la enfermedad (7). Se han ensayado tambin mtodos que intentan \par}{\phpg\posx1418\pvpg\posy2240\absw6070\absh2752 \sl-236 \f20 \fs17 \cf0 imitar las condiciones naturales de la infeccin como la inoculacin \par}{\phpg\posx1418\pvpg\posy2240\absw6070\absh2752 \sl-237 \f20 \fs17 \cf0 intradrmica, subcutnea e intramuscular. Ocasionalmente la inoculacin
muy inervada) causa la muerte de los animales inoculados, en \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-244 \f20 \fs17 \cf0 tanto que la inoculacin subcutnea o en la piel con dosis comparables \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-243 \f20 \fs17 \cf0 puede no causar la muerte en absoluto (8), (Mondrag6n 1, observaciones \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-243 \f20 \fs17 \cf0 no publicadas). La influencia de la distancia por recorrer del sitio de \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-244 \f20 \fs17 \cf0 inoculacin al SNC se vera entonces complicada por componentes \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-243 \f20 \fs17 \cf0 relativos al grado de inervacin del sitio \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-301 \f20 \fs17 \cf0 \fi36 inoculado. \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-195 \f20 \fs17 \cf0 \fi332 La especie animal tiene tambin influencia sobre el periodo de \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-271 \f20 \fs17 \cf0 incubacin, dado que los animales tienen un grado variable de suscep- \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-243 \f20 \fs17 \cf0 tibilidad a la rabia. Los zorros, gatos y bovinos se encuentran entre los \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-244 \f20 \fs17 \cf0 animales altamente susceptibles; el perro, los monos y el hombre entre \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-243 \f20 \fs17 \cf0 los de susceptibilidad intermedia{\f10 \fs16 y} los zorrillos, murcilagos{\f10 \fs16 y} ratas se \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-243 \f20 \fs17 \cf0 encuentran entre los de alta resistencia (16). \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-238 \f20 \fs17 \cf0 \fi94 La edad tiene una influencia importante sobre la susceptibilidad a la rabia. \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 Los animales lactantes son ms susceptibles que los animales adultos{\f10 \fs16 y } \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 stos a su vez son ms susceptibles que los animales viejos. Si se titula la \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 cepa Flury HEP en ratones de un da de nacidos arroja un ttulo \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 determinado, si se utilizan ratones de cuatro das, el ttulo obtenido puede \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 reducirse en ms de dos logaritmos{\f10 \fs16 y} es incapaz de matar ratones de 21 \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 das (Roldn de Gord6n, 1972, observaciones no publicadas). Si bien sta \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 es la caracterstica del virus vacuna1 cepa Flury HEP, la baja \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 patogenicidad de esta cepa viral sirve en este caso para ilustrar la \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 diferencia de susceptibilidad que ocurre Con la edad de los animales. Esta \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 diferencia, si bien en forma menos dramtica, se ha observado con una \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 cepa de vampiro adaptada a cultivos celulares (17) en la que hubo una \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 diferencia de dos logaritmos entre el ttulo del virus en ratones lactantes{\f10 \fs16 y } \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 el obtenido en ratones de 21 das (17). El aumento de la resistencia con la \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 edad de los animales ha sido observado en bovinos (18, 19). Una dosis de \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 {\fs18 800000} DL50 ratn bast para matar a 4 de{\fs18 5} becerros de seis meses de \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 edad, en tanto que bovinos de cinco aos necesitaron 5 x 106 DL50 rat6n \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 para matar un nmero comparable. La diferencia es ms notable cuando \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-237 \f20 \fs17 \cf0 \fi94 se compara animales jvenes con animales adultos que cuando se \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-236 \f20 \fs17 \cf0 \fi94 comparan animales adultos con animales viejos \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-295 \f20 \fs17 \cf0 \fi238 (20). \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-193 \f20 \fs17 \cf0 \fi526 La cepa de virus tambin tiene influencia sobre el periodo de \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-229 \f20 \fs17 \cf0 \fi238 incubaci6n de la enfermedad. Los virus fijos (cepa Pasteur, CSV, Flury, \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-243 \f20 \fs17 \cf0 \fi238 SAD, etctera) causan periodos de incubacin ms cortos que las cepas \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-244 \f20 \fs17 \cf0 \fi238 de calle. Aun entre las cepas de virus rbico de calle, el periodo de
