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Conict of interest
Over and above the top ten risk factors for morbidity and mortality I have no conict of interest.
in patients with chronic systolic failure [1], it now appears that account
will also have to be taken of elevated serum neprilysin levels when
References
predicting cardiovascular death and heart failure hospitalisation in
patients with systolic heart failure [2]. The predictive role of serum [1] I. Ford, M. Robertson, M. Komadja, M. Bohm, J. Borer, L. Tavazzi, et al., Top ten risk
factors for morbidity and mortality in patients with chronic systolic heart failure
neprilysin was documented in a study which enrolled 1069 consecutive
and elevated heart rate: the SHIFT Risk Model, Int. J. Cardiol. 184 (2015) 163169.
ambulatory patients of mean age 66.2 (71.8% males) receiving treat- [2] A. Bayes-Genis, J. Barallat, A. Galan, M. de Antonio, M. Domingo, E. Zamora, et al., Sol-
ment for systolic heart failure in a multidisciplinary heart failure clinic uble neprilysin is predictive of cardiovascular death and heart failure hospitalization
between May 22, 2006 and May 22, 2013. The patients were followed- in heart failure patients, J. Am. Coll. Cardiol. 65 (2015) 657665.
[3] A. Jaffe, Unwinding the interaction of natriuretic peptides and neprilysin, J. Am. Coll.
up for a mean of 4.1 years. In comprehensive multivariate analyses, Cardiol. 65 (2015) 666667.
neprilysin concentrations were signicantly associated with the
1 Philip Godlee Lodge, 842 Wilmslow Road, Manchester M20 2DS, United Kingdom.
E-mail address: oscarjolobe@yahoo.co.uk.
http://dx.doi.org/10.1016/j.ijcard.2015.03.257
0167-5273/ 2015 Published by Elsevier Ireland Ltd.