I.

LATAR BELAKANG

Coronary artery disease (CAD) is the single most frequent cause of death. Over
seven million people every year die from CAD, accounting for 12.8% of all
deaths. When there is an occlusion of a coronary artery, ST elevation is shown on
ECG which is a manifestation of the pathophysiological changes and is also
known as ST-elevation Myocardial Infarction (STEMI). The diagnostic tool for
STEMI is the electrocardiogram (EKG) and should be done immediately on
admission.
EPIDEMIOLOGY OF CAD IN INDO. The mortality of STEMI is influenced by
many factors, among them age, time delay to treatment, mode of treatment,
history of prior myocardial infarction, diabetes mellitus, renal failure, number of
diseased coronary arteries, ejection fraction and treatment.
Thrombus causes closure of vessels in acute myocardial infarction and
compromises flow in unstable angina. Successfull epicardial vessel thrombolysis
is necessary for better prognosis, but the outcome correlates with the micro
vascular flow. ST segment on EKG is a better indicator of prognosis.
One of the well known and effective treatments apart from percutaneous
interventions for STEMI is thrombolysis. The aim of thrombolysis in STEMI is
early and complete referfusion.
Acute myocardial infarction are life-threatening conditions that, without
immediate treatment, may lead to serious complication including death. These
conditions may result when an acute thromboembolism decreases blood flow and
oxygen delivery to organs. Administering thrombolytics can reverse underlying
blockage limiting tissue damage and enhance patient outcomes. While the
standard of care treatment for STEMI remains percutaneous coronoary
intervention (PCI), thrombolytic therapy is considered an alternative for patients
unable to undergo PCI due to patient variable or lack of availability. Alteplase and
tenecteplase have evidence advocating use within 6 hours of symptom onset,
while streptokinase and reteplase may be considered within 12 hours of symptom
onset.
II. RUMUSAN MASALAH
Bagaimana pengaruh pemberian terapi trombolitik pada pasien STEMI terhadap
perubahan EKG?
III. TUJUAN PENELITIAN
1. Tujuan umum: Untuk menilai pengaruh pemberian terapi trombolitik pada
pasien STEMI terhadap EKG di RS PKU Muhammadiyah Gamping.
2. Tujuan khusus
IV. MANFAAT PENELITIAN
V. KEASLIAN PENELIATAN
1. Saleem & Khan (2015) PubMed, Post thrombolytic resolution of ST
elevation in STEMI patients. Penelitian ini menggunakan metode cohort pada
83 peserta.
2. Nascimento & de Sousa (2014) PubMed, Risks and Benefits of
Thrombolytic, Antiplatelet, and Anticoagnulant therapies for ST Segment
Elevation Myocardial Infarction: Systematic Review.