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InvestorPresentation

3Q2017
Stereotaxis
at a Glance

Global Leader in Endovascular Robotics


Focused on the Treatment of Cardiac Arrhythmias

Extensive Presence
300+ Physicians | 100+ Active Systems | 31 Countries

Validated & Protected


100,000+ Procedures | 250+ Publications | 100+ Issued Patents

Attractive Market
$4B+ Existing Market | 10-15% Annual Growth | No Robotic Competitor

Financial Highlights
$32m Sales | 82% Recurring Revenue | 77% Gross Margin *2016

$5.0m Cash and No Debt *6/30/2017

Market Cap ~$35m

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Surgical Progress

Open Laparoscopic Endovascular


Open surgical incision used to access patient Use rods with cameras and surgical tools on Catheter inserted into blood vessel through
anatomy. Large incisions as surgeons hands, the distal ends to perform surgical operations one small incision and navigated through the
instruments and light must reach procedure through multiple small incisions. Reduced vascular system to procedure site. Functional
site. Significant trauma, risk and recovery. trauma. Increased skill and complexity. capabilities at tip perform procedure.

Less Invasive. Less Risk. Improved Patient Care.

Technological innovation has enabled various procedures to progress to less invasive surgery.
This progress shifts clinical practice but more importantly causes a significant overall increase
in the number of patients treated as reduced surgical risk and invasiveness increases access to therapy.

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Endovascular
Surgery
TraditionalEndovascularSurgeryisWidelyUtilizedAcrossBroadClinicalApplications. butwithInherentLimitations.
Partial List of Multi-Billion Dollar
Endovascular Surgery Markets: Mechanism of Action Catheter Design
Clot Aspiration/Retrieval
& Endovascular Coils Manipulation of the tip of the In order to allow for the transfer of
catheter is accomplished in an force along its length, catheters
indirect inelegant fashion. Force is must be designed with rigid shafts
transferred from the physicians and internal pull wires.
Transcatheter Valves fingers/hands to the base of the
catheter and then over the entire
length of the catheter.

Coronary Angioplasty & Stents


Limited Catheter Increased Catheter Rigidity
Precision, Reach and Stability Reduces Patient Safety

Cardiac Ablation
Reliance on X-Ray Difficult & Complex

Navigation and visualization of the Performing endovascular surgeries


catheter in the vascular system is requires significant training and
accomplished using x-ray imaging. skill. Procedures often take
Endovascular Stent Grafts significant amounts of time. Often
simple movements are difficult to
accomplish.

Peripheral Vascular Stents, Radiation Exposure to Complex Long Procedures,


Balloons and Atherectomy Patients, Physicians and Staff Operator Dependent

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Robotics in Surgery

Thelastdecadehasseendramaticadoptionofrobotictechnologiesthataddressthelimitationsofopenandlaparoscopicsurgery.

Intuitive Surgical: Pioneered Robotics for Laparoscopic Surgery Manyothercompaniesspendinghundredsof


>4,000 Systems Installed and >750,000 Procedures in 2016 millionsofdollarstoparticipate:
Used in ~85% of US Prostatectomy and ~45% of US Hysterectomy
$36 Billion Valuation, $2.7 Billion 2016 Revenue

MAKO Surgical: Pioneered Robotics for Knee and Hip Arthroplasty


>400 Systems Installed, 86 Sold in 2016, 40% to Competitive Accounts
Acquired by Stryker for $1.65 Billion or ~16x Sales in 2013

Mazor Robotics: Pioneered Robotics for Spine Surgery


Strategic Collaboration with Medtronic in 2016
$1 Billion Valuation, ~$60 Million Revenue Expected in 2017

Twoobservations:
Roboticscapturedsignificantmarketsharedespitealackofmaterialclinicalsuperioritydata
RoboticsprovidesforDemocratizationofSkill:moresurgeonsenabledtoperformmoreproceduresmoreeffectively

Butthefieldofrobotictechnologiesforendovascularapplicationsissparse
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Endovascular Robotics
Mechanisms of Action

Three Mechanisms of Action:


Robotic-lite Push Pull
Description
The handle of a standard catheter is placed in a A computer-controlled catheter or sheath is A catheter with tiny magnets at the tip and with
mechanical grasper that is computer-controlled. designed with additional pull-wires for no pull-wires or rigidity along the shaft is
additional degrees of motion. robotically manipulated by modifying external
magnetic fields with a computer interface.
Examples
Stereotaxis V-Drive system for robotic control Hansens Sensei system for cardiac ablation. Stereotaxis Niobe system for cardiac ablation.
of sheaths and ICE or Lasso catheters.
Corindus CorPath system for coronary stents.

