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Review Article
Phytochemical and Pharmacological Accounts of Some Reviewed Plants with
Antidiabetic Potential
Kharjul Mangesh1*, Kharjul Ashwini2, Bhairy Srinivas2, Gupta Shivram2, Kale Aaditi2
1
Research Scholar, Department of Pharmacy, JJT University, Vidhya Nagari, Jhunjhunu-Churu Road, Chudela,
Jhunjhunu- 333001, Rajasthan, India
2
Department of Pharmacognosy, Shivajirao S. Jondhle College of Pharmacy, Asangaon, Thane-421601,
Maharashtra, India
*Corresponding author
Kharjul Mangesh
Email:
Abstract: With increased morbidity and mortality, diabetes mellitus is emerging as major health problem. 69% adults of
developing countries and 20% of developed countries are susceptible to diabetes. Insulin therapy is suggested only when
diet or oral hypoglycemic fails to control blood glucose levels and in case of postpancreatectomy. Insulin analogues are
advantageous with low risk of hypoglycemia particularly nocturnal hypoglycemia. Drawbacks of insulin therapy are like
local pain, inconvenience of multiple injections, insulin edema, lipohypertropy, insulin allergy, resistance and above all
of this are weight gain. Oral hypoglycemic agents like Sulphonylureas (Glibenclamide, Glipizide, Gliclazide), Non-
Sulphonylureas (Nateglinide, Repaglinide), Alpha-glucosidase inhibitors (Acarbose, Miglitol), Dipeptidylpeptidase(DPP)
IV inhibitors (Sitagliptin, Linagliptin, Alogliptin, Dutogliptin, Gemiglaptin) are used for treatment of diabetes but they
have their own limitations due to selective mechanism of action. WHO in 1976 officially recognized importance of
traditional medicine as source of primary health care by globally addressing its traditional medicine programme. India
being the botanical garden of the world, is the largest producer of medicinal herbs. 21,000 plants are listed by WHO,
used for medicinal purposes around the world. This review covers phytochemical and pharmacological accounts of some
plants with antidiabetec potential. Herbal drugs are the oldest known healthcares available to mankind, enlisted in
naturopathic, ayurvedic, homeopathic and other medicine systems obtained from natural sources. Herbal drugs becomes
advantageous over allopathic drugs due to their safety, low cost, complete accessibility with enhance tolerance.There is
more preclinical research warranted for exploration of antidiabetic potential of new plants/herbs whichever is not yet
studied and there is also need of clinical establishment of antidiabetic plants which are already found promising in their
preclinical evaluation.
Keywords: diabetes mellitus, Oral hypoglycemic agents, phytochemical, Herbal drugs
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Kharjul M et al., Sch. Acad. J. Pharm., 2014; 3(2):162-177
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inhibitors
(DPP) IV
Fenugreek Seeds
[34] [33]
(English
vernacular)
Trigonelline
(1-methylpyridinium-3-carboxylate) [35-36]
165
Kharjul M et al., Sch. Acad. J. Pharm., 2014; 3(2):162-177
4-hydroxyisoleucine
(2-amino-4-hydroxy-3-methylpentanoic acid)[35,36]
Sotolon [35,37]
Vicine [38]
withaferin-A [38]
Momordicin [42]
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Kharjul M et al., Sch. Acad. J. Pharm., 2014; 3(2):162-177
(-)-Epicatechin [45]
Pterostilbene [46]
Marsupin [47]
Liquiritigenin [47]
Isoliquiritigenin [47]
Gymnema sylvestre [48] Gurmar,
mera-singi Leaves
[48] [49]
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Kharjul M et al., Sch. Acad. J. Pharm., 2014; 3(2):162-177
Guduchi,
Tinospora cordifolia [51] Giloy or
Amrita [51] Stem
[52]
Columbin [53]
Tinosporaside [53]
Cordifolioside A [53]
Marrubium vulgare L. [54] Horehound Leaf,
[54] roots
[39]
Marrubiin [39,55]
Sesquiterpene [37,57]
(-Sesquiphellandrene)
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Kharjul M et al., Sch. Acad. J. Pharm., 2014; 3(2):162-177
-amyrin [44,63]
Lupeol [44,63]
cucurbitacin B [44,63]
Camellia sinensis(L.) [64] Chha [64] Leaf
[65]
Epigallocatechingallate [66,67]
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Kharjul M et al., Sch. Acad. J. Pharm., 2014; 3(2):162-177
Azadirachtin [68,69]
Nimbin [69,70]
Aloe vera [71] Goddess, Leaves
Kumari, [72]
Guarpatha
[71]
4-Methylenecycloartanol [73]
Biophytumsensitivum [74] Life plant, Leaves
[75]
little tree
plant,
sensitive
plant [74]
Amentoflavone [76,77]
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Kharjul M et al., Sch. Acad. J. Pharm., 2014; 3(2):162-177
Capsaicin[79,80]
Aconitine [81,82]
Table 4: Mechanism of action, available dose and dosage form of antidiabetic plants
Plant name Antidiabetic mechanism of action Dose Dosage form
Trigonellafoenum It diminishes the carbohydrate 10-15 grams per day in Seed powder. [83]
graecum metabolism by inhibiting intestinal divided doses with meals.
