MCQS On Protein

Metabolism

BY  Siraj Ul Islam
1. Plasma proteins are completely replaced after
a. 24 hours
b. 15 days
c. 40 days
d. 120 days

2. Which among the following favour uptake of amino acid by tissue?

a. insulin
b. testosterone
c. growth hormone
d. all of these

3. All of the following are essential amino acid EXCEPT?

a. valine
b. lysine
c. proline
d. methionine

4. Transamination is a process
a. of combined deamination and amination
b. by which nitrogen of amino acid is removed as ammonia
c. which is reversible
d. both A and C

5. Coenzyme required for transamination is

a. pyrodixal phosphate
b. FAD
c. NAD+
d. CoASH

6. Normal blood ammonia level is

a. 40-70 ug/ 100 ml
b. 80-180 ug/ 100 ml
c. 60-90 mg/ 100 ml
d. none of these

7. All of the following are related to intoxication of ammomia EXCEPT

a. blurring of vision
b. coma
c. slurring of speech
d. kidney stones

8. How many reactions are there in urea cycle?

a. 4
b. 5
c. 6
d. 7

9.Enzymes of urea cycle is/are present in

a. mitochondria
b. cytosol
c. both of these
d. none of these

10. How many ATP are consumed in urea cycle when carbamoyl phosphate is formed?
a. one
b. two
c. three
d. four

11. Urea cycle consume

a. no ATP
b. one ATP
b. Two ATP
d. three ATP

12. Carbamoyl Phosphate synthetase I occur in

a. cytosol of liver
b. mitochondria of liver
c. lysosomes
d. none of these

13. Urea cycle is linked to TCA cycle through production of

a. succinate
b. fumarate
c. citrtae
d. isocitrtate

14. In which form skeletal muscle transport ammonia into the liver cell
a. valine
b. alanine
c. glycine
d. all of these

15. Which of the following function is related to glutamine

a. conservation of Na+
b. detoxification of ammonia
c. anti tumor
d. all of these

16. Ketogenic amino acid is

a. leucine
b. lysine
c. alanine
d. serine

17. Which of the following is not related to tyrosine?

a. contract uterus
b. increase B.p
c. vasodilator
d. both a and C

18. Which of the following is best marker for tumour cell destruction?
a. spermidine
b. putrescine
c. spermine
d. none of these

19. In phenyl ketonuric patient which of the following amino acid become essential?
a. glycine
b. tyrosine
c. alanine
d. histidine

20. Metabolic role of tyrosine is

a. synthesis of T4
b. synthesis of melanin pigment
c. synthesis of catecholamines
d. all of these

21. In urea formation two nitrogen atoms are derived from

a. ammonia
b. ammonia and aspartic acid
c. ammonia and glutamine
d. alanine and aspartic acid

22. Norepinephrine is converted into epinephrine by

a. carboxylation
b. deamination
c. methylation
d. hydroxylation

23. Which of the following is vasodilator?

a. histidine
b. ornithine
c. tyrosine
d. all of these

24. Urea is synthesized in

a. liver
b. brain
c. kidney
d. spleen

25. Glycine is involved in synthesis of

a. heme
b. creatine
c. purines
d. all of these

26. phenylketonuria is due to deficiency of

a. phenyl alanine hydoxylase
b. hydroxy phenyl pyruvate deoxygenase
c. homogenastic oxidase
d. all of these

27. Hartnup`s disease is due to

a. tyrosinase
b. histidase
c. proline oxidase
d. defect in intestinal absorption

28. Homocysteine is a risk factor for

a. lung disease
b. heart disease
c. kidney disease
d. joint disease

29. Maple syrup urine disease is due to disorder of

a. aromatic amino acid
b. branched chain amino acid
c. sulphur containing amino acid
d. all of these

30. Alkaptonuria is due to deficiency of

a. homogentisate oxidase
b. phenyl pyruvate oxidase
c. hepatic transaminase
d. none of these

31. Neonatal tyrosinemia can be improved by administration of

a. vitamin B12
b. vitamin C
c. vitamin E
d. vitamin B1

32. Lipotropic agent among the following is

a. methionine
b. glycine
c. glutamine
d. arginine

33. Glutathione contains all of the following EXCEPT

a. glycine
b. leucine
c. cystine
d. glutamic acid

34. Excessive oxalate arise from

a. tyrosine
b. glycine
c. methionine
d. aspatate

35. Niacin is formed from

a. methionine
b. trypotphan
c. histidine
d. all of these

36. Nitric oxide is formed from amino acid

a. arginine
b. leucine
c. tryptophan
d. none of these

37. Maple syrup urine disease is characterized by all of the EXCEPT

a. mental retadration
b. seziure
c. poor muscle tone
d. diabetes melitus

38. Ochronsis is related to

a. alkaptonuria
b. tyrosinaemia
c. phenylketonuria
d. not realetd to any of the above
39. Which among the following is more sensitive to ammonia?
a. brain
b. blood
c. liver
d. kidney

40. Transamination take place in

a. liver
b. brain
c. kidney
d. all of these

41. Urea formation occur through

a. ornithine cycle
b. Krebs-Henseleit cycle
c. both of these
d. none of these

42. Synthesis of citrulline in urea cycle occur in

a. cytosol
b. mitochondria
c. lysosomes
d. ribosomes

43. Carbon atom is provided to urea by

a. HCO3-
b. aspartate
c. glycine
d. proline

44. Hyperammonameia is caused by deficiency of all of the following except

a. carbamomyl phosphate synthetase I
b. argininosuccinase
c. arginase
d. phenyl pyruvate oxidase

