105 gern mara A fos of aie Signature of Taviiiator ENTRANCE EXAMINATION, 2018 Integrated M.Sc.-Ph.D. in MOLECULAR MEDICINE [ Field of study Code : cameat (233) } Time Allowed : 3 hours Maximum Marks : 70 INSTRUCTIONS FOR CANDIDATES Candidates must read carefully the following instructions before attempting the Question Paper (i) Write your Name and Registration Number in the space provided for the purpose on the top of this Question Paper and in the Answer Sheet pares ae (i) Please darken the appropriate Circle of Question Paper Series Code on the Answer Sheet. {ii} The Question Paper is divided into two Parts : Par—A and Par—B. Both Parts have multiple-choice questions. All answers are (0 be entered in the Answer Sheet provided with the Question Paper for the Purpose by darkening the correct choice, i... (a) or (bor (c} or (d) with BLUE/ BLACK BALLPOINT PEN only {Against each question in the corresponding Circle. (iv) Part—A consists of 30 questions and all are compulsory. (>) Part—B contains 60 questions, Answer any 40 questions. In case any candidate answers more than the required 40 questions, the first 40 questions attempted will be evaluated. (wi) Each correct answer carries 1 mark, There will be negative marking and ¥ mark will be deducted for each wrong answer. (vi) Simple Calculators and Log Tables may be used (vi) Pages at the end have been provided for Rough Work. Return the Question Paper and Answer Sheet to the Invigilator at the end of the Entrance Examination DO NOT FOLD THE ANSWER SHEET. INSTRUCTIONS FOR MARKING ANSWERS Use only Blue/Black Ballpoint Pen (do not use pencil) to darken the appropriate Circle. Please darken the whole Circle. 3. Darken ONLY ONE.CIRCLE for each question as shown in example below : Wrong Wrong ‘Wrong Wrong Correct ©HOO|GOHOO|FOHOG\OHOS|OHO@ Once marked, no change in the answer is allowed. Please do not make any stray marks on the Answer Sheet. Please do not do any rough work on the Answer Shect. Mark your answer only in the appropriate space against the number corresponding to the question, Ensure that you have darkened the appropriate Circle of Question Paper Serfes Code on the ‘Answer Sheet. 7105-A/108-APART—A Answer all questions ‘Two candles are of the same height. One burns in four hours, while the other burns in five hours, When does one become twice the height of the other? (a) 2h30m (b) 3h ) 3h20m (a) 2hS0m ‘There are 5624 students in JNU, out of which 1679 are Ph.D. students. Ifyou meet any. one student on the campus, the probability of meeting a Ph.D. student will be fa) 206% (b) 25:3% () 299% (a) 307% Ram weighs twice as much as Shyam. Shyam’s weight is 60% of Rohit’s weight. Virat weighs 75% of Ram's weight. Who amongst these men weighs the least? (a) Ram () Shyam {e) Virat (@) Rohit 4. Ina rectangle, if the breadth is halved and the length is doubled, what will be the percent change in area? fa) 0% (0) 5% (10% (a) 15% 105-A 3 [P-T.0.What is the area of the sector shown in the figure below? (The angle is measured in radians.) i fa) 10 & 15 fe} 20 (a) 25 6. While travelling through a solid wooden uniform platform of thickness 10 cm, the velocity of a bullet is reduced from 200 m/s to 100 m/s. The retardation of the bullet will be (a) 15 «10% m/s? (©) 145 m/s? (2) 12 = 104 m/s? (@) 10 * 104 m/s? 7. Two projectiles are projected with the same velocity. If one is projected at an angle of 30° and the other at 60° to the horizon, then the ratio of maximum heights reached by them is fa) 1:3 bh) 2:1 3:2 Ce Who is the English physicist responsible for the ‘Big Bang Theory’? (@) Albert Einstein (0) George Gamow (©) Michael Skube (4) - Roger Penrose ‘The absolute configuration of the two chiral centers in the molecule is (a) 2R and 38 (o) 2R and 38 (9 28 and 3s (a) 28 and 3R 105-A 410. Which of the following are correct for the statement ‘Phenol is more acidic than ethanol."? 1, Resonance would assign acidity 2. sp?-hybridized C atom in benzene 3. Bulkiness of phenyl ring fa) land 2 (b) 1,2 and 3 (J Land3 {d) None of the above 11. Which of the following does not undergo Cannizzaro’s reaction? cHo CHO cHo cHO on a Me “ ®) 1 m fay) (b) (B) « © (a) (D) 12. Complete the following reaction (i cHycoct Mg in CoH. (i alc. KOH (it) heat CH3COCHCOOEt Product (a) CHyC(CH3)(OH)CH,COCH, (b) CH,COCH,COCH, (6) CH,CICgHs(OH)CH,COCH, (a) CH,COCH,COOH 7105-A 5 [P.