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ABSTRACT:
The goal of our research is to study the human heart structure, functions and its cardiac
cycle. It’s also discussed the relationship of the study of heart to physics. This study is
made to confirm the presence, extent and contributors of total heart volume and pressure
variation during the cardiac cycle in atria and ventricle. But then its major purpose is to
about total heart volume and pressure variation during the cardiac cycle and the
respective contributors to this variation. This will allow the opportunity to explore total
heart volume variation and pressure from a structural (planimetry) and functional (flow)
perspective.
KEYWORDS:
Cardiac cycle, volume, pressure, atria, ventricle
INTRODUCTION:
The heart is one of the most important organs in the entire human body and has a cone
shaped, muscular and powerful organ and is about the size of a fist and has a mass of
between 250 and 350 grams. It is located slightly left of middle in the chest between two
lungs, anterior to the vertebral column and posterior to the sternum. It is really nothing
more than a pump, composed of muscle which pumps blood throughout the body,
beating approximately 72 times per minute of our lives. On average each day human
heart beats about 100,000 times and pumps around 7,571 liters of blood. The heart
pumps the blood, which carries all the vital materials which help our bodies function and
removes the waste products that we do not need. For example, the brain requires oxygen
and glucose, which, if not received continuously, will cause it to loose consciousness.
Muscles need oxygen, glucose and amino acids, as well as the proper ratio of sodium,
calcium and potassium salts in order to contract normally. The glands need sufficient
supplies of raw materials from which to manufacture the specific secretions. If the heart
ever ceases to pump blood the body begins to shut down and after a very short period of
EXPLANATION:
Heart is enclosed in a double-walled sac called the pericardium. The superficial part of
this sac is called the fibrous pericardium. This sac protects the heart,and prevents
overfilling of the heart with blood. The outer wall of the human heart is composed of
three layers. The outer layer is called the epicardium, or visceral pericardium since it is
also the inner wall of the pericardium. The middle layer is called the myocardium and is
composed of muscle which contracts. The inner layer is called the endocardium and is in
contact with the blood that the heart pumps. Also, it merges with the inner lining
The human heart is composed of four chambers, each separated from the others. The left
side of the heart has two connected chambers, the left atrium and the left ventricle the
right side of the heart also has two connected chambers, the right atrium and the right
ventricle. These two sides, or pumps, of the heart are not directly connected with one
another. Oxygenated blood from the lungs travels through larger vessels called the
pulmonary veins and enters the left side of the heart, emptying directly into the left
atrium, the pulmonary veins are unusual in that they carry oxygenated blood; other veins,
because they carry blood back to the heart form the body tissue, carry deoxygenated
blood. From the left atrium, Blood through a one way value, called the left
atrioventricular valve that is also known as bicuspid valve, into the left ventricle. Most of
this flow roughly 70 percent occurs while the heart is relaxed. The atrium then contracts,
filling the remaining 30 percent of the ventricle with its blood. After a slight delay, the
ventricle contracts. The contraction forces the blood to exit into an opening that leads to
the largest artery in the body the aorta. The atrioventricular value closes and prevents the
backflow of blood into the atrium. The aorta is closed off from the left ventricle by a one
way value, the aortic semi lunar value. It is oriented to permit the flow of the blood out
of the ventricle, but it snaps shut in response to backflow. Many arteries branch from the
aorta, carrying oxygen rich blood to all parts of the body. The pathway of blood vessels
to the body regions and organs other than the lungs is called the systemic circulation. The
systemic circulation brings blood to the neck and head and to organs in the rest of the
body. The systemic circulation gives up oxygen to the body tissues and receives carbon
dioxide. The blood that flows into the arterial system eventually returns to the heart after
flowing through the capillaries. As it returns, blood passes through a series of veins,
eventually entering the right side of the heart. Two large veins collect blood form the
systemic circulation. The superior vena cava drains the upper body, and the inferior vena
cava drains the lower body. These veins dump deoxygenated blood into the right atrium.
