-N-methylethanolamine
CH3(CH2)2CH2CH2COSCoA
1.3.99.3
CH3(CH2)2CH=CHCOSCoA
4.2.1.17
CH3(CH2)2CH(OH)CH 2COSCoA
1.1.1.35
CH3(CH2)2COCH 2COSCoA
2.3.1.16 ACETYL-CoA CH3CH2COCOO
Oxobutyrate
isovalerate isovalerate -Alanine 4.2.1.19 Imidazoleglycerol-phosphate dehydratase
N-methyltransferase G Hexanoyl-CoA 2, 3-Hexenoyl-CoA 3-OH-Hexanoyl-CoA 3-Oxohexanoyl-CoA
2.3.1.9 CH3 CH3 CH3 CH3
1.2.1.25
3.5.1.22
6.3.2.1
4.2.1.20
4.2.1.22
Tryptophan synthase
Cystathionine B-synthase
R
2.1.2.1 Glycine hydroxymethyltransferase
2.1.2.2 Phosphoribosylglycinamide formyltransferase HOCH 2CHCOO HOCH 2CHCOS-CoA- CH2 = CCOSCoA CH3CHCO-SCoA 4.2.1.24 Porphobilinogen synthase
CH3CH2CH2COSCoA CH3CH=CHCOSCoA HOCH 2 C(CH3)2CH(OH)CO NHCH 2CH2COO
CH3CH(OH)CH 2COSCoA CH3COCH 2COSCoA 3.1.2.4 4.2.1.17
A 4.1 1.3.99.3 4.2.1.33 3-Isopropylmalate dehydratase
2.1.2.3 Phosphoribosylaminoimidazole
carboxamide formyltransferase Butanoyl-CoA
1.3.99.2
Crotonoyl-CoA
4.2.1.55
3-OH-Butanoyl-CoA
1.1.1.157
Acetoacetyl-CoA .3.1 3-Hydroxy- 3-Hydroxy- Methyl Isobutyryl-CoA PANTOTHENATE 4.2 1.46 dTDPglucose 4,6-dehydratase
CH3 8
4.1.3.5 isobutyrate Isobutyryl-CoA acrylyl-CoA
2.1.2.5
2.1.2.10
Glutamate formiminotransferase
Aminomethyl transferase D Odd C Fatty acids 2.6.1.4
4
4.1.1.32 OHCCHCOO 1.1.1
.31
2.7.1.33
4.2.1.47
4.2.1.49
GDPmannose 4,6-dehydratase
Urocanate hydratase
2.1.3.1 Methylmalonyl-CoA carboxyltransferase A CH 3CH2CH 2CH2COSCoA CH3CH2CH=CHCOSCoA CH3CH2CH(OH)CH 2COSCoA CH3CH2COCH 2COSCoA Methylmalonyl CH 3 4.2.1.51 Prephenate dehydratase
1.1.1.35 2.6.1.4 CH3 CH3 +
2.1.3.2 Aspartate carbamoyltransferase
T Pentanoyl-CoA Pentenoyl-CoA 3-OH-Pentanoyl-CoA 3-Oxopentanoyl-CoA semialdehyde COO
CHCH(NH 3)COO P OCH 2C(CH 3)2CH(OH)CONHCH 2CH2COO 4.2.1.52 Dihydrodipicolinate synthase
2.1.3.3 Ornithine carbamoyltransferase 1.1.1.39 C(OH)CH(OH)COO CHCOCOO
CH3CH2 4-P-Pantothenate 4.2.1.55 3-Hydroxybutyryl-CoA dehydratase

