LECTURE 1:

COURSE OUTLINE
9/10 JANUARY 2017

Smith & Kohalmi

where am I?

& who are you?

 Hi e
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We clas
to =) BIO
LOG
258 Y
GE 1 B
NET
ICS
 Team 2581B
Dr. Susanne Kohalmi Dr. David Smith

course coordinator & instructor instructor

course email: bio2581@uwo.ca
subject line: person you want to talk to (Prof. Smith or Kohalmi or TA) and/or topic

office hours
Thu 3:30-5:00 Fri 3:00-5:00
Western Science Biological & Geological
Centre, room 319 Sciences, room 3026
We will update OWL if office hours change
 Email conduct
Please use the course email rather than our
personal Western accounts.

Please dont bombard us with multiple emails

wait at least 48 h before sending a reminder,
otherwise youll only slow things down.
 Email conduct
Give yourself time to cool off

Wait at least 24 hours to email us after

an exam or the posting of exam marks
 Questions

?
General questions/concerns/exams,
missed exams/tutorials
Contact Dr. Susanne Kohalmi

Questions about lecture

Contact Professor responsible for lecture

Questions about your tutorial

Your TA or lead TA

Remember, the course email is bio2581@uwo.ca

 course information

https://owl.uwo.ca/portal

2581B OWL site contains all of the course information.

Use UWO email ID & password to access site.

lecture schedule powerpoints tutorial info admin info

Mon Tue Wed Thu
9:30 1:30 9:30 1:30
stick
to your
section
Tentative BIOLOGY 2581B LECTURE & TUTORIAL SCHEDULE (2017)
Date Topic (text reference & accompanying papers) Lecturer Tutorials (4)
Schedule Jan 9-10 Lec1. Course outline
Smith &
Kohalmi
UNIT1 (SMITH) FROM BIG TO SMALL (Lec2-6) No tutorials
Lec2. The tree of life: what is a genome, where are they
Jan 11-12 Smith
found, & where did they come from?
Lec3. You are what you eat: endosymbiosis shapes
Jan 16-17 Smith
genomes. No tutorials
Jan 18-19 Lec4. Organelles & their genomes. Smith
Jan 23-24 Lec5. Genomic architectural diversity: size. Smith
Tutorial #1: Meiosis
Lec6. Genomic architectural diversity: chromosomes & & genetic mapping
Jan 25-26 Smith
chromatin.
UNIT2 (KOHALMI) CHANGES TO DNA SEQUENCES (Lec7-
13)
Jan 30-31 Lec7. Understanding mutation. Kohalmi Tutorial #1: Meiosis
Feb 1-2 Lec8. Allele classification. Kohalmi & genetic mapping
Feb 6-7 Lec9. Selected genetic technologies. Kohalmi Tutorial #2:
Feb 8-9 Lec10. Mapping and genome sequencing. Kohalmi Mutations
Feb 13-14 Lec11. Generating mutants. Kohalmi Tutorial #2:
Feb 15-16 Lec12. Detection of mutation and genetic variation. Kohalmi Mutations
Feb 20-24 READING WEEK No tutorials
Feb 27-28 Lec13. Chromosomal rearrangements. Kohalmi
Drop in for
UNIT3 FROM SMALL TO BIG (Lec14-17)
questions
Mar 1-2 Lec14. Genes & gene expression (part 1). Smith
Smith &
Mar 2 REVIEW SESSION 4:30-6:30 Room NCB-101
Kohalmi
Mar 4 MIDTERM (Lec2-12) 9:00-12:00 (Locations TBA)
Mar 6-7 Lec15. Genes & gene expression (part 2). Smith Tutorial #3: Genetic
Mar 8-9 Lec16. Genetic modifications: methylation, RNA-editing. Smith techniques
Mar 13-14 Lec17. Mechanisms of genome evolution. Smith
Tutorial #3: Genetic
UNIT4 GAME CHANGERS (Lec18-19)
techniques
Mar 15-16 Lec18. Bioinformatics & big genomic breakthroughs. Smith
Mar 20-21 Lec19. Synthetic genomics & sci-fi genetics. Smith
UNIT5 SELECTED TOPICS IN APPLIED GENETICS (Lec20- Tutorial #4:
24) Bioinformatics
Mar 22-23 Lec20. Guest lecture: Synthetic biology part 2. Guest lecturer
Mar 27-28 Lec21. TEs and copy number variation. Kohalmi Tutorial #4:
Mar 29-30 Lec22. The ins and outs of transgenics. Kohalmi Bioinformatics
Apr 3-4 Lec23. Developmental genetics. Kohalmi Drop in for
Apr 5-6 Lec24. SFTs. Kohalmi questions
Smith &
Apr 6 Review Session TBA
Kohalmi
Smith &
Apr 10-14 Extended office hours & TA hours TBA
Kohalmi
TBA FINAL EXAM (Lec13-23)
This is a tentative timetable topics & schedule might deviate from what is
listed above.
Tutorials

4
Bi-weekly, 2hrs long
Begin week of Jan 23 / Jan 30

1) Meiosis & genetic mapping

2) Mutations
3) Genetic Techniques
4) Bioinformatics
Tutorials
Tutorial material will be posted on
OWL the Thursday before the first
tutorial.