incubacin, si bien es ms irregular en su duracin, tiende a ser ms \par}{\phpg\posx1445\pvpg\posy1693\absw6289\absh8865 \sl-242 \f20 \fs17 \cf0 \fi238 largo (8Y. \par } \sect\sectd\pard\plain \pgwsxn9180\pghsxn12980 {\phpg\posx0\pvpg\posy0\absw9180\absh12980 \overlay {\*\shppict {\pict\jpegblip\picw459 \pich649 \picwgoal9180 \pichgoal12980 \picscalex135 \picscaley135 ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101010 10101010101010101010101010101010101010101010101010101010101010101010101010101010101 010101010101ffdb0043010101010101010101010101010101010101010101010101010101010101010 1010101010101010101010101010101010101010101010101010101010101010101ffc0001108028901 cb03012200021101031101ffc4001f00000105010101010101000000000000000001020304050607080 90a0bffc400b5100002010303020403050504040000017d010203000411051221314106135161072271 14328191a1082342b1c11552d1f02433627282090a161718191a25262728292a3435363738393a43444 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entre}{\fs17 el}{\fs17 virus} fijo{\fs19 y} el \par}{\phpg\posx1720\pvpg\posy2527\absw6092\absh601 \sl-223 \f20 \fs18 \cf0 virus de calle (15). \par } {\phpg\posx2563\pvpg\posy3751\absw4289\absh199 \f20 \fs18 \cf0 \f20 \fs18 \cf0 III. Patognesis para el sistema nervioso central \par } {\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \f20 \fs18 \cf0 \fi64 \f20 \fs18 \cf0 Una vez que el virus rbico ha invadido el SNC, la primera{\fs17 evidencia}{\fs17 de } \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 {\fs17 multiplicacin}{\fs17 viral}{\fs17 ocurre}{\fs17 en}{\fs17 los} {\fs17 ganglios}{\fs17 espinales} que proporcionan \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 inervacin al sitio inoculado. Si la inoculacin se efectu en el cojinete \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 plantar izquierdo, algunas horas despus de la misma, el virus se \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 encuentra en los ganglios espinales lumbares del lado izquierdo \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 tambin. De este punto, progresa gradualmente por las astas dorsales \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 {\fs17 y} neuronas de las races de los{\fs17 nervios}{\fs17 dorsales}{\fs17 y} {\fs17 rara}{\fs17 vez}{\fs12 Se}{\fs17 le}{\fs17 encuentra}{\fs17 en } \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 {\fs17 las}{\fs17 astas}{\fs17 ventraIes.} Ocasionalmente algunos{\fs16 axones} de la substancia blanca \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 espinal mostraban fluorescencia 12). Es importante notar que el \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 ascenso del virus rbico al sistema nervioso central no se efecta como en el \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 caso de{\i Herpes}{\i simplex} por la infeccin ascendente de la clulas de \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 Schwann (21), segn estudios de microscopa de fluorescencia{\fs17 y} ms \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 tarde confirmada por microscopia electrnica (22). No existe \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 evidencia de multiplicacin neural en los sitios de penetracin del virus. \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 Despus de un periodo de latencia de duracin variable, segn la \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 cepa de virus{\fs17 y} otros factores{\i (vide}{\i supra,} H-2), el antgeno viral \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 reaparece, como se ha indicado, en los ganglios espinales{\fs17 de}{\fs17 donde} {\fs17 procede}{\fs17 la } \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 {\fs17 inervacin}{\fs17 al}{\fs17 sitio}{\fs17 de}{\fs17 la}{\fs17 inoculacin.}{\fs17 A}{\fs17 partir}{\fs17 de}{\fs17 este}{\fs17 momento,}{\fs17 los}{\fs17 eventos}{\fs17 se } \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 {\fs17 aceleran,}{\fs17 de}{\fs16 forma}{\fs17 que}{\fs17 algunas}{\fs17 horas} despus (48 en caso de CVS) el \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 virus ha invadido el SNC{\fs17 y} la{\fs17 muerte}{\fs17 del}{\fs17 animal}{\fs17 ocurre}{\fs17 cierto}{\fs17 tiempo } \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 {\fs17 despus.}{\fs17 La}{\fs17 invasin}{\fs17 gene}ralizada del SNC ocurre en el caso de CVS, \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 entre 96{\f10 \fs16 y} 110 horas despus de la inoculacin{\fs19 y} la muerte puede \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-237 \f20 \fs18 \cf0 \fi64 sobrevenir entre las 130{\f10 \fs16 y} 168 horas despus de la inoculacin (8). \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-236 \f20 \fs18 \cf0 \fi64 Con virus de calle, \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-240 \f20 \fs18 \cf0 \fi20 {\fs17 el}{\fs17 tiempo}{\fs17 de}{\fs17 localizacin}{\fs17 del}{\fs17 virus}{\fs17 en}{\fs17 ganglios}{\fs17 espinales}{\fs17 es}{\fs17 alrede}dor de \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-222 \f20 \fs18 \cf0 \fi20 las 120 horas