Comments
Relatively simple and inexpensive system can Increased navigational capabilities compared Control of a catheter directly at the tip allows
be used with existing catheters. Does not with traditional catheter. More rigid catheter for unmatched catheter precision, reach and
address the inherent limitations or expand the and increased size raises safety concerns. stability. Removal of pull-wires and shaft
capabilities of traditional catheters. rigidity creates a very safe catheter.

The pull mechanism of action is the most elegant in allowing for the
design and control of catheters in ways otherwise unachievable.
Stereotaxis is the only company that has developed a functional pull robotic system. The
system is robust with significant validation in >100,000 procedures at >100 hospitals.
The benefits of robotics can be combined in a synergistic and additive fashion with the
advances in mapping and manual ablation tip technology.
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Cardiac Ablation
Market

Large Rapidly Growing


$4 Billion Existing Annual Sales 10-15% Annual Growth

Annualsalesofablationandmappingproductsused Consistent,longterm,robustgrowthdrivenbyclinical
incatheterbasedablationprocedures evidence,agingpopulationandimprovedtechnology

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Setup of
Robotic Ablation

Robotic Magnetic Physician Computer Disposables & Other Synergistic


Navigation System Control Station Magnetic Catheter Products
External computer controlled Physician sits at a control A disposable device advances Nonmagnetic robot for
permanent magnets create a station, views procedure data and retracts a cardiac ablation ancillary catheters. Large
magnetic field within which a on a large computer screen, catheter with a magnetic tip screen displays for non
catheter with a magnetic tip and uses a mouse/joystick to developed exclusively for our robotic rooms. Information
can be precisely controlled. perform the procedure. robot by J&J. Systems.

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Current Benefits of
Robotic Ablation

Patient Physician Hospital


Safer Procedure: Health Benefits: Procedure Growth:
Gentle Catheter: lower perforations Radiation Reduction Improve Skill: Enable Difficult Cases
Radiation Reduction Orthopedic Injury: no lead vest Perform Procedures Not Possible with
Extend Career Manual Catheters
Effective Procedure: Competitive Differentiation
Catheter Precision, Reach & Stability Successful Procedures: Lab Efficiency: Complex Procedure
Consistent Catheter Contact Catheter Precision, Reach & Stability Time Reduced and Consistent
Focus on Essentials of Therapy
Pronounced Benefits In: Lower Complications Risk Reduction
Pediatric & Young Adults Democratization of Skill Health Benefits to Staff
Elderly Patient Safety
Frail Convenience:
Pregnant Seated and Unscrubbed Differentiation:
Complicated Anatomy Attracting Patients
Pronounced Benefits In Complex Cases: Attracting Staff
Improved Safety, Efficacy & Efficiency

Robust Clinical & Real-World Validation


250+ Peer-Reviewed Publications | 100,000+ Procedures Performed at Over 100 Hospitals by Hundreds of Physicians

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Global Commercial
Presence
>9,000 Procedures Annually at >100 Hospitals by >300 Physicians

Europe
North America

Asia Pacific

~15 Person Direct Sales Team


Complemented by Distributors ~5 Person Direct Sales Team
>20 Person Direct Sales Team ~35 Active Hospitals Complemented by Distributors
>60 Active Hospitals >4,000 Procedures/Year ~10 Active Hospitals
>4,000 Procedures/Year ~1,000 Procedures/Year

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Leadership in
Complex Procedures

Stereotaxis is the most effective, and sometimes only option,


for the most complicated ablation procedures.

The benefits of robotics are applicable across a broad range of


cardiac ablation procedures, but are pronounced in the most
complex procedures. The unmatched precision, reach and
stability of a magnetic catheter enables the effective treatment
of arrhythmias that otherwise could not be treated at all using
a manual catheter, or could not be treated effectively by the
vast majority of physicians. In ventricular arrhythmias,
congenital procedures, and certain other special situations,
Stereotaxis provides increased efficacy and efficiency in
combination with a first-in-class safety profile.

Stereotaxis identified complex arrhythmias as a beachhead


indication only recently. The market for these procedures is
large and significantly underpenetrated. The value provided in
these procedures is validated by many leading hospitals that
have recently adopted Stereotaxis for all of their ventricular
procedures and seen significant growth following adoption of
the technology.

