SIZE CONTROL IN THE SYNTHESIS OF MAGNETIC NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

A. I. Hurtado-Arias1, J. J. Ibarra-Snchez2, J. J. Bernal-Alvarado1, G de la Rosa2, T. Cordova-Fraga1

1
Departamento de Ingeniera Fsica, Divisin de Ciencias e Ingeniera, Campus Len, Universidad de Guanajuato, Loma del
Bosque 103 Lomas del Campestre, 37151, Len, Guanajuato, Mxico
2
Departamento de Ingenieras Qumica, Electrnica y Biomdica, Divisin de Ciencias e Ingeniera, Campus Len, Universidad
de Guanajuato, Loma del Bosque 103 Lomas del Campestre, 37151, Len, Guanajuato, Mxico

Introduction: At present, the use of nanotechnology for biomedical applications has had an
important development, specifically the use of magnetite, where the main challenge is to
obtain particles with high crystallinity and low polydispersity, as well as a fine size control. Objective:
To present the effect of mass balance in the synthesis of magnetic nanoparticles (Fe3O4) over
the particle size. Methods and materials: The synthesis of magnetic nanoparticles (MNPs) was studied
to determine the effect that the mass balance (molar relation x Fe: y Dodecanodiol: 3-Oleylamine:
3-Oleic Acid: 2-Octadecene) has over the particle size, and its polydispersity. This analysis was
carried through a 3k factorial design assisted by Minitab 16 where we related the synthesis
conditions to the particle size we obtained. The synthesis was accomplished through thermal
decomposition of the iron (III) acetylacetonate in the presence of oleic acid, oleylamine and
1-octadecene. The relations studied were 1, 2, 3, for x and 4, 5, 6 for y. Subsequently, the
size of the synthetized MNPs was determined using TEM, as well as their crystallinity using
their XRD spectrum, and their magnetic properties with a vibrating sample magnetometer. Results
: The results shown that the maximum particle size obtained was 15 nm, which is to a
relation of 2 for the precursor of iron and 5 for the 1,2-dodecanodiol. On the other hand,
the correlation coefficient for the obtained model was 0.9. Finally, the nanoparticles were
transferred to aqueous media and coated with DMSA, where the dissipated power was
determined in a hyperthermia device. Conclusion: This characterization suggests
that the MNPs can be used in biomedicine for oncological therapy. Acknowledgements: Authors thank
to CONACyT and UG by economic support.

Keywords: Magnetic nanoparticles, Size control, Hyperthermia

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Presenting authors email: hurtado.arias.antonio@gmail.com