post-inoculacin{\f10 \fs15 y} la invasin de todo el sistema \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-223 \f20 \fs18 \cf0 \fi20 nervioso central ha ocurrido para las 192 horas (12). La{\fs16 muerte}{\fs17 de} {\fs17 los } \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-223 \f20 \fs18 \cf0 \fi20 {\fs17 animales}{\fs17 inoculados}{\fs17 con}{\fs17 virus}{\fs17 de}{\fs17 calle}{\fs17 ocurre}{\fs17 a}{\fs17 partir} de las 210 horas. \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-303 \f20 \fs18 \cf0 \fi301 {\fs17 La}{\fs17 forma}{\fs17 de}{\fs17 invasin}{\fs17 del}{\fs16 sistema-} {\fs16 nervioso}{\fs16 central}{\fs17 y}{\fs17 la}{\fs16 distribu}{\fs17 cin} {\fs17 final}{\fs17 de } \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-215 \f20 \fs18 \cf0 {\fs17 virus}{\fs17 en}{\fs17 el}{\fs17 animal,}{\fs16 varan}{\fs17 considerablemente}{\fs17 de}{\fs17 acuer}do a la va de entrada \par}{\phpg\posx1425\pvpg\posy4483\absw6591\absh6583 \sl-214 \f20 \fs18 \cf0 de la infeccin. \par } \sect\sectd\pard\plain \pgwsxn9180\pghsxn12980 {\phpg\posx0\pvpg\posy0\absw9180\absh12980 \overlay {\*\shppict {\pict\jpegblip\picw459 \pich649 \picwgoal9180 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28a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a 28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a 0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a002 8a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a2 8a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0 028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028 a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28 a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a00 28a28a0028a28a00ffd9 }}\par}{\phpg\posx3456\pvpg\posy1821\absw1803\absh129 \b \f20 \fs11 \cf0 \b \f20 \fs11 \cf0 PATOGENIA DE LA RABIA \par } {\phpg\posx7250\pvpg\posy1698\absw245\absh209 \f20 \fs19 \cf0 \f20 \fs19 \cf0 79 \par } {\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \f20 \fs17 \cf0 \f20 \fs17 \cf0 1. {\i Efecto}{\i de}{\i la}{\i va}{\i de}{\i entrada}{\i del}{\i virus}{\i rbico}{\i sobre}{\i la}{\i patognesis } \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-243 \par\f20 \fs17 \cf0 La penetracin del virus rbico en las extremidades posteriores, ya sea en el \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 cojinete plantar o intramuscular, independientemente del hecho de que mate a \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 menos animales que por otros sitios de entrada ms cercanos{\i \fs18 al} encfalo, \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 causa una distribucin final diferente (8, 12). La inoculacin intraplantar \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 posterior causa una infeccin ascendente postero anterior, como podra \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 esperarse de un ascenso gradual del virus. El ttulo del virus en cada uno \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 de los segmentos del SNC infectados aumenta con el tiempo y los titulas \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 ms altos de virus se encuentran en el encfalo y el mesencfaIo principal4 \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 mente (12). Ocurre que as lesiones patolgicas no siguen necesariamente \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 el titulo del virus. En el tipo de infeccin que se discute, el mayor ttulo de \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 virus ocurre en el encfalo, pero la lesin ms vieja se localiza en la mdula \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 lumbar, Examinando diferentes secciones del SNC por medio de \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 inmunofIuorescencia, se observa que las neuronas de la porcin lumbar de la \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 mdula espinal y de los glanglios espinales lumbares ipisilaterales al sitio de \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 inoculacin muestran un mayor acmulo de ,material fluorescente que las \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 porciones torcica o cervical de la mdula o que el encfalo. El encfalo \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 muestra acumulas muy numerosos pero pequeos de material fluorescente, \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 sobre todo localizado en el cuerpo estriado{\fs18 y} el asta de Amn, ambas estructuras \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 del piso de los ventrculos laterales (12). Los cambios patolgicos y las \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 reacciones tisulares siguen estrechamente esta distribucin de material \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 fluorescente (23). \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 \fi387 Podra pensarse que la multiplicacin enceflica del virus rbico despus de \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 \fi79 la inoculacin intracerebral, seguira ms o menos el camino abierto por la \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 \fi79 puncin de la aguja. En realidad el virus inoculado no se distribuye en el \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 \fi79 sitio de la inoculacin. Si se inoculan ratones con tinta china por va \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 \fi79 intracerebral, se observar que la distnbucin de partculas de carbn no sigue \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 \fi79 en absoluto al camino de la aguja sino que perfunde el cerebro bandolo por \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 \fi79 toda la corteza desde los espacios subdurales y aracnoideos (12). Es vlido \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 \fi79 asumir que el virus de rabia perfunde de manera 'similar el cerebro de los \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 \fi79 animales inoculados. Basta recordar que la cavidad craneana no tiene espacios \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 \fi79 huecos. El encfalo, meninges, lquido cefalorraqudeo (LCR) y vasos \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 \fi79 enceflicos ocupan todo el espacio disponible. Lo nico que puede ser \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 \fi79 desalojado de la cavidad craneana en el momento de la inoculacin \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 \fi79 intracerebral es un pequeo volumen de sangre venosa que sale rpidamente al \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 \fi79 aumentar la presin intracraneana{\fs18 y} un poco de LOR. Si el volumen de inculo \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-236 \f20 \fs17 \cf0 \fi79 es excesivo, puede causar severos daos enceflicos y la muerte del animal. \par}{\phpg\posx1431\pvpg\posy2243\absw6178\absh8305 \sl-237 \f20 \fs17 \cf0 \fi79 El volumen de 0.03 mi que se \par } \sect\sectd\pard\plain \pgwsxn9180\pghsxn12980 {\phpg\posx0\pvpg\posy0\absw9180\absh12980 \overlay {\*\shppict {\pict\jpegblip\picw459 \pich649 \picwgoal9180 \pichgoal12980 \picscalex135 \picscaley135 ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101010 10101010101010101010101010101010101010101010101010101010101010101010101010101010101 010101010101ffdb0043010101010101010101010101010101010101010101010101010101010101010 1010101010101010101010101010101010101010101010101010101010101010101ffc0001108028901 cb03012200021101031101ffc4001f00000105010101010101000000000000000001020304050607080 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028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028 a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28 a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a00 28a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a 28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a 0028a28a0028a28a0028a28a0028a28a0028a28 a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a00 28a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a 28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a 0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a002 8a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a2 8a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0 028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028 a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28 a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a00 28a28a0028a28a00ffd9 }}\par}{\phpg\posx1627\pvpg\posy1710\absw316\absh213 \f30 \fs19 \cf0 \f30 \fs19 \cf0 80 \par } {\phpg\posx3434\pvpg\posy1755\absw2160\absh190 \f20 \fs11 \cf0 \f20 \fs11 \cf0 CIENCIA VETERINARIA{\f10 \fs17 2-1978 }\par } {\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \f20 \fs17 \cf0 \fi158 \f20 \fs17 \cf0 inocula en ratones de 21 das es casi el lmite mximo de volumen que \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi158 puede inocularse por esta va en ratones (12). Despus de la inoculacin \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi158 intracerebral el virus permanece en la corteza cerebral por{\fs18 cuatro} {\fs18 horas } \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi158 {\fs18 aproximadamente}{\fs19 y}{\fs18 despus}{\fs18 desaparece.}{\fs18 Con} {\fs18 virus}{\fs18 fijo,} dos das despus de \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi158 la inoculacin se encuentran neuronas infectadas en la corteza cerebral. La \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi158 infeccin aparece simultneamente en ambos hemisferios cerebrales{\fs18 y } \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi158 procede en forma descendente{\fs18 y} caudal hasta el momento de ocurrir la \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi158 muerte (12). \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-258 \f20 \fs17 \cf0 \fi387 La infeccin por instilacin nasal o por aerosol no va seguida de una \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 localizacin rpida del virus rbico. El antgeno viral es localizado en la \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 pituitaria nasal al cuarto da postinfeccin y se encuentra en el cerebro al \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 quinto da, El camino que sigue el virus desde la nariz{\fs18 hasta} {\fs18 el}{\fs18 cerebro } \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 {\fs18 no}{\fs18 es}{\fs18 conocido.