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Iglesias - Ligsay
HPI
3 weeks PTA- Bloody nipple discharge, Palpable mass on the right breast
No other associated symptoms.
Case
PG, 41 year old, nulligravid, at 10 weeks gestational age, presents with bloody
nipple discharge and a palpable mass on her right breast of three weeks duration.
There were no other associated symptoms.
She has no family history of breast cancer and denies any use of alcohol,
cigarettes, or intravenous drugs.
Menarche was at 11 years of age. She has regular menstrual periods and denies ever
using oral contraceptive pills.
OB history is unremarkable.
PE: Normal vital signs, BMI of 34.1. There was a firm, non-tender mass
SURGICAL ONCOLOGY
Lancero - Ledesma
GQ #2: If you plan to do surgery, what type of surgical procedure is best for the
patient?
Pregnancy-Associated Breast Cancer, Keyser et.al ,Rev Obstet Gynecol. 2012; 5(2):
94–99. PMCID: PMC3410508
MRI has not yet been prospectively studied for the diagnosis of breast masses in
pregnant or lactating women. The use of gadolinium during pregnancy is not widely
accepted. Gadolinium has been shown to cross the placenta and be associated with
fetal abnormalities in animal models
ULTRASOUND
routine imaging method during pregnancy
used to distinguish between cystic and solid breast masses and does not carry with
it any risk for fetal radiation exposure
It is usually used before mammography to evaluate a palpable lump
MAMMOGRAPHY
should be ordered in pregnancy with proper abdominal shielding. Radiation exposure
for the fetus is estimated at 0.4 cGy
According to the American Cancer Society, it's fairly safe to have a mammogram when
you're pregnant.
BIOPSY
Any clinically suspicious mass should be biopsied, even if the ultrasound and
mammogram are nondiagnostic. Fine needle aspirate (FNA) in the pregnant breast is a
well-established technique
BREAST MRI
According to the U.S. Food and Drug Administration, the safety of magnetic
resonance imaging (MRI) during pregnancy hasn't been established.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753540/
MRI has not yet been prospectively studied for the diagnosis of breast masses in
pregnant or lactating women. The use of gadolinium during pregnancy is not widely
accepted. Gadolinium has been shown to cross the placenta and be associated with
fetal abnormalities in animal models
Bone scanning and pelvic X-ray computed tomography are not recommended because of
the possible effect of irradiation on the fetus.- In women who are not pregnant, X-
ray computed tomography (CT) and isotope bone scan are the preferred methods of
investigation to establish or exclude metastases.These methods are not appropriate
in women who are pregnant, in whom chest X-ray and liver ultrasound are preferred.
If there is concern about bone involvement, a plain film of the relevant area
and/or magnetic resonance imaging to minimise radiation exposure to the fetus is
suggested.
OBSTETRICS
Legaspi - Ligsay
Most series report a lower frequency of estrogen receptor (ER) and progesterone
receptor (PR) expression in pregnancy-associated breast cancer compared to breast
cancer in nonpregnant patients (approximately 25 versus 55 to 60 percent). It is
thought that high levels of circulating steroid hormones during pregnancy may
interfere with ligand-binding assays or down regulate estrogen receptors found in
neoplastic cells and thus immunohistochemistry should be used for assessing tumour
receptor status.
Ultrasound
Fetal heart rate, fetal growth, amniotic fluid volume and fetal activity
Maternal BP, weight, other vitals signs (HR, Temperature, RR)
Lab tests such as CBC, Urinalysis, FBS
Symptoms (Bleeding, headache, altered vision, abdominal pain, nausea and vomiting,
dyspnea)
Risks are dependent primarily on fetal age at exposure and most agents are
potentially detrimental when given on the first trimester of pregnancy
Chemotherapy in the 1st trimester:
Antimetabolites (methotrexate) and alkylating agents (cyclophosphamide) associated
with miscarriage and malformations
When pregnant women with early breast cancer needs chemotherapy after surgery
(adjuvant), it’s usually delayed until at least the second trimester
Chemotherapy in 2nd and 3rd trimesters:
NO increase risk in risk of malformation
Anthracycline based treatments
Chemotherapy should not be given after 35 weeks of pregnancy or within 3 weeks it
can lower the mother’s blood count
MEDICAL ONCOLOGY
Kinoshita - Lacson, JM
Surgery vs Chemotherapy
Our patient is 41 years old, nulligravid, at 10 weeks age of gestation. According
to the NCCN Guideline of the breast cancer management in the pregnancy, patient who
is confirmed to have breast cancer diagnosis (in our case it is confirmed by core
needle biopsy as invasive ductal carcinoma) without distant metastasis (our patient
has mass at the right axilla, but it is considered as regional metastasis and other
imaging showed no masses), and at 1st trimester, termination of the pregnancy is
discussed. If the patient wishes to continue her pregnancy, then the primary
treatment is surgical resection by modified radical mastectomy. Axillary lymph node
dissection is recommended in all invasive ductal carcinoma where nodal involvement
is high. Breast surgery is is done safely in all trimesters with negligible risk to
fetus.
