TABLE OF CONTENTS

TheJOURNAL
of PEDIATRICS
November 2017 Volume 190 Copyright 2017 by Elsevier Inc.

The Editors Perspectives

This Month in The Journal of Pediatrics ................................................................................................................. 1

Notes from the Association of Medical School Pediatric Department Chairs, Inc.
Work Equity and Investment-based Pediatric Departmental Reorganization
ScottA.Rivkees, MD ......................................................................................................................................................... 6

Editorials
Threading the Needle for the Tiniest Babies
BreeAndrews, MD, MPH, and LainieFriedmanRoss, MD, PhD . ............................................................................................ 8

Newborn Screening for Spinal Muscular Atrophy and Lysosomal Storage Disorders Takes Advantage
of Novel Therapies
HansC.Andersson, MD .................................................................................................................................................... 9

Searching for the Best Oral Treatment for Hypoglycemic Newborns

PaulJ.Rozance, MD, ShashaBai, PhD, and JeffR.Kaiser, MD, MA .......................................................................................... 10

The Unintended Consequences of Marijuana Legalization

GeorgeSamWang, MD, KennonHeard, MD, PhD, and GenieRoosevelt, MD, MPH .................................................................. 12

Medical Progress
Subclinical Atherosclerosis in Youth: Relation to Obesity, Insulin Resistance, and Polycystic
Ovary Syndrome
BrendaMendizbal, MD, MS, and ElaineM.Urbina, MD, MS . ............................................................................................... 14

Everolimus for the Treatment of Tuberous Sclerosis ComplexRelated Cardiac Rhabdomyomas in

Pediatric Patients e
NagibDahdah, MD ........................................................................................................................................................... 21

e contains additional content that can be found at www.jpeds.com

The Journal of Pediatrics (ISSN 0022-3476) is published monthly by Elsevier Inc., 230 Park Avenue, Suite 800, New York, NY 10169-0901, USA. Periodicals
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Can We Understand the Pathobiology of Bronchopulmonary Dysplasia?

CristinaM.Alvira, MD, and RoryE.Morty, PhD . ................................................................................................................. 27

Original Articles
The Relationship between Coronary Artery Disease Risk Factors and Carotid Intima-Media
Thickness in Children
DanWhite, BS, RebeccaPlace, MS, TimothyMichael, PhD, EricHoffman, PhD, PaulM.Gordon, PhD, and PaulVisich, PhD ......... 38

The Use of Echocardiography for Pediatric Patients Presenting with Syncope

JonathanH.Pelletier, MD, SarahBlanchard, MD, ReidC.Chamberlain, MD, ChristophP.Hornik, MD, MPH,
MichaelJ.Campbell, MD, and KevinD.Hill, MD, MS . .......................................................................................................... 43

50 Years Ago in The Journal of Pediatrics Diagnosis of Cerebrospinal Fluid Rhinorrhea: Lack of
Specificity of the Glucose Oxidase Test Tape
SusyJeng, MD . ............................................................................................................................................................ 48

Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury
and Major Cardiovascular Events e
JesseA.Davidson, MD, MPH, TracyT.Urban, BS, ChristineBaird, BS, SuhongTong, MS, AlanWoodruff, MD, MarkTwite, MD,
JamesJaggers, MD, EricA.F.Simes, MB, BS, DCH, MD, and PaulWischmeyer, MD ................................................................. 49

Body Composition in Children with Chronic Illness: Accuracy of Bedside Assessment Techniques
EnidE.Martinez, MD, CraigD.Smallwood, RRT, NicolleL.Quinn, RD, LDN, KatelynAriagno, RD, LoriJ.Bechard, PhD, RD,
Christopher P.Duggan, MD, MPH, and NileshM.Mehta, MD ................................................................................................ 56

The Use of Different International References to Assess Child Anthropometric Status in a

Malaysian Population e
UttaraPartap, MPhil, ElizabethH.Young, PhD, PascaleAllotey, PhD, ManjinderS.Sandhu, PhD, and
DanielD.Reidpath, PhD .................................................................................................................................................... 63

Assessing Childrens Report of Stool Consistency: Agreement Between the Pediatric Rome III
Questionnaire and the Bristol Stool Scale
ManaH.Vriesman, MD, CarlosA.Velasco-Benitez, MD, CarmenR.Ramirez, MD, MarcA.Benninga, MD, PhD,
CarloDi Lorenzo, MD, and MiguelSaps, MD ....................................................................................................................... 69