Blood passes from the right atrium into the right ventricle through a one way valve, the
right atrioventricular valve that is also known as tricuspid value. Blood passes out of the
contracting right ventricle through a second valve, the pulmonary semi lunar value, into a
single pulmonary artery, sometimes called the pulmonary trunk, which subsequently
branches into arteries that carry deoxygenated blood to the lungs, replenished with
The pumping of the heart is a repeated cardiac cycle of relaxation and contraction of the
atria and ventricles. Cardiac cycle is the term referring to all or any of the events related
to the flow or blood pressure that occurs from the beginning of one heartbeat to the
beginning of the next. The frequency of the cardiac cycle is the heart rate. Each beat of
the heart involves five major stages: The first, "late diastole", is when the semilunar
valves close, the atrioventricular (AV) valves open, and the whole heart is relaxed. The
second, "atrial systole", is when the atrium contracts, the AV valves open, and blood
flows from atrium to the ventricle. The third, "isovolumic ventricular contraction", is
when the ventricles begin to contract, the AV and semilunar valves close, and there is no
change in volume. The fourth, "ventricular ejection", is when the ventricles are empty
and contracting, and the semilunar valves are open. During the fifth stage, "Isovolumic
ventricular relaxation", pressure decreases, no blood enters the ventricles, the ventricles
stop contracting and begin to relax, and the semilunar valves close due to the pressure of
blood in the aorta. Throughout the cardiac cycle, blood pressure increases and decreases.
The cardiac cycle is coordinated by a series of electrical impulses that are produced by
specialized heart cells found within the sino-atrial node and the atrioventricular node.
The cardiac muscle is composed of myocytes which initiate their own contraction
without help of external nerves (with the exception of modifying the heart rate due to
metabolic demand). Under normal circumstances, each cycle takes approximately one
second.
The cardiac cycle diagram shown to the right depicts changes in aortic pressure (AP), left
ventricular pressure (LVP), left atrial pressure (LAP), left ventricular volume (LV Vol),
and heart sounds during a single cycle of cardiac contraction and relaxation. These
inserting a pressure
from a peripheral
ventricular pressure is
obtained by placing a
measuring changes in
intraventricular pressure as the heart beats. Left atrial pressure is not usually measured
A single cycle of cardiac activity can be divided into two basic stages. The first stage
is diastole, which represents ventricular filling and a brief period just prior to filling at
which time the ventricles are relaxing. The second stage issystole, which represents the
phases. The first phase begins with the P wave of the electrocardiogram, which
represents atrial depolarization. The last phase of the cardiac cycle ends with the
appearance of the next P wave. In order to understand the events of the cardiac cycle,
The entire cardiac cycle diagram, which contains information on aortic, left ventricular
and left atrial pressures, along with ventricular volume, heart sounds and the
• This is the first phase of the cardiac cycle because it is initiated by the p
the atrial musculature. As the atria contract, the pressure within the atrial
chambers increases, which forces more blood flow across the open
ventricles. Blood does not flow back into the vena cava because of inertial
effects of the venous return and because the wave of contraction through the
that can be noted as the "a-wave" of the left atrial pressure (LAP). Just
into the left atrium, then into the left ventricle through the open mitral valve.
At high heart rates, however, the atrial contraction may account for up to
causing a pressure gradient reversal across the AV valves. This causes the
about 120 ml, represents the ventricular preload and is associated with end-
diastolic pressures of 8-12 mmHg and 3-6 mmHg in the left and right
ventricles, respectively.
sound, S4). This sound is caused by vibration of the ventricular wall during
older individuals.
• This phase of the cardiac cycle begins with the appearance of the QRS
muscles with their attached chordae tendineae that prevent the AV valve
leaflets from bulging back into the atria and becoming incompetent (i.e.,
“leaky”). Closure of the AV valves results in the first heart sound (S1). This
sound is normally split (~0.04 sec) because mitral valve closure precedes
tricuspid closure.
• During the time period between the closure of the AV valves and the
opening of the aortic and pulmonic valves, ventricular pressure rises rapidly
volume does not change because all valves are closed during this phase.
governingexcitation-contraction coupling.
• The "c-wave" noted in the LAP may be due to bulging of mitral valve
leaflets back into left atrium. Just after the peak of the c wave is the x'-
descent.
RESULT:
This section was about to discuss the most important and reliable member of cardiac
cycle. It has been shown experimently that the right depicts changes in aortic pressure
(AP), left ventricular pressure (LVP), left atrial pressure (LAP), left ventricular volume
(LV Vol), and heart sounds during a single cycle of cardiac contraction and relaxation.
REFERENCE:
2. Guyton, A.C. & Hall, J.E. (2006) Textbook of Medical Physiology (11th
6. Plethysmograph
7. The Heart