SwissHuge List of Impurities

List of API molecules and their Impurities
Drug Name, EP Impurity CAS No Chemical Name Structure
ALBENDAZOLE SULFONE methyl 5-(propylsulfonyl)-1H- H

N
benzo[d]imidazol-2-ylcarbamate NH
O N
S O
H3C O CH3
O
ALBANDAZOLE Impurity D H
N
(albendazole-2-amino NH2
sulfone) O N
S
H3C
O
ALLENDRONATE d6 di disodium [4-amino-1-hydroxy(2H6)butane- D D D

O
D
sodium salt 1,1-diyl]bis[hydrogen (phosphonate)] HO P O Na
H2N OH
D D
P O Na
HO
O
AMIODARONE-B
CH3
O
I
O NH
I CH3
ATENOLOL IMPURITY A 2-(4-hydroxyphenyl)acetamide OH

O
H2N
ATENOLOL IMPURITY B 2-[4-(oxiran-2-ylmethoxy)phenyl]acetamide

O O
O
H2N
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ATROPIC ACID 2-phenyl-2-propanoic acid O

OH
CH2
ASPARTAME RELATED (5-benzyl-3,6-dioxo-2-piperazine acetic H

O N
COMPOUND acid) O
HO N O
H
ACECLOFENAC 89796-99-6 2-(2-(2-(2,6-dichlorophenylamino) O

O
OH
phenyl)acetoyloxy)acetic acid O
NH
Cl Cl
ACECLOFENAC Impurity A 2-(2-(2,6-dichlorophenylamino) OH
(diclofenac) phenyl)acetic acid NH

O
Cl Cl
ACECLOFENAC Impurity B methyl 2-(2-(2,6- O
(diclofenac methyl ester) dichlorophenylamino)phenyl)acetate NH

O
Cl Cl
ACECLOFENAC Impurity C ethyl 2-(2-(2,6- O
(diclofenac ethyl ester) dichlorophenylamino)phenyl)acetate NH

O
Cl Cl
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ACECLOFENAC Impurity D methyl[[[2-[(2,6- O

O
O
(methyl ester of dichlorophenyl)amino]phenyl]acetyl]oxy]ac O
NH
aceclofenac) etate Cl Cl
ACECLOFENAC Impurity E ethyl[[[2-[(2,6- O

O
O
(ethyl ester of dichlorophenyl)amino]phenyl]acetyl]oxy]ac
O
aceclofenac) etate Cl
NH
Cl
ALFUZOSIN 81403-68-1
O H O
HYDROCHLORIDE N N
H HCl
O O
and enantiomer
NH2
ALFUZOSIN Impurity A 98902-29-5 N-[3-[4-amino-6,7-dimethoxy-quinazolin-2- H

O N N N
yl)methylamino]propyl]furan-2- O
carboxamide O
N O
NH2
ALFUZOSIN Impurity C 72104-34-8 N-(3-(4-amino-6,7-dimethoxyquinazolin-2- H

O N N N
ylamino)propyl)-tetrahydro-N-methylfuran- O
2-carboxamide O
N O
NH2
ALFUZOSIN Impurity E N-[3-[(4-amino-6,7-dimethoxyquinazolin-2- H

O N N N H
yl)methylamino]propyl]formamide
N O
O
NH2
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H
AMLODIPINE BESILATE 111470-99-6 N NH2
O
SO3H
O O
H
O O
Cl
H
AMLODIPINE Impurity E 140171-65-9 diethyl 2-((2-aminoethoxy)methyl)-4-(2- N NH2
O
chlorophenyl)-1,4-dihydro-6- O O
methylpyridine-3,5-dicarboxylate O O
Cl
H
AMLODIPINE Impurity F 140171-66-0 dimethyl 2-((2-aminoethoxy)methyl)-4-(2- N NH2
O
chlorophenyl)-1,4-dihydro-6- O O
methylpyridine-3,5-dicarboxylate O O
Cl
AMLODIPINE Impurity G 43067-01-2 dimethyl 4-(2-chlorophenyl)-1,4-dihydro- H

N
2,6-dimethylpyridine-3,5-dicarboxylate O O
O O
Cl
AMLODIPINE Impurity H 318465-73-5 2-[[2-[[(4R)-4-(2-Chlorophenyl)-3- H H

N N
(ethoxycarbonyl)-5-(methoxycarbonyl)-6- O
O O O
methyl-1,4-dihydropyridin-2- O O
O OH
yl]methoxy]ethyl]carbamoyl]benzoic acid Cl
H
AMOXICILLIN 61336-70-7 O COONa
N
TRIHYDRATE H2N HN S
H H H
O
HO
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AMOXICILLIN Impurity C 4S)-2-[5-(4-Hydroxyphenyl)-3,6- H

COOH
dioxopiperazin-2-yl]-5,5- H HN
N
S
dimethylthiazolidine-4-carboxylicacid
N
H
HO
AMOXICILLIN Impurity D (2R)-2-amino-2-(4- H COOH

hydroxyphenyl)acetyl]amino]carboxymethy NH2 H HN
H
N
l]-5,5-dimethylthiazolidine-4-carboxylicacid S
O COOH
HO
AMPICILLIN TRIHYDRATE 7177-48-2

O
H COOH
H NH2 H N
N S
H H
O
AMPICILLIN Impurity C (4S)-2-(3,6-dioxo-5-phenylpiperazin-2-yl)- H

COOH
HN
5,5-dimethylthiazolidine-4-carboxylic acid O
H
N
S
N O
H
AMPICILLIN Impurity D (4S)-2-[[[(2R)-2-amino-2- H COOH

phenylacetyl]amino]carboxymethyl]-5,5- NH2 H HN
H
N
dimethylthiazolidine-4-carboxylic acid S
O COOH
ATENOLOL 29122-68-7 2-(4-((R)-2-hydroxy-3- H OH H

(isopropylamino)propoxy)phenyl)acetamid O N
O
e
H2N and enantiomer
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Atenolol Impurity A 2-(4-hydroxyphenyl)acetamide O

OH
H2N
Atenolol Impurity B 2-(4-((oxiran-2-

O O
yl)methoxy)phenyl)acetamide O
H2N
Atenolol Impurity C 2-(4-(2,3- OH

dihydroxypropoxy)phenyl)acetamide O
O OH
H2N
Atenolol Impurity D 2-(4-(3-chloro-2- OH

hydroxypropoxy)phenyl)acetamide O Cl
O
H2N
ATENOLOL Impurity F 87619-83-8 2,2-[(1-methylethyl)-iminobis(2- OH OH

O N O
hydroxypropan-3,1-diyloxy-4,1- O O
phenyene)]diacetamide H2N NH 2
ATENOLOL Impurity G 56392-14-4 2-(4-((R)-2-hydroxy-3- H OHH

O N
(isopropylamino)propoxy)phenyl)acetic O
acid
HO
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Atorvastatin WS (3R,5R)-7-(3-(phenylcarbamoyl)-5-(4- F
fluorophenyl)-2-isopropyl-4-phenyl-1H-
OH OH O
pyrrol-1-yl)-3,5-dihydroxyheptanoic acid H
N
N (R) (R)
+2
O Ca
Ph
O
Atorvastatin Lactone 5-(4-fluorophenyl)-1-(2-((2R,4R)- F
tetrahydro-4-hydroxy-6-oxo-2H-pyran-2- O
yl)ethyl)-2-isopropyl-N,4-diphenyl-1H- N
O
(R)
(R)
pyrrole-3-carboxamide HN
OH
Ph O
Atorvastatin Methyl ester (3R,5R)-methyl 7-(3-(phenylcarbamoyl)-5- F
(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-
OH OH O
pyrrol-1-yl)-3,5-dihydroxyheptanoate H N O
N
Ph
O
Atorvastatin Amide F
OH OH O OH OH O
H N N O)Ca +2
N H
Ph
O
Atorvastatin isomer (3S, 5S) (3S,5S)-7-(3-(phenylcarbamoyl)-5-(4- F
pyrrol-1-yl)-3,5-dihydroxyheptanoic acid H N
OH OH O
+2
N (S) (S) O Ca
Ph
O
Atorvastatin Diastereomer (3S,5R)-7-(3-(phenylcarbamoyl)-5-(4- F
(3S, 5R) fluorophenyl)-2-isopropyl-4-phenyl-1H-

pyrrol-1-yl)-3,5-dihydroxyheptanoic acid OH OH O
H N +2
N (R) (S) O C a
Ph
O
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Desfluoro Atorvastatin (3R,5R)-7-(3-(phenylcarbamoyl)-2-

isopropyl-4,5-diphenyl-1H-pyrrol-1-yl)-3,5-
OH OH O
dihydroxyheptanoic acid H N (R) (R) O Ca
+2
N
Ph
O
3-O-methyl Atorvastatin (3R,5R)-7-(3-(phenylcarbamoyl)-2-

isopropyl-4,5-diphenyl-1H-pyrrol-1-yl)-5-
OH O O
hydroxy-3-methoxyheptanoic acid H N (R) (R) O Ca
+2
N
Ph
O
5-O-methyl Atorvastatin (3R,5R)-7-(3-(phenylcarbamoyl)-2-