Contains readings, assignments, and

sample problems to be completed prior
to the tutorial.

New material (not from lecture or textbook).

Do you have to go? You betcha!

Its 10% of the final grade.

You must go to your assigned tutorial to

receive the grade. (If not, you need special
permission from the Deans office).
Tutorials schedule
Monday Tuesday Wednesday Thursday Friday
9:3011:30 am 9:3011:30 am

Section 006 Section 016 Section 017

BGS 0165 KB K208 P&AB 36


Section 025 Section 035 Section 036

BGS 0165 KB K208 P&AB 36

11:301:30 pm 11:301:30 pm 11:301:30 pm 11:301:30 pm 11:301:30 pm

Section 003 Section 007 Section 011 Section 013 Section 018
TC 202 P&AB 148 NCB 296 NCB 296 BGS 0165


Section 022 Section 026 Section 030 Section 032

TC 202 P&AB 148 NCB 296 NCB 296

1:303:30 pm 1:303:30 pm 1:303:30 pm

Section 004 Section 014 Section 019 Section 020

P&AB 117 HSB 236 P&AB 36 BGS 0153


Section 023 Section 033 Section 038 Section 039

P&AB 117 HSB 236 P&AB 36 BGS 0153

3:305:30 pm 3:305:30 pm 3:305:30 pm 3:305:30 pm 3:305:30 pm

Section 005 Section 008 Section 009 Section 010 Section 012 Section 015 Section 021
P&AB 150 P&AB 117 P&AB 36 BGS 0165 KB K103 P&AB 117 BGS 0165


Section 024 Section 027 Section 028 Section 029 Section 031 Section 034

P&AB 150 All three sections are in P&AB 117 KB K103 P&AB 117


BGS - Biological & Geological Sciences Bldg. HSB - Health Science Building KB - Kresge Building
NCB - North Campus Building P&AB - Physics & Astronomy Bldg. TC - Talbot College


Yellow Fill: Tutorials Begin Week of January 23rd

Be there or be square
Brown Fill: Tutorials Begin Week of January 30th
 Grading
Expect results
multiple choice
after a week

45%
45%
midterm
final exam
exam

Tutorials 13: 10%

multiple choice quiz YOU MUST PASS AT LEAST
Tutorial 4: tutorials ONE OF THE EXAMS TO PASS
assignment THE COURSE!
Tutorials: 0.5% for attending & 2% for answering questions
This course uses cheating detection software for analyzing multiple choice exams
Questions about exams &
tutorial outcomes

There is a specific protocol to look at exams and

tutorial outcomes, and this must be carried out
within a specific window of time.

We will provide opportunity for you to see

exams and tutorial outcomes (if necessary).

Stay posted.
 Important dates

First tutorial: week of Jan 23 or Jan 30

(depending on which week you start)

Midterm Exam Sat Mar 4, 9am12pm.

(Locations TBA)

Final Exam Date/Time/Locations TBA

Midterm & final exams have ONLY ONE
make-up session.
Electronic devices during exam

NOT ALLOWED:
If calculations are required, they will be simple
and can be done using paper and pencil.

NOT ALLOWED:
any electronic devices, such as cell phones,
iPods & smart watches. Cheating will be
assumed if present.
Missed exam or tutorial

Only those with permission from Deans office

(Academic Counsellor) will be able to write a make-
up exam or will be assigned to a new tutorial
section.

Carefully review and follow Westerns Medical

Accommodation policy (Medical Notes) available
on OWL
 Course foundation

Builds on material from

1st year Biology & Biochemistry 2280A

You must have received >60% in 1st-year Biology and a

passing grade in Biochemistry 2280A to remain in this course.
switch
 Lectures
Dr. Smith Dr. Kohalmi Tutorials

Lec 26 Lec 712 Tut 1 & 2

MIDTERM EXAM

Lec 1419 Lec 13, 2124 Tut 3 & 4

Lec 20 (guest lecture)

FINAL EXAM

EXAMS WILL BE BASED ON MATERIAL COVERED IN LECTURE,

ASSIGNED READING MATERIAL & TUTORIALS
& WILL BE PROPORTIONAL
Doing well in 2581B

come to
class

pay attention
 Doing well in 2581B
keep up
with
material
get help
sooner
rather
than later
Assistance Office hours
Textbook
Lectures
Profs
TAs
Web
 posted lectures

come to class

YOU: read & study

 genes
and their role in genomes &
shaping the diversity, DNA,
dude!
complexity &
evolution of life whats this
course
all about?
 GENETICS
in a modern framework
 GENETICS
in a modern framework
500,000
VAST
Biol 2581B
Hartwell LH, et al. (2014) Genetics: From Genes to Genomes, 1st Canadian Edition,
McGraw-Hill, Ryerson, Toronto, ON. (ISBN-13:978-0-07-094669-9)
Great resource but not the sole
authoritative voice on genetics.

Doesnt contain all of the info

relevant to the course.

Feel free to use other resources.

 GENETICS
in a modern framework
TED TALK

Craig Venter