I
2.1.4.1 Glycine amidinotransferase CH 2O-CO-R 4.2.1.58 Crotonoyl-[acyl-carrier-protein] hydratase
CH3COC(OH)CH 2CH3 CH3CH2 CH3CH2
2.2.1.1 Transketolase
CH2O-CO-R CH 2O-CO-R OHCCOO 4.1.3.5 4.1.3.4 2.3.1 2.6.1.32 Cysteine 4.2.1.59 3-Hydroxyoctanoyl-[acyl-carrier
OH OH 2.7.7.41 Glyoxylate .16 2-Aceto-2- 2:3-Di-OH-
4.2.1.9
2-Oxo-3-methyl ISOLEUCINE
6.3.2.5
O
2.2.1.2 Transaldolase R'-CO-OCH R'-CO-OCH O COO R'-CO-OCH protein] dehydratase
O O COO
hydroxy- 1.1.1.86 3-methylvalerate
+ CH2COO OOCCOCH 2COO
2.3.1.1 Amino-acid N-acetyltransferase
CH 2O PO CH 2CHNH 3 4.1.3.8 valerate 4.2.1.60 3-Hydroxydecanoyl-[acyl-carrier
2.3.1.4 Glucosamine-phosphate N-acetyltransferase
N CH2O-PO 1.3.99.7
- Serine
CH2O POCMP 1.1.1.79
1.2.3.5
CH3C(OH)CH 2COSCoA OXALOACETATE butyrate
P OCH 2C(CH 3)2CH(OH)CONHCH 2CH 2CO NHCHCH 2SH
4-P-Pantothenylcysteine
protein] dehydratase
2.3.1.5 Arylamine N-acetyltransferase O - HO OH O
2.7.8.8
O
-OH--Methyl- 4.2.1.1 CH3 CH 3 CH 3 1.2.1.25
4.2.1.61 3-Hydroxypalmitoyl-[acyl-carrier protein]
2.3.1.6 Choline O-acetyltransferase
PHOSPHATIDYL CDP-diacyl HOCH 2COO
glutaryl-CoA 8
CH3 dehydratase
2.3.1.7 Carnitine O-acetyltransferase OH
2.7.8.11 Inositol glycerol Glycolate 1.1.1.37 CH3COCHCOSCoA CH3CH(OH)CHCOSCoA CH3CH=CHCOSCoA CH3CH 2CHCOSCoA 4.1.1.36 4.2.1.75 Uroporphyrinogen-III synthase
2.3.1.8 Phosphate acetyltransferase
Phosphatidyl SERINE CH2COO OOCCH(OH)CH 2COO
4.1.1.12
2-Methylaceto-1.1.1.35 2-Methyl-3-4.2.1.17Tiglyl-CoA 2 Methylbutyryl- 4.2.1.80 2-Oxopent-4-enoate hydratase
2.3.1.9 Acetyl-CoA C-acetyltransferase 1.2.1.21 HOOC-COOH 1.3.99.3
4.2.99.2 Threonine synthase
2.3.1.12 Dihydrolipoamide S-acetyltransferase inositol CH2O-CO-R CH 2O-CO-R CH2O-CO-R
Oxalate 1.1.1.34 C(OH)COO MALATE acetyl-CoA hydroxy- CoA P OCH 2C(CH 3)2CH(OH)CONHCH 2CH 2CO NHCH 2CH 2SH 4.2.99.8 Cysteine synthase
2.3.1.15 Glycerol-3-phosphate O-acyltransferase R'-CO-OCH O O HCO-CO-R R'-CO-OCH O 2.7.8.5 HOCH 2CHO CH2COO
4.1.3.7
4.2.1.2
2.6.1.1 CH 3CH2COSCoA butyryl-CoA 4-P-Pantetheine 4.2.99.9
4.3.1.1
O-Succinylhomoserine (thiol)-lyase
Aspartate ammonia-lyase
2.3.1.16
2.3.1.20
Acetyl-CoA C-acyltransferase
Diacylglycerol O-acyltransferase P CH 2O-CO-R
4.1.1.65 CH2 O-POCH 2CH(OH)CH 2 O-P-OCH 2 CH2O-PO CH 2CHOHCH 2OH Glycol 1.3
