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Pathophysiology of Chronic Glomerulonephritis

PRIMARY CAUSES SECONDARY CAUSES


Unknown SLE, Good pastures,
Direct glomerular Infection
damage

Inflammation

Damage to the glomerular


membrane Lodging of antigen-antibody
complexes in the glomerular
membrane
Fibrosis, scarring, sclerosis
of the glomerulus
Release of inflammatory Pain and
mediators
tenderness
on the back
Decrease in glomerular
Hyperpermeability of the Renal failure
filtration rate
glomerular membrane

Fatigue, difficulty of
Sodium and water breathing, anemia,
Increased urinary retention nausea and vomiting
frequency, proteinuria,
albuminuria, hematuria
Diuretics
Decreased urinary output,
Edema, Hypertension

Dark frothy urine Angiotensin Converting


Enzyme Inhibitors,
Amgiotensin II receprotr
Congestive heart failure, blockers for hypertension
Pulmonary edema

LEGEND:

Causes
Diet modifications: low
salt, low fat, low protein Disease process
diet. Fluid restrictions as
Reaction/compensation
advised
Signs and symptoms

Complications

Treatment and management