Physical Therapy for Fecal Incontinence in Children with Pelvic Floor Dyssynergia
SwathiMuddasani, MBBS, AmandaMoe, PT, DPT, CaitlinSemmelrock, PT, DPT, CaroylLuanGilbert, PNP,
ValentineEnemuo, MD, EricHowardChiou, MD, and BrunoPedroChumpitazi, MD, MPH . ..................................................... 74

50 Years Ago in The Journal of Pediatrics Prenatal Treatment of Cretinism: Preliminary Studies
of Its Value in Postnatal Development
Raye-AnndeRegnier, MD .............................................................................................................................................. 78

The Effect of Level of Care on Gastroschisis Outcomes e

JordanC.Apfeld, MD, ZacharyJ.Kastenberg, MD, KarlG.Sylvester, MD, and HenryC.Lee, MD ................................................ 79

Pancreatic Enzyme Replacement Therapy in Children with Severe Acute Malnutrition: A Randomized
Controlled Trial e
RosalieH.Bartels, MD, ClineBourdon, MSc, IsabelPotani, MSc, BrianMhango, MSc, DeborahA.van den Brink, BSc,
JohnS.Mponda, MSc, AnnekeC.Muller Kobold, PhD, RobertH.Bandsma, MD, PhD, MichaelBoele van Hensbroek, MD, PhD,
and WiegerP.Voskuijl, MD, PhD ........................................................................................................................................ 85

Time Trends in Food Allergy Diagnoses, Epinephrine Orders, and Epinephrine Administrations in
New York City Schools
ElizabethFeuille, MD, CherylLawrence, MD, CarolineVolel, MD, MPH, ScottH.Sicherer, MD, and JulieWang, MD . .................. 93

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Genome-Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in

Hispanic Boys e
JuliaWattacheril, MD, MPH, JoelE.Lavine, MD, PhD, NagaP.Chalasani, MD, XiuqingGuo, PhD, SoonilKwon, PhD,
JeffreySchwimmer, MD, JeanP.Molleston, MD, RohitLoomba, MD, ElizabethM.Brunt, MD, Yii-DerIdaChen, PhD,
MarkO.Goodarzi, MD, PhD, KentD.Taylor, PhD, KatherineP.Yates, ScM, JamesTonascia, PhD, and JeromeI.Rotter, PhD .......... 100

50 Years Ago in The Journal of Pediatrics Cholestyramine Therapy in Patients with a Paucity of
Intrahepatic Bile Ducts
KaitlinGiblerWhaley, MD ............................................................................................................................................ 107

Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very
Low Birth Weight Infants e
RaviM.Patel, MD, MSc, KaneciaZimmerman, MD, MPH, DavidP.Carlton, MD, ReeseClark, MD, DanielK.Benjamin, PhD, and
P.BrianSmith, MD, MHS, MPH ......................................................................................................................................... 108

Early Mortality and Morbidity in Infants with Birth Weight of 500Grams or Less in Japan e
HirosukeInoue, MD, PhD, MasayukiOchiai, MD, PhD, KazuakiYasuoka, MD, KoichiTanaka, MD, HiroakiKurata, MD,
JunkoFujiyoshi, MD, YukiMatsushita, MD, PhD, ShutaroSuga, MD, KazuakiNonaka, DDS, PhD, TomoakiTaguchi, MD, PhD,
KiyokoKato, MD, PhD, and ShouichiOhga, MD, PhD, on behalf of theNeonatal Research Network of Japan (NRNJ) .................... 112

Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding

of Life Support e
JenniferJames, MD, DavidMunson, MD, SaraB.DeMauro, MD, MSCE, JohnC.Langer, MS, AprilR.Dworetz, MD,
GirijaNatarajan, MD, MargaritaBidegain, MD, ChristineA.Fortney, PhD, RN, RuthSeabrook, MD, BettyR.Vohr, MD,
JonE.Tyson, MD, MPH, EdwardF.Bell, MD, BrendaB.Poindexter, MD, MS, SeethaShankaran, MD, RosemaryD.Higgins, MD,
AbhikDas, PhD, BarbaraJ.Stoll, MD, and HareshKirpalani, MB, MSc, on behalf of theEunice Kennedy Shriver National Institute
of Child Health and Human Development Neonatal Research Network .................................................................................... 118