.2 1.4.3.1 Propanoyl-CoA 4.3.1.2 Methylaspartate ammonia-lyase
2.7.7.3
2.3.1.23 Lysolecithin acyltransferase
H R'-CO-OCH O
O - O - O- aldehyde CH2COO
CITRATE 4.
OOCCH=CHCOO 2.1.3.1 COOH COOH
+ 4.3.1.3 Histidine ammonia-lyase
2.3.1.24 Sphingosine N-acyltransferase + Cardiolipin Phosphatidylglycerol CH3C(OH)CH 2CHO
FUMARATE 4.1.1.41 6.4.1.3 (CH3)2CHCH 2 CH(NH 3)COO 4.3.1.5 Phenylalanine ammonia-lyase
2.3.1.30 Serine O-acetyltransferase
O CH 2O P OCH 2CH2 NH 3
-
+ +
1.4.3.8 Mevaldate 4.2.1.3
HOOCCHO 4.3 5.1.99.1
(CH3)2CHC(OH)CH 2COO (CH3)2CHCHCH(OH)COO (CH3)2CHCH 2COCOO 2.6.1.6
LEUCINE
ADP- OCH2 C(CH 3)2CH(OH)CONHCH 2CH2CO NHCH 2CH2SH
Dephospho-Coenzyme A
4.3.2.1 Argininosuccinate lyase
2.3.1.37 5-Aminolevulinate synthase O CPP- OCH 2CH2 NH3 POCH2CH2 NH3 .1. 2-Isopropyl- 3-Isopropyl- 1.1.1.85 Oxoleucine 4.3.2.2 Adenylosuccinate lyase
2.3.1.38 [Acyl-carrier-protein] S-acetyltransferase S 2.7.8.1 CDP-Ethanolamine 2.7.7.14
Ethanolamine-P 2.7.1.82
+
HOCH 2CH 2NH 3 Glyoxylate 1
malate 4.2.1.33
malate 1.4.1.9 4.4.1.1 Cystathionine g-lyase
2.3.1.39 [Acyl-carrier-protein] Phosphatidyl Ethanolamine 1.1.1.32 1.3.5.1 2.7.1.24 4.4.1.8 Cystathionine -lyase
S-malonytransferase P ethanolamine CH2O-CO-R
CH2OH CHOHCOO
+
CH3
OOC-CH-COSCoA 4.2.1.18
CH3 CH3 1.2.1.25
4.4.1.15
4.6.1.1
D-Cysteine desulfhydrase
Adenylate cyclase
H
2.3.1.41 3-Oxoacyl-[acyl-carrier-protein] synthase HOCH O OOCCH 2CH(NH 3)COO
CEPHALIN CH3COCH 2CH2N(CH 3 )3 CHCOO
Methylmalonyl-CoA OOCCH 2C = CHCOSCoA CH3C = CHCOSCoA (CH3)2CHCH 2COSCoA P-ADP- OCH 2 C(CH 3)2CH(OH)CONHCH 2CH 2CO NHCH 2CH2SH
A
+ 4.6.1.3 3-Dehydroquinate synthase
2.3.1.46 Homoserine O-succinyltransferase
HOCH O CH COO 4.1.3.1 6.4.1.4 1.3.99.10
2.3.1.50 Serine C-palmitoyltransferase
O + CH2OPO CH2CH 2N(CH 3) Acetylcholine CH C(OH)CH
2
CH2COO
ASPARTATE 3-Methyl- 3-Methyl- Isovaleryl-CoA Coenzyme A
4.6.1.4 Chorismate synthase
- OOCCH 2CH2COO 4.2.1.18
2.3.1.51
2.3.1.76
1-Acylglycerol-3-phosphate O-acyltransferase
Retinol O-fatty-acyltransferase
L CH2OCH=CHR
2.1.1.17
2.1.1.71
CH2OPO CH2CH2N(CH 3)3
O - Lysolecithin 3.1.1.5
O
Glycerophosphocholine 3.1
.4.2
3
Mevalonate
2 CH2OH
ISOCITRATE SUCCINATE
2.7
. 2.4 1.1.1.3
glutaconyl-CoA crotonyl-CoA M 4.99.1.1 Ferrochelatase