isopropyl-4,5-diphenyl-1H-pyrrol-1-yl)-3-
hydroxy-5-methoxyheptanoic acid H
O OH O
(R) (R)
+2
N N O Ca
Ph
O
Atorvastatin L1 tert-butyl 2-((4R,6R)-6-(2-(3- F
(phenylcarbamoyl)-5-(4-fluorophenyl)-2- O O O
isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)- N O
2,2-dimethyl-1,3-dioxan-4-yl)acetate HN
Ph O
Atorvastatin Acetonide 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4- F
O O O
pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan- N OH
4-yl)acetic acid
HN
Ph O
Atorvastatin t-Butyl ester (3R,5R)-tert-butyl 7-(3-(phenylcarbamoyl)- F
5-(4-fluorophenyl)-2-isopropyl-4-phenyl-
OH OH O
1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate N O
HN
Ph O
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O-Hydroxy Atorvastatin (3R,5R)-7-(3-(2-hydroxyphenylcarbamoyl)- F
5-(4-fluorophenyl)-2-isopropyl-4-phenyl- OH OH O
1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid N
OH
HN
O
OH
(3R,5R)-7-(3-(4-hydroxyphenylcarbamoyl)-
F
P-Hydroxy Atorvastatin
5-(4-fluorophenyl)-2-isopropyl-4-phenyl- OH OH O
N
1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid HN
OH
HO
O-Hydroxy Atorvastatin 5-(4-fluorophenyl)-1-(2-((2R,4R)- F
O
Lactone tetrahydro-4-hydroxy-6-oxo-2H-pyran-2- O
yl)ethyl)-N-(2-hydroxyphenyl)-2-isopropyl- N (R)
(R)
OH
4-phenyl-1H-pyrrole-3-carboxamide HN
O
OH
P-Hydroxy Atorvastatin 5-(4-fluorophenyl)-1-(2-((2R,4R)- F
O
Lactone tetrahydro-4-hydroxy-6-oxo-2H-pyran-2- O
(R)
yl)ethyl)-N-(4-hydroxyphenyl)-2-isopropyl- N (R)
OH
4-phenyl-1H-pyrrole-3-carboxamide HN
O
ATS diketoene (E)-2-(2-(4-fluorophenyl)-2-oxo-1- F
phenylethylidene)-4-methyl-3-oxo-N-
phenylpentanamide O
(E) O
HN
Ph O
ATS diepoxide lactone F
O
O
N OH
HN O
Ph O
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ATS impurity 5-(4-fluorophenyl)-2-isopropyl-N,4- F
diphenylfuran-3-carboxamide
O
HN
Ph O
O
BALSALAZIDE IMPURITY HN
B O OH HO
N
N
O N
NH
OH
BALSALAZIDE IMPURITY C
N N NH2 N
O
N H 2
O
BECLOMETASONE 5534-09-8
O O
DIPROPIONATE HO
H CH 3 O O
CH 3
H3C H CH 3
H
Cl
O
O
BECLOMETASONE 69224-79-9 9-chloro-11 beta,17-dihydroxy-16 beta- O O
Impurity A methyl-3,20-dioxopregna-1,4-dien-21-yl HO OH
(beclometasone 21- propanoate

Cl
propinate) O
BECLOMETASONE 5534-18-9 9-chloro-11 beta,21-dihydroxy-16 beta- O OH O
Impurity H methyl-3,20-dioxopregna-1,4-dien-17-yl HO O
(beclometasone 17- propanoate

Cl
propionate) O
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Betahistine Impurity A 2-vinylpyridine

N
Betahistine Impurity B 2-(pyridin-2-yl)ethanol N OH
Betahistine Impurity C N-methyl-2-(pyridin-2-yl)-N-(2-(pyridin-2- N

yl)ethyl)ethanamine
N N
BISACODYL 603-50-9 H3 C O O CH3
O O
BISACODYL Impurity A 603-41-8 4-((4-hydroxyphenyl)(pyridin-2- HO OH
yl)methyl)phenol
N
BUDESONIDE 51333-22-3 O OH
O
HO
O
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BUDESONIDE Impurity B 68293-08-3 16 alpha,17-[(1RS)-ethylidenebis(oxy)]-11 O OH
beta,21-dihydroxypregna-1,4-diene-3,20- HO
O
O
dione
O
BUDESONIDE Impurity D 85234-63-5 16 alpha, 17-[(1RS)-butylidenebis(oxy)]-11 O O
beta-hydroxy-3,20-dioxopregna-1,4-dien- HO
O
O
21-al
O
14-HYDROXY 14-hydroxy clarithromycin H3C

O
H3C
CLARITHROMYCIN
CH3
CH3 O
CH3 CH3
H3C
H3C N
O CH3
HO OH O HO
HO O O
CH3 CH3
CH3 H3C O
O
OH
CH3
CLOPIDOGREL methyl (2-chlorophenyl)(thieno[3,2- O O

IMPURITY-A c]pyridin-5(4H)-yl)acetate
N
Cl S
CLOPIDOGREL methyl (2-chlorophenyl)(4,7- O O
IMPURITY-B dihydrothieno[2,3-c]pyridin-6(5H)-
N S
yl)acetate
Cl
NH2
CPP LYSINE 6-amino-2-[(1-carboxy-3-
phenylpropyl)amino]hexanoic acid O OH
O
NH
OH
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HYDROCHLOROTHIAZI H2N
O OO
S S
DE IMP NH
O
A(CHLOROTHIAZIDE)
Cl N
CAPTOPRIL 62571-86-2 O
H COOH
N
HS
H
CAPTOPRIL Imputity A (2S,2 s)-1,1-[disulphanediylbis[(2S)-2- O

H COOH
(CAptopril disulfide) methyl_1-oxopropane-3,l]-bis[pyrrolidine- N H N
HOOC S S H
2-carboxylic]acid H
O
HO
CARVEDILOL 72596-09-3 1-(2-(2-methoxyphenoxy)ethylamino)-3- H
N
O O
(9H-carbazol-4-yloxy)propan-2-ol O
HN
CARVEDILOL Impurity B 5-(2-methoxyphenoxy)-4-(9H-carbazol-1- OH HN
yloxy)-1-(3-(9H-carbazol-4-yloxy)-2- OH
O
O N
hydroxypropyl)piperidin-3-ol O
O
HN
CARVEDILOL Impurity C 72955-94-3 1-(9H-carbazol-4-yloxy)-3-(N-(2-(2-

OH
methoxyphenoxy)ethyl)-N- O N
O
benzylamino)propan-2-ol O
HN
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CETIRIZINE 83881-52-1 2-(2-(4-((4- Cl O

O
N OH
DIHYDROCHLORIDE chlorophenyl)(phenyl)methyl)piperazin-1- N
yl)ethoxy)acetic acid .2HCl .2HCl
CETIRIZINE Impurity C 2-(2-(4-((R)-1-(2-chlorophenyl)-1- O

O
phenylethyl)piperazin-1-yl)ethoxy)acetic N OH
N
acid Cl
CETIRIZINE Impurity E 2-(2-(2-(4-((R)-1-(4-chlorophenyl)-1- Cl

N
O
O
OH
phenylethyl)piperazin-1- N O
yl)ethoxy)ethoxy)acetic acid
CETIRIZINE N-OXIDE Cl
O
O
O
N OH
N
H
CHLORPHENAMINE 113-92-8 Cl O
MALEATE N OH
OH
N
O
CHLORPHENAMINE 22630-25-7 (3RS)-3-(4-chlorophenyl)-N-methyl-3- Cl O

H
Impurity C (pyridin-2-yl)propan-1-amine maleate N OH
OH
N
O
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CHLORPHENAMINE 65676-21-3 2-(4-chlorophenyl)-4-(dimethylamino)-2- Cl N

C
Impurity D (pyridin-2-yl)butanenitrile
N N
CHLORPROMAZINE 69-09-0 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-

HYDROCHLORIDE dimethylpropan-1-amine N N
S
Cl
CHLORPROMAZINE 969-99-3 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-

ImpurityA dimethylpropan-1-amine S-Oxide N N
S
O
Cl
CIMETIDINE 70059-30-2 (Z)-(2-((5-methyl-1H-imidazol-4- NC

N
N
HYDROCHLORIDE yl)methylthio)ethyl)-2-cyano-3- HN S HCl
methylguanidine hydrochloride N N
H H
CIMETIDINE Impurity A 52378-40-2 1-(2-((5-methyl-1H-imidazol-4- H

N
S
yl)methylthio)ethyl)-3-cyano-2- S
N N
methylisothiourea N
N
H
CINNARIZINE 298-57-7 1-benzhydryl-4-cinnamylpiperazine N

N
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CINNARIZINE Impurity B 750512-44-8 (Z)-1-(Diphenylmethyl)-4-(3-phenylprop-2-

enyl)piperazine
N
N
CINNARIZINE Impurity C (4-(Diphenylmethyl)-1,1-bis[(E)-3- N

phenylprop-2-enyl]piperazinium Chloride N Cl-
CINNARIZINE Impurity D 1-(Diphenylmethyl)-4-[(1RS,3E)-4-phenyl-1-