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Automation

Robotics is the only technology providing the opportunity for


fully automated ablation procedures.

Automation enables efficient patient-specific therapy.

Stereotaxis currently has functional automation software designed into its system. The
software allows for automated movement of the catheter to specific points, along defined
paths, and in preprogrammed motions. A plan is in place to methodically improve the
software towards reliable, reproducible and rapid automation. This would allow rapid
mapping using software as a replacement for expensive mapping catheters. It would also
allow efficient ablation in both the atrium and ventricle in a patient-specific
individualized fashion. Automation will be transformational for the EP field by enabling
physicians to focus on the planning and design of treatment rather than the physical
manipulation of a catheter. Only a robotic platform can allow for automation.

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Cardiac Ablation
Market Outlook
Convergence & Differentiation

Ablation Market Convergence of Features Differentiation of Stereotaxis Technology

While the cardiac ablation market is highly attractive, the Robotics has a differentiated mechanism of action providing
challenge for companies operating in it over the coming additive clinical benefits to patients and physicians when
years will be maintaining differentiation and avoiding combined with manual technologies. Stereotaxis is the only
commoditization. robotic EP company and significant barriers to entry exist.

The convergence of features is characterized by: The advances in manual technologies do not address four
Ablation Catheters - the development of balloon-based key ways robotics provides meaningful differentiation:
technologies for rapid pulmonary vein isolation, high- Safety - Unmatched safety for patients and physicians.
flow and contact force sensing capability in single point Gentle catheter significantly reduces perforation risk.
catheters, and tools for lesion prediction and assessment. Reduced radiation exposure to patients and physicians.
Mapping Systems - localization is being performed Reduced orthopedic injury to physicians.
using electric fields as well as an imbedded sensor, and Catheter Precision & Reach - Navigation of catheter
more rapid and detailed anatomic and electrical mapping from the tip allows precise access to difficult to reach
is being pursued using multi-electrode catheters. anatomies, enabling otherwise impossible procedures.
Catheter Stability - Magnetic catheter maintains contact
with beating heart tissue at consistent force ensuring
effective lesions and maintained contact.
Automation - Robotics is the only technology that will
enable full automation of procedures, allowing
physicians to focus on designing and planning
individualized therapy of patients rather than mechanics
of catheter manipulation.

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Primary Focus

Ensure Existing Customers Build Successful Robotic Ablation Practices

Sales &
Customer
Related

Training/Education Clinical Literature Clinical/Technical Support Market Development

R&D Robust innovation plan across key aspects of robotic cardiac ablation
&
BusDev Planting initial seeds for potential broader applications

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Innovation Plan

3GuidingGoals:

1 2 3
Patient Physician Technology
Care Choice Availability

5CoreTechnologiesinRoboticAblationProcedure:

Navigation Software X-Ray Fluoroscopy Robotic System Ablation Catheter Mapping System

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Financial Summary
& Commentary
Revenue Profitability

Robust and High Margin: >$30m annual revenue at >75% GM% Low Cash Utilization
Recurring Revenue: ~85% of revenue is recurring at >80% GM% ~$700,000 negative free cash flow in 2Q17

Loyal & Sticky Customers and Revenue Model Efficient Organization


No robotic competitor; Users long-term and loyal Breakeven or positive free cash flow achievable with modest
Service contracts often multi-year terms increase in sales

Diversification of Revenue: >100 customers; largest ~2% of revenue

Significant Growth Opportunities: ~1% share in $4B market


Market growing >10% per year; Only robotic option
Current revenue has no system replacement cycle or catheter

Balance Sheet Ownership

Clean Balance Sheet: $5.0m cash and no debt at 6/30/2017 Financial Strength/Depth & Medical Device Experience/Expertise
DAFNA Capital, Mr. Joe Kiani, and limited partners of DAFNA
Clean Liability Profile own majority of Stereotaxis following $24m investment late 2016
No lawsuits. Top-tier service providers and clean financial, DAFNA Capital - $200 million assets managed, 18+ year track
regulatory, and compliance history. No IP disputes. record, focus on life sciences, >21% annualized net return
Mr. Joe Kiani - Founder, CEO, Chairman and largest shareholder
Guaranteed Future Revenue at High Margin of Masimo, global leader in noninvasive patient monitoring. $4.5B
Multi-year service contracts provide assured future revenue/income valuation, ~$350m net cash, >$700m sales, >$150m profit

Alignment of Interest
CEO and Board Members are majority shareholders of Stereotaxis

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