After the primary treatment by surgery, patient may begin the adjuvant treatment by
chemotherapy starting 2nd trimester and/or radiation therapy or endocrine therapy
postpartum.
Anthracycline-‐containing (Doxorubicin)
Taxane-‐containing (Paclitaxel)
Chemotherapy
Chemotherapy
Chemotherapy often improves long-‐term maternal outcomes however there are several
fetal concerns which we should consider. The considerations are:
• Malformations
• Growth restrictions
• Mental retardation
• Risk of future malignancies
Chemotherapy often improves long-‐term maternal outcomes however there are several
fetal concerns which we should consider. The considerations are:
• Malformations
• Growth restrictions
• Mental retardation
• Risk of future malignancies
Chemotherapy
• Risks are dependent primarily on fetal age at exposure and most agents are
potentially detrimental when given on the first trimester of pregnancy
• When a pregnant woman with early breast cancer needs chemo after surgery
(adjuvant chemo), it’s usually delayed until at least the second trimester
• Chemotherapy should not be given after 35weeks of pregnancy or within 3 weeks of
delivery because it can lower the mother’s blood counts
Staging of Breast Cancer
PATHOLOGY
Iglesias - Javier
Breast Lesions
BENIGN
MALIGNANT
Smooth, rubbery
Often painful
Well-defined
Easily moves under skin
Skin dimpling unlikely
May have green/yellow coloured nipple discharge
No nipple retraction
Hard consistency
Painless (pain in 1/100)
Irregular edge
Fixation to skin or chest wall
Can cause dimpling of the skin
May have unilateral, bloody nipple discharge
Can have nipple retraction
Fibrocystic changes accounts for most of the signs observed in benign tumors.
A general lumpiness that can be described as “ropy” or “granular,” these lumps are
the most commonly seen benign breast condition, affecting at least half of all
women. Other symptoms include tenderness, fibrous, rubbery tissue; a thickening of
tissue; or a round, fluid-filled cyst. These changes, related to hormone
fluctuation, may increase as you approach middle age and then disappear with
menopause.
Sometimes women experience nipple discharge with or without a breast lump. The
color of nipple discharge related to benign fibrocystic changes can vary from
yellow to green. A clear to milky discharge may mean a hormonal malfunction. Green-
black discharge could be related to duct ectasia, a narrowing or blockage of the
duct. It can even be bloody in appearance, which can, in fact, mean cancer. More
than likely though, a red discharge means injury, infection, or a benign tumor.
Each of these are scored from 1-3 and then each score is added to give a final
total score ranging from 3-9.
Nuclear Grading
Score 1
Nuclei small with little increase in size, regular outlines, uniform nuclear
chromatin, little variation in size
Score 2
Cells larger than normal with open vesicular nuclei, visible nucleoli, and moderate
variability in both size and shape
Score 3
Vesicular nuclei, often with prominent nucleoli, exhibiting marked variation in
size and shape, occasionally with very large and bizarre forms
Grading of Breast Cancer
http://pathology.jhu.edu/breast/grade.php
http://www.breastpathology.info/Grading.html
Nuclear Grading is the evaluation of the size and shape of the nucleus in the tumor
cells.
https://www.cancer.gov/about-cancer/diagnosis-staging/prognosis/tumor-grade-fact-
sheet
There are 3 scores
Score 1 is
Score 2 is
Score 3 is …..
