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Actions
Biguanide oral hypoglycemic agent. Unlike
sulfonylureas, biguanides do not stimulate the
release of insulin from the beta cells of the
pancreas. Mechanism of action is thought to be
due to both increasing the binding of insulin to
its receptor and potentiating insulin action.
Therapeutic effects
Improves tissue sensitivity to insulin, increases
glucose transport into skeletal muscles and fat,
and suppresses gluconeogenesis and hepatic
production of glucose, thus lowering blood
glucose levels.
Description
Celecoxib (Celebrex) is a non-opioid analgesic
Therapeutic actions
Analgesic and anti-inflammatory activities
related to inhibition of the COX-2 enzyme,
which is activated in inflammation to cause the
signs and symptoms associated with
inflammation; does not affect the COX-1
enzyme, which protects the lining of the GI tract
and hasbloodclotting and renal functions.
Folic acid
Action:
Vitamin B complex essential for nucleoprotein
synthesis and maintenance of normal
erythropoiesis. Acts against folic acid deficiency
that impairs thymidylate synthesis and results in
production of defective DNA that leads
to megaloblast formation and arrest of bone
marrow maturation.