Elisio Polynephron:

Confidence From
The Inside Out
By combining more than 30 years of global experience in design and
manufacture of dialyzers with extensive research and engineering
innovation, Nipro created the ELISIO Polynephron Single Use,
Hollow-Fiber Dialyzer. This state-of-the-art product evolves and
advances our extensive fiber and dialyzer manufacturing expertise
to your benefit. The result: state-of-the-art performance through a
synthesis of a remarkable new membrane material and significant
design improvements.

Numerous clinical studies have been done using ELISIO dialyzers.

The results show that usage of ELISIO dialyzers lead to:

Improved low molecular weight protein removal

Improved hemoglobin outcomes

Decrease in ESA (Erythropoesis Stimulating Agent)

doses administered

Reduction in EPO resistance index

Lower coagulation activation

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Table Of
Contents
Evaluation of the New Nipro ELISIO-17H in Comparison WithTwo Reference Filters....... 4

Clinical Performance of the ELISIO-190H Dialyzer in Hemodialysis

and Hemodiafiltration.............................................................................................................. 5

Consequences on Renal Anemia of Two Synthetic High-Flux Dialyzers............................. 6

Do Dialyzers Designed for Increased Internal Filtration Cause Increased

Platelet Activation and Thrombin Generation?......................................................................7

Influence of the Nipro ELISIO-190H on the Proinflammatory Activity of

Circulating Mononuclear Cells................................................................................................ 8

Impact of Nanotechnologically Modified Dialyzer on Dialysis Removal Capacity............. 9

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 NOTES

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ELISIO Polynephron:
Performance Parameters and Specifications
Performance ELISIOTM-H
Parameter Qb/Qd (ml/min) 9H 11H 13H 15H 17H 19H 21H 25H
Effective Surface Area (m2) 0.9 1.1 1.3 1.5 1.7 1.9 2.1 2.5
KOA Urea (mL/min)* 778 916 1190 1351 1614 1771 1976 2269
Clearances (mL/min)**
Urea 200/500 190 193 196 198 198 199 200 200
300/500 246 257 272 278 285 288 291 294
400/500 278 298 316 326 337 345 348 363
400/800 307 327 347 359 368 373 378 386
500/800 339 365 392 408 420 430 437 460
Creatinine 200/500 177 184 191 196 197 198 199 200
300/500 218 233 250 259 268 273 275 285
400/500 242 261 280 296 306 314 326 342
400/800 275 297 318 333 349 358 363 377
500/800 292 326 353 368 388 409 415 431
Phosphate 200/500 163 171 178 184 188 192 195 196
300/500 200 213 230 241 254 258 265 276
400/500 223 246 265 275 292 305 314 329
400/800 242 263 291 305 322 335 339 352
500/800 259 293 317 337 357 371 378 405
Vitamin B12 200/500 116 128 140 150 157 164 166 178
300/500 134 148 165 180 190 200 206 224
400/500 139 161 181 194 211 222 228 247
400/800 151 173 197 215 231 245 254 273
500/800 159 183 209 231 248 263 270 296
Inulin 200/500 81 86 96 102 110 119 124 153
300/500 89 94 102 112 121 132 145 171
400/500 92 96 109 118 129 139 151 182
400/800 97 97 113 125 132 149 159 195
500/800 101 102 117 131 140 156 166 210
Myoglobin 200/500 58 63 74 84 91 101 104 116
300/500 61 68 80 90 98 107 111 126
400/500 63 76 84 94 107 113 122 137
400/800 68 78 88 99 111 116 125 139
500/800 70 87 99 110 123 131 138 145
KUF (mL/hr/mmHg)*** 53 59 64 67 74 76 82 93
Sieving Coefficient**** Vitamin B12 0.99
Inulin 0.93
Myoglobin 0.22
Albumin <0.01

Item Name Description Packaging

DD+ELISIO-09H ELISIO-09H PP (0.9 m2) Synthetic Hemodialyzer
DD+ELISIO-11H ELISIO-11H PP (1.1 m2) Synthetic Hemodialyzer
DD+ELISIO-13H ELISIO-13H PP (1.3 m2) Synthetic Hemodialyzer
DD+ELISIO-15H ELISIO-15H PP (1.5 m2) Synthetic Hemodialyzer
24/Case
DD+ELISIO-17H ELISIO-17H PP (1.7 m2) Synthetic Hemodialyzer
DD+ELISIO-19H ELISIO-19H PP (1.9 m2) Synthetic Hemodialyzer
DD+ELISIO-21H ELISIO-21H PP (2.1 m2) Synthetic Hemodialyzer
DD+ELISIO-25H ELISIO-25H PP (2.5 m2) Synthetic Hemodialyzer

* Qb 300mL/min, Qd 500mL/min, Qf 10mL/min.

** In Vitro Test Condition (EN1283):Qf 10mL/min.
*** KUF (EN1283):Bovine Blood (Hct 322%, Protein 60g/L, 37C), Qb 300mL/min.
**** SC (EN1283):Qb 300mL/min, Qf 60mL/min.

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2014 Nipro Medical Corp. All Rights Reserved. ELISIO and Polynephron are trademarks of Nipro Corporation.
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Printed in U.S.A. RN-BRUS-ELClin Rev. 1 www.nipro.com