Maximum Likelihood Estimation

S. Purcell.

Contents and Keywords

1. Introduction
probability
models
parameters
conditional probability
binomial probability distribution
2. Model-fitting
likelihood
maximum likelihood estimation
parameter space
3. MLE in Practice
analytic approachs
numerical optimsiation algorithms
log-likelihood
identification
local minima
4. Likelihood ratio test
alternate and null hypothesis
chi-squared
significance testing
degrees of freedom
5. MLE analysis of twin data
normal distribution
multivariate normal distribution
covariance structure
reparameterisation
6. MLE analysis of linkage data
recombination
recombination fraction (theta)
lod score

Further Reading
Edwards AWF (1972) Likelihood. Cambridge University Press.
Sham PC (1998) Statistics in Human Genetics. Arnold

Site created by S.Purcell, last updated 20.05.2007