enzyme alpha-amylase. It stimulates [35]
glucose dependant insulin secretion
from pancreatic beta cells to induce
hypoglycemia.[83]
Momordica charntia It mimics insulin activity by Fresh juice- 57-113 gm daily, Crude drug, extracts,
stimulating muscle cells glucose and Tincture- 1.3 ml/ twice/ fruit juice and
aminoacid uptakes, decreases hepatic daily, Juice extract- 300-600 tablets.[77]
gluconeogenesis. [84, 85] mg.[10]
Pterocarpus It exerts protective, restorative, Wood extract (pterostilbene ) The wood extract &
marsupium regenerative effects in diabetic beta 10 mg/ kg, Bark decoction- bark decoction [10]
cells. Insulin releasing activity is 1 gm/ 100 mg body weight
correlated to potential increase in the for 10 days [10]
cyclic adenosine monophosphate
(cAMP) in pancreatic islets, along
with significant convertion of
proinsulin to insulin [86]
Gymnema sylvestre Hypoglycemic activity of gymnemic Powder leaf- 2-4 mg/daily, It is used as water
acid isdue to regeneration of islet Water soluble acidic soluble acidic solution
cells, stimulation of insulin release , solution- 400 mg/day [10] &as powered leaf [10]
increase glucose uptake by cells,
inhibition of glucose absorption, and
suppression of gluconeogenic
enzymes and sorbitol dehydrogenase
[87]
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Kharjul M et al., Sch. Acad. J. Pharm., 2014; 3(2):162-177
Tinospora cordifolia Decreased blood glucose by level and aqueous extract at a dose of the hydro alcoholic
increased glucose tolerance is 400 mg/kg,its effect is and chloroform
correlated with regeneration of beta equivalent to only one extract of t.cordifolia
cells of islets of langerhans [88] unit/kg of insulin [89] stem [90]
Marrubium vulgare Promotes insulin release from beta the aqueous extract at 200 Decoction.[92]
L cells of islets of langerhans or and and 300 mg/kg/ twice daily
inhibit processs of insulin breakdown for 2 weeks [91]
[91]
Zingiber officinale By improving insulin sensitivity it 310 g fresh ginger, or 24 g Fresh ginger juice
reduces fasting blood glucose and dry ginger, 13 /day [93] [93]
improves serum insulin level [65]
Grewia asiaticaL Hypoglycemic effect is mainly result 1 kg sugar, 1 glass of water Syrup (One kg fruit is
of improving glucose utilization by and 2 teaspoon of ghee are crushed with fingers
cells [94] heated to make sheera. Then in 1 liter of water and
1 kg crushed fruit of then strained. Sugar is
Grewiais mixed with it and added to the strained
strained through a fine cloth. juice to make syrup.
2-3 teaspoon strained The syrup is taken
mixture is used With one according to the need)
glass of water twice a day [95]
[95]
Coccinia indica Glucose synthesis is inhibited by Dried extract (500 mg/kg Bimb or Kanturi [97]
suppression of gluconeogenic p.o., for 6 weeks), 36 g
enzymes like glucose-6- phosphatase powder of Whole plant and
and fructose-1, 6-bisphosphatase. 510 ml juice [96]
Activates glucose-6-phosphate
dehydrogenase thre by promoting
glucose oxidation. Hypoglycemic
effect is also due to insulin
secretagogue activity [96]
Camellia Inhibits development of insulin 1.5 g/body of green tea Tea [97]
sinensis(L.) resistance, hypoglymia and other promoted glucose
metabolic effects .also decreases metabolism in healthy human
glucose absorption from intestine [64, volunteers [99]
98]
Azadirachta indica Improves peripheral glucose uptake Aq. Leaf extract is taken at a decoction and juice of
by inhibiting action of epinephrine on dose of 2-3 tea spoons daily leaves[101] &
glucose metabolism [100] in empty stomach.[68] and capsules [10]
Capsule- 1-2 capsules/ twice
daily [10]
Aloe vera Maintains glucose homeostasis by Aloe vera gel at 200 mg/kg gel extract [71]
interfering with carbohydrate possesses significant
metabolizing enzymes. Increases antidiabetic activity[102]
production and release of insulin [44]
Biophytumsensitivum Possess insulotrophic effects i.e. 200 mg/kg body weight is -
improvement in synthesis and release optimum for hypoglycaemia
of insulin from the beta cells of [89]
langerhans [89]
Capsicum annum Insulin producing cells are protected 1g and 2g Capsicum -
from autoreactive T cells. Anti- frutescence supplemented
inflammatory effects of capsaicin diet [104]
results due to binding of capsaicin to
the VR1 receptors which activates
pancreatic macrophages [103]
Acontium Improvement in peripheral glucose - -
carmichaeii uptake is due to activation of opioid
receptors of peripheral tissues,
thereby lowering plasma glucose
levels [81]
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