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Year: 2009

E/S/C/O/P Monographs. The Scientific Foundation for Herbal Medicinal


Edited by: Anton, R; Delaveau, P; Franz, G; Harvala, C; Kemper, F H; Kraft, K; Kubelka, W; Loew,
D; Ollivier, E; Saller, R; Schilcher, H; Simmet, T; Sticher, O; Vincieri, F F; Vlietinck, A J

Posted at the Zurich Open Repository and Archive, University of Zurich


Originally published at:

E/S/C/O/P Monographs. The Scientific Foundation for Herbal Medicinal Products. Edited by: Anton,
R; Delaveau, P; Franz, G; Harvala, C; Kemper, F H; Kraft, K; Kubelka, W; Loew, D; Ollivier, E; Saller,
R; Schilcher, H; Simmet, T; Sticher, O; Vincieri, F F; Vlietinck, A J (2009). Exeter, UK; Stuttgart, DE;
New York, USA: European Scientific Cooperative On Phytotherapy (ESCOP); Thieme Verlag.
ElSie 101P
The Scientific Foundation for
Herbal Medicinal Products

Second edition
Supplement 2009

ESCOPMonographs were first published in loose-leaf form progressively
from 1996 to 1999 as Fascicules 1-6, each of 10 monographs
ESCOP1996, 1997, 1999

Second edition, completely revised and expanded


Second edition, Supplement 2009


Published by ESCOP,the European Scientific Cooperative on Phytotherapy

Argyle House, Gandy Street, Exeter EX4 3LS, United Kingdom

in collaboration with

Georg Thieme Verlag, Rudigerstrasse14, D-70469 Stuttgart, Germany

Thieme New York, 333 Seventh Avenue, New York, NY 10001, USA

ISBN 978-1-901964-08-0 (ESCOP)

ISBN 978-3-13-149981-3 (GTV)

All rights reserved.

Except for the purposes of private study, research, criticism or review no part of this
book may be reproduced, stored in a retrieval system or transmitted, in any form
or by any means, without the written permission of the publisher.

Important Note: Medical knowledge is ever-changing. As new research and clinical experience broaden
our knowledge, changes in treatment and drug therapy may be required. The authors of the material herein
have consulted sources believed to be reliable in their efforts to provide information that is complete and in
accordance with standards accepted at the time of publication. However, in view of the possibility of human
error by the authors or publisher of the work herein, or changes in medical knowledge, neither the authors
nor the publisher, nor any other party who has been involved in the preparation of this work, warrants that the
information contained herein is in every respect accurate or complete, and they are not responsible for any
errors or omissions or for the results obtained by the use of such information. Readers are advised to check the
product information sheet included in the package of each drug they plan to administer, to be certain that the
information contained in this publication is accurate and that changes have not been made in the recommended
dose or in the contra,indications for administration.

Some of the product names, patents and registered designs referred to in th is book are in fact registered trademarks
or proprietary names even though specific reference to this fact is not always made in the text. Therefore, the
appearance of a name without designation as proprietary is not to be construed as a representation by the
publisher that it is in the public domain.

Cover illustration by Trevor Wilson

Cover and text design by Martin Willoughby
Typeset in Optima by Roberta Hutchins
Printed in Great Britain by the MPG Books Group, Bodmin and King's Lynn
Prof. Robert Anton
Professeur Emeritus de Pharmacognosie, Universite Louis Pasteur, Strasbourg

Prof. Pierre Delaveau

Professeur Emeritus de Pharmacognosie, Universite Rene Descartes, Paris

Prof. Dr. Gerhard Franz

Institut fUr Pharmazie, Universitat Regensburg

Professor Dr. Catherine Harvala

School of Pharmacy, University of Athens

Prof. Dr. med. Dr. h.c. mult. Fritz H. Kemper

Direktor Emeritus des Instituts fUr Pharmakologie und Toxikologie
Universitat Munster

Prof. Dr. med. Karin Kraft

Lehrstuhl fUr Naturheilkunde, Universitat Rostock

Em. Prof. Dr. Wolfgang Kubelka

Institut fUr Pharmakognosie, Universitat Wi en

Prof. Dr. med. Dr. med. dent. Dieter Loew

Arzt fUr Pharmakologie, klinische Pharmakologie, Wiesbaden

Prof. Evelyne Ollivier

Professeur de Pharmacognosie, Universite de la Mediterranee, Marseille

Prof. Dr. Reinhard Saller

Institut fUr Naturheilkunde, UniversitatsSpital Zurich

Prof. Dr. Dr. h.c. mult. Heinz Schilcher

Professor Emeritus fUr Pharmazeutische Biologie, Freie Universitat Berlin

Prof. Dr. Thomas Simmet

Naturheilkunde und klinische Pharmakologie, Universitatsklinikum Ulm

Prof. Dr. Otto Sticher

Professor Emeritus fUr Pharmakognosie und Phytochemie, ETH Zurich

Prof. Franco F.Vincieri

Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Firenze

Prof. Arnold J. Vlietinck

Professor Pharmacognosie en Fytochemie, Universiteit Antwerpen