2.4.1.1 Phosphorylase
I R'-CO-OCH O
CH 2 O-CO-R
3.1.1.32
3.1.4.4 2.3.1.6
GTP 6.2.1.4 +
I ISOMERASES

CO2
2.4.1.9 Inulosucrase 5.1.3.1 Ribulose-phosphate 3-epimerase
R'-CO-OCH O 2.7.1.36 1.2.1
2 4.1.11 Glycogen (starch) synthase
P
+
CH2OPO CH2CH2N(CH 3)3 +
CH2OPOCH2CH2N(CH 3)3 +
3.1.4.3
+ +
2.7.4.2 1.1.1.41 GDP+Pi 3.1.2.3 .16 P OOCCH 2CH(NH3)COO
Aspartyl-P H H2
+ N 5.1.3.2
5.1.3.4
UDPglucose 4-epimerase
l-Ribulose-phosphate 4-epimerase
2.4.1.13 Sucrose synthase
-O O - CPP-O CH2CH2N(CH 3)3 P OCH 2CH2 N(CH 3)3 HOCH 2CH2N(CH 3)3 - OOCCH CH COSCoA 1 .2 C C
OOCCH 2CH2CONH NH3
O 5.1.3.6 UDPglucuronate 4-epimerase
I
2.4.1.16 Chitin synthase 2.7.7.15 2 2 HC CH 2 H 2C CH2
2.4.1.17 Glucuranosyltransferase Choline LECITHIN CDP-choline Choline-P CHOLINE CH2COO 5-Amino SUCCINYL-CoA
5.1.99.1 .1.
11 + CH-COO
OOCCH 2CH2CONH OOCCHCH 2CH2CH 2CH-COO
+
OOCCH-CH 2CH2CH2CHCOO
+
5.1.3.7 UDP-N-acetylglucosamine 4-epimerase
plasmalogen 1.3.1.35 2.7.8.2 2.7.1.32 OOCC OOCC CH-COO
D .3 OOCCOCH 2CH2CH2CH-COO NH3 NH 3
2 5.1.3.12 UDPglucuronate 5-epimerase
2.7.8
2.4.1.21 Starch synthase levulinate OHCCH 2CH (NH3)COO
3.1.4.1 CH3C(OH)CH 2CH2OPP 5.4.99.2 N N
1.3.1.26
2.4.1.22
2.4.1.23
Lactose synthase
Sphingosine -galactosyltransferase
S
Serine +NH + + + Diphospho- 1.2.4.2
6.3.5.4 Aspartyl
OOCCH 2CH2CHO 4.2.1.52
2, 3-Dihydro- Piperideine- N-Succinyl- 2.6.1.17
N-Succinyl-2, 6 3.5.1.18
Diamino- A 5 1.3.13 dTDP-4-Dehydrorhamnose 3,5-epimerase
5.1.3.14 UDP-N-acetylglucosamine 2-epimerase
2.4.1.29 Cellulose synthase (GDP-forming) 2.3.1.50 3 NH 3 NH 3 NH 3
mevalonate Succinic Semialdehyde dipicolinate 2, 6-dicarboxylate 2-amino-6-oxo- diaminopimelate pimelate C 5.1.99.1 Methylmalonyl-CoA epimerase
CH3(CH2)12CH=CHCH(OH)CHCH 2O- Galactose -OOCCOCH CH COO- 4.1.1.71
2.4.1.32 Glucomannan 4--mannosyltransferase CH 3(CH2)14COCHCH 2OH CH3(CH2)14CH(OH)CHCH 2OH CH3(CH2)12CH=CHCH(OH)CHCH 2OH
2.3.1.37 2 2 semialdehyde pimelate 5.2.1.2 Maleylacetoacetate isomerase
2.4.1.33 Alginate synthase Dehydrosphinganin
1.1.1.102
Sphinganin 4-Sphingenin Psychosine 2-OXOGLUTARATE + +
OH
+ + + + + .7
5.1.1 0
I 5.2.1.3
5.2.1.7
Retinal isomerase
Retinol isomerase
D
2.4.1.47 Acylsphingosine galactosyltransferase (H3N)(CH2)4 CH(NH 3)COO
2.4.1.62 Ganglioside galactosyltransferase
UDP-Sugars Acyl-CoA 2.4.1.23 Glycine
+
H2NOCCH 2CH (NH3) COO
(CH3)3NCH2CH(OH)CH 2COO (CH3)3N(CH 2)3 CH2CH(NH 3)COO (CH3)3N(CH 2)3 CH2CH(NH 3)COO
4.1.1
.2 5.3.1.1 Triose-phosphate isomerase
