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Please cite this article in press as L. Satyanarayana and N. Sandeepthi, Formulation and Evaluation of
Atenolol Floating Microspheres, Indo Am. J. P. Sci, 2018; 05(01).
Design of Experiment
Table 1: Formulation of AtenololTartarate Floating Microsphere
Particle size
The particle size decreased from 223.2 to 97.1 μm 4%, decreases the particle size from 120.9 to 100.9
with increase in speed from 800 to 1400 rpm at 1 μm increase in the HPMC conc 2 to 4%, increases
% EC conc. And increases the particle size from the particle size from174.4 to 200.5 μm increases
130.5 to 240.6 μm with increases the EC conc 1 to the temperature 450 ,600.