Presymptomatic Diagnosis of Spinal Muscular Atrophy Through Newborn Screening e

Yin-HsiuChien, MD, PhD, Shu-ChuanChiang, MS, Wen-ChinWeng, MD, PhD, Ni-ChungLee, MD, PhD, Ching-JieLin, MS,
Wu-ShiunHsieh, MD, Wang-TsoLee, MD, PhD, Yuh-JyhJong, MD, PhD, Tsang-MingKo, MD, and
Wuh-LiangHwu, MD, PhD ................................................................................................................................................ 124

Newborn Screening for Lysosomal Storage Disorders in Illinois: The Initial 15-Month Experience
BarbaraK.Burton, MD, JoelCharrow, MD, GeorgeE.Hoganson, MD, DarrellWaggoner, MD, BradTinkle, MD,
StephenR.Braddock, MD, MichaelSchneider, MD, PhD, DorothyK.Grange, MD, ClaudiaNash, MS, HeatherShryock,
RebeccaBarnett, BA, RongShao, PhD, KhajaBasheeruddin, PhD, and GeorgeDizikes, PhD . ...................................................... 130

What Happens to Blood Glucose Concentrations After Oral Treatment for Neonatal Hypoglycemia?
DeborahL.Harris, PhD, GregD.Gamble, MSc, PhilipJ.Weston, MBChB, and JaneE.Harding, DPhil . ....................................... 136

Unintentional Cannabis Ingestion in Children: A Systematic Review

JohnR.Richards, MD, NishelleE.Smith, MS, and AimeeK.Moulin, MD . ............................................................................... 142

Trial of Music, Sucrose, and Combination Therapy for Pain Relief during Heel Prick
Procedures in Neonates e
SwapnilR.Shah, FRACP, ShahajahanKadage, MBBS, and JohnSinn, FRACP . .......................................................................... 153

Bilirubin Uridine Diphosphate-glucuronosyltransferase Polymorphism as a Risk Factor for

Prolonged Hyperbilirubinemia in Japanese Preterm Infants e
TakahideYanagi, MD, SayuriNakahara, MD, and YoshihiroMaruo, MD, PhD ......................................................................... 159

Shifting Risks and Conflicting OutcomesECMO for Neonates with Congenital Diaphragmatic
Hernia in the Modern Era e
JosephW.Turek, MD, PhD, JosephR.Nellis, MBA, BrentonG.Sherwood, BS, MeeraKotagal, MD, MPH, FACS,
AndrewL.Mesher, MD, RaviR.Thiagarajan, MBBS, MPH, SonaliS.Patel, MD, PhD, JeffreyR.Avansino, MD, FACS,
PeterT.Rycus, MPH, D.MichaelMcMullan, MD, FACS, and ThomasV.Brogan, MD ................................................................ 163

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Effects of Intrapartum Antibiotic Prophylaxis on Neonatal Acquisition of Group B Streptococci e

MeiwaToyofuku, MD, MiyukiMorozumi, PhD, MarikoHida, MD, PhD, YoshitakeSatoh, MD, PhD, HiroshiSakata, MD, PhD,
HiroyukiShiro, MD, PhD, KimikoUbukata, PhD, MitsuruMurata, MD, PhD, and SatoshiIwata, MD, PhD ................................. 169

Influence of Socioeconomic Context on the Rehospitalization Rates of Infants Born Preterm e

OliviaLaugier, MD, PatriciaGarcia, MD, MohamedBouckine, MD, PhD, AlexandreDaguzan, PhD, SophieTardieu, MD, PhD,
RolandSambuc, MD, PhD, and FaridBoubred, MD, PhD ....................................................................................................... 174

Increased DNA Methylation of ABCB1, CYP2D6, and OPRM1 Genes in Newborn Infants of
Methadone-Maintained Opioid-Dependent Mothers e
PoppyMcLaughlin, PhD, HelenMactier, MBChB, MD, FRCPCH, CherylGillis, MBChB, TamasHickish, MA, MD, FRCP,
AntonParker, BSc, Wei-JunLiang, PhD, and M.DavidOsselton, PhD, FRCS . ........................................................................... 180