Gangliosides 2.4.1.62 3.5.1.23 Acyl-CoA 4.1.1.33 Carnitine N -Trimethyl-
6
N -Trimethyllysine
6
LYSINE 1.5.1.7 - 10
S
5.3.1.3 Arabinose isomerase
2.4.1.68 Glycoprotein 6-a-l-fucosyltransferase
UDP-Galactose Asparagine 1.14.11.1 1.14.11.8
3-OH-lysine 5.3.1.4 l-Arabinose isomerase
NADH+H +
2.4.1.69 Galactoside 2-a-l-fucosyltransferase
NHAcyl O NHCOR
2.4.2.1 Purine-nucleoside phosphorylase + NHCOR 2.6.1.19 COO 5.3.1.5 Xylose isomerase
+
CH3(CH2)12CH=CHCH(OH)CHCH 2O PO CH2CH2N(CH 3)3 CH3(CH2)12CH=CHCH(OH)CHCH 2O- Galactose 5.3.1.6 Ribose-5-phosphate isomerase
2.4.2.2 Pyrimidine-nucleoside phosphorylase
O - CH3(CH2)12CH=CHCH(OH)CHCH 2OH CH2 R-CH(NH3) COO
+ +
NH CHCH 2CH2COO
+ 5.3.1.8 Mannose-6-phosphate isomerase
2.4.2.4
2.4.2.8
Thymidine phosphorylase
Hypoxanthine phosphoribosyltransferase SPHINGOMYELIN
2.7.8.3
Ceramide 3.2.1.46 2.4.1.47 Cerebroside CH3C-CH2CH2OPP 2-AMINO ACID 1.3.99.7 OOCCH 2CH 2CH2COSCoA OOCCH 2CH2CH2COCOO OOCCH 2CH2CH2CH (NH3) COO OHCCH 2CH2CH2CH (NH3) COO CH 2CH2CH2CH2CH (NH3) COO 5.3.1.9 Glucose-6-phosphate isomerase
3.1.4.12
2.4.2.9 Uracil phosphoribosyltransferase
1.3.99.7 Isopentenyl-PP 2.6.1.- 4.1.1.70
Glutaryl-CoA 2-Oxoadipate 2.6.1.39
2-Aminoadipate 1.2.1.31 2-Aminoadipate 1.5.1.9
Saccharopine 5.3.1.16 N-(5-Phospho-d-ribosylformimino)-
2.4.2.10 Orotate phosphoribosyltransferase CH3
(C5) NAD + TR R-CO-COO OOCCH 2CH2CH2NH2 semialdehyde 5-amino-1-(5-phosphoribosyl)-
4-imidazolecarboxamide isomerase
2.4.2.11 Nicotinate phosphoribosyltransferase
2.4.2.14 Amidophosphoribosyltransferase I CH3C = CHCH 2OPP I
1.6.5.3
FMN AN
SA 2-OXO ACID 4-Aminobutyrate Adenosyl 5.3.3.2 Isopentenyl-diphosphate -isomerase
Lycopene (C40) Phytoene Dimethylallyl-PP MI (GABA) CH3-SCH 2CH2CHNH 2
S
2.4.2.15 Guanosine phosphorylase 5.3.99.3 Prostaglandin-E synthase
Fe--S N H2N(CH 2)3NH(CH2)4NH (CH2)3NH2
2.4.2.17 ATP phosphoribosyltransferase (C40) (C5) FMNH 2 AT + 5.3.99.5 Thromboxane-A synthase
To Brain - VISION 2.5.1.1 IO Spermine S-Adenosylmethyl L E G E N D
2.4.2.18
2.4.2.19
Anthranilate phosphoribosyltransferase
Nicotinate-nucleotide pyrophosphorylase O hv CH3
2e- +
2H+ N +
.1.1
5
thiopropylamine
5.4.2.1
5.4.2.2
Phosphoglycerate mutase
Phosphoglucomutase
CH 3
4H +
4H OOCCH 2CH 2CH (NH3) COO 4.1 Carbohydrates
(carboxylating)
P -CAROTENE (C40) 2.5.1.32 2.5.1.29 CH3C= CHCH 2 CH2C= CHCH 2OPP
(Decarboxylated SAM)
Biosynthesis Degradation
5.4.2.3 Phosphoacetylglucosamine mutase

