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Hannah Nielsen
Chemistry 1010
December 10, 2017
Often used to treat narcolepsy, depression, and ADHD, Adderall contains a small portion
of the active ingredient, amphetamine. Amphetamine, a synthetic stimulant, was first synthesized
in 1887 by Lazr Edeleanu, a Romanian chemist. The drug didnt actually hit the pharmaceutical
market until 1933 and, at the time, was called Benzedrine. In 1943, the U.S. and British Armys
shipped an estimated 150 million used pep pills, or pills of straight amphetamine, to make troops
more awake, focused, and encourage higher moral (Tien Nguyen, 2015). With such great
popularity, the question becomes, how/why is the drug so effective in making a person more alert,
Amphetamine works in the bodys central nervous system by boosting the production of
dopamine in the brains reward center (Tien Nguyen, 2015). Adderall is a combination of two
stereoisomers of the chemical amphetamine (Meyers, 2013). Stereoisomers are two molecules
made up of the same combination of atoms differing only slightly in the arrangement of the atoms
closely resemble the catecholamine family of neurotransmitters in the brain including epinephrine
and dopamine (otherwise known as the feel-good hormones in the brain). This close resemblance
allows Adderall to act as these chemicals would in the brain (Meyers, 2013). Adderall works by
being the catecholamine agonist (or the thing that, when combined with a receptor, initiates the
to create the sensations associated with the reward center of the brain. This binding, for example,
can promote satisfaction, arousal, and the fight-or-flight response (Meyers, 2013).
constantly seeks stimuli (Tien Nguyen, 2015). A person who seems overstimulated (is constantly
adequate amount of dopamine produced in the brain, causing them to constantly search for outside
stimuli (which would result in the dopamine production that person is lacking) and ultimately lose
focus (Tien Nguyen, 2015). By increasing the production of dopamine in the brain, Adderall helps
the person with ADHD maintain better focus by not needing outside stimulants to receive an
adequate amount of dopamine. With an adequate amount of dopamine the persons brain no longer
needs excess stimuli, and is therefore not bothered by minor distractions. A person who takes
Adderall, even without ADHD, can experience euphoria, heightened alertness, more focus.
On the tail end of the amphetamine molecule, you will find CH4 otherwise known as a
methyl group. Interestingly, with the addition of just one more methyl group, the relatively
harmless, and only potentially addictive, amphetamine becomes the infamous recreational drug,
effectively identical in atomic makeup, have been found to be addictive, scientists have found that
methamphetamine users have a greater risk of addiction. Why? Scientists have found that the
additional methyl group in methamphetamine increases the chemicals fat solubility and is
Amphetamine V. Methamphetamine
Difference of just one methyl group (CH4)
Bibliography
Chemicool Dictionary :
https://www.chemicool.com/definition/stereoisomers.html
Meyers, E. (2013, March 13). How Does Adderall Work?: A PSA. Columbia Science Review.
https://columbiasciencereview.com/2013/03/29/how-does-adderall-work-a-psa/
Tien Nguyen, P. E. (Writer), & Seward, E. (Director). (2015). How Does Adderall Work?