STEMENHANCE ULTRA

FREQUENTLY ASKED
QUESTIONS
What is StemEnhance Ultra?

StemEnhance Ultra concentrates and combines extracts from nature's

most primitive superfoods, fresh water microalgae and marine
macroalgae, proving the body with the ultimate in stem cell support.

Why is StemEnhance Ultra beneficial

StemEnhance Ultra assists the body's inherent ability for long-term

self-renewal by supporting the body's natural release of bone
marrow stem cells.

What are the ingredients in StemEnhance Ultra?

StemEnhance Ultra provides the ultimate in stem cell support

containing a proprietary blend of highly concentrated extracts,
including Fucoidan, Cerule's own exclusive patented ingredients,
StemEnhance and Mesenkine.

StemEnhance Ultra (AFA concentrate) is shown to support the

release of stem cells from the bone marrow.

Fucoidan (undaria pinnatifida) is a marine algae well known to support

the immune system. Cerule's fucoidan comes from undaria harvested
from pristine environments like the Tasman Sea and Patagonia.
Fucoidan from undaria pinnatifida has been documented to increase
the number of circulating stem cells.

Mesenkine is a unique extract from Spirulina, isolated through our

patented extraction process, that supports the release and homing of
stem cells by balancing key messengers involved in stem cell
function.

StemEnhance Ultra does not contain dairy, wheat, gluten, peanut,

soy, corn, or allergens. There are no artificial flavors or colors. It is
100% vegetarian, non-GMO, and free from herbicides and pesticides.

The StemEnhance Ultra supplement fact sheet can be viewed here.

What are stem cells and why are they considered important?

'The primary roles of adult stem cells in a living organism are to

maintain and repair the tissue in which they are
found.' http://stemcells.nih.gov/info/basics/4.html. Furthermore, stem
cells released from the bone marrow can migrate to various tissues
where they contribute to the process of tissue repair.

How do I take StemEnhance Ultra?

Suggested usage is 2 capsules, 1 to 2 times daily.

Can children consume StemEnhance Ultra?

The clinical studies were done using adults therefore we recommend

StemEnhance Ultra for adult consumption, however there are no
known contraindications for children.

Can pets consume StemEnhance Ultra?

StemEnhance Ultra is formulated for human consumption. We know
of no reason that it may be harmful to pets. AFA and spirulina have
been used in the pet nutrition industry for years. However, no studies
have been done using the product for pet consumption. Please
consult with your Veterinarian.

Is there research on StemEnhance Ultra?

StemEnhance Ultra is the result of 16 years of research and

constitutes the most efficacious and scientifically proven stem cell
nutrition product on the market.

Through multiple clinical trials, StemEnhance Ultra was documented

to optimize stem cell function in the body by increasing the number of
both stem cells and and Endothelial Progenitor Cells (EPCs) in the
bloodstream, supporting optimum renewal and repair of tissues and
organs.

StemEnhance Ultra also contains Mesenkine, that was shown to

increase the blood concentration of G-CSF that plays a key role in
stem cell release.

How does StemEnhance Ultra work?

'The story of the development and the discovery

of StemEnhance started nearly 2 decades ago, when I started to
investigate an aquatic botanical called aphanizomenon flos aquae, in
short afa. Afa is a blue green algae in Klamath lake in southern
Oregon. So my starting point was to do a survey, to do an over view
of all the benefits reported by people consuming afa.

And it became very rapidly clear that people consuming afa reported
benefits overall touching overall inflammation, touching the immune
system and also many of the consumers of afa were reporting an
increase in mental clarity, mental energy, an ability to concentrate, an
overall feeling of well being. So we started the investigation and
rapidly discovered that afa is a source of phycocyanin, which is the
blue pigment in all blue-green algae.

Now phycocyanin was already known at the time to be one of the

most potent anti-inflammatory molecules coming from the plant world.
So it explained a lot of the benefits that people had touching
inflammation. Now we identified in afa, a polysaccaride that supports
various aspects of the immune system, and we identified a molecule
called PEA.

PEA is a molecule that the brain makes naturally, whenever someone

feels happy, content, satisfied. It is known in chemistry as the
molecule of love, or the molecule of joy. A deficiency of PEA has been
associated with low mood, reduced ability to concentrate, attention
deficit and it could go down even to depression. An oral dose of PEA
can really reverse these kinds of conditions.

So discovering that afa contains PEA really explained all the benefits
that people had experienced over the years in terms of this feeling of
well being or mental clarity. But as we we're doing all this work, a lot of
people reported other benefits that we could not explain on the basis
of these 3 compounds.

And from a scientific standpoint what was challenging was not only
the extent of these benefits, but the wide variety of these benefits.
People were reporting benefits on the skin, the liver, on pancreatic
function, the lungs, joints, nervous system, on the retina. So the
question was, what is it that this product is doing that touches so
many different aspects of human health.

So over the years, we had many hypotheses that we tested in the lab,
we got good data, but nothing that gave us that 'a ha' that discovery t
tell us what the product is doing. Until one day, when a colleague of
mine sent me an article and the title of the article was turning blood
into brain. It was a study in which scientists had observed that stem
cells in circulation in the blood stream had the ability migrate in the
brain and to become brain cells.