Risk of Mortality into Adulthood According to Gestational Age at Birth e

RavishaSrinivasjois, FRACP, WendyNembhard, PhD, KingsleyWong, MSc, JennyBourke, PhD, GavinPereira, PhD, and
HelenLeonard, MPH . ....................................................................................................................................................... 185

Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study e
AnnikaKlopp, MD, LorenaVehling, MSc, AllanB.Becker, MD, PadmajaSubbarao, MD, PiushkumarJ.Mandhane, MD,
StuartE.Turvey, MBBS, DPhil, DianaL.Lefebvre, PhD, MalcolmR.Sears, MD, the CHILD Study Investigators
MeghanB.Azad, PhD . ...................................................................................................................................................... 192

The Child Opportunity Index and Disparities in Pediatric Asthma Hospitalizations Across One Ohio
Metropolitan Area, 2011-2013 e
AndrewF.Beck, MD, MPH, BinHuang, PhD, KathrynWheeler, NikkiR.Lawson, BS, RobertS.Kahn, MD, MPH, and
CarleyL.Riley, MD, MPP, MHS .......................................................................................................................................... 200

Lidocaine Gel for Urethral Catheterization in Children: A Meta-Analysis e

MichaelE.Chua, MD, DPBU, PaulNimrodB.Firaza, MD, JessicaM.Ming, MD, JanMichaelA.Silangcruz, MD,
LuisH.Braga, MD, PhD, and ArmandoJ.Lorenzo, MD, MSc, FRCSC, FAAP, FACS ................................................................... 207

Recognition of Infantile Spasms Is Often Delayed: The ASSIST Study e

ShaunA.Hussain, MD, MS, JohnsonLay, BS, EmilyCheng, BS, JuliusWeng, BS, RamanSankar, MD, PhD, and
ChristineB.Baca, MD, MSHS . ........................................................................................................................................... 215

Comparison of Noninvasive High-Intensity Focused Ultrasound with Radiofrequency Ablation of

Osteoid Osteoma e
KarunV.Sharma, MD, PhD, PavelS.Yarmolenko, PhD, HaydarCelik, PhD, AvinashEranki, MS, AriPartanen, PhD,
AnilawanSmitthimedhin, MD, AerangKim, MD, PhD, MatthewOetgen, MD, DomicianoSantos, MD, JanishPatel, MD, and
PeterKim, MD, PhD . ........................................................................................................................................................ 222

Effect of Antiandrogen, Aromatase Inhibitor, and Gonadotropin-releasing Hormone Analog on Adult

Height in Familial Male Precocious Puberty
EllenWerberLeschek, MD, ArmandoC.Flor, MD, JoyC.Bryant, RN, JanetV.Jones, RN, KevinM.Barnes, PhD, and
GordonB.Cutler Jr, MD .................................................................................................................................................... 229

Case Not Closed: Prescription Errors 12 Years after Computerized Physician Order Entry
Implementation e
GiliKadmon, MD, MichalPinchover, BSc(Pharm), AvichaiWeissbach, MD, ShirleyKogan Hazan, RN, and
ElhananNahum, MD ........................................................................................................................................................ 236

Language Growth in English Monolingual and Spanish-English Bilingual Children from 2.5 to
5 Years e
ErikaHoff, PhD, and KrystalM.Ribot, PhD ......................................................................................................................... 241

Evaluation of Dorsal Midline Discolorations with Physical Examination and Ultrasound

LiatBen-Sira, MD, PeninaPonger, MD, and ShlomiConstantini, MD, MSc .............................................................................. 246

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Timing and Chronicity of Maternal Depression Symptoms and Childrens Verbal Abilities
MarilynN.Ahun, BA, Marie-ClaudeGeoffroy, PhD, CatherineM.Herba, PhD, MaraBrendgen, PhD, JeanR.Sguin, PhD,
Anne-LaureSutter-Dallay, MD, MichelBoivin, PhD, RichardE.Tremblay, PhD, and SylvanaM.Ct, PhD .................................. 251

Clinical and Laboratory Observations

Shivering in Febrile Children: Frequency and Usefulness in Predicting Serious Bacterial Infections
A Prospective Case-Control Study e
YairErell, MD, IlanYoungster, MD, IbrahimAbu-Kishk, MD, and EranKozer, MD . ................................................................. 258

Clinical Detection of Hemodynamically Significant Isolated Secundum Atrial Septal Defect e

RobertL.Geggel, MD ........................................................................................................................................................ 261