Mitotic Grading
Score 1
less than or equal to 7 mitoses per 10 HPF
Score 2
8-14 mitoses per 10 HPF
Score 3
equal to or greater than 15 mitoses per 10 HPF
Grading of Breast Cancer
http://tvmouse.ucdavis.edu/bcancercd/311/images/MitoticCounts.html
http://pathology.jhu.edu/breast/grade.php
(deo)Mitotic grading is as follows:
RADIOLOGY
Jurilla - King, R
“Breast Imaging Reporting & Data System” developed by American College of Radiology
in 1993 - standardized classification for mammographic studies
Risk assessment and quality assurance tool to make the reporting of mammograms
comprehensible to the non-radiologist reading the report
BIRADS
Eberl, M. M., Fox, C. H., Edge, S. B., Carter, C. A., & Mahoney, M. C. (2006). BI-
RADS Classification for Management of Abnormal Mammograms. The Journal of the
American Board of Family Medicine,19(2), 161-164. doi:10.3122/jabfm.19.2.161
Table presents BI-RADS classifications and management recommendations as an
evidence table
Classifications are divided into assessments (categories 0, 1, 2, 3, 4, 5, 6)
Possible outcomes: (1) additional imaging studies, (2) routine interval
mammography, (3) short-term follow-up, and (4) biopsy
All categories reflect the radiologist’s level of suspicion for malignancy, and
these assessment categories have been shown to be correlated with the likelihood of
malignancy
Mammography
Normal
BI-RADS 4B
Burivong, W., Amornvithayacharn., O. 2011. Accuracy of subcategories A, B, C in BI-
RADS 4 lesions by combined mammography and breast ultrasound findings. Journal of
Medicine and Medical Sciences Vol. 2(3) pp. 728-733
LEFT: normal
RIGHT: BIRADS 4B: Mammogram of right breast shows a lobulated shape with indistinct
border lesion at lower inner quadrant. (The final pathology is mucinous carcinoma)
This category (BIRADS 4) is reserved for findings that do not have the classic
appearance of malignancy but are sufficiently suspicious to justify a
recommendation for biopsy.
Raza, S., Goldkamp, A., Chikarmane, S., Birdwell, R. (2010). US of Breast Masses
Categorized as BI-RADS 3, 4, and 5: Pictorial Review of Factors Influencing
Clinical Management. Radiology Society of North America
BI-RADS 4: US
INTRO:
The US lexicon includes six morphologic features of solid breast masses: shape,
orientation, margin, lesion boundary, internal echo pattern, and posterior acoustic
features. Shape is described as oval, round, or irregular; and the orientation of a
mass can be described as parallel or not parallel (often described as “taller-than-
wide” or “vertical,” which includes round). Margins. The margins of solid breast
masses on US images should be categorized as either circumscribed or
noncircumscribed. (a) Circumscribed margins (arrows) are well defined, with an
abrupt transition between the lesion and the surrounding tissue. Noncircumscribed
margins include microlobulated, indistinct, angular, and spiculated. A mass with
noncircumscribed margins should be categorized as either BI-RADS 4 or 5, with a
recommendation for biopsy.Internal echo pattern. The echo pattern, or echotexture,
of a lesion on US images is described in reference to the echo pattern of the
subcutaneous fat within the breast. The lesion (arrows) is described as hypoechoic
(a), isoechoic (b), or hyperechoic (c) relative to the fat (arrowheads). Posterior
acoustic features (Fig 4) may or may not be seen when imaging solid masses.
Posterior acoustic shadowing is a suspicious finding and may be seen in cases of
invasive carcinoma, postoperative scar, complex sclerosing lesion, or
macrocalcifications and may even be seen in patients with dense breast tissue.
RIGHT: US image of a 47-year-old woman with a vague right breast density on a
screening mammogram (not shown) shows a hypoechoic mass (arrows). Histologic
findings from core-needle biopsy disclosed ductal carcinoma in situ. Pathologic
concordance is particularly important for category 4B lesions, given that both
malignant and benign lesions can be evenly distributed in this group. Recommended
BI-RADS description is a hypoechoic irregular mass with indistinct margins, a
heterogeneous internal echo pattern, and parallel orientation: BI-RADS 4B.
BIOETHICS
Jimenez - Juan Loa
Ethical Issues
How will breast cancer affect:
Pregnancy of the mother
Should she undergo chemotherapy/radiotherapy?
What will happen to the pregnancy?
Will it affect the health of the mother?
Health of the baby
Effects of chemotherapy/radiotherapy on the baby?
Health of mother VS health of baby?