[(E)2-phenylethenyl]but-3-enyl] N
H
-piperazine N
CINNARIZINE Impurity E 216581-01-0 1,4-Bis(diphenylmethyl)piperazine

N
N
CITALOPRAM 59729-32-7 1-(3-(dimethylamino)propyl)-1-(4- F
HYDROBROMIDE fluorophenyl)-1,3-dihydroisobenzofuran-5- HBr
carbonitrile hydrobromide
O N
F
CITALOPRAM IMPURITY A (R)-1-(3-(dimethylamino)propyl)-1-(4-
fluorophenyl)-1,3-dihydroisobenzofuran-5-
carboxamide
O N
H2N
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CITALOPRAM IMPURITY B (1R)-1-(3-(dimethylamino)propyl)-1-(4- F
fluorophenyl)-1,3-dihydro-3-
hydroxyisobenzofuran-5-carbonitrile
O N
NC
OH
CITALOPRAM IMPURITY C (R)-1-(3-(dimethylamino)propyl)-1-(4- F
fluorophenyl)-1,3-dihydro-3-
oxoisobenzofuran-5-carbonitrile
O N
NC O
CITALOPRAM IMPURITY D (R)-1-(4-fluorophenyl)-1,3-dihydro-1-(3- F
(methylamino)propyl)isobenzofuran-5-
carbonitrile
O NH
NC
CITALOPRAM IMPURITY F 3-(5-bromo-1-(4-fluorophenyl)-1,3- F
dihydroisobenzofuran-1-yl)-N,N-
dimethylpropan-1-amine
O N
Br
CITALOPRAM IMPURITY G 4-(dimethylamino)-1-((R)-1-(3- F
(dimethylamino)propyl)-1-(4-fluorophenyl)- N
1,3-dihydroisobenzofuran-5-yl)butan-1-one
O N
CLONAZEPAM 1622-61-3 (E)-6-(2-chlorophenyl)-3,4-dihydro-8- H O

N
nitrobenzo[b][1,5]diazocin-2(1H)-one
O2N N
Cl
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CLONAZEPAM IMPURITY (2-amino-5-nitrophenyl)(2- NH2
A chlorophenyl)methanone O
O2N
Cl
H
Clonazepam Impurity B 3-amino-4-(2-chlorophenyl)-6- N O
nitroquinolin-2(1H)-one
O2N NH2
Cl
Clozapine 5786-21-0 Cl
N
N N
HN
Cl
Clozapine Impurity B 263366-81-0 11,11-(Piperazine-1,4-diyl)bis(8-chloro-
5Hdibenzo b,e 1,4-diazepine N
HN N N NH
N
Cl
Clozapine Impurity C 6104-71-8 8-Chioro-11-(Piperazin-1-yl)-5H-dibenzo b,e NH
1,4 diazepine N
N
Cl
N
H
Clozapine Impurity D 65514-71-8 (2-(2-amino-4- Cl NH2
chlorophenylamino)phenyl)(4- NH O
methylpiperazin-1-yl)methanone N
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Cyclobenzaprine n-oxide
N
O
Cyproheptadine 963-35-5
Hydrochloride
N
Cyproheptadine Impurity 256-81-5 Dibenzo a,d cycloheptene

A
Dipyramidole Impurity A 2-[(2-Hydroxy-ethyl)-(4,6,8-tri-piperidin-1- OH

N
yl-pyrimidol[5,4-d]-amino]-ethanol N
N
OH
N
N N
N
Dipyramidole Impurity B 2-[{4,6-Bis-[bis-(2-hydroxy-ethyl)-amino]-8- OH

N
piperidin-1-yl-pyrimido[5,4-d]pyrimidin-2- N N OH
yl}-(2-hydroxy-ethyl)-amino]-ethanol HO N N N
N
OH
HO OH
Dipyramidole Impurity C 2-[(6-Chloro-4,8-di-piperidin-1-yl- OH

N
pyrimido[5,4-d]pyrimidin-2-yl)-(2-hydroxy- N
N
OH
ethyl)-amino]-ethanol Cl N
N
N
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Dipyramidole Impurity D 2-{(2-Hydroxy-ethyl)-[6-(2-hydroxy-

ethylamino)-4,8-di-piperidin-1-yl- N H
NN
N OH
pyrimido[5,4-d]pyrimidin-2-yl]-amino}- N
NN
ethanol OH N
OH
Dipyramidole Impurity E 2-[{2-[Bis-(2-hydroxy-ethyl)-amino]-6,8-di- OH

N
piperidin-1-yl-pyrimido[5,4-d]pyrimidin-4- N
N
OH
yl}-(2-hydroxy-ethyl)-amino]-ethanol NN
N
N
HO OH
Dipyramidole Impurity G G 2,6-dichloro-4,8-dipiperidin-1-

N
ylpyrimido[5,4-d]pyrimidine N Cl
N
N
Cl N
N
Diazepam 439-14-5 (Z)-7-chloro-1-methyl-5-phenyl-1H- H3C

N
O
benzo[e][1,4]diazepin-2(3H)-one
Cl N
Diazepam Impurity A (Z)-7-chloro-5-phenyl-1H- H O

N
benzo[e][1,4]diazepin-2(3H)-one
Cl N
Diazepam Impurity A (2-amino-5- NH2
(USP) chlorophenyl)(phenyl)methanone Cl O
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Dicioxacillin Sodium 13412-64-1

Cl H CO2Na
Cl H O N CH3 H2O
N N
O S CH 3
O H H
CH3
Dicioxacillin Impurity A (4S)-2-((3-(2,6-dichlorophenyl)isoxazole-4-

carboxamido)(carboxy)methyl)-5,5- Cl H CO2H
Cl
dimethylthiazolidine-4- N H HN CH3
O N
carboxylic acid S CH 3
O CO2H
Diphenhydramine 147-24-0
Hydrochloride
N
O
HCl
Diphenhydramine 4024-34-4 N,N-dimethyl-2-(phenyl(p-

Impurity A tolyl)methoxy)ethanamine
N
O
Disopyramide 3737-09-05 4-(diisopropylamino)-2-phenyl-2-(pyridin-2-

N
yl)butanamide N
NH2
O
Disopyramide Impurity A 5005-46-9 4-(diisopropylamino)-2-phenyl-2-(pyridin-2-

N
yl)butanenitrile N
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Disopyramide Impurity C 38236-46-3 4-(isopropylamino)-2-phenyl-2-(pyridin-2- NH

yl)butanamide N
NH2
O
Domperidone 57808-66-9 5-chloro-1-(1-(3-(1,2-dihydro-2- O NH

oxobenzo[d]imidazol-3-yl)propyl)piperidin- N
4-yl)-1H-benzo[d]imidazol-2(3H)-one Cl
N N
HN
O
Domperidone Impurity B 4-(6-chloro-1,2-dihydro-2- O

NH
oxobenzo[d]imidazol-3-yl)piperidine-1-
N
carbaldehyde
O Cl
N
O
Domperidone Impurity F 1,3-bis(3-(4-(6-chloro-1,2-dihydro-2- NH
N
O NH
oxobenzo[d]imidazol-3-yl)piperidin-1- N N N N
N
Cl
yl)propyl)-1H- Cl O
benzo[d]imidazol-2(3H)-one
Doxorubicin 25316-40-9 O OH
O
OH
Hydrochloride OH
HCl
OMe O OH H
O
O
OH
NH2
Doxorubicin Impurity D (8S,10S)-7,8,9,10-tetrahydro-6,8,10,11- O OH O

tetrahydroxy-8-(2-hydroxyacetyl)-1- OH
methoxytetracene-5,12-dione OH
OMe O OH H OH
SwissHuge.com 22
Doxylamine Succinate O
OH
N
N O OH
Doxylamine Impurity A 2-(1-phenyl-1-(pyridin-4-yl)ethoxy)-N,N-

dimethylethanamine N
O
Doxylamine Impurity B 19490-92-7 1-phenyl-1-(pyridin-2-yl)ethanol
OH
N
Doxylamine Impurity C N,N-dimethyl-2-(phenyl(pyridin-2-

yl)methoxy)ethanamine
N
N
O
ECPPA-RR Isomer N-[1-(R)-Ethoxy carbonyl-3-phenyl propyl]- O CH3
(R)-Alanine CH3
NH
HO
ECPPA-cyclo hexyl analogue H3C
N-[1-(S)-Ethoxy carbonyl-3-cyclohexyl O O
CH3O
propyl]-(S)-Alanine NH
OH
H H
SwissHuge.com 23
Enalapril related compound

