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The number of commercially marketed skin cleansing agents continues to grow, provid-
ing clinicians with an increasingly large variety of products from which to choose. This
variety may lead to confusion about which product to choose, particularly for persons
without expertise in the area of skin care. This article reviews common types of skin
cleansers, their formulation, ingredients, skin compatibility, pH, and related infection con-
trol issues. (J WOCN 2000;27:260-8)
260
JWOCN
Volume 27, Number 5 Nix 261
Box
Glossary
Alkali salts: Strongly basic salt
Antimicrobial: An agent that kills or inhibits the growth and multiplication of microbes
Colonization: The formation of compact population groups of the same type of microor-
ganism when a bacterial cell begins reproducing
Decolonization: A procedure attempting to eradicate unwanted organisms by using antimi-
crobial agents
Detergent: Cleansing or purging agent; detergents allow fats to be suspended in water
Emollient: Any agent that softens the skin and renders it more pliant; soothes irritation in the
skin or mucous membrane
In vitro: In an artificial environment, referring to a process or reaction occurring therein, as in
a test tube or culture media
Fatty acids: Acids that occur in biologic material, particularly as esters in fats and phospho-
lipids
Irritant: An agent that causes an inflammatory response to tissue such as skin redness,
swelling, or itching
Humectant: An agent that brings about a moisturizing effect
Hydrophilic: Having an infinity for water; attracting or associating with water molecule
In vivo: In the living body, referring to a process or reaction occurring within
pH: An expression of the acidity or alkalinity of a solution; pH of 7 is neutral
propylbetaine
combine incorporated in ointments and creams, the
surfactant is used to keep the oil and the
gent properties with cationic disinfectant
properties. Activation of the surfactant
anionic water from separating. In addition, when
applied to the skin, the surfactant helps lift
relies on the pH of the media used; most
amphoteric products have a pH of 7 or
detergent dirt and oil.1,12,13 higher. Amphoterics are often found in
SLS is also commonly used as a gold baby products because of their reputation
properties standard when demonstrating the irritat- for avoiding irritation of the eye. Never-
ing potential of detergent products. A one- theless, a pH higher than 7 can disrupt
with cationic time occlusive test is typically used for skin barrier function.1,12,13
such comparisons. In this design, a sub- Nonionic surfactants include polysor-
disinfectant stance is placed in contact with the skin bate 20 and 60. Nonionic surfactants are
properties. under an occlusive dressing for a given
time period (usually 24 hours). More
compatible with all other types of surfac-
tants. Pharmaceutical systems use nonion-
recently, some researchers have criticized ic surfactants because they are minimally
this method as limited because it fails to affected by pH. They also have a low toxi-
adequately replicate the effects of cumula- city potential and are often used in cos-
tive use in clinical situations.14,15 metic and food products. Nonionic surfac-
Cationic surfactants such as cetrimide tants are used for emulsifying, foam
and benzalkonium play only a minor role boosting, and solubilizing (dissolution
in routine skin cleansers because of their of a substance within a solvent solu-
incompatibility with anionic surfac- tion).1,12,13
tants.1,3,14 Cationic surfactants are report-
ed to be less irritating than anionic surfac- Antimicrobials
tants, and they have some disinfect prop- Some cleansers combine an antimicro-
erties. Because of these limitations, cation- bial and surfactant to reduce bacterial col-
ic surfactants are typically used as preser- onization. Commonly used antimicrobials
vatives based on their bactericidal activity. include triclosan, chlorhexidine gluconate
For example, benzalkonium is widely (CHG), and para chloroxylenol (PCMX).
used as a preservative for ophthalmic Products with CHG and PCMX are often
products. used in health care facilities. For example,
Amphoteric surfactants such as cocami- Hibiclens (ICA Americas, Inc, Wilming-
dopropylbetaine combine anionic deter- ton, Del) contains 4% CHG, and Sween
JWOCN
Volume 27, Number 5 Nix 263
*Specific ingredients are less important than the effects of all the ingredients combined.
remains
Some alcohols are emollients and are not drying to the skin.
controversial.