Patterns of Emergency Department Care for Newly Diagnosed Immune Thrombocytopenia in

United States Childrens Hospitals
LaQuitaJones, DO, TerahKoch, MPH, JosephStanek, MS, and SarahH.OBrien, MD, MSc ....................................................... 265

Delayed Presentation and Prolonged Survival of a Child with Surfactant Protein B Deficiency e
JuanA.Lpez-Andreu, PhD, AntonioD.Hidalgo-Santos, MD, MiguelA.Fuentes-Castell, MD, NuriaMancheo-Franch, MD,
JuanA.Cern-Prez, MD, MariaJ.Esteban-Rics, MD, LaiaPedrola-Vidal, PhD, and LawrenceM.Nogee, MD . ........................... 268

Pediatric Orthopedic Hoverboard Injuries: A Prospectively Enrolled Cohort

AndrewD.Sobel, MD, DanielB.Reid, MD, MPH, TravisD.Blood, MD, AlanH.Daniels, MD, and AristidesI.Cruz Jr, MD . .......... 271

Prenatal Risk Factors for PHACE Syndrome: A Study Using the PHACE Syndrome International
Clinical Registry and Genetic Repository
JoyWan, MD, JackSteiner, BS, EulaliaBaselga, MD, FrancineBlei, MD, MariaCordisco, MD, MariaC.Garzon, MD,
DeborahS.Goddard, MD, AnitaHaggstrom, MD, AlfonsKrol, MD, IlonaJ.Frieden, MD, DeniseMetry, MD,
KimberlyD.Morel, MD, JudithM.A.Verhagen, MD, OrliWargon, MD, BethA.Drolet, MD, and DawnH.Siegel, MD . ................. 275

Rediscovering the Physical Exam

Striatal Toe Sign: False-Positive Extensor Plantar Response in Dystonia
DebabrataGhosh, MD ....................................................................................................................................................... 280

Artistic Clues to Psychogenic Tremor Using Pen and Paper

LaurenJames, MD, and DebabrataGhosh, MD ..................................................................................................................... 281

Pseudoparalysis of Parrot: A Diagnostic Aid in Congenital Syphilis

AnnelyseArajoPereira, MD, SandraMrciaCastro, MD, RaniellyRibeiroVenturini, MD, FernandaOliveiraCsar, MD,
PatriciaMarquesFortes, MS, and PauloSucasasCosta, PhD ................................................................................................... 282

Beyond Folliculitis: Recognizing Herpes Gladiatorum in Adolescent Athletes

ElizabethY.Wei, MD, and DanielT.Coghlin, MD . ............................................................................................................... 283

Insights and Images

Bowel Dilation Diagnosed Prenatally e
TaiebChouikh, MD, NicolasMottet, MD, MarionLenoir, MD, and YannChaussy, MD . ............................................................ 284

Iliac Subperiosteal Hematoma with Ossification in a 15-Year-Old Boy e

SunHwaLee, MD, and SeongJongYun, MD . ....................................................................................................................... 285

Pulmonary Calcification in a Congenital Cytomegalovirus Infection

KazuhiroUda, MD, YukaSasaki, MD, KensukeShoji, MD, and IsaoMiyairi, MD ...................................................................... 286

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Current Best Evidence

Translating Best Evidence into Best Care ................................................................................................................ 287

Letters to the Editor

Creatine Kinase: How an Obsolete Test for Skeletal Muscle Disease Became a Risk Factor
for Hypertension
LizzyM.Brewster, MD, PhD . ............................................................................................................................................. 291

Understanding Cardiopulmonary Resuscitation

BenjaminJamesMasters, BM, JaspreetMandeir, JohnOShaughnessy, and SanthanamSundar, MBBS, FRCR ............................... 291

Reply
DerekB.Hoyme, MD, and DianneL.Atkins, MD . ................................................................................................................ 292

European Paediatric Association Pages

Public Health Practice and Policy to Improve Child and Adolescent Health in Europe
DanielleJansen, PhD, SoniaSaxena, MD, and NatashaAzzopardi-Muscat, MD, PhD ................................................................. 293

Reader Services
Information for Readers ............................................................................................................................................ A8

Announcement and Upcoming Events . ........................................................................ Available at www.jpeds.com

Guide for Authors ............................................................................................................ Available at www.jpeds.com

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