GLUTAMATE
5.4.2.8 Phosphomannomutase
Mitochondrial Intermembrane Space

2.4.99.1-11 Sialyltransferases
2.4.99.7 Sialyltransferase R Metarhodopsin Rhodopsin CH2OPP Geranyl-PP 2H+ 2.7.2
2.5.1.22 5.4.3.8 Glutamate-1-semialdehyde 2,1-aminomutase
O _ .11 +
Mitochondrial Outer Membrane

Amino Acids
Mitochondrial Inner Membrane

2.5.1.1 Dimethylallyltranstransferase (C10) POOCCH2CH 2CH(NH3) COO 5.4.99.2 Methylmalonyl-CoA mutase

2.5.1.6 Methionine adenosyltransferase E 1.13.11.21
COO- Opsin
CH3O CH3
Geranyl-geranyl-PP II
SUCCINATE NO3 1.4.1.2 1.4.1.14 3.5.1.2 Glutamyl-P
H2N(CH 2)4NH (CH2)3NH2
Biosynthesis Degradation
5.4.99.5 Chorismate mutase
CH3O (C20) UQ
Spermidine
N
2.5.1.10 Geranyltranstransferase n 5.4 99.7 Lanosterol synthase
1.3.5.1 Fe--S FAD 6.3.1.2
2.5.1.16 Spermidine synthase
Retinoate
O Ubiquinone 2.5.1.10 UQH2
FUMARATE
1.6.6.1
Lipids
5.5.1.4 myo-Inositol- l-phosphate synthase
2.5.1.19
2.5.1.21
3-Phosphoshikimate 1-carboxyvinyl-transferase
Farnesyltransferase O 1.2.1.36
CHO (Coenzyme Q) OPP
2H+ 2H+
1.7.99.4 3.5.1.2
1.2.1.41 Biosynthesis Degradation LIGASES
_
NH+
2.5.1.16
2.5.1.22 Spermine synthase
I trans-Retinal 5.2.1.3
11-cis-Retinal CHO Menaquinone CH2OH CH2 1.7.7.1 6.2.1.3 Long-chain-fatty-acid-CoA ligase
2.5.1.29
2.5.1.32
Farnesyltranstransferase
Geranylgeranyl-diphosphate geranylgeranyl D
Light Phytol (C20) NO2 1.6.6.4
4 +
H2NOCCH 2CH2CH (NH3) COO + H2NCH2CH2CH2CH2NH2
Purines & Pyrimidines 6.3.1.1
6.3.1.2
Aspartateammonia ligase
Glutamateammonia ligase
transferase Retinol esters 1.1.1.105 1.1.1.105 Plastoquinone Glutamine OHCCH 2CH 2CH(NH3) COO
Putrescine
Biosynthesis Degradation 6.3.1.4 Aspartateammonia ligase (ADP-forming)
2.6.1.- Transaminases S O HO
CH3
Farnesyl-PP
III 1.10.2.2
Fe-S and 2e- 1.1
8.6
.1
ATP Glutamic 6.3.1.5 NAD+ synthetase
2.6.1.1 Aspartate transaminase 2.3.1.76
CH 3
semialdehyde Vitamins, Co-Enzymes & Hormones 6.3.2.1 Pantoate-alannine ligase
(C15) Cytochromes CO2
2.6 1.2
2.6.1.4
Alanine transaminase
Glycine transaminase 3.1.1.21
CH2OH
5.2.1.7
CH2OH
CH 3 O
CH3 2H+ 2H+
MITOCHONDRIAL
MATRIX N2 6.3.4.16
6.3.5.5 CH2 CH2
CH3COCOO OHCCOO
6.3.2.2
6.3.2.3
Glutamatecysteine ligase
Glutathione synthase
2.6 1.5 Tyrosine transaminase trans-Retinol 11-cis-Retinol O
Phylloquinone -Tocopherol Pyruvate Glyoxylate Pentose Phosphate Pathway 6.3.2.5 Phosphopantothenatecysteine ligase
2.6 1.6 Leucine transaminase S (Vitamin A) Dark (Vitamin K) (Vitamin E)
2.5.1.21
CH CHCOO 6.3.2.6 Phosphoribosylaminoimidazole-
Cyt.c 2.6.1.13 succinocarboxamide synthase
T
2.6.1.9 Histidinol-phosphate transaminase H2NCOOP N
2.6.1.13 Ornithineoxo-acid transaminase STEROIDS Carbamoyl-P + Photosynthesis Dark Reactions 6.3.2.7 UDP-N-Acetylmuramoyl-l-alanyl-
IV 2H+ H 2NCONHCH 2CH2CH2CH(NH3) COO Pyrroline-5-
E
2.6.1.16 Glutaminefructose-6-phosphate transaminase d-glutamatelysine ligase
1.9.3.1 4.1.3.16
2.6.1.17 Succinyldiaminopimelate transaminase
Cu and H2O CITRULLINE carboxylate 6.3.2.8 UDP-N-acetylmuramatealanine ligase
2.6.1.18
2.6.1.19
-Alaninepyruvate transaminase
4-Aminobutyrate transaminase R Progesterone Cytochromes 2.1.3.3 4.1.1.17
OOCCH(OH)CH 2COCOO
Human Metabolism is identified as far as possible by black arrows
Biosynthesis Degradation
6.3.2.9 UDP-N-acetylmuramoylalanine
d-glutamate ligase
2.6.1.22 l-3-Aminoisobutyrate transaminase O H
HO
H
HO
H 2H+ 2H+ 3H + 1.5.99.8
CH2 CH2
4-Hydroxy- 6.3.2.10 UDP-N-acetylmuramoylalanyl-
HO
2.6.1.23 4-Hydroxyglutamate transaminase HO 1.5.1.2 2-oxoglutarate Small numbers refer to the IUBMB Enzyme Commission d-glutamyl-lysined-alanyl-d-alanine ligase
2.6.1.27 Tryptophan transaminase I Pregnenolone CHOLESTEROL Desmosterol
H
Zymosterol
H
Lanosterol 5.4.99.7
Squalene Pi +
H2NCH2CH2CH2CH (NH3) COO
CH2 CHCOO Reference Numbers for Enzymes
6.3.2.13 UDP-N-Acetyl muramoylalanyl-d-
M I TO