CH3
O O
Enalapril Maleate cyclohexyl analogue

CH3 N
NH O
H H O HO
O OH
S)-1-[N-[1-Ethoxy carbonyl-3-cyclohexyl
O
HO
OH
propyl]-L-Alaninyl]-L-proline, (Z)-2-
Estrone Sulphate D4 CH3 O
D
H D
D
H H
HO
Estrone Sulphate CH3 O
H
H H
H H
O
O S OOH
ETODOLAC 41340-25-4 2-(1,8-diethyl-1,3,4,9- O

tetrahydropyrano[3,4-b]indol-1-yl)acetic H
N OH
acid O
ETODOLAC Impurity A 41339-67-7 2-(1-ethyl-1,3,4,9-tetrahydropyrano[3,4- O

b]indol-1-yl)acetic acid OH
HN O
ETODOLAC Impurity B 41340-19-6 2-(1-ethyl-1,3,4,9-tetrahydro-8- O

methylpyrano[3,4-b]indol-1-yl)acetic acid OH
HN O
SwissHuge.com 24
ETODOLAC Impurity D 57917-63-2 2-(1-ethyl-1,3,4,9-tetrahydro-8- O

isopropylpyrano[3,4-b]indol-1-yl)acetic acid OH
HN O
ETODOLAC ImpurityK 122188-02-7 2-(1,8-diethyl-1,3,4,9- O

tetrahydropyrano[3,4-b]indol-1-yl)acetic OH
O
acid HN
O
ETOFENAMATE 30544-47-9 2-(2-hydroxyethoxy)ethyl 2-(3- O
O OH
(trifluoromethyl)phenylamino)benzoate NH
F
F F
ETOFENAMATE Impurity 101-23-5 3-(trifluoromethyl)-N-phenylbenzenamine

C NH
F
F F
Famciclovir A [4-(2-amino-9H-purin-9-yl)-2- N N
N
(hydroxymethyl)butyl acetate] H2N N
OH
O
H3C
O
Cl
Famciclovir B [4-(2-amino-6-chloro-9H-purin-9-yl)butyl N N
acetate] H 2N N N
O
O
CH3
SwissHuge.com 25
Na+
Fosinopril cyclohexyl L-proline, 4-cyclohexyl-1-[[[2-methyl-1-(1- O-
O
analogue oxopropoxy) propoxy](4-cyclohexyl O
P
butyl)phosphonyl]acetyl]-sodium salt H3C O O
CH3
H3C O
O
O
Fosinoprilate O
OH O O-
O O
P
O
O
FAMOTIDINE 76824-35-6 2-(4-(((E)-2- H2 N

NH2
amidinoethylthio)methyl)thiazol-2- N S N NH2
H2N S
yl)guanidine N O O
S
FAMOTIDINE Impurity A 2-(4-((2-amidinoethylthio)methyl)thiazol-2- HN

yl)guanidine NH2
N S NH2
HN
2 N
S
O OH
FAMOTIDINE Impurity B 109467-08-5 3,5-Bis[2-[[[2-[(diaminomethylene)amino]- N
S
N H2N
NH2 NH2
thiazol-4-yl]methyl]sulphanyl]-4H-1,2,4,6- H2N
N
N S N
H
S
N
O S
S
OH
2
OH
FAMOTIDINE Impurity C 3-[[[2-(diaminomethylene)amino]thiazol-4- O

NH2
yl]methyl]sulphanyl]-N- N S
NH NH2
H2N N S
sulphamoylpropanamide O O
S
SwissHuge.com 26
FAMOTIDINE Impurity F 3-[[[2-(diaminomethylene)amino]thiazol-4- O

yl]methyl]sulphanyl]propanoic acid NH 2
N S OH
H2N
N
S
FENOFIBRATE 49562-28-9 O
Cl O
O
FENOFIBRATE Impurity B 42017-89-0 2-[4-(4-chlorobenzoyl)phenoxy]-2- O

methylpropanoic acid(Fenofiberic acid) Cl O
OH
FENOFIBRATE Impurity C 217636-47-0 (3RS)-3-[4-(4- O

chlorobenzoyl)phenoxy]butan-2-one Cl O
FENOFIBRATE Impurity F 154356-96-4 (4-chlorophenyl)(4- Cl O

isopropoxyphenyl)methanone
FENOFIBRATE Impurity G 217636-48-1 1-Methylethyl 2-[[2-[4-(4- O

Cl O O
chlorobenzoyl)phenoxy]-2-methyl- O
O
propanoyl]oxy]-2-methylpropanoate
O
SwissHuge.com 27
FEXOFENADINE 153439-40-8 2-(4-(1-hydroxy-4-(4-

HYDROCHLORIDE (hydroxydiphenylmethyl)piperidin-1- OH OH
O
yl)butyl)phenyl)-2-methylpropanoic acid N OH
HCl
FEXOFENADINE Impurity 76811-98-8 2-(4-(4-(4-

A (hydroxydiphenylmethyl)piperidin-1- OH O
O
yl)butanoyl)phenyl)-2-methylpropanoic N OH
acid
FEXOFENADINE Impurity 154825-96-4 methyl 2-(4-(1-hydroxy-4-(4-

D (hydroxydiphenylmethyl)piperidin-1- OH OH
O
yl)butyl)phenyl)-2-methylpropanoate N O-
FINASTERIDE 98319-26-7 (4aR,6aS,7S)- O H

N
2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-
tetradecahydro-N-isopropyl-4a,6a-
dimethyl-2-oxo-1H-indeno[5,4-f]quinoline- O N
H
7-carboxamide
FINASTERIDE Impurity A 98319-24-5 (4aR,6aS,7S)-hexadecahydro-N-isopropyl- O H
N
4a,6a-dimethyl-2-oxo-1H-indeno[5,4-
f]quinoline-7-carboxamide
O N
H
FLUCLOXACILLIN SODIUM 1847-24-1 Cl H COONa

O N CH 3
N F H2O
O H S CH 3
O N H H
CH3
SwissHuge.com 28
FLUCLOXACILLIN [3-(2-chloro-6-fluorophenyl)-5- Cl
H COOH
Impurity A methylisoxazol-4-y F HN
CH3
N H
carbonyle]amino]methyl]-5,5- O
N
S CH 3
O
dimethyl;thioazolidine-4-carboxylic CH 3 HOOC
acid(penicilloic acids of flucloxacillin
FLUCLOXACILLIN sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7- O
H COONa
Impurity C oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2- N CH3
carboxylate H2N S CH3
H H
FLUCONAZOLE 86386-73-4 2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4- N F

F
HO
triazol-1-yl)propan-2-ol
N N
N
N
N
FLUCONAZOLE Impurity D 81886-51-3 2-(4-fluorophenyl)-1,3-di(1H-1,2,4-triazol-1- N

F
HO
yl)propan-2-ol
N N
N
N
N
FLUCONAZOLE Impurity H 150194-52-8 1-bromo-2-(2,4-difluorophenyl)-3-(1H- F

N F
1,2,4-triazol-1-yl)propan-2-ol HO
N N
Br
FLUPHENAZINE 146-56-5 2-(4-(3-(2-(trifluoromethyl)-10H-

DIHYDROCHLORIDE phenothiazin-10-yl)propyl)piperazin-1- N N 2 HCl
S N
yl)ethanol dihydrochloride OH
F
F
F
SwissHuge.com 29
FLUPHENAZINE Impurity 1476-79-5 2-[4-[3-[5,5-dioxo-2-(trifluoromethyl)-10H-

B 56-phenothiazin-10-yl]propyl]piperazin-1- N N
O S N
yl]ethanol (fluphenazine S,S- O
OH
F
dioxide) F
F
FLURBIPROFEN 5104-49-4
F OH
FLURBIPROFEN Impurity 6341-72-6 (2RS)-2-(biphenyl-4-yl)propanoic acid

OH
A
O
FLURBIPROFEN Impurity 61466-95-3 (2RS)-2-(2-fluorobiphenyl-4-yl)-2- HO

F OH
C hydroxypropanoic acid
O
Glibenclamide 10238-21-8 O O
S
O N N
O H H
Cl
N
H
OMe
Glibenclamide Impurity A 5-chloro-2-methoxy-N-[2(4- O O

S
sulphamoylphenyl)ethyl]benzamide O N NH2
OH
Cl
N
H
OMe
SwissHuge.com 30
GLICLAZIDE 21187-98-4
O O
S N
N N
O H H
GLICLAZIDE Impurity A 4-methylbenzenesulphonamide O

S
NH2
O
GLICLAZIDE Impurity C 5577-13-9 Ethyl [(4-Methylphenyl)sulphonyl]- O O

carbamate S
N O
O H
H H O
Glipizide 29094-61-9 N N
S
O
O O
N
N
H
N
Glipizide Impurity A 33288-71-0 5-methyl-N-[2-(4-sulphamoyl-

O
phenyl)ethyl]pyrazine- N N
2-carboxamide H2 N S
O O
NH2
H H O
Glipizide impurity C 13554-93-3 Ethyl [2-[4-[(cyclohexylcarbamoyl)- N N
S
sulphamoyl]phenyl]ethyl]carbamate O
O O
N O
H
SwissHuge.com 31
Glipizide impurity E 66375-96-0 1-cyclohexyl-3-[[4-[2-[[(6-methylpyrazin-2- H

