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Garlic
Garlic, also called Allium Sativum belongs to the Liliaceae family of vegetables (1) therefore
some of the research below also relates to other members of this family (onion, leek,
chives).
Originally native to central Asia it is now cultivated throughout the world. (2)
Most of the herbs pharmacological activity is due to the action of its organosulfur
components: alliin, allyl cysteine, allyl disulphide and allicin.(1) Allicin (diallyl thiosulphate)
gives garlic the typical pungent smell. Allicin does not exist in garlic until it is crushed or cut,
at which time the enzyme allinase is activated and alliin is metabolized to allicin.(5)
Nutrients
Key Nutrients Major Actions (10,12,15) Amount (per Amount RDI / AI % of
(3,4) 100g) per SSS RDI / AI
(3,11) (3) 30yo female
per
SSS
Macronutrients
Protein Proteins contribute to the plasma 6.1g 0.18g 46g 0.4%
pool of amino acids
Phytonutrients
Key Phytonutrients Major Actions
Carotenoids
Beta-carotene (1,4) Anti-carcinogenic, antioxidant
May reduce the risk of lung cancer in smokers
Alkaloids
Saponins The crushing of garlic leads to many types of
steroid saponins
Anticholesterolemic
Inhibit absorption of cholesterol in the small
intestine, therefore reducing plasma cholesterol
level (14)
Anti-bacterial
Eruboside-B, a steroidal saponin in garlic has
antifungal effects on Candida albicans (14)
Antithrombotic
Beta-chlorogenin has the ability to reduce platelet
aggregation in vivo (13)
OHTH2132. Garlic Food Monograph
Alliin
Allicin Antioxidant (1)
Anti-inflammatory (1)
Increased survival rate in mice due to significantly
OHTH2132. Garlic Food Monograph
Allixin Antibacterial
Found in aged garlic extract, inhibits the activity of
Helicobacter Pylori (6)
Anticancer
Inhibits skin cancer (vivo) (7)
Neurotrophic
Recommended prophylactically at 1ng/ml in
neurodegenerative diseases (8); significantly
promotes survival of neurons, increases the
number of axonal branches
Allyl polysulfides (APS)
Diallyl sulfide (DAS) Anti-inflammatory(1,4), anti-arthritic (4)
Antineoplastic and chemoprotective (1,4)
Inhibits metabolism of cytochrome p450 in nasal
mucosa (vivo)
Induced apoptosis in human cervical cell cancer
lines via p-53 induced cell cycle arrest and
mitochondrial disruption
Inhibits angiogenesis and metastasis in human cell
lines by inhibition of capillary-tube like formation,
cellular proliferation and migration
Anticholesterolemic (1)
Inhibits enzymes involved in cholesterol and
triglycerides synthesis at high dose 500mg/kg
Antineoplastic and chemoprotective (1,4)
Arrests the G2/M phase of cell cycle and promotes
cell apoptosis in colon cancer
Induced apoptosis in prostate cancer cells through
modulation of insulin growth factors
Inhibits angiogenesis and metastasis in human cell
lines by inhibition of capillary-tube like formation,
cellular proliferation and migration
N-acetylcysteine (NAC)
N-acetyl-S-allylcysteine
(NASC)
S-allylcysteine (SAC) Antiatherosclerotic (1)
Prevents cerebrovascular damage in Alzheimers
disease
Antihypertensive (1)
Potentiates the antihypertensive and cardio-
OHTH2132. Garlic Food Monograph
S-ethylcysteine (SEC)
S-methylcysteine (SMC)
S-propylcysteine (SPC)
1,2-vinyldithiin (1,2-DT)
Thiacremonone Anti-inflammatory, anti-arthritic (4)
Therapeutic claims
Cardiovascular health (1)
Epidemiological studies demonstrate an inverse correlation between garlic
consumption and progression of cardiovascular disease
Double-blind, placebo-controlled study demonstrated that Alicor garlic tablets
administered for 12 months are:
o Effective in reducing the risks associated with cardiovascular disease in
hyperlipidaemia patients
o Significant reduction in coronary heart disease CHD, in both gender, in
high-risk patients.
o Reduced risk of myocardial infarction and sudden death in high-risk man but
not women
Long term, randomised, double blind and placebo controlled study demonstrated that
garlic powder supplements, administered in a dose controlled manner 900mg/day,
significantly reduced arteriosclerotic plaque
Double-blind, placebo-controlled, randomised study demonstrated that long term use
of aged garlic extract, 1200mg/day, in high-risk patients retards calcification of
coronary arteries, slowing the progression of disease
Multiple studies indicate the efficacy of using garlic supplements in combination with
both statin medication and other supplements (CoQ10, B6, B12, folic acid, l-
arginine), in treating atherosclerosis
o Significant favourable changes in oxidative biomarkers (reduced C-reactive
protein, coronary artery calcium) and reduced progression of atherosclerosis
Hypertension (1)
Earlier meta-analysis studies and more recent ones have confirmed that garlic
treatment significantly reduces blood pressure in hypertensive individuals
(SBP>140mmHg) after 12 weeks of supplementation with AGE 900mg/day
OHTH2132. Garlic Food Monograph
Hyperlipidaemia (1)
Diabetes (1)
300mg*2/day of Alicor, reduces fasting blood sugar level and maintained it at the
mean level below 7.0mmol/L during 4 weeks of treatment in diabetic patients
Comparable effects with metformin diabetic medication in diabetic subjects at high
doses of 1200-1500mg/day over 24 weeks
Significant improvement in postprandial blood glucose level, total cholesterol,
triglycerides, LDL and C-reactive protein when 250mg garlic was combined with
500mg metmorfin
Infection (1)
1% ajoene cream 100% cure rate of tinea pedis, tinea corporis and tinea cruris
after 60 days
AGE 2.5 g/day for 90 days significantly reduces the incidence of cold and accelerates
recovery in individuals taking allicin-containing garlic preparations. At day 45, T-cells
and natural killer cells proliferation was significant.