45. Clinical findings of Richnar Hanhart syndrome is

a. mental retadration
b. hypoglycemia
c. tufted hairs
d. all of these

46. Richnar Hanhart syndrome is due to deficiency of

a. fumryal acetoacetate hydrolase
b. hepatic transaminase
c. homogentisate oxidase
d. vitamin C

47. Which of the following is related to creatnuria ?

a. vitamin B12
b. vitamin A
c. vitamin D
d. vitamin E

48. Clinical finding of homocystinuria is

a. Charlie chaplan gait
b. formation of oxalate stones in kidney
c. lethargy
d. all of these

49. Speech development may be retared due to

a. histidinaemia
b. Maple syrup urine disease
c. glycinuria
d. cystinuria

50. Even slightly increased level of NH3 cause serious damage to

a. liver
b. heart
c. kidney
d. brain

51. In albinism the patient becomes

a. blue
b. black
c. white
d. brown

52. Which of the following is related to albinism?

a. skin cancers
b. photophobia
c. ataxia
d. both A and B
53. Decreased synthesis of dopamine lead to
a. hartnup`s disease
b. parkinson disease
c. phenylketonuria
d. all of these

54. Hartnup`s disease is due to deficiency of

a. glycine
b. cysteine
c. tyrosine
d. tryptophan

55. Transamination occur in

a. glutamate
b. lysine
c. tryptophan
d. both A and C

Answer Key

1.B 2.D 3.C 4.D 5.A 6.A 7.D 8.B 9.C 10.B 11.C 12.B
13.B 14.B 15.D 16.A 17.C 18.A 19.B 20.D 21.B 22.C
23.A 24.A 25.D 26.A 27.D 28.B 29.B 30.B 31.B 32.A
33.B 34.B 35.B 36.A 37.D 38.A 39.B 40.D 41.C 42.B
43.A 44.D 45.A 46.B 47.D 48.A 49.A 50.D 51.C 52.D
53.B 54.D 55.D
 MCQS On Biological
Oxidation

By  Siraj Ul Islam
1. Enzymes of Eelectron Transport Chain are embedded in
a. outer mitochondrial membrane
b. inner mitochondrial membrane
c. mitochondrial space
d. both B and C

2. Complex II in ETC is?

a. NADH-CoQ reductase
b. Cytochrome C ocidase
c. Succinate-CoQ reductase
d. none of these

3. Protons are passed in all of the following complexes in ETC EXECPT

a. complex I
b. complex II
c. complex III
d. complex IV

4. Shuttle between complex III and complex IV is

a. cytochrome c
b. cytochrome b
c. coenzyme-Q
d. all of these

5. ADP:O ratio in FADH2 is

a. zero
b. one
c. two
d. three

6.Inhibitor of Complex I in ETC is

a. retenone
b. cyanide
c. malonate
d. all of these
7. Substrate level phosphorylayion occur in
a. glycolysis
b. TCA cycle
c. Lohman reaction
d. all of these

8. Which among the following is not related to ETC?

a. FAD
b. NADP
C. coenzyme-Q
d. cytochrome a +a3

9. Oxidation of NADPH produces

a. one ATP
b. two ATP
c. three ATP
d. none of these

10. Which Complex in ETC is responsible for ATP formation?

a. complex I
b. Complex II
c. Complex IV
d. complex V

11. Malate aspartate shuttle produces

a. no ATP
b. 1 ATP
c. 2 ATP
d. 3 ATP

12. Which of the following cytochrome contains Cu?

a. cytochrome a3
b. cytochrome b
c. cytochrome c
d. none of these

13. Hydride ion is related to

a. FADH2
b. NADH
c. both of these
d. none of these

14.inner mitochondrial membrane is impermeable to

a. ADP
b. H+
c. Na+
d. all o these

15. NADH dehydrogenase has prosthetic group

a. FMN
b. NAD+
c. Fe++
d. all of these

16. Mediator of programmed cell death is

a. cytochrome a
b. cytochrome b
c. cytochrome c
d. coenzyme-Q

17. All of the following are protein except

a. coenzyme-Q
b. cytochrome b
c. succinate Q reductase
d. cytochrome a

18. Which of the following is a component of Succinate dehydrogenase in Electron transport

chain ?
a. niacin
b. FMN
c. FAD
d. coenzyme Q

19. Which of the following ETC components accepts only one electron ?
a. oxygen
b. FMN
c. FAD
d. Cytochrome b

20. MELAS is a mitochondrial disorder characterized by

a. mitochondrial encephalopathy
b.lactic acidosis
c. stroke
d. all of these

21. The standard free energy of hydrolysis of terminal phosphate group of ATP is
a. –7,300 cal/mol
b. –8,300 cal/mol
c. 10,000 cal/mol
d. +7,300 cal/mol

22. All of the following are true about Anaerobic dehydrogenase EXCEPT
a. H2O2 never formed
b. ATP is never produced
c. cannot react directley with O2
d. transfer electron to NAD+

23. Which complex of ETC reacts with oxygen ?

a. I
b. II
c. IV
D. V

Answer Key

1.B 2.C 3.B 4.A 5.C 6.A 7.D 8.B 9.C

10.D 11.C 12.A 13.B 14.D 15.A 16.C
17.A 18.D 19.C 20.D 21. 22.B 23.C