glutamate2,6-diaminopimelate ligase
D
2.6.1.32 Valine3-methyl-2-oxovalerate transaminase
1.14.99.7 (C30)
2.6.1.36 l-Lysine 6-transaminase
COO-
ADP ORNITHINE
NH
2.6.1.23 COMPARTMENTATION
6.3.3.1 Phosphoribosylglycinamidine cyclo-ligase

S COO- 3.6.1.34 6.3.4.5

PROLINE 6.3.4.1 GMP synthase
CH

2.6.1.39 2-Aminoadipate transaminase

1H+ The "BACKBONE" of metabolism involves GLYCOLYSIS, the TCA CYCLE
TRA N SLO

2.6.1.42 Branched-chain-amino-acid transaminase

COO- ATP and OXIDATIVE PHOSPHORYLATION. It is a major source of energy (ATP)
6.3.4.2 CTP synthase
ON

CH2 CH2 CH2 +

2.6.1.44 Alanine-glyoxylate transaminase CHLOROPHYLL COO- CH2
COO- 1.14.11.2 6.3.4.3 Formatetetrahydrofolate ligase
OOCCH(OH)CH 2CH(NH 3)COO and is the origin and termination of most of the pathways. GLYCOLYSIS
DR

OOCCHCH 2COO
2.6.1.51 Serinepyruvate transaminase
P CH H
CH3
CH2
CH H2 CH3 CH CH2 H2 CH3
CH2 -OOC CH2 H CH2 -OOCCH CH COCH NH
2 2 2 2
H2NCONH 2
4-Hydroxy- occurs in the CYTOPLASM. The TCA CYCLE is in the MITOCHONDRIAL
6.3.4.4 Adenylosuccinate synthase
IA