-T.0.13. von Gierke’s disease, Andersen's disease, McArdle's disease and Pompe’s disease are genetic diseases associated with carbohydrate metabolism and are commonly known as (@) hyperinsulinemia (b) phenylketonuria disease (c) glycogen storage disease (a) gluconeogenesis 14, Which of the following statements about enzymes or their functions is true? (a) Enzymes do not alter the overall change in free energy for a reaction (0) Enzymes are proteins, whose three-dimensional forms are key to their functions (c) Enzymes expedite reactions by lowering activation energy (a) All of the above 15. The function of the E. coli pyruvic acid dehydrogenase complex is to (@) catalyze the oxidation of pyruvic acid to acetyl CoA and Oy (b) catalyze the oxidation of pyruvic acid to acetyl CoA and CO, (6) retard the reduction of pyruvic acid to acetyl CoA and CO, (€) catalyze the reduction of pyruvic acid to acetyl CoA and 0, 16. Photophosphorylation in @ chloroplast is most similar to which one of the following mitochondrial reactions? (a) Oxidative phosphorylation (b) Hydrolysis (c) Oxidative decarboxylation (4) Substrate-level photophosphorylation 17, Production of NADPH in a chloroplast takes place during (a) PEP pathway (b) cyclic photophosphorylation (6) noncyclic photophosphorylation (4) substrate-level photophosphorylation /105-A 618. Transamination is widely known as the transfer of (a) an amino acid to a carboxylic acid plus ammonia production (&) an amino group from an amino acid to a keto acid (c} an amino acid to @ keto acid plus ammonia production (a) an amino group from an amino acid to a carboxylic acid 19. The length of H, if the area of the right-angled triangle below be 400 sq. unit 2x, - (a) 20V5 7 (by 10v8 WS (a) 20 20. Which of the following statements is incorrect? (a) Prokaryotes have single cellular chromosomes (b) Prokaryotes have cell membrane (c]_ Prokaryotes have plasmids (a) Prokaryotic genetic material is not surrounded by membranes 21. Which of the following is not a characteristic of chordate? (a) Flexible internal skeleton or notochord (b) A pharynx with gill slits () A dorsal hollow nerve cord (a) Trochophore larvae with a band of cilia 22, Fats give rise to more energy than simple sugars, because fats have many more (a) carbon atoms (b} hydrogen atoms (6) covalent bonds (4) hydrogen bonds 1105-A 7 {P-T.0.23. Antibodies, that can cross placenta and are involved in allergic reaction, respectively (a) IgG and Iga (b) IgM and IgE (€) IgG and IgE (4) IgD and igM 24. In an atom bomb, the energy is released, because of the chain reaction of (a) neutrons and 97Uy4o, (b) neutrons and %Upa5 (0) neutrons and 9? Uysq (€) neutrons and 9255 25. A simple pendulum is executing simple harmonic motion with time period T. If the length of the pendulum is increased by 21%, then the increase in the time period of the pendulum is te 50% (by 22% (13% fa 10% 26. Who among the following is the author of the book, My Experiments with Truth? (a) Mahatma Gandhi (&) Winston Churchill (o) Michaet Anderson (4) James Mowis 27. If the enthalpy change for a reaction is zero, 4G° is fa) Tas? (e) -ras? (aH? (a) InKeq 1108-A 828. What will be the value of cos@ of the triangle given below? Pp R. 20 em 12em (a) 20/V5a4 o) 12 /V5aF f) 06 (a) 1-667 29. What will be the measure of 2 in the following figure? fa) 58° (b) 122° ()_ 180° (a) 32° 30. Two electric bulbs of 50 W and 100 V are glowing at full power when used in parallel with a battery of EMF 120 V and internal resistance 10 ohm. The maximum number of bulbs that can be connected in the circuit glowing at full power is @ 6 4 2 a) 8 /105-A. 9 [P.7.0.PART—B Answer any forty questions 31. Hospital-acquired infections are termed a: (a) persistent infections (b) wansient infections (e) notifiable infections (a) nosocomial infections 32. Which of the following statements about ‘bilirubin’ is not true? (2) lis converted to biliverdin in liver (0) It is devoid of iron (6) It is a porphyrin pigment (a) Tis