N
H
N
O
S
yl)carbonyl]amino]ethyl]phenyl]sulphonyl] O O
O
N
urea N
H
N
GUAIFENESIN 93-14-1 OH
O OH
GUAIFENESIN Impurity B 14007-09-01 2-(2-methoxyphenoxy)propane-1,3-diol (B- HO OH

isomer) O
Ibuprofen related 4-Isobutylphenylacetophenone O
compound C CH 3
H3C
CH 3
Ibuprofen Imp F. 3-[4-(n butyl) phenyl] propionic Acid O
OH
H3C
N- Acetyl imidazolidine- N- Acetyl imidazolidine-2-thione H

N
S
2-thione
N
O
H 3C
SwissHuge.com 32
Ketrolac Impurity A (1-hydroxy-2,3-dihydro-1H-pyrrolizin-5- O
yl)(phenyl)methanone
N
OH
Ketrolac Impurity B O
5-(phenylcarbonyl)-2,3-dihydro-1H-
pyrrolizin-1-one N
Ketrolac Impurity I 2,3-dihydro-1H-pyrrolizin-5- O

yl(phenyl)methanone
N
Ketoprofen 22071-15-4 H CH
3
OH
O
and enantiomer
O
Ketoprofen Impurity B 22071-22-3 (3-benzoylphenyl)acetic acid O
O
and enantiomer
H
H OH
Ketoprofen Impurity J (2RS)-2-[3-(2,4- O
dimethylbenzoyl)phenyl]propanoic acid O and enantiomer
OH
H CH 3
SwissHuge.com 33
Ketotifen Fumarate 34580-14-8 N

O
S HO
OH
O
O
Ketotifen Impurity A 4673-38-5 4-(4H-benzo[4,5]cyclohepta-[1,2- N

b]thiophen-4- S N
S
ylidene)-1-methylpiperidine
Ketotifen Impurity B 59743-88-3 (4RS)-10-methoxy-4-(1-methylpiperidin-4- N

yl)-
S
4H-benzo[4,5]-cyclohepta[1,2-b]thiophen- OH
4-ol O
Ketotifen Impurity C 59743-88-3 (4RS)-4-hydroxy-4-(1-methyl-piperidin-4- N

yl)-4,9- N
S
dihydro-10H-benzo[4,5]-cyclohepta[1,2- OH
b]thiophen-10- O
one
Lansoprazole Sulfone N- H
N
O
S
CH3
Oxide N
O O
N
O
F
F
F
Lisinopril cyclohexyl NH 2
analogue O OH
O
NH
O
N
OH
SwissHuge.com 34
Lisinopril Impurity A 2-amino-4-phenylbutanoic acid H2 N
O
OH
Lisinopril Impurity B 4-methylbenzenesulfonic acid O

H3 C S OH
O
Lisinopril RS
NH2
O OH
O
NH
O
N
OH
Loratadine related 8-Chloro-6,11-dihydro-11(4-

compound piperidinylidene)-5H- Cl
N
Desloratidine benzo[5,6]cyclopenta[1,2-b] pyridine

N
H
Desloratidine Impurity A 4-(8-chloro-5,6-dihydro-11H- O
N
benzo[5,6]cyclohepta[1,2-b]pyridin-11-
ylidene)piperidine-1-carbaldehyde N
Cl
N-Hydroxy Desloratidine 4-(8-chloro-5,6-dihydro-11H- HO

N
benzo[5,6]cyclohepta[1,2-b]pyridin-11-
ylidene)piperidin-1-ol N
Cl
SwissHuge.com 35
Loratadine Related com B 8-chloro-11-(1-methylpiperidin-4-ylidene)- H3C

N
6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-
b]pyridine N
Cl
Lorsartan Carboxylic Acid

Cl
N
H3 C O
H
N N N
OH
N N
Lacidipine 103890-78-4
O
O
O O
HN O
Lacidipine Impurity B 130996-24-6 Diethyl (E)-4-{2-[2-(tert- O

O
butoxycarbonyl)vinyl]phenyl}-2,6-
O O
dimethylpyridine-3,5- dicarboxylate
N O
LAmotrigene Impurity B 2-((2,3- Cl

dichlorophenyl)(cyano)methyleneamino)gu Cl
NH 2
anidine N
N NH
2
CN
Lansoprazole 103577-45-3
NH F F
N S O F
O N
SwissHuge.com 36
Lansoprazole Impurity B 131926-99-3 Lansoprazole Sulfone H

N OO
S N
N F F
F
O
Leflunomide 75706-12-6 N-(4-(trifluoromethyl)phenyl)-5- N

H
O
methylisoxazole-4-carboxamide N
F
O
F
F
Leflunomide Impurity B 163451-81-8 (2Z)-2-cyano-3-hydroxy-N-[4- N
(trifluoromethyl)phenyl]but-2-enamide H
N
(Teriflunomide) OH O
F
F
F
Leflunomide Impurity C 61643-23-0 N-(4-(trifluoromethyl)phenyl)-5- N

O H
methylisoxazole-4-carboxamide N
F
O
F
F
Leflunomide Impurity G 724429-16-7 5-methyl-N-(4-methylphenyl)isoxazole-4- N

carboxamide O H
N
Lidocaine Hydrochloride 6108-05-0 2-(diethylamino)-N-(2,6- H

dimethylphenyl)acetamide N HCl
H2O
O
SwissHuge.com 37
Lidocaine Impurity D 7729-94-4 N -(2,6-dimethylphenyl)-2- H

(ethylamino)acetamide N
N
H
O
Lidocaine Impurity E 745798-07-6 free 2,2'-(azanediyl)bis(N-(2,6- H H

dimethylphenyl)acetamide N N
base N
H
O O
Lidocaine Impurity F 857170-72-0 2-(Dietylamino)-N-(2,3- H

dimethylphenyl)acetamide N
N
O
Lidocaine Impurity G 35891-87-3 N-(2,6-dimethylphenyl)-2-[(1- H

methylethyl)amino]acetamide N
N
H
O
Cl
Loperamide 34552-83-5 OH
Hydrochloride N HCl
Cl
Loperamide Impurity H 61299-42-1 4-[4-(4-chlorophenyl)-3,6-dihydropyridin-
1(2H)-
yl]-N,N-dimethyl-2,2-diphenylbutanamide N
SwissHuge.com 38
Loratadine 79794-75-5 Cl O
N O
Loratadine Impurity C 165739-83-3 ethyl 4-(4,8-dichloro-5,6-dihydro-11H - Cl O
benzo[5,6]cyclohepta[1,2-b ]pyridin-11- N O
ylidene)piperidine-1-carboxylate N
Cl
Mesalamine N-acetyl O
5-(acetylamino)-2-hydroxybenzoic acid HN CH3
HO
O OH
Metoprolol impurity-E HO O
[2-(2-methoxyethyl)phenoxy][(1- O
NH
methylethyl)amino]methanol
Metoprolol impurity-G 4-(2-hydroxyethyl)phenol HO

OH
Metoprolol impurity-N 3-[(1-methylethyl)amino]propane-1,2-diol OH
H3C NH OH
CH3
SwissHuge.com 39
Metoprolol impurity-H 1-[4-(2-hydroxyethyl)phenoxy]-3-[(1- H3C CH3
methylethyl)amino]propan-2-ol OH
NH
O
HO
H O
N
N
N
O O H
1,3-bis[(1-methylethyl)amino]propan-2-ol OH
H3C NH NH CH3
CH3 CH3
Mebendazole 31431-39-7 (2-amino-1H -benzimidazol-5- H

O
N O
yl)phenylmethanone
NH
N
O
Mebendazole Impurity A 52329-60-9 (2-amino-1H -benzimidazol-5- H

yl)phenylmethanone N
NH2
N
O
Mebendazole Impurity B 21472-33-3 (2-hydroxy-1H-benzo[d]imidazol-5- H
N
yl)(phenyl)methanone OH
N
O
Mebendazole Impurity C 66066-76-0 (2-amino-1-methyl-1H-benzo[d]imidazol-5-

N
yl)(phenyl)methanone NH2
N
O
SwissHuge.com 40
Mebendazole Impurity D 132119-11-0 Methyl (5-benzoyl-1-methyl-1H - O

N O
benzimidazol-2- yl)carbamate
NH
N
O
OH H
METOPROLOL TARTRATE 56392-17-7 O N
O 2
OH O
HO
OH
O OH
METOPROLOL TARTRATE 62572-94-5 1-(4-(2-hydroxyethyl)phenoxy)-3- OH

H
(isopropylamino)propan-2-ol O N
HO
METRONIDAZOLE 443-48-1 2-(2-methyl-5-nitro-1H-imidazol-1- OH

yl)ethanol O2 N
N
N
METRONIDAZOLE 5006-69-9 2-(4-nitro-1H-imidazol-1-yl)ethanol OH
Impurity C
N
O2 N N
METRONIDAZOLE 16156-94-8 2-(2-(2-methyl-5-nitro-1H-imidazol-1- OH
O
Impurity F yl)ethoxy)ethanol
O2N
N
SwissHuge.com 41
METRONIDAZOLE 1010-93-1 2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetic O2N COOH