Around the same time, other studies had been published showing that
stem cells had the ability to also migrate into the heart and the liver
and to become heart cells and liver cells. So what we started to think,
Dr Jensen and I, was that if stem cells can become brain cells, heart
cells and liver cells, why not pancreatic cells, skin cells, joint cells,
lung cells, why not all the other types of cells of the body.

So on the basis of data existing in the scientific literature, we

proposed in a journal called medical hypotheses, that indeed stem
cells constitute the natural repair system of the body. But what we had
in mind when we made that proposal is that if that turns out to be true,
and it did turn out to be true, that's what stem cells are doing in the
body, but if that is true, that means that a product that would support
the natural role of stem cells should lead to various benefits in various
people. And that's what we had with AFA.

So with this thought, we went to the lab and we tested afa with regard
to its ability to trigger stem cell release from the bone marrow. And we
discovered that indeed, afa contains a specific molecule that blocks
an adhesion molecule on the surface of stem cells called l-selectin.
And that triggers the release of stem cells from the bone marrow.

So afa contains an l-selectin blocker. So we developed a concentrate

of afa that we call StemEnhance and the consumption of 2 capsules
of StemEnhance triggers the release of stem cells from the bone
marrow and leads to a significant increase in the number of circulating
stem cells and all these stem cells can then participate in the natural
process of tissue repair.
Now after developing the assets to quantify stem cells and
discovering the natural of stem cells in the body it was obvious to Dr
Jensen and I, that given that this is a natural part of human physiology
it cannot be that there's only one plant having an effect on stem cells.
So we then asked the question, what other plant has been known
throughout history to be associated to many different kinds of health
benefits. So the ideas is to go and test these plants in the lab with the
hypothesis that maybe their mechanism of action is that they also
trigger the release of stem cells from the bone marrow.

So we tested many plants, and we discovered one that also triggers

release of stem cells from the bone marrow. It is a brown seaweed
called undaria pinnatifida also known in Japanese cuisine as
Wakame. So undaria contains a polysaccaride called fucoidan. The
consumption of fucoidan from undaria pinnatifida increases the
number of stem cells, the baseline number of stem cells over time as
we consume the product everyday.

Now, when we discovered the effect of afa on stem cells and

developed StemEnhance and all the afa produced by Cerule started
to be used to produce stem enhance, then Cerule started to take a
different direction with the development of a phycocyanin concentrate.
They started to concentrate phycocyanin, not from afa, but from
spirulina. And it became another product called Cyactiv, that we will
talk about later.

But, as they developed Cyactiv, concentrated phycocyanin, they

discovered that spirulina contains another compound, it is a yellow
compound. This yellow compound has not yet been identified, but
when we feed this compound to people, it increases the concentration
of GCSF in the blood. GCSF is a compound very well known to trigger
stem cell release from the bone marrow.
So StemEnhance Ultra is the blend of these 3
products, StemEnhance, the fucoidan from undaria pinnatifida and
mesenkine, this yellow compound isolated from spirulina. So since
these 3 product trigger the release of stem cells form the bone
marrow using different mechanisms of action, it means that blending
them gives a unique and strong synergy. So the consumption of 2
capsules of StemEnhance Ultra triggers a very significant release of
stem cells from the bone marrow, increasing the number of stem cells
in circulation by anywhere between 4 to 10 million new stem cells.
And all these stem cells are available to participate in the process of
tissue repair.

So StemEnhance Ultra is a unique product, probably one of the best

products out there to support the natural process of tissue repair and
tissue renewal in the body.'

What is the StemEnhance Ultra capsule made from?

As stated on the label, the vegetarian capsule is made from

hypromellose. Hypromellose is cellulose derivative or plant fiber.

Is StemEnhance Ultra certified Kosher and Halal?

StemEnhance Ultra ingredients are certified Kosher.

It is not certified Halal.

What is the shelf-life of StemEnhance Ultra?

There is an expiration date at the bottom of each bottle. StemEnhance

Ultra has a shelf life of 3 years from manufacturing. All bottles should
be stored in a cool, dry place.

Can StemEnhance Ultra be consumed with other Cerule

products and other nutrients?
Yes, the Cerule products can be consumed together and were
designed to enhance the beneficial effects of each other. We know of
no concerning interaction between the Cerule products and other
nutritional supplements.

Are there any known nutrient-medication interactions?

Like many green foods, StemEnhance Ultra contains naturally

occurring vitamin K, which could interfere with vitamin K blockers
used to thin the blood, such as coumadin.

If you have any health condition and/or are using medication, then
consult your attending health care provider before consuming any
nutritional supplement.

For some people, due to their conditions and medications, they need
to manage their intake of certain nutrients. Below are the amounts of
naturally occurring nutrients found in the plant based ingredients
within StemEnhance Ultra:

Vitamin K: around 20 ug per serving (2 capsules)

Iron: 0.34 mg per serving (2 capsules)
Iodine: around 4 ug per serving (2 capsules)
Sodium: 9.66 mg per serving (2 capsules)
PEA: >0.5%

Why does the StemEnhance Ultra label state 'consult your

physician if you are pregnant or nursing?'

Pregnancy and nursing are considered special conditions. We

recommend that your attending Doctor(s) be made aware of any and
all supplements consumed during this time. At this time, we do not
advise StemEnhance Ultra consumption during pregnancy.