}{\fs18 Se}{\fs18 supone}{\fs18 que} {\fs18 avanza}{\fs18 por}{\fs18 va}{\fs18 de}{\fs18 los} nervios olfatorios, \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 pero no est demostrado. Faltara investigar la susceptibilidad, por esta va, \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 de animales privados quirrgicamente del bulbo olfatorio, a fin de \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 incriminar en forma ms confable al primer par craneano como ruta de \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 entrada del vrus (12). \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-258 \f20 \fs17 \cf0 \fi387 Una vez que el virus se ha localizado en el encfalo, procede a \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 diseminarse caudalmente en forma ms o menos rpida. La infeccin por \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 aerosol fue reportada originalmente, por Constantine (3) en Frio Cave,
Texas. Colocando animales susceptibles en las cuevas, en jaulas de \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 diferente diseo, observ que los animales expuestos moran tanto en \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 jaulas abiertas en las que los murcilagos podan morderlos, como en \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 jaulas en las que podran penetrar slo los insectos. Lo ms sorprendente \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 fue que{\i \fs19 los} animales experimentales murieron aun cuando se les coloc en \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 jaulas en las que slo poda entrar el aire (3). La dosis de exposicin \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 permanece desconocida ya que por una parte no se ha logrado aislar el \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 virus del aire,{\f10 \fs16 y} por otra han muerto zorras despus de slo 12 horas de \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 permanencia en las cuevas infectadas (3). \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-259 \f20 \fs17 \cf0 \fi387 La inoculacin intramuscular arroja resultados de invasin del{\fs18 SNC } \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 diferentes, segn la masa muscular inoculada. La inoculacin en el tren \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 posterior muestra un esquema de invasin anteroposterior del SNC similar \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 al observado con la inoculacin del cojinete plantar. La inoculacin en los \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 msculos maseteros, por otra parte, representa un esquema diferente de \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 ascenso. El primer siti de multiplicacin viral en el sistema nervioso es el \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 ganglio estrellado del mismo lado que el sitio de la inoculacin, dos a tres \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-237 \f20 \fs17 \cf0 \fi43 das despus de sta. El istmo enceflico{\f10 \fs16 y} despus el cerebro, cerebelo{\f10 \fs16 y } \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 \fi43 mdula oblonga Se infectan en los das subsecuentes (12). \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-259 \f20 \fs17 \cf0 \fi302 La infeccin por va intravenosa es quiz la forma ms rara de \par}{\phpg\posx1418\pvpg\posy2240\absw6321\absh8796 \sl-236 \f20 \fs17 \cf0 transmisin en la naturaleza, si es que alguna vez llega a ocurrir. Los
animales son susceptibles a grandes dosis de virus por esta va. Despus \par } \sect\sectd\pard\plain \pgwsxn9180\pghsxn12980 {\phpg\posx0\pvpg\posy0\absw9180\absh12980 \overlay {\*\shppict {\pict\jpegblip\picw459 \pich649 \picwgoal9180 \pichgoal12980 \picscalex135 \picscaley135 ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101010 10101010101010101010101010101010101010101010101010101010101010101010101010101010101 010101010101ffdb0043010101010101010101010101010101010101010101010101010101010101010 1010101010101010101010101010101010101010101010101010101010101010101ffc0001108028901 cb03012200021101031101ffc4001f00000105010101010101000000000000000001020304050607080 90a0bffc400b5100002010303020403050504040000017d010203000411051221314106135161072271 14328191a1082342b1c11552d1f02433627282090a161718191a25262728292a3435363738393a43444 5464748494a535455565758595a636465666768696a737475767778797a838485868788898a92939495 969798999aa2a3a4a5a6a7a8a9aab2b3b4b5b6b7b8b9bac2c3c4c5c6c7c8c9cad2d3d4d5d6d7d8d9dae 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28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a 0028a28a0028a28a0028a28a0028a28a0028a28 a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a00 28a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a 28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a 0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a002 8a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a2 8a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0 028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028 a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28 a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a00 28a28a0028a28a00ffd9 }}\par}{\phpg\posx6988\pvpg\posy1689\absw281\absh218 \f20 \fs19 \cf0 \f20 \fs19 \cf0 81 \par } {\phpg\posx3268\pvpg\posy1856\absw1830\absh139 \f20 \fs12 \cf0 \f20 \fs12 \cf0 PATOGENIA DE LA RABIA \par } {\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \f20 \fs17 \cf0 \f20 \fs17 \cf0 de la inoculacin intravenosa, la enfermedad presenta un largo periodo \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-253 \f20 \fs17 \cf0 de incubaci6n (hasta 144 horas para Flury) y despus se infecta todo el \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-251 \f20 \fs17 \cf0 SNC en forma sincronizada. Los sitios de mayor localizacin viral son el \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-251 \f20 \fs17 \cf0 bulbo y los pednculos cerebrales e istmo del encfalo (8, 12). La \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-251 \f20 \fs17 \cf0 infecci6n por va endovenosa no va precedida de multiplicacin viral o \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-251 \f20 \fs17 \cf0 localizacin antignica en el endotelio vascular del encfalo, indicando \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-251 \f20 \fs17 \cf0 que quiz el virus penetra directamente por las terminaciones nerviosaS \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-251 \f20 \fs17 \cf0 vasculares (8). \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-246 \f20 \fs17 \cf0 \fi351 La infeccin por va oral ocurre en ratones como consecuencia de \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 consumo de un encfalo infectado, y an esto, en caso de algunas cepas \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-244 \f20 \fs17 \cf0 \fi43 de virus, solamente (24). Las cepas de murcilago tienden a ser mejores \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 para transmitirse por va oral. Baer (8) encontr que los zorrillos son \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 susceptibles por esta va a cepas de murcilago. Esto es un hecho que \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-244 \f20 \fs17 \cf0 \fi43 reviste importancia epidemiolgica en virtud de que los zorrillos \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 acostumbran entrar a las cuevas para alimentarse de murcilagos (8). El \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 virus es detectable primeramente como antgeno inmunofluorescente en \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-244 \f20 \fs17 \cf0 \fi43 la mucosa lingual, bucal, esofgica, gstrica e intestinal sin que ello \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 indique otra cosa que la posible adherencia de antgeno viral a las \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 superficies del tracto digestivo. Aparentemente la penetracin oral ocurre \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-244 \f20 \fs17 \cf0 \fi43 realmente a travs de las terminaciones nerviosas papilares{\f10 \fs15 y} celulares \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 epiteliales de la lengua y carrillos. La infecci6n ocurre temprano en la
cavidad oral (3 das){\f10 \fs15 y} de ah procede al sistema nervioso central, \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-244 \f20 \fs17 \cf0 \fi43 probablemente por va de los nervios linguales. La infeccin del encfalo \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 asemeja estrechamente otras invasiones extraneurales en que las \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-243 \f20 \fs17 \cf0 \fi43 principales estructuras afectadas son las estructuras basales del encfalo \par}{\phpg\posx1418\pvpg\posy2293\absw6064\absh5732 \sl-244 \f20 \fs17 \cf0 \fi43 (8). \par } {\phpg\posx1548\pvpg\posy8909\absw158\absh188 \i \f20 \fs17 \cf0 \i \f20 \fs17 \cf0 2. \par } {\phpg\posx1870\pvpg\posy8909\absw5703\absh543 \i \f20 \fs17 \cf0 \i \f20 \fs17 \cf0 Efecto de la reaccin individual sobre la patognesis \par}{\phpg\posx1870\pvpg\posy8909\absw5703\absh543 \sl-196 \par\i \f20 \fs17 \cf0 {\i0 Quiz}{\i0 una}{\i0 de}{\i0 las}{\i0 principales}{\i0 razones}{\i0 por}{\i0 la}{\i0 que}{\i0 algunos}{\i0 animales}{\i0 no }\par } {\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \f20 \fs17 \cf0 \f20 \fs17 \cf0 mueren de rabia despus de la inoculacin en extremidades posteriores, \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-236 \f20 \fs17 \cf0 sea la respuesta individual. Algunos animales son capaces de montar una \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-237 \f20 \fs17 \cf0 respuesta inmune bastante rpida y en un momento dado pueden \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-236 \f20 \fs17 \cf0 eliminar la enfermedad antes de que tenga oportunidad de penetrar el \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-237 \f20 \fs17 \cf0 SNC en donde se vuelve inaccesible, por lo menos temporalmente, a los \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-236 \f20 \fs17 \cf0 anticuerpos. La infeccin por va respiratoria, en aerosol con cepas de \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-237 \f20 \fs17 \cf0 murcilago, ocurre en un periodo prodrmico de slo 12 horas, seguido \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-236 \f20 \fs17 \cf0 rpidamente de la muerte, lo que se considera tpico de las