Impurity G acid N
MICONAZOLE NITRATE 22832-87-7 1-((R)-2-(2,4-dichlorobenzyloxy)-2-(2,4- Cl
dichlorophenyl)ethyl)-1H-
imidazole O
N
Cl H Cl Cl
and enantiomer.HNO3
N
MICONAZOLE Impurity C (R)-2-(2,4-dichlorobenzyloxy)-2-(2,4- Cl
dichlorophenyl)ethanamine
Cl
H
O
NH 2 and enantiomer
Cl Cl
MINOXIDIL 38304-91-5
N N NH2
N
O
NH2
MINOXIDIL Impurity C 3-(cyanoimino)-3-(piperidin-1- N

yl)propanamide N
H2N N
MINOXIDIL Impurity D 75105-16-7 6-[[(4-methylphenyl)sulphonyl]- NH2

oxy]pyrimidine- O N
2,4-diamine 3-oxide S O N + O-
O
NH2
SwissHuge.com 42
MIRTAZAPINE 85650-52-8
N
N
MIRTAZAPINE Impurity A 155172-12-6 (14bRS)-2-methyl-1,2,3,4,10,14b-

O
hexahydropyrazino[2,1-a]pyrido[2,3- N
c][2]benzazepine2-0xide N
MIRTAZAPINE Impurity B 61337-89-1 (2-(4-methyl-2-phenylpiperazin-1-

yl)pyridin-3-yl)methanol N
HO N
MIRTAZAPINE Impurity D 61337-68-6 (14bRS)-1,2,3,4,10,14b- N

S
hexahydropyrazino[2,1-a]pyrido[2,3- Cl N
c][2]benzazepine N N O
NH CH3
HO
Monteleukast Z-isomer 2-(1-(((R)-1-(3-((Z)-2-(7-chloroquinolin-2- O
yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2- (Z)
S H
yl)phenyl)propyl)sulfanyl)cyclopropyl)acetic (R)
N
acid HO
Cl
MYCOPHENOLATE (E)-2-morpholinoethyl 6-(1,3-dihydro-7- O OH

O
MOFETIL hydroxy-5-methoxy-4-methyl-1- O
N
oxoisobenzofuran-6-yl)-4-methylhex-4- O
CH 3 O O
enoate CH 3
SwissHuge.com 43
MYCOPHENOLATE (E)-2-morpholinoethyl 6-(1,3-dihydro-5,7- O OH

O
MOFETIL Impurity A dihydroxy-4-methyl-1-oxoisobenzofuran-6- N
O
yl)-4-methylhex-4-enoate OH
O O
MYCOPHENOLATE (E)-2-morpholinoethyl 6-(1,3-dihydro-5,7- O O

MOFETIL Impurity D dimethoxy-4-methyl-1-oxoisobenzofuran-6- O
N
O
yl)-4-methylhex-4-enoate O O
O
MYCOPHENOLATE 24280-93-1 (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3- O OH

MOFETIL Impurity F oxo- OH
1,3-dihydroisobenzofuran-5-yl)-4- O
O
methylhex-4-enoic acid (mycophenolic O
acid)
MYCOPHENOLATE 224052-51-1 2-(morpholin-4-yl)ethyl (4E)-6-(4-hydroxy- O OH O
O
MOFETIL Impurity G 6- methoxy-7-methyl-3-oxo-1,3- O
N
dihydroisobenzofuran-5-yl)- O
O O
4-methylhex-4-enoate N-oxide
MYCOPHENOLATE 26675-76-3 7-hydroxy-5-methoxy-4-methyl-6-[2-[(2RS)- O OH

MOFETIL Impurity H 2- methyl-5-oxotetrahydrofuran-2-
yl]ethyl]isobenzofuran- O O O
1(3H)-one O
O
Niacin metabolite N-methyl-2-pyridone-5-carboxamide
NH2
O N
CH3
SwissHuge.com 44
Nordiphenhydramine 2-(diphenylmethoxy)-N-
methylethanamine
O
NH
CH3
Naproxen 22204-53-1 O
OH
Naproxen Impurity B 89617-86-7 (2S)-2-(5-Chloro-6-methoxynaphthalen-2- Cl

yl)propanoic acid
O O
OH
Naproxen Impurity C 84236-26-0 (2S)-2-(5-Bromo-6-methoxynaphthalen-2- Br

yl)propanoic acid
O O
OH
NEVIRAPINE 129618-40-2
N N N
NH
O
NEVIRAPINE Impurity A 133627-17-5 11-ethyl-methyl-5,11-dihydro-6H-

N N
dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one N
NH
O
SwissHuge.com 45
NEVIRAPINE Impurity B 287980-84-1 4-methyl-5,11-dihydro-6H-dipyrido[3,2- N H N

N
b:2',3'-e][1,4]diazepin-6-one
NH
O
NEVIRAPINE Impurity C 287980-85-2 4-methyl-11-propyl-5, 11-dihydro-6H-

dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one N N N
NH
Nimesulide O2N
O O NH
S
O
Nimesulide Impurity D 5422-92-4 4-Nitro-2-phenoxyaniline NH 2
-O N+
O
Nimesulide Impurity E N,N-Bis(methylsulphonyl)-2-phenoxyaniline

O
OO N S
S O
O
Nimesulide Impurity F 51765-72-1 N,N-Bis(methylsulphonyl)-4-nitro-2- O2N
phenoxyaniline
O
OO N S
S O
O
SwissHuge.com 46
Nimesulide Impurity G 70995-08-3 4-Nitro-2-phenoxyphenol OH
O N+
O-
Nizatidine 76963-41-2 N-(2-((2-((dimethylamino)methyl)thiazol-4- O2N

N
yl)methylthio)ethyl)-N-methyl-2-
nitroethene-1,1-diamine N
S S N N
H H
Nizatidine Impurity J 82586-70-7 [2-[(dimethylamino)methyl]thiazol-4- HO S

yl]methanol N
N
Nortriptyline 894-71-3
HCl
Hydrochloride N
H
Nortriptyline Impurity B 438-59-5 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N-

H
methylpropan-1-amine
N Cl
hydrochloride(norcyclobenzaprine)
Nortriptyline Impurity C 1156-99-6 10,11-Dihydro-5-[3-(methyl-

amino)propylidene]- N
5H-dibenzo[a,d][7]-annulen-10-ol H
HO
SwissHuge.com 47
OH OH
Nebivolol 99200-09-.6 H
O N O
F F
Nebivolol N-Benzylated Nebivolol N-Benzylated

OH OH
O N O
F F
Olanzapine Impurity (1Z)-1-((E)-1,2-dihydro-4-(4- N
methylpiperazin-1-yl)-2-
N
thioxobenzo[b][1,4]diazepin-3- N
ylidene)propan-2-one
N
H S O
Olanzapine-d3 2-methyl-4-[4-(2H3)methylpiperazin-1-yl]- H 3C
D
N
D
D
10H-thieno[2,3-b][1,5]benzodiazepine S N
HN N
Omeprazole N-oxide H
O
CH3
O H3C
N
S CH3
H3C
O N
N
Omeprazole sulfone N- O
CH3
H O H3C
oxide N
S
CH3
H3C
O N
O N
SwissHuge.com 48
O-Desmethyl Venlafaxine 4-[2-(dimethylamino)-1-(1- CH3
N
hydroxycyclohexyl)ethyl]phenol CH3
OH
OH
Ofloxacin 82419-36-1 9-fluoro-3,7-dihydro-3-methyl-10-(4- O

F
methylpiperazin-1-yl)-7-oxo-2H-
[1,4]oxazino[2,3,4-ij]quinoline-5-carboxylic N N
OH
acid N O O
Ofloxacin Impurity B 123155-82-8 (RS)-9-fluoro-3-methyl-10-(4- O

F
methylpiperazin-1-
yl)-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4- N N
benzoxazin-7-one N O
Ofloxacin Impurity E 82419-52-1 (RS)-9-fluoro-3-methyl-7-oxo-10-(piperazin- O

F
1- yl)-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-
benzoxazine-6- carboxylic acid N N OH
O
HN O
Omeprazole 73590-58-6 O
H
N
S
O N O
Omeprazole Impurity E 176219-04-8 5-methoxy-2-[[(4-methoxy-3,5- O

dimethylpyridin- O N
2-yl-1-oxide)methyl]sulfinyl]-1H- S N+
benzimidazole N O -O
H
SwissHuge.com 49
Omeprazole Impurity I 176219-04-8 4-methoxy-2-[[(5-methoxy-1H-

benzimidazol-2- yl)sulphonyl]methyl]-3,5- O N+ O-
O
O N
dimethylpyridine 1-oxide S
O N
H
Ondansetron 103639-04-9
N N HCl
Hydrochloride Dihydrate
N 2 H2O
Ondansetron Impurity D 99614-64-9 9-methyl-3-methylene-1,2,3,9-tetrahydro-

N
4H-
carbazol-4-one
O
Ondansetron Impurity H 99614-14-9 (3RS)-3-[(2-methyl-1H-imidazol-1- H

