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DRUG ANALYSIS

Indication Mechanism of Adverse Reaction Contraindications Nursing responsibility


Action
Generic Name: Relief for moderate Opioid partial CNS: sedation,  Contraindicated to  Reassess patient’s level of pain
Nalbuphine to severe pain agonist dizziness, vertigo, patient with at least 15-30 minutes after
Hydrochloride headache hypersensitivity to parenteral administration.
drug.  Monitor circulatory and
Brand Name: CV: hypotension,  Alert: certain respiratory status and bladder
Nubain hypertension commercial and bowel function. If
preparations contain respirations are shallow or rate
4mg IV q4h x EENT: dry mouth sodium metabisulfate. is below 12 bpm, withhold dose
6 doses and notify prescriber.
GI: nausea, vomiting  Constipation is often severe
with maintenance therapy.
Skin: sweaty/clammy Make sure stool softener or
other laxative is ordered.
 Teach patient how to manage
troublesome adverse effects
such as constipation.

Indication Mechanism of Adverse Reaction Contraindications Nursing responsibility


Action
Generic Name: Treatment for 3rd generation CNS: fever ,  . Contraindicated to  Before giving drug, ask patient
Ceftriaxone susceptible cephalosporin, headache, dizziness patient with if he is allergic to penicillins or
Sodium infection bactericidal hypersensitivity to cephalosporin.
Hematologic: drug or other  Obtain C&S test before giving
Brand Name: eosinophilia, cephalosporin.. the first dose. Therapy may
Rocephin thrombocytosis,  Use cautiously in begin before results.
leucopenia. Elevated patients  If large doses are given,
SGOT/SGPT & BUN hypersensitive to monitor patient for signs and
penicillin because of symptoms of super infection.
Skin: pain, possibility of cross-  Monitor PT and INR in patients
tenderness at sensitivity with other with impaired vitamin K
injection site, rash beta-lactam synthesis. Vitamin K therapy
DRUG ANALYSIS

antibiotics. may be needed.


GI: Diarrhea  Tell patient to report adverse
reactions promptly.
 Instruct patient to report
discomfort at I.V. insertion site.
 Teach patient and family
receiving home care how to
prepare and give drug.
 Tell patient to notify prescriber
about loose stool or diarrhea.

Indication Mechanism of Adverse Reaction Contraindications Nursing responsibility


Action
Generic Name: Maintenance Rifampicin CNS: headache,  Hypersensitivity,  Monitor patient compliance
Rifampicin phase treatment of inhibits DNA- drowsiness,ataxia jaundice, severe with treatment regimen
all forms of dependent hepatic disease  Assess results of periodic
Classification: pulmonary and polymerase, GI: GI disturbances laboratory tests and chest x-
Anti-infectives extra-pulmonary decreases ray, therapeutic effectiveness
tuberculosis(TB) replication Hematologic: and adverse reactions
Dosage: eosinophilia,  Assess lung sounds and
200mg/50ml thrombocytopenia, character and amount of
syrup OD leukopenia sputum periodically during
therapy

Indication Mechanism of Adverse Reaction Contraindications Nursing responsibility


Action
Generic Name: Treatment of fever Paracetamol CNS: drowsiness,  Hypersensitivity,  Monitor liver and renal
Paracetamol exhibits delirium, convulsion, jaundice, severe functions
analgesic action coma hepatic disease  Assess patient’s fever
Classification: by peripheral  Assess for allergic reactions
DRUG ANALYSIS

Analgesics blockage of pain GI: nausea, vomiting,  Assess hepatotoxicity


impulse abdominal pain
generation. It
produces Hematologic:
antipyresis by luekopenia,
inhibiting the neutropenia,
hypothalamic hemolytic anemia,
heat-regulating thrombocytopenia,
centre. Its weak pancytopenia
anti-
inflammatory
activity is related
to inhibition of
prostaglandin
synthesis in the
CNS.

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