Bahan semsol

Methatmpyrone sinonim :

lgopyrin Methanesulfonate Sodium, Novalgin

Noramidopyrine
Analgin Novamidazophen
Methanesulfonate,
Biopyrin Noramidopyrine Novaminsulfone

Dipyrone Narone Optalgin

Dipyronium Noramidopyrine Pyralgin

Metamizol Methanesulfonate Sulpyrin

Metamizole Noramidopyrine Sulpyrine

Methanesulfonate Sodium
Methamizole
Normelubrine
Methampyrone
Novalgetol

Sodium (pINN); Aminopyrine-sulphonate Sodium;

Analginum; Dipiron; Dipyron; Dipyroni; Dipyronum; Metamitsolinatrium;

Metamizol; Metamizol sdico; Metamizol sodn sl

monohydrt; Metamizol sodowy; Metamizol Sodyum; Mtamizole

sodique; Metamizolnatrium; Metamizol-ntrium; Metamizolo

natrio druska; Metamizolum natricum; Metamizolum Natricum

Monohydricum; Methampyrone; Methylmelubrin; Natrium

Novaminsulfonicum; Noramidazophenum; Novamidazofen; Novaminsulfone

Sodium; NSC-73205; Sodium Noramidopyrine

Methanesulphonate; Sulpyrine. Sodium N-(2,3-dimethyl-5-oxo-

1-phenyl-3-pyrazolin-4-yl)-N-methylaminomethanesulphonate

monohydrate.

(martindale)
Hayooo apalagi

Rumus molekul : C13H16N3NaO4S,H2O Mr 351.4

(Japanese Pharmacopeia)

C13H16N3NaO4S,H2O 351.4

(british pharmacopeia)

Pemerian :

A white or almost white, crystalline powder, very soluble in water, soluble in alcohol.

(Japanese Pharmacopeia) A white or almost white crystalline powder. Very soluble in water; soluble

in alcohol. Protect from light.

(martindale)

Bubuk kristal putih atau hampir putih, sangat larut dalam air, larut dalam alkohol.
(Japanese Pharmacopeia) Bubuk kristal putih atau hampir putih. Sangat larut dalam air; larut
dalam alkohol. Lindungi dari cahaya.

Kegunaan : analgesic (dipyrone)

(british pharmacopeia 2009)

Kelarutan : Very soluble in water, soluble in ethanol (96 per cent).

(british pharmacopeia)

Penyimpanan : Protected from light. terlindung dari cahaya (british pharmacopeia)

Stabilitas :

Stable. Incompatible with strong oxidizing agents.

http://www.chemicalbook.com/ChemicalProductProperty_EN_CB7741339.htm (1909)

Dosis : Oral or intranasal administration. For oral, the adult should take 0.5g of the medicine and three
times a day, the amount of the child is 8-10mg/ kg, the number of the times is according to the
necessary. For intranasal, the child under 5 years old can take 1-2drops for each nostril, can take the
medicine another time if necessary,for the patient above 5 years old increase the dosage appropriately.

http://www.chemicalbook.com/ChemicalProductProperty_EN_CB7741339.htm
oral dose of 0.5 to 1 gram.'

Administrasi lisan atau intranasal. Untuk oral, orang dewasa harus minum 0,5g obat dan tiga kali sehari,
jumlah anak 8-10mg / kg, berapa kali sesuai kebutuhan. Untuk intranasal, anak di bawah 5 tahun dapat
minum 1-2drop untuk setiap lubang hidung, dapat minum obat lain jika diperlukan, karena pasien di
atas 5 tahun meningkatkan dosisnya dengan tepat.