derived from heme 33. Cytochrome P-450, the drug-metabolizing family of enzymes, is located in (2) Golgi bodies (©) nuclear compartment (6) rough endoplasmic reticulum {d) smooth endoplasmic reticulum 34, Which of the following statements about ‘ymphatic system’ is true? {a) It is part of the circulatory system (©) The term tymph’ is derived from Latin, meaning ‘water’ {c} Unlike cardiovascular system the lymphatic system is not a closed system (@) All of the above 35. The lampbrush chromosomes’ are observed during (a) mitotic metaphase (®) meiotic prophase (c) endomitosis (4) cytokinesis /105-A, a36. The longest cells in human body are (a) calf muscle cells o) hair follicular cells (c) heart muscle celts (@) nerve cells 37. The length of DNA molecule exceeds the dimensions of the nucleus in eukaryotic cells. How is then DNA accommodated? (a) By decondensation {b) By elimination of repetitive DNA {c]_ By supercoiling in nucleosomes (a) By HAT and HDAC activities 38. Which of the following constitute the part of the male reproductive system? fa) Leydig cells (b) Graafian follicles {ce} Islets of Langerhans (4) Both (a) and (b) 39. A fluid-filled chamber that is located between lens and retina of eyeball is known as (a) alveolar chamber (b) amniotic cavity {c) vitreous humor (@) aqueous humor 40. The ‘tidal volume’ is the lung volume representing the normal volume of air displaced between normal inhalation and exhalation when extra effort is not applied. In a young healthy adult at rest, the tidal volume in liter is about {a} 01 () 05 12 (a) 18 1108-A u [P.7.0.41. ‘The hormone ACG (human chorionic gonadotropin} is (a) an estrogen-derived steroid () produced by corpus luteum (@) produced in posterior pituitary gland (@) produced by placenta of @ pregnant woman 42. The average diameter of a human red blood cell is (a) in the range of 1-2 micron (b) in the range of 3-4 micron (c)_ im the range of 6-8 micron (@) ~ 100 micron 43. Specialized cells that nourish the developing spermatozoa are known as (a) interstitial cells (b) stem cells () germ cells (a) Sertoli cells 44, Which of the following is referred to as the ‘blood bank’ in our body? fa) Liver (6) Bone marrow {) Thymus (a) Spleen 45. Before the use of recombinant insulin, the source of insulin to treat diabetic patients was (a) bovine () chicken () pig. (a) horse /108-A 1246. The preferred agent used for induction of ovulation in the case of polycystic ovary disease is (a) FSH only (0) hCG only (0 FSH + LH (a) LH only 47. Which of the foliowing hormones does not act via extracellular receptors? (@) TRH {b) FSH () ACTH (a) 17B-estradiol 48, Alpha blockers are a class of pharmacological agents that are used in the treatment of (a) anxiety disorder {b) post-traumatic stress disorder {c) hypertension {4} All of the above 49. Ina laboratory specialized on Drosophila, a student crosses different flies to generate mutant fies, In one cross, he gets 25% Mies which have legs where the antennae should be leg-antennae and 75% flies which have vestigial wings. If both variables are independent, what would be the probability of obtaining flies that have both eg-antennae and vestigial wings? (a) 937% fe) 18-75% fe) 37:50% (a 75:25% 50. When cells become cancerous, they undergo (a) epithelial-mesenchyma! transition (ob) mesenchymal-epithclial transition {c) apoptosis (a) necrosis /105-A 13 { P.7.0.51. Mycoplasmas are different from other prokaryotes by the (a) presence of chitin in cell walls (6) presence of murrain in cell walls (©) presence of proteins in cell walls {@) absence of cell wall itself 52. “A newly discovered microscopic structure is hypothesized to be a living organism.” Which ef the following lines of evidence would support the contention that the organism is alive? (a) It contains DNA (b) It is made of a single cell (c) It utilizes energy (4) All of the above 53. A kidney biopsy specimen taken from a patient with acute glomerulonephritis and stained with Nuorescein-conjugated antihuman IgG antibody would probably show (a) no fluorescence (b} uniform fluorescence of the glomerular basement membrane (c] patchy, irreguiar fluorescence of the glomerular basement