PATHOPHYSIOLOGY: OSTEOMYELITIS

Surgery
Age: Children and Adult Open fracture from Injury/ Trauma
Sex: Male Systemic Infection: Respiratory and
Medical Condition: DM Type I, Genitourinary
Sickle cell anemia etc. Bacteria
DM Type II

Increase in blood flow and Inflammatory response

vascular permeability

Small terminal vessels

Chemotaxis: Delivery of thrombose and exudate
polymorphonuclear leukocytes/
Neutrophils

Mononuclear cells arrive Sealing of

within 24-48 hours and bones canaliculi
assist in eradication of
bacteria and necrotic tissue

Phagocytosis: Leukocytes
phagocytize and destroy
bacteria and nonviable
tissue

Extends in subperiosteal
Extends into the Decrease blood space
metaphysis and marrow supply
cavity and through small
openings in the cortex
Formation of
Necrosis abscess

Weakening of cortical
bone
Death of area of bone Periosteum lifts
infected from the bone

Pathologic fracture
Osteoblastic
Sequestrum
response

Pain
Involucrum