DELIMA, Christine Mae M.

Group 6
3Biology5
EXPERIMENT 5

ACID-BASE PROPERTIES OF ORGANIC COMPOUNDS

I Methodology

In this experiment, twelve representative organic compounds were used to differentiate the

solubility and acid-base properties of different organic compounds. The compounds used in this

experiment were cyclohexane, ethanol, octanol, phenol, acetone, n-pentanone, ethyl amine,

diethyl amine, benzoic acid, caproic acid, amyl acetate and acetanilide. Prior to conducting the

solubility/miscibility test, the physical properties, such as physical state, color and odor of each

organic compound were observed and examined. For each of the organic compounds, ten drops

of sample (or microspatula, if solid) were placed inside four separate labelled test tubes. The

miscibility and solubility of the organic compounds were then tested by adding 1 mL of 1 M

H2O to the first test tube, 1 mL of 1 M HCl to the second test tube, 1 mL of NaOH to the third

test tube, and 1 mL of 1 M NaHCO3 to the fourth test tube. The procedures were repeated to all

the other remaining samples and the solubility or immiscibility of each compound to the four

different reagents were observed and tabulated.

II Bibliography

Bodor, N., Harget, A., Huang, M. (1991). Estimation of the aqueous solubility of organic

compounds. Journal of the American Chemical Society, 113 (25), 9480-9483. doi: 10.1021

ja00025a009
DELIMA, Christine Mae M. Group 6
3Biology5
Dyumaev, K. & Korolev, B. (1980). The influence of solvation on the acid-base properties of

organic compounds in various media. The Royal Society of Chemistry and the British

Library, 49 (11), 1021. doi: ttps://doi.org/10.1070/RC1980v049n11ABEH002521

Narayan, S., Muldoon, J., Finn, M., Fokin, V., Kolb, H., Sharpless, K. (2005) . On water:

unique reactivity of organic compounds in aqueous suspensions. Angewandte Chemie

International Edition, 44 (21), 3275- 3279. doi: 10.1002/anie.20046288

Solomons, G., Fryhle, C., & Synder, S. (2014). Organic Chemistry. USA: John Wiley & Sons,

Inc.

Stephen, H. & Stephen, T. (1979). Ternary Systems: Solubilities of Inorganic and Organic

Compounds. Oxford: Pergamon Press.