N N
yl)methyl]-
1,2,3,9-tetrahydro-4H-carbazol-4-one (N- N
demethylondansetron) O
Orphenadrine 341-69-5
Hydrochloride
H
N
O
Orphenadrine Impurity C 17752-32-8 (RS)-2-[(2-

methylphenyl)phenylmethoxy]ethanamine
H
NH2
O
SwissHuge.com 50
Orphenadrine Impurity E 17630-53-4 (RS)-N,N-dimethyl-2-[(3- H

S
methylphenyl)phenylmethoxy]ethanamine
H
(meta-methyl O
N
Hbezyl isomer)
Pravastatin HO O
CH3
HO
3-alpha-hydroxy pravastatin sodium salt

-
O Na
OH
HO
O
H3C O
CH3
CH3
OH
Pantoprazole Sulfone Sodium 5-(difluoromethoxy)-2-[[(3,4- H3C

O CH3
dimethoxy-2-pyridinyl)methyl] sulfonyl]- O NH
O
1H-benzimidazole O
N
F
S F
N
O
Pantoprazole Sulfone N- H
N O
F
Oxide S O CH3
F O NO
N O
O
CH3
Pantoprazole Sodium 138786-67-1 F O N O N

S
F N O
Na O
SwissHuge.com 51
Pantoprazole Impurity A 127780-16-9 5-(difluoromethoxy)-2-[[(3,4- F O N O N

dimethoxypyridin- S
F O
2yl)methyl]sulphonyl]-1H-benzimidazole N O
H O
Pantoprazole Impurity B 102625-64-9 5-(difluoromethoxy)-2-[[(3,4- F O N N

dimethoxypyridin- S
F O
2yl)methyl]sulphanyl]-1H-benzimidazole N
H O
78246-49-8 F
Paroxetine Hydrochloride
(anhydrous)
O O NH.HCl
Paroxetine Impurity A 324024-00-2 (3S,4R)-3-[(1,3-benzodioxol-5-

yloxy)methyl]-4- phenylpiperidine
hydrochloride (desfluroparoxetine O O NH
Paroxetine Impurity C 105813-13-6 (3S,4R)-3-[(1,3-benzodioxol-5- F
yloxy)methyl]-1- benzyl-4-(4-
O
fluorophenyl)piperidine hydrochloride (N- O N
benzyl paroxetine) O
Paroxetin Impurity F (3S,4R)-3-[(1,3-benzodioxol-5-

yloxy)methyl]-1- benzyl-4-phenylpiperidine
O O N
hydrochloride (N-benzyl
desfluoro paroxetine) O
SwissHuge.com 52
Pindolol 13523-86-9 HO
H
HN O N
Pindolol Impurity D 61212-32-6 (2RS)-3-(1H-indol-4-yloxy)propane-1,2-diol OH

HN O OH
Pindolol Impurity F 130115-66-1 (2RS)-1-chloro-3-(1H-indol-4-yloxy)propan- OH

2-ol HN O Cl
Piroxicam 36322-90-4 O O
S
N
H
N N
OH O
Piroxicam Impurity L 118854-48-1 1-methylethyl 4-hydroxy-2-methyl-2H-1,2- O O

S
benzothiazine-3-carboxylate 1,1-dioxide N
O
OH O
Prazosin Hydrochloride 19237-84-4 O
O N
N N
O HCl
O N
H2N
SwissHuge.com 53
Prazosin Impurity C 60547-97-9 6,7-dimethoxy-2-(piperazin-1-yl)- O NH

N
quinazolin-4- N
amine O N
H2N
PROMETHAZINE 58-33-3 N,N-dimethyl-1-(10H-phenothiazin-10-

HYDROCHLORIDE yl)propan-2-amine hydrochloride N N
S HCl
PROMETHAZINE Impurity 5568-90-1 N,N-dimethyl-2-(10H-phenothiazin-10-

B yl)propan-1-amine N N
S
PROMETHAZINE Impurity 60113-77-1 N-methyl-1-(10H-phenothiazin-10- H

C yl)propan-2-amine N N
S
PROMETHAZINE Impurity 7640-51-9 (2RS)-N,N-dimethyl-1-(10H-phenothiazin-

D 10-yl)propan-2-amineS-oxide N N
S
O
Prazosin Hydrochloride O
O N
N N
O HCl
O N
H2N
SwissHuge.com 54
6,7-dimethoxy-2-(piperazin-1-yl)- O NH
N
Prazosin Impurity C quinazolin-4- N
amine O N
H2N
PROMETHAZINE N,N-dimethyl-1-(10H-phenothiazin-10-
yl)propan-2-amine hydrochloride N N
S HCl
PROMETHAZINE Impurity N,N-dimethyl-2-(10H-phenothiazin-10-

B yl)propan-1-amine N N
S
PROMETHAZINE Impurity N-methyl-1-(10H-phenothiazin-10- H

C yl)propan-2-amine N N
S
PROMETHAZINE Impurity (2RS)-N,N-dimethyl-1-(10H-phenothiazin-

D 10-yl)propan-2-amineS-oxide N N
S
O
Propranolol OH
H
Hydrochloride O N HCl
SwissHuge.com 55
Propranolol Impurity C 1,3-bis(naphthalen-1-yloxy)-propan-2-ol OH

(bis-ether derivative O O
Quetiapine sulfoxide N
O OH
N
N
HO S
7-hydroxylated S
quetiapine
HO
N
N
N
O OH
OH
Ramipril hydrate O
CH3
O
NH
N
HO
H3C
Ramipril(RS) O O
H3C
O
NH
N
HO
O
Ramipril related Ramipril cyclohexyl derivative H3C O O

CH3
compound hydrochloride salt NH

O
H H
H HCl
HO N
O
H
SwissHuge.com 56
Ramipril related Ethyl(2S)-2-[(3s,5as,8as,9as)-3- methyl- H3C O O

H3C
compound 1,4dioxodecahydro-2H- O
N
H
cyclopenta[4,5]pyrrole[1,2-a] pyrazin-2-yl]- H H
N
4-phenyl butanoate O
N-(2-((5-((dimethylamino)methyl)furan-2- H3C
RANITIDINE N NO2
HYDROCHLORIDE yl)methylthio)ethyl)-N-methyl-2- H3C
O
CH3
nitroethene-1,1-diamine hydrochloride S
N
N
H H
HCl
RANITIDINE Impurity B 2-((5-((dimethylamino)methyl)furan-2- H3C

N
yl)methylthio)ethanamine H3C
O
S
NH2
RANITIDINE Impurity C N-(2-((5-((dimethylamino)methyl)furan-2- H3C

NO2
N
yl)methylsulfinyl)ethyl)-N-methyl-2- H3C O
O
nitroethene-1,1-diamine S N
CH3
N H
H
sibutramine (Mono 1-[1-(4-chlorocyclohexyl)cyclobutyl]-N,3-

desmethyl sibutramine ) dimethylbutan-1-amine
Cl HN
CH3
sildenafil (N-desmethyl O
sildenafil) OO HN
N
N
S
N
N
HN CH3
O CH3
SwissHuge.com 57
Simvastatin hydroxyl acid

O
CH3 OH OH
H OH
H
O O
CH3
H3C
H3C
CH3
H3C
Simvastatin Acetate O O
Impurity B H3C
O
H3C CH3 O
CH3
H3C
O
Simvastatin anhydro
O
Impurity C H3C
H3C CH3 O
CH3
H3C
HO
Simvastatin impurity D O
O O
(Lovastatin) H3C
O
H 3 C CH 3
CH3
H3C
Sertraline Hydrochloride HN
HCl
C
Cl l
CH3
Sertraline Impurity A (+/-)-trans-4-(3,4-dichlorophenyl)-1,2,3,4- HN H
tetrahydro-N -methyl-1-naphthalenamine
H
Cl
Cl
SwissHuge.com 58
Sertraline Impurity B (1RS,4RS)-N-methyl-4-Phenyl-1,2,3,4- HN
tetrahydronaphthalen-1-amine
Sertraline Impurity F 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H )- O
naphthalenone (tetralone)
H
Cl
Cl
Sertraline Impurity G 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N H HN CH3
- methyl-1-naphthalenamine
((1R,4R)enantiomer) H
Cl
Cl
Sertraline Hydrochloride Unknown: Isomer of 2,3 Dichloro O
Sertralone
H
Cl
Cl
Unknown: Isomer of 2,3 Dichloro H

H
N CH3
Serteraline
H
Cl
Cl
Unknown: Trans form of 2,3 Dichloro CH3

HN H
Sertraline and enantiomer
H
Cl
Cl
SwissHuge.com 59
Unknown: Cis form of 2,3 Dichloro H H

N
Sertraline and enantiomer
H
Cl
Cl
Sulfaguanidine OO NH
S
N NH2
H
H2N
Sulfaguanidine Impurity B N[(4- OO O

aminophenyl)sulphonyl]urea(sulphacarbam S
N NH2
ide) H
H2N
Sulfamethoxazole
O O O
S
N N
H
H2N
Sulfamethoxazole N-[4-[(5-methylisoxazol-3-yl)- H O
N
Impurity A sulphamoyl]phenyl]acetamide S
O
ON O
N
H
Tizanidine related N-(5-chloro-2,1,3-benzothiadiazol-4-yl)-N- N