Lactation
Is it safe to breastfeed? If not, how will the baby receive sustenance for the
first months of life?
Principles Involved
Pregnant mother
Autonomy
Totality
Double effect
Mother VS unborn child
Nonmaleficence
Beneficence
Unborn child
Inviolability of life
Autonomy
Self governance
Allow the pregnant mother to make decision
Free and informed consent. It is her body.
Breast cancer
Should I undergo treatment?
Chemotherapy or Radiotherapy or Surgery?
Will it affect my pregnancy?
Pregnancy
What will be the effect of cancer treatment on my unborn child?
Priority: Treat cancer or protect pregnancy?
Best options for the mother?
Totality
Surgery: Mastectomy
The principle of totality → care for all parts of the human body (Whole > Parts)
Sacrifice a part ONLY if:
It harms the whole human body
No alternative
Removal does not destroy intrinsic nature effort to compensate
Conflicts: Breastfeeding
Double Effect
According to the principle of double effect, it is morally permissible to perform
an act that has both a good effect and bad effect if all of the following
conditions are met:
The act to be done must be good in itself or at least indifferent
The good effect must not be obtained by means of the bad effect
The bad effect must not be intended for itself, but only permitted
There must be a proportionately grave reason for permitting the bad effect
Double Effect
Mastectomy
“In the absence of metastatic disease, either a wide excision or a modified or
total mastectomy - each with axillary node staging - can be performed (Rosenkranz,
2006 & Woo, 2003)”
Breast feeding
“There are also no data indicating that lactation adversely affects the course of
previously diagnosed breast cancer. Also, lactation and breastfeeding are possible
after conservative surgery and radiation of the treated breast (Higgins, 1994)” -
William’s Obstetrics
Nonmaleficence
DO NO HARM
Chemotherapy
“Chemotherapy is usually given with either positive or negative node breast
cancers. In pre-menopausal women, survival is improved even if lymph nodes are
cancer free.”
Radiotherapy
Mammography
“Mammography is appropriate if indicated, and fetal radiation risk is negligible
with appropriate shielding.”
Pregnancy following breast cancer
“After breast cancer treatment, chemotherapy will render some women infertile, and
options for childbearing are limited (Kim, 2011)”
For those who became pregnant, there appear to be no adverse effects on long-term
maternal survival rates (Avarette, 1999 & Velentgas, 1999)”
Beneficence
DO GOOD
What’s best for BOTH the mother and the unborn child
Inviolability of life
If treatment modalities of the breast cancer affects the fetus,
“Life is sacred” (from conception to natural death)
PROTECT LIFE
Life of baby = Life of mother
Choose the best treatment option that will contribute least harm to unborn child!
“Most evidence does not suggest increased maternal survival following therapeutic
abortion” - SOGC Clinical Practice Guidelines
Ethical Considerations
ALWAYS balance maternal and fetal interests
Consider cancer type, stage, age of gestation, maternal and fetal risks
Discuss situation with pregnant patient AND family, providing all treatment
alternatives
Have a multidisciplinary team:
Family physician, hematologist and/or oncologist, OB-GYN, social worker,
psychologist, and in some cases, a religious advisor
Cancer Chemotherapy and Pregnancy, SOGC Clinical Practice Guidelines
Summary:
41yo, Female, nulligravid
Chief complain: Bloody nipple discharge
PE: Right breast mass (2cmx1.5) irregular, 2cm firm movable mass at right axilla
Workup→ Ultrasound (if suspect malignancy: Mammogram with abdominal shield)
Important to establish Benign vs Malignant, Staging, Grade, Hormonal panel
(HER2/Neu, ER, PR +/-)
Mammography, BIRADS
Management: Modified radical mastectomy
Definitive for Stage 1-3
Safe in pregnancy
Ethical principles: Autonomy, Totality, Double effect, Non-maleficence,
Beneficence, Inviolability of life
BIRADS
standardized classification for mammographic studies
Risk assessment and quality assurance tool to make the reporting of mammograms
comprehensible to the non-radiologist reading the report
ALWAYS balance maternal and fetal interests
Consider cancer type, stage, age of gestation, maternal and fetal risks
Discuss situation with pregnant patient AND family, providing all treatment
alternatives
Have a multidisciplinary team:
Family physician, hematologist and/or oncologist, OB-GYN, social worker,
psychologist, and in some cases, a religious advisor