membrane (a) fluorescent macrophages 54. Ultraviolet radiation causes DNA damage by the formation of (a) cytidine dimer (b) thymidine dimer (c} adenine dimer (@) guanine dimer 105-A 1455. Diploid chromosome number in human is 46. However, if you count chromatids that are visible during mitotic or meiotic cell division, you would be able to count different sets of chromatid numbers depending on the stage and the type of the ceil division in question. Match the table given below showing chromatid numbers on the left and cell division stage on the right : A 46 1. Mitotic metaphase B. 23 2. Aneuploid meiotic telophase i c. 92 3. Meiotic telophase 1 D. 24 4. Meiotic anaphase II A-3, B4, C—1, D-2 A~2, B-4, C—1, D-3 A-1, B—4, C—2, D-3 , B-2, C—3, D4 66. Ramachandran plot illustrates the fact that fa) } ) @ the peptide bond is planer the © and ¥ angles can assume only a single value in a protein the © and ¥ angles can assume approximately three different values the @ and ¥ angles can assume any value in a peptide 87. _ If the rate of addition of a species increases with respect to individual loss of the same species within the populatiofi, then the population has (@) {b) C) @) 7108-A. decline in growth zero population growth exponential growth None of the above 15 [PT.0.59. 60, 61. ‘The correct order of basicity of the compounds BOEod a 6 © (0) @) >) >B)> A) fe) (C) > (D) > (A) > B) © M>O>Aa>eB @ ©>@)>B> A ‘The basic order in aqueous solutions Mew Mey MES NH HW N—Me Me~ uO Me~ ry) ® © is @ <)> (C) (b) (C) > (A) > B) () (By > (A) > (C) @ A> B>~ Which of the following statements is not true about cytochrome P-450 enzymes? (a) They contain heme and magnesium (&) They belong to @ general class of enzymes called monooxygenases (@) There are over 30 different cytochrome P-450 enzymes (a) Variation in cytochrome P-450 enzyme profile between individuals can explain individual variation in drug susceptibility Which of the following is one of the rules in Lipinski’s rule of five? (a) A molecular weight equal to 500 (b) No more than § hydrogen bond acceptor groups (c)_ No more than 10 hydrogen bond donor groups (4) A calculated tog P vaiue less than +5 /105-A 1662. Which of the following reactions is not a phase-I metabolic transformation? (@) Reduction of ketones () Conjugation to alcohols (c) Oxidation of alkyl groups (@) Ester hydrolysis 63. Alkenes and aromatic groups can be metabolized to diols by the enzyme (a) cytochrome P-450 (b) epoxide hydrolase (c) Both of the above (@) Neither of the above 64. Which of the following terms is used to describe a drug that binds to a receptor, fails to activate it and leads to a drop in inherent biological activity? (a) Agonist (b) Antagonist (c) Partial agonist (a) Inverse agonist 65. Activation of gene in the euchromatic region requires fa) histone deacetylation (0) histone methylation (c) histone hyperacetylation (a) histone phosphorylation 66. ‘The enzyme that induces double-strand breaks in DNA and rejoins them is called (a) restriction endonuclease (o) DNA gyrase ()_ DNA ligase (d) DNA polymerase 1108-A 17 [P.T.0.67. Which of the following enzymes is required for the conversion of glucose-6-phosphate to 6-phosphogluconolactone? (a) Transaldolase () Glucose-6-phosphate pentolase (c)_ Glucose-6-phosphate dehydrogenase (4) 6-phosphogluconate dehydrogenase 68. _Hyperphosphorylation of the tau protein is a hallmark of (a) Alzheimer's disease (©) Parkinson’s disease (c) multiple sclerosis (@) cerebral malaria 69. The effect of a reversible competitive inhibitor can be overcome by (a) increasing the product formation {b) increasing the substrate concentration te {d) None of the above \creasing the temperature 70. Which of the following is true for steroid hormones? (@)_ They have only cell-surface receptor (0) They are lipophilic (¢) They are produced by adrenal cortex (a) They are produced by adrenal medulla 71. Microbial resistance to drugs is acquired through a) conjugation (b) transformation (c) transduction (d) All of the above 1105-A 1872. Which of the following will not cause triploidy? (a) Fusion of an egg and polar body with subsequent fertilization by sperm cells (b) Meiotic