CH2
2.6.1.52 Phosphoserine transaminase C C 2
C C
2
5-Amino N 2.1.4.1 UREA N + 6.3.4.5 Argininosuccinate synthase
L

HOCH CH2 MATRIX. OXIDATIVE PHOSPHORYLATION (ATP SYNTHESIS) spans the

O H3 C CH H3 C CH NE glutamate 6.3.4.7 Ribose-5-phosphateammonia ligase
I

2.6.1.66 Valinepyruvate transaminase H3 C CH2 H 2C CH2 H2NCNHCH 2CH 2CH2CH(NH3) COO

2.7.1.1 Hexokinase N N N N N N N levulinate R
ME Glycine + Arginino- H2C CHCOO MITOCHONDRIAL INNER MEMBRANE. This last part has been redesigned 6.3.4.13 Phosphoribosylamineglycine ligase
R H H H H N 3.5.3.1 3.5.3.6 to illustrate the activation of ATP-synthase and formation of ATP - driven by
H H COO- MB 3.6.1.3 NO N CH2 6.3.4.16 Carbamoyl-phosphate synthase (ammonia)
CAT

2.7.1.2 Glucokinase HOCH

RAN
HC Fe CH H2 C CH2 H2 C CH2 H 2C CH2 E NH2 succinate H 1.5.1.12 the electromotive translocation of protons across the mitochondrial inner 6.3.4.17 Formatedihydrofolate ligase
P
2.7.1.3 Ketohexokinase
H H H H -OOC + HC CHCOO
2.7.1.4 Fructokinase HEMOGLOBIN N N N N N N H H CH2 H2NCNHCH 2CH2CH2CH (NH3) COO 1.14.13.39 membrane. A similar compartmentation occurs in the chloroplast, where 6.3.5.1 NAD+ synthetase (glutamine-hydrolysing)
N N
HYDROXY
ED

N light-driven proton translocation across the inner thylakoid membrane

H
2.7.1.6 Galactokinase 6.3.5.2 GMP synthetase (glutamine-hydrolysing)
H3 C CH3 H3 C CH3 H3 C CH3 H 2C CH2 CH2 3-Hydroxy-
2.7.1.7 Mannokinase C C C - C
H2 C
RO ARGININE PROLINE
initiates synthesis of the ATP necessary for Photosynthesis. In both 6.3.5.3 Phosphoribosylformylglycinamidine synthetase
P

COO- pyrroline-
2.7.1.11 6-Phosphofructokinase
Y CH2
H CH2 CH2 H2 CH2 CH2 H2 CH2 OOC CH2 H2 CH2
4.2.1.24
TO
cases flow of electrons and protons is shown in red or blue arrows 6.3.5.4
6.3.5.5
Asparagine synthase (glutamine-hydrolysing)
Carbamoyl-phosphate synthase
H2 C N N 1H+ 4.3.2.1 5-carboxylate
R CH2
COO-
CH2
COO-
CH2
COO-
CH2
COO-
CH2
COO-
CH2
COO-
CH2
COO-
CH2
COO- H2 N
H S
+ + NH + NH2 HN C
NH CO Electron Flow Proton Flow 6.4.1.1
(glutamine-hydrolysing)
Pyruvate carboxylase
I 1.3.3.3 4.3.1.8
3H 2
+ NH2
N CH 2 6.4.1.2 Acetyl-CoA carboxylase
HEME 1.3.3.4
Protoporphyrinogen Coproporphyrinogen 4.1.1.37Uroporphyrinogen 4.2.1.75 Porphobilinogen ADP Pi
H2NCNHCH 2COO H2NCN(CH 3)CH2COO P- HNCN(CH 3)CH2COO 1.5.1.2 6.4.1.3 Propionyl-CoA carboxylase
N 4.99.1.1 2.1.1.2 CH3 Some other pathways occurring in the mitochondria
ATP
2.7.3.2 P-Creatine
IX III III Guanidoacetate Creatine Creatinine are identified by a pale yellow background
6.4.1.4 Methylcrotonoyl-CoA carboxylase

S 3.5.2.10

Cytoplasm
Cytoplasmic Membrane

Enzymes available from Sigma Enzymes available from Sigma Enzymes available from Sigma