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3 PHARMACEUTICAL FORM
Aqueous Solution
4 CLINICAL PARTICULARS
Adults, the elderly and children: Apply full strength as a pre-operative and
post-operative antiseptic skin cleanser. Avoid pooling both under the patients
and in the skin folds. Wash off excess solution before using occlusive
dressings.
4.3 Contraindications
Use of this preparation may interfere with tests of thyroid function. Iodine is
absorbed through burns and broken skin and to a lesser extent through intact
skin and may lead to toxic levels of iodine in the blood, particularly in patients
with renal insufficiency. If used for long periods thyroid function tests should
be performed. Particular care should be taken when treating patients with
excessive burns. Use of this preparation In patients with renal impairment
may possibly result in the development of toxic levels of iodine" Therefore,
iodine levels should be monitored in these patients. Particular care should also
be taken when treating neonates and very low birth weight infants.
Avoid contact with eyes. In case of contact with the eyes, immediately flush
the eyes liberally with water for at least 15 minutes and seek medical attention.
If easy to do, remove contact lenses.
4.5 Interaction with other medicinal products and other forms of interaction
Use with concurrent lithium therapy has been shown to exhibit additive hypothyroidic
effects. Absorption of iodine from povidone iodine through either intact skin or
broken skin may interfere with thyroid function tests. Contamination with povidone
iodine of several types of tests for the detection of occult blood in faeces or blood in
urine may produce falsepositive results.
Iodine freely crosses the placenta and is secreted in breast milk. Therefore it is
recommended that breastfeeding should stop during treatment, unless no
alternative is possible. Thyroid function disorders have been reported in the
offspring of mothers exposed to pharmacological doses of iodine. Povidone
iodine should not be used regularly during pregnancy unless there is no
alternative treatment available.
4.9 Overdose
5 PHARMACOLOGICAL PROPERTIES
6 PHARMACEUTICAL PARTICULARS
6.2 Incompatibilities
None.