failure, producing diploid sperm or egg (@)Dispermy (@) Mitotic failure in the early embryo 73. Which of the following statements is incorrect for GPI anchor? (a) Itattaches proteins to the cytosolic face of the plasma membrane (b) it can be cleaved to release proteins (©) It contains phosphoethanolamine (@) It contains sugar and lipid components 74. In E, coli, the tp operon is transcribed from one promoter yielding a long continuous trp mRNA. However, the end products are five different proteins. This is possible due to (a) translation of a long polypeptide followed by proteolytic cleavage to give five proteins (b) translation initiated at five different start sites (c)_ long mRNA first processed into five smaller mRNAs followed by its translation (4) None of the above 78. A polypeptide contains six glutamine, five aspartic acid, five arginine, two glutamic acid, three histidine and two lysine residues. The overall charge would be (a) five {b] two (+) {c]_ three (+) (a) four 76. Collagen is the most abundant protein of vertebrates comprising 30% of their protein mass. It is an extracellular protein that is organized into insoluble fibers with great tensile strength that arises due to its (a) triple helical structure (0) double helical structure {c) periodic helical and beta sheet structure (a) periodic helical, beta sheet and random coil structure 7105-A 19 [P.T.0.77. Double fertilization was first discovered in (@)_ mango and pear () papaya and wheat (c) Lilium and Fritillaria (@) Brassica and Iberis 78. The function of lymphatic system is to (a) circulate body fluids during active exercise (b) transport waste product from tissue to the lungs {c) act as a conduit for lymphocyte migration (a) act as a barrier to pathogens 79. Lysozyme is present in (a) sweat (b) cerebrospinal fluid (CSF) (urine (2) saliva 80. What is red shift? (a) Shifting of absorption towards the blue end of the spectrum (b) Shifting of absorption to higher energy {e) Shifting of absorption to lower energy (a) Shifting of absorption towards shorter wavelength 81. Specialized protein complex that creates an aqueous pore between the cytoplasms of two adjacent cells is called (a) gap junction (b) tight junction (c] transmembrane receptor (@) ion channel 1105-A 2082. In ion-exchange chromatography, proteins are separated on the basis of (a) size (&) net charge (@) shape (d) size and net charge 83. Which of the following is a serine protease? (a) Chymotrypsin (ob) Trypsin (c) Blastase (@) All of the above 84, Which of the following statements is true of Na+/K+-adenosine triphosphatases? la] They use the free energy from the hydrolysis of ATP to transport K+ out the cell and Nat into the cell (b) They are tetramers consisting of four equally sized polypeptide chains (c) They indirectly control the volume of the cell (a) Their actions maintain a membrane potential with a value often of approximately ~ 60 mY, the interior of the cell being positive with respect to the exterior 85. Which of the following does not possess membrane-bound organelle? (a) Plasmodium (b) Streptococcus {c) Saccharomyces (@) Chlamydomonas 86. _Isozymes or isoenzymes are those enzymes which (2) have same structural forms (vo) have different structural forms but identical catalytic properties (c) catalyze oxidation reactions {@)_ None of the above 1105-A 21 [P.7.0.87. Which of the following drugs) can prevent a viral nucleic acid from being replicated? (a) Azidothymidine (b) Acyclovir (c) Amantadine (a) Both (a) and (b) 88. Which of the following cellular organelles is involved in the initiation of the intrinsic pathway of apoptosis? fa) Nucleus {b) Mitochondrion () Endoplasmic reticulum (a) Lysosome 89. The length of DNA associated with protein is determined using the technique of (0) DNA fingerprinting {c)_ DNA printing (a) DNA footprinting 90. A scientist has purified mRNA for a gene which she/he wants to clone into a bacterial vector. What must be done as a first step in this process? (a) RT-PCR using appropriate primers () PCR using appropriate primers (c) Sequence the mRNA {a} All of the above tee 1105-A 22SPACE FOR ROUGH WORK PTO. /105-A 23 :SPACE FOR ROUGH WORK aoa 7 E15—7503