Soft Touch (Coloplast Corp, North Man- tine use of an antimicrobial cleanser is
kato, Minn) contains PCMX. Triclosan is effective or necessary. These researchers
also frequently used in skin cleansing also raise concerns that regular use of an
products for health care settings and com- antimicrobial cleanser may increase the
mercial use.2,9 Examples of the many risk of selecting for organisms that are
products containing triclosan in a health resistant to the agents used.16,17
care setting include Provon Medicated The area of greatest agreement regard-
Lotion Soap and Gentle Rain All Body ing use of an antimicrobial agent occurs
Cleanser by Coloplast Corp. Commercial in the context of hand washing among
products containing troclosene include health care personnel. Several studies
Dial liquid soap (The Dial Corporation, have compared the benefits of antimicro-
Scottsdale, Ariz) and Softsoap Gentle bial cleansers in hand washing among
Antibacterial Body Wash (Colgate-Palm- health care personnel with cleansers with-
olive Company, New York, NY). out an antimicrobials ingredient.6,18-20
The addition of an antimicrobial agent Based on data from these studies, an an-
for skin cleansing remains controver- timicrobial cleanser is recommended for
sial.8,16,17 Some researchers suggest that health care providers with a high frequen-
the use of antimicrobial-based skin clean- cy of hand washing (8 or more times per
sers may be beneficial when manag- day). This advantage disappears among
ing patients who are colonized with persons with relatively low hand-washing
methicillin-resistant Staphylococcus aureus frequency (6 times or less per day).21
(MRSA).18 However, others contend that Current guidelines promulgated by the
little convincing evidence exists that rou- Association for Professionals in Infection
JWOCN
264 Nix September 2000
because Time kill study Rapid microbial kill rate Measures the time that an antimi-
crobial product takes to reduce
clinicians microbial contamination of the skin
to an acceptable level
can easily *A product effective against methicillin-resistant Staphylococcus aureus does not necessarily mean it
misinterpret a removes methicillin-resistant Staphylococcus aureus from skin; it could simply meet the preservative chal-
lenge test.
product claim Celsis Laboratory Group, New Jersey Division, Edison, NJ 08837.
such as ly accessible for use after handwashing MRSA as implying use of the cleanser
may enhance compliance by minimizing removes MRSA from skin. Instead, the cor-
effective skin irritation associated with frequent rect interpretation of such as claim is limit-
handwashing. ed to testing that demonstrated that MRSA
against MRSA does not grow when placed in the product
as implying Product Testing Data package or on an object other than human
Before marketing a skin cleanser, the skin.
use of the product may be tested for safety and func-
tion40,41 (Table 2). If safety testing is not
cleanser done, a warning statement must be applied
SUMMARY
to the package. Provided safety testing has The consequences of choosing an inap-
removes been completed, the manufacturer can sup- propriate cleansing product are significant
ply a summary of the safety tests that have because this can lead to reduced compli-
MRSA from been performed on a specific product. ance with hand washing, increased noso-
These tests should evaluate stability, poten- comial infection, and an increased inci-
skin. tial for allergy, dermal irritancy, and preser- dence of dermatitis. The primary factors
vative efficacy. Antimicrobial effectiveness the WOC nurse should consider when
should also be demonstrated when indicat- offering advice for the selection of a skin
ed using an in vitro minimum inhibitory cleansing products must begin with the
concentration technique or an in vivo time purpose, the clinical goals, and the per-
kill study technique using human subjects. sons expected to use the product. Clearly,
When reviewing product safety data, it one product will not meet all of the needs
should be emphasized that a preservative in a health care setting. Products pur-
challenge test implies that a certain type of chased for hand washing, for example,
microorganism is not likely to grow inside can be inappropriate for general bathing.
the product. This test was not designed to Components such as surfactant type, pH,
indicate the effect of the product on the humectants, and moisturizers can have a
skin. This distinction is clinically relevant significant impact on how skin cleansers
because clinicians can easily misinterpret a perform for health professionals and the
product claim such as effective against patients they serve.
JWOCN
Volume 27, Number 5 Nix 267
Acknowledgments
resistant Staphylococcus aureus colonization in
I thank Sharon Carlson, RN, CIC, for her
residents and staff of a Veterans Affairs nursing
guidance and expertise in the area of infection
home care unit. Infect Control Hosp Epidemiol
control. I thank Cathy Garvin, RN, CWOCN,
1992;13:151-9.
and Clark L. Thompson, BS, MS, for sharing
18. Litsky BY, Litsky W. The evaluation of single-
their knowledge related to formulations and
use bar soaps for surgical scrub. Hosp Manage
testing.
1967;103:74-86.
19. Jarvis JD, Wynne CD, Enright L, Williams LD.
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