cepas de \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-237 \f20 \fs17 \cf0 murcilago en zorras por esta va de exposicin (25). La va respiratoria \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-236 \f20 \fs17 \cf0 ha servido para detectar diferencias finas en la susceptibilidad de la zorra \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-237 \f20 \fs17 \cf0 roja en comparacin con la zorra gris, cosa que no se haba notado en la \par}{\phpg\posx1569\pvpg\posy9540\absw6008\absh2534 \sl-236 \f20 \fs17 \cf0 inoculacin intramuscular o \par } \sect\sectd\pard\plain \pgwsxn9180\pghsxn12980 {\phpg\posx0\pvpg\posy0\absw9180\absh12980 \overlay {\*\shppict {\pict\jpegblip\picw459 \pich649 \picwgoal9180 \pichgoal12980 \picscalex135 \picscaley135 ffd8ffe000104a46494600010100000100010000ffdb004300010101010101010101010101010101010 10101010101010101010101010101010101010101010101010101010101010101010101010101010101 010101010101ffdb0043010101010101010101010101010101010101010101010101010101010101010 1010101010101010101010101010101010101010101010101010101010101010101ffc0001108028901 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8a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0 028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028 a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28 a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a0028a28a00 28a28a0028a28a00ffd9 }}\par}{\phpg\posx1648\pvpg\posy1691\absw281\absh201 \f10 \fs18 \cf0 \f10 \fs18 \cf0 82 \par } {\phpg\posx3470\pvpg\posy1768\absw2293\absh209 \f20 \fs13 \cf0 \f20 \fs13 \cf0 CIENCIA VETEJUNARIA{\fs19 2-1978 }\par } {\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \f20 \fs17 \cf0 \fi108 \f20 \fs17 \cf0 subcutnea de estos animales (25). No todos los animales se han estudiado \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-236 \f20 \fs17 \cf0 \fi108 por referencia a la susceptibilidad por aerosol pero bien pudieran \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-236 \f20 \fs17 \cf0 \fi108 encontrarse diferencias similares alas ya mencionadas (25). \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-253 \par\f20 \fs17 \cf0 \fi1093 IV. Infectividad{\fs18 y} patogenicidad; efecto en el{\fs18 sistema } \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-236 \f20 \fs17 \cf0 \fi2563 {\fs18 nervioso}{\fs18 central } \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-249 \par\f20 \fs17 \cf0 \fi410 La infectividad, definida como la capacidad de invasin de clulas y \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 tejidos, puede diferenciarse de la patogenicidad, definida como la \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 capacidad de causar enfermedad. \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-273 \f20 \fs17 \cf0 \fi410 Estas dos caractersticas de el virus de la rabia no necesariamente \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-222 \f20 \fs17 \cf0 \fi72 evolucionan en forma paralela. La seleccin hacia una{\dn006 \fs10 ti} otra caracterstica \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 puede dar como resultado final o bien una cepa vacunal (alta infectividad \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 sin patogenicidad) o un virus fijo (alta patogenicidad con infectividad \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 disminuida) (3). \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-266 \par\f20 \fs17 \cf0 \fi135 {\fs18 1.}{\i \fs18 Cambios}{\i \fs18 patolgicos } \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-271 \par\f20 \fs17 \cf0 \fi410 Uno de los aspectos ms notables de la infeccin rbica, en la \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-222 \f20 \fs17 \cf0 \fi72 mayora de los casos, es la ausencia casi total de reaccin inflamatoria. \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-273 \f20 \fs17 \cf0 \fi410 La reaccin glial{\f10 \fs16 y} neuronofaga, si bien se han descrito, son ms bien \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 raras en rabia (26). El virus fijo causa una invasin rnultifocal. Se sabe \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-222 \f20 \fs17 \cf0 \fi72 desde hace tiempo que las cepas de virus fijo de rabia no son muy \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 negrignicas{\fs18 (12).} Sin embargo, al microscopio electrnico, resulta \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 evidente que estas estructuras) m1lchas veces no identificable5 en el \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 microscopio ptico como corpsculos de Negri por su morfologa poco \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 caracterstica{\f10 \fs16 y} por la ausencia de grnulos intracorpuscuIares, son matrices \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 virales caractersticas y aparentemente forman el corpsculo de Negri por \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-222 \f20 \fs17 \cf0 \fi72 coalescencia de varias de estas estructuras agranulares que de esta forma