S
compound (4,5-dihydro-1H-imidazol-2-yl)acetamide N
Cl
N-Acetyl Tizanidine N N O
NH CH3
SwissHuge.com 60
H3C
Trandolapril cyclohexyl O
OH
analogue O
O
CH
3
N
NH
HO
Trandolapril Diketo O
analougue
CH3
O O
N H
Trandolaprilate
HO
O
NH
H 3C
O
H
N O
OH
H
Tamoxifen Citrate
O OH OH
O O .N
O
HO OH
Tamoxifen Citrate 2-[4-[(Z)-1,2-diphenylprop-1- O

N
Impurity D enyl]phenoxy]-N,N- dimethylethanamine
Terbinafine (E)-N,6,6-trimethyl-N-((naphthalen-1- H
Hydrochloride yl)methyl)hept-2-en-4-yn-1-amine Cl
N
hydrochloride
SwissHuge.com 61
Terbinafine Impurity B 2Z)-N,6,6-trimethyl-N-(naphthalen-1-

ylmethyl)hept-2-en-4-yn-1-amine
hydrochloride (cis- N
terbinafine hydrochloride)
Ticlopidine S
Hydrochloride N HCL
Ticlopidine Impurity B 6,7-dihydrothieno[3,2-c]-pyridin-4(5H)-one O
HN
S
Tinidazole 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro- O2N O

O
1H-imidazole S
N CH3
N
CH3
Tinidazole Impurity B 1-[2-(ethylsulphonyl)ethyl]-2-methyl-4- O O

nitro-1H- imidazole O2N N S CH3
N
CH3
Trimipramine Maleate
N N COOH
COOH
SwissHuge.com 62
Trimipramine Maleate (2RS )-3-(5H -dibenzo[b,f]azepin-5-yl)-N ,N

Impurity C ,2- trimethylpropan-1-amine N N
Trimipramine Maleate (2RS )-N -[(2RS )-3-(10,11-dihydro-5H -

Impurity E dibenzo[b,f]azepin-5-yl)-2-methylpropyl]-N N N N
,N' ,N' ,2- tetramethylpropane-1,3-diamine
dihydrochloride
O-Desmethyl Venlafaxine 4-[2-(dimethylamino)-1-(1- CH3
N
hydroxycyclohexyl)ethyl]phenol CH3
OH
OH
Venlafaxine 1-(2-(dimethylamino)-1-(4-
OH
Hydrochloride methoxyphenyl)ethyl)cyclohexanol
N
Venlafaxine Impurity A 2-(4-methoxyphenyl)ethyl]-N,N-

dimethylethanamine N
Venlafaxine Impurity D 1-(1-(4-methoxyphenyl)-2-

OH
(methylamino)ethyl)cyclohexanol H
N
SwissHuge.com 63
Zidovudine 1-((2R,4R,5S)-4-azido-tetrahydro-5- O
HN
(hydroxymethyl)furan-2-yl)-5- HO O N
methylpyrimidine-2,4(1H,3H)-dione O
N3
Zidovudine Impurity B 1-(3-chloro-2,3-dideoxy-?-D-erythro- O

HN
pentofuranosyl)-5-methylpyrimidine- HO O N
2,4(1H,3H)-dione O
Cl
SwissHuge.com 64

SwissHuge List of Impurities

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List of API molecules and their Impurities

Drug Name, EP Impurity CAS No Chemical Name Structure

ALBENDAZOLE SULFONE methyl 5-(propylsulfonyl)-1H- H

ALLENDRONATE d6 di disodium [4-amino-1-hydroxy(2H6)butane- D D D

ATENOLOL IMPURITY A 2-(4-hydroxyphenyl)acetamide OH

ATENOLOL IMPURITY B 2-[4-(oxiran-2-ylmethoxy)phenyl]acetamide

Drug Name, EP Impurity CAS No Chemical Name Structure

ATROPIC ACID 2-phenyl-2-propanoic acid O

ASPARTAME RELATED (5-benzyl-3,6-dioxo-2-piperazine acetic H

ACECLOFENAC 89796-99-6 2-(2-(2-(2,6-dichlorophenylamino) O

ACECLOFENAC Impurity A 2-(2-(2,6-dichlorophenylamino) OH

(diclofenac) phenyl)acetic acid NH

ACECLOFENAC Impurity B methyl 2-(2-(2,6- O

(diclofenac methyl ester) dichlorophenylamino)phenyl)acetate NH

ACECLOFENAC Impurity C ethyl 2-(2-(2,6- O

(diclofenac ethyl ester) dichlorophenylamino)phenyl)acetate NH

Drug Name, EP Impurity CAS No Chemical Name Structure

ACECLOFENAC Impurity D methyl[[[2-[(2,6- O

ACECLOFENAC Impurity E ethyl[[[2-[(2,6- O

ALFUZOSIN Impurity A 98902-29-5 N-[3-[4-amino-6,7-dimethoxy-quinazolin-2- H

ALFUZOSIN Impurity C 72104-34-8 N-(3-(4-amino-6,7-dimethoxyquinazolin-2- H

ALFUZOSIN Impurity E N-[3-[(4-amino-6,7-dimethoxyquinazolin-2- H

Drug Name, EP Impurity CAS No Chemical Name Structure

AMLODIPINE Impurity G 43067-01-2 dimethyl 4-(2-chlorophenyl)-1,4-dihydro- H

AMLODIPINE Impurity H 318465-73-5 2-[[2-[[(4R)-4-(2-Chlorophenyl)-3- H H

Drug Name, EP Impurity CAS No Chemical Name Structure

AMOXICILLIN Impurity C 4S)-2-[5-(4-Hydroxyphenyl)-3,6- H

AMOXICILLIN Impurity D (2R)-2-amino-2-(4- H COOH

AMPICILLIN TRIHYDRATE 7177-48-2

AMPICILLIN Impurity C (4S)-2-(3,6-dioxo-5-phenylpiperazin-2-yl)- H

AMPICILLIN Impurity D (4S)-2-[[[(2R)-2-amino-2- H COOH

ATENOLOL 29122-68-7 2-(4-((R)-2-hydroxy-3- H OH H

Drug Name, EP Impurity CAS No Chemical Name Structure

Atenolol Impurity A 2-(4-hydroxyphenyl)acetamide O

Atenolol Impurity B 2-(4-((oxiran-2-

Atenolol Impurity C 2-(4-(2,3- OH

Atenolol Impurity D 2-(4-(3-chloro-2- OH

ATENOLOL Impurity F 87619-83-8 2,2-[(1-methylethyl)-iminobis(2- OH OH

ATENOLOL Impurity G 56392-14-4 2-(4-((R)-2-hydroxy-3- H OHH

Drug Name, EP Impurity CAS No Chemical Name Structure

Atorvastatin Lactone 5-(4-fluorophenyl)-1-(2-((2R,4R)- F

Atorvastatin Methyl ester (3R,5R)-methyl 7-(3-(phenylcarbamoyl)-5- F

Atorvastatin isomer (3S, 5S) (3S,5S)-7-(3-(phenylcarbamoyl)-5-(4- F

Atorvastatin Diastereomer (3S,5R)-7-(3-(phenylcarbamoyl)-5-(4- F

(3S, 5R) fluorophenyl)-2-isopropyl-4-phenyl-1H-

Drug Name, EP Impurity CAS No Chemical Name Structure

Desfluoro Atorvastatin (3R,5R)-7-(3-(phenylcarbamoyl)-2-

3-O-methyl Atorvastatin (3R,5R)-7-(3-(phenylcarbamoyl)-2-

5-O-methyl Atorvastatin (3R,5R)-7-(3-(phenylcarbamoyl)-2-

Atorvastatin L1 tert-butyl 2-((4R,6R)-6-(2-(3- F

Atorvastatin Acetonide 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4- F

Atorvastatin t-Butyl ester (3R,5R)-tert-butyl 7-(3-(phenylcarbamoyl)- F

Drug Name, EP Impurity CAS No Chemical Name Structure

O-Hydroxy Atorvastatin (3R,5R)-7-(3-(2-hydroxyphenylcarbamoyl)- F

O-Hydroxy Atorvastatin 5-(4-fluorophenyl)-1-(2-((2R,4R)- F

P-Hydroxy Atorvastatin 5-(4-fluorophenyl)-1-(2-((2R,4R)- F

ATS diketoene (E)-2-(2-(4-fluorophenyl)-2-oxo-1- F

ATS diepoxide lactone F

Drug Name, EP Impurity CAS No Chemical Name Structure

ATS impurity 5-(4-fluorophenyl)-2-isopropyl-N,4- F

(beclometasone 21- propanoate

BECLOMETASONE 5534-18-9 9-chloro-11 beta,21-dihydroxy-16 beta- O OH O

(beclometasone 17- propanoate

Drug Name, EP Impurity CAS No Chemical Name Structure