A drug that no one needs

Farmakologi :

Irrespective of the inhibition of PGE2 synthesis, other mechanisms participate in the production of
theanalgesic effect of metamizole.It is a well-known fact that activation of CB1 receptors reduces
GABAergic transmission in periaqueductal grey matter (PAG), which disinhibits activating neurons
(mainly glutaminergic ones) and initiates antinociception, as a consequence of the activation of the
descending pathway (Rutkowska and

Jamontt 2005). jurnal farmakologi di folder download

The third mechanism most likely to be involved in

the induction of metamizoles analgesic effect is the

activation of the endogenous opioidergic system

Metamizole (dipyrone) adalah obat analgetik dan non-opioid yang populer, biasa digunakan pada
pengobatan manusia dan kedokteran hewan. Dalam beberapa kasus, agen ini masih salah
diklasifikasikan sebagai obat antiinflamasi non steroid (NSAID). Metamizole adalah pro-obat, yang secara
spontan rusak setelah pemberian oral ke senyawa pirazolon yang terkait secara struktural. Terlepas dari
efek analgesiknya, obat tersebut adalah agen antipiretik dan spasmolitik. Mekanisme yang bertanggung
jawab atas efek analgesik sangat kompleks, dan kemungkinan besar bergantung pada penghambatan
siklooksigenase-3 pusat dan aktivasi sistem opioidergik dan sistem cannabinoid. Metamizol dapat
menghalangi jalur PG-dependent dan PG-independent fever yang diinduksi oleh LPS, yang menunjukkan
bahwa obat ini memiliki profil tindakan antipiretik yang sangat berbeda dengan NSAID. Mekanisme yang
bertanggung jawab atas efek spasmolitik metamizol dikaitkan dengan pelepasan Ca2 + intraselular
sebagai hasil sintesis inositol fosfat yang dikurangi. Metamizol sebagian besar diaplikasikan pada terapi
nyeri dari berbagai etiologi, kondisi kejang, terutama yang mempengaruhi saluran pencernaan, dan
demam refrakter terhadap pengobatan lainnya. Co-administrasi morfin dan metamizol menghasilkan
efek superaditif dan antinociceptive. Metamizol adalah sediaan farmasi yang relatif aman meskipun
tidak sepenuhnya bebas dari efek yang tidak diinginkan. Diantara efek samping ini, yang paling serius
yang menimbulkan sebagian besar kontroversi adalah efek myelotoxic. Kelihatannya di masa lalu, risiko
agranulositosis yang diinduksi metamizol dibesar-besarkan. Meskipun ada bukti yang menunjukkan tidak
adanya risiko efek teratogenik dan embriotoksik, obat tersebut tidak boleh diberikan kepada wanita
hamil, walaupun diizinkan untuk diberikan pada hewan hamil dan menyusui. Makalah ini berusaha
untuk menggambarkan karakteristik metamizol dalam terang pengetahuan saat ini.

Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human and veterinary
medicine. In some cases, this agent is still incorrectly classified as a non-steroidal anti-inflammatory drug
(NSAID). Metamizole is a pro-drug, which spontaneously breaks down after oral administration to
structurally related pyrazolone compounds. Apart from its analgesic effect, the medication is an
antipyretic and spasmolytic agent. The mechanism responsible for the analgesic effect is a complex one,
and most probably rests on the inhibition of a central cyclooxygenase-3 and activation of the opioidergic
system and cannabinoid system. Metamizole can block both PG-dependent and PG-independent
pathways of fever induced by LPS, which suggests that this drug has a profile of antipyretic action
distinctly different from that of NSAIDs. The mechanism responsible for the spasmolytic effect of
metamizole is associated with the inhibited release of intracellular Ca2+ as a result of the reduced
synthesis of inositol phosphate. Metamizole is predominantly applied in the therapy of pain of different
etiology, of spastic conditions, especially affecting the digestive tract, and of fever refractory to other
treatments. Co-administration of morphine and metamizole produces superadditive, antinociceptive
effects. Metamizole is a relatively safe pharmaceutical preparation although it is not completely free
from undesirable effects. Among these side-effects, the most serious one that raises most controversy is
the myelotoxic effect. It seems that in the past the risk of metamizole-induced agranulocytosis was
exaggerated. Despite the evidence showing no risk of teratogenic and embryotoxic effects, the drug
must not be administered to pregnant women, although it is allowed to be given to pregnant and
lactating animals. This paper seeks to describe the characteristics of metamizole in the light of current
knowledge.

https://www.ncbi.nlm.nih.gov/pubmed/24724493

Pharmacological characteristics of
metamizole.
Jasiecka A, Malanka T, Jaroszewski JJ.