adquiere{\i grnulos} constituidos por ribosomas citoplsmicos atrapados entre \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 las matrices virales en coalescencia (27, 28). La infeccin del sistema \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 nervioso central con virus fijo causa una degeneracin neuronal rpida, \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 seguida de muerte en corto plazo. Generalmente en el cerebelo no se \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-223 \f20 \fs17 \cf0 \fi72 observan grandes cambios morfologicos (26). \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-291 \f20 \fs17 \cf0 \fi315 En el caso de virus de cabe, aparentemente lo que ocurre es que el \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-236 \f20 \fs17 \cf0 periodo de incubacin es ms largo, lo cual da lugar a que los cambias
\par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-237 \f20 \fs17 \cf0 sean
ms lentos{\f10 \fs15 y} observables, as ,como para un mayor desarrollo de \par}{\phpg\posx1418\pvpg\posy2276\absw6286\absh8747 \sl-236 \f20 \fs17 \cf0 corpsculos de Negri) desde que su desarrollo est en funcin del tiempo
merosos grnulos intracorpusculares, que a diferencia de los producidos \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-236 \f20 \fs17 \cf0 \fi165 por virus de calle estn formados por estructuras membranosas conte-
niendo numerosos' viriones asociados a los corpsculos{\f10 \fs16 y} en divertculos \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-236 \f20 \fs17 \cf0 \fi165 del retculo endoplsmico. \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-279 \f20 \fs17 \cf0 En el SNC se encuentran afectadas en forma casi exclusiva las neuronas sin \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 afectarse las clulas gliales, ependimaIes y meningeas. Slo ocasionalmente
\par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 se
encuentran algunos astrocitos infectados por el virus rbico (12, 26). La
neurona soporta el crecimiento viral en el pe. rikaryon alrededor del ncleo \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 {\f10 \fs16 y} ms tarde pueden encontrarse matrices virales secundarias en dendritas{\f10 \fs16 y } \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 el{\fs16 axon.} La situacin del virus rbico en las neuronas semeja la relacin \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-244 \f20 \fs17 \cf0 endosimbitica que ocurre en cultivos celulares (12, 29). A diferencia de la \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 situacin de las clulas en cultivos en que existe una gran cantidad de \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 espacios libres, el sistema nervioso carece de espacias. Al microscopio \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-244 \f20 \fs17 \cf0 ptico parece verse una gran cantidad de espacios libres que en el \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 microscopio electrnico revelan estar densamente poblados de \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 interdigitaciones celulares entrelazadas (27, 28). Bajo estas circunstancias
\par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-244 \f20 \fs17 \cf0 no se
observa la maduracin viral en la membrana plasmtica y slo ocurre \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 en la vecindad de las matrices virales, semejando de manera bastante
cercana lo que ocurre en estadios tardos del ciclo del virus en clulas en \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-244 \f20 \fs17 \cf0 cultivo (29). Un hecho un tanto desconcertante es que las matrices virales \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 del virus fijo contienen pocas partculas virales asociadas a ellas (ver figuras \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 3{\f10 \fs16 y} 4) en tanto que el cerebro contiene altos ttulos de virus{\fs18 10'.'} DL50 o \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-244 \f20 \fs17 \cf0 ms{\i \f10 \fs18 Iml).} El virus de calle, por otra parte contiene una gran cantidad de \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 partculas asociadas a las neuronas infectadas, pero bajo titulo (alrededor de \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 {\fs18 10'.'} DL,0 mI). Si bien esta es una observacin un tanto sorprendente a \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-244 \f20 \fs17 \cf0 primera vista, cabe hacer notar que Matsumoto (26) nota un gran nmero de \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 estructuras virales aberrantes en las neuronas, lo cual es comparable a lo \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 observado en la fase de maduracin intracitoplsmica del virus (29) en \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-244 \f20 \fs17 \cf0 cultivo celular. La diferencia cualitativa de la negrigenesis entre CVS y
de calle sera ms o menos la que se observa entre las matrices \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 tempranas{\f10 \fs16 y} las tardas en cultivos celulares{\f10 \fs16 y} por tanto la diferencia sera. \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-244 \f20 \fs17 \cf0 slo funcin de tiempo, explicable por la diferencia en los tiempos de \par}{\phpg\posx1418\pvpg\posy2161\absw6243\absh8307 \sl-243 \f20 \fs17 \cf0 incubacin producido por los diferentes virus (27, 28). Con las cepas de