Garlic is effective against H. Pylori infection. 275mg*3/day garlic oil, with or without
omeprazole, produced similar results (confirmed by another study)
Cancer (1)
Has a preventative effect in stomach and colorectal cancer when eaten at least once
a week for stomach cancer and twice a week for colon cancer, raw or cooked
Other studies found no benefit in either dietary or supplement garlic use in reducing
the risk of cancer
High dose AGE 2.4ml/day for 6-12 months, significantly suppressed both the size
and number of colon adenomas
High intake of raw/cooked garlic has a chemoprotective effect
High intake of garlic showed significant protective role against endometrial cancer.
Topical application of ajoene cream showed a reduction in tumour size
Safety issues.
Precautions and Contraindications
OHTH2132. Garlic Food Monograph
Adverse Reactions
Effects are limited to gastrointestinal discomfort, mainly: bloating, reflux, flatulence
when consumed in large doses (~960mg/day).
Some reports indicated bad odour and breath, allergic reactions, nausea, abdominal
discomfort and diarrhoea when taken on an empty stomach and doses greater than
1g.
Garlic is a type 1 allergen due to DADS, allyl propyl disulphide and allylmercaptin.
The enzyme alliinase can be inactivated by heat. In one study, microwave cooking of
unpeeled, uncrushed garlic totally destroyed alliinase enzyme activity. (9)
Prolonged oven heating or boiling (>6 min.) suppressed the inhibitory effect of
uncrushed and crushed garlic on platelet aggregation, but crushed garlic retained
more antiaggregatory activity compared to uncrushed garlic. (9)
For optimal nutrient formation crush the garlic and allow it to stand for 10 min. before
eating or cooking. (9)
Add chopped garlic towards the end of the cooking time to retain maximum flavour
and nutrition. Too much heat reduces the activity of sulfur compounds and it will also
make garlic bitter. Do not cook longer than 5-15 min. (2)
Store garlic in a cool, dark place to avoid sprouting and maintain freshness, for no
longer than two months.
Several different types of garlic supplements are available commercially, and each
type provides a different profile of organosulfur compounds depending on how it was
processed. (9)
References
1. Braun L, Cohen M. (2007) Broccoli. In: Herbs & Natural supplements: an evidence based
guide. 2nd ed. Australia: Elsevier;. p. 44-7, 54-5.
2. Max Wichtl (2004) Herbal drugs and phytopharmaceuticals . A handbook for practice on a
scientific basis. 3rd ed. Medpharm Scientific Publishers Stuttgart
3. USDA (2009) USDA National Nutrient Database for Standard Reference, Release 22:
https://ndb.nal.usda.gov/ndb/foods/show/2968?
fgcd=&manu=&lfacet=&format=&count=&max=35&offset=&sort=&qlookup=GARLIC
4. WHFoods. (2010) Garlic, raw. World's Healthiest Foods:
http://whfoods.org/genpage.php?tname=foodspice&dbid=9
5. S.H. Omar, N.A. Al-Wabe (2010) Organosulfur compounds and possible mechanism of
garlic in cancer. Saudi Pharmaceutical Journal Volume 18, Issue 1, January 2010, Pages
5158
6. Mahady, G.B., Allixin, a phytoalexin from garlic, inhibits the growth of Helicobacter Pylori
in vitro, Am. Journal of Gastroenterology, 96:3454-3455, 2001
7. Nishino, H., Nishino, A., Takayasu, J., Iwashima, A., Itakura, Y., Kodera, Y., Matsuura, H.,
and Fuwa, T., Antitumor promoting activity of allixin, a stress compound produced by
garlic, Cancer Journal, 3:20-21, 1990
8. Moriguchi, T., Saito, H., and Nishiyama, N., Aged garlic extract prolongs longevity and
improve spatial memory deficit in senescence accelerated mouse, Biol. Pharm. Bull.,
17:395-307, 1996
9. Linus Pauling Institute
Micronutrient Information Center - Garlic and Organosulfur Compounds
OHTH2132. Garlic Food Monograph
http://lpi.oregonstate.edu/mic/food-beverages/garlic#sources
10. WHFoods (2010) Essential Nutrients in the Worlds Healthiest Foods:
http://www.whfoods.com/nutrientstoc.php
11. FSANZ (2006) NUTTAB 2006 Online Version:
http://www.foodstandards.gov.au/science/monitoringnutrients/nutrientables/nuttab/Pages/
default.aspx
12. NIH (2016) National Institute of Health Fact sheets for health professionals
https://ods.od.nih.gov/factsheets/list-all/
13. Hiromichi Matsuura (2001), Saponins in Garlic as Modifiers of the Risk of Cardiovascular
Disease, JN The journal of nutrition, vol. 131 no. 3 1000S-1005S
14. Harunobu Amagase (2006) Clarifying the Real Bioactive Constituents of Garlic, JN The
journal of nutrition, vol. 136 no. 3 716S-725S
15. University of Maryland Medical Center, Medical reference guide, Complementary and
alternative medicine guide, Supplement
http://umm.edu/health/medical/altmed
Turnitin submission
Author:
Carleta Elena Stan
Assignment title:
Garlic Monogrpah
Submission title:
Garlic Monograph
File name:
Garlic Monograph.doc
File size:
145.5K
Page count:
15
Word count:
4033
Character count:
25342
Submission date:
15-Apr-2016 22:33 AEST
Submission ID:
659950082