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CLEANING

OF TABLET
COMPRESSION TOOLING &
EQUIPMENT
YASAR SHAIKH

INTERNATIONAL BUSINESS
DEVELOPMENT MANAGER

NATOLI ENGINEERING COMPANY


www.natoli.com
What Is Compression Equipment ?
Components responsible for compressing Tablets can be termed
as Compression Equipment

Such as…

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What Is Compression Equipment
Components responsible for compressing Tablets can be termed as Compression
Equipment
Such as…

Tablet
Compression
Tooling…

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What Is Compression Equipment
Components responsible for compressing Tablets can be termed as Compression
Equipment
Such as…

Tablet Press…

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What Is Compression Equipment
Components responsible for compressing Tablets can be termed as Compression Equipment

Contact Parts for Tablet Press

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What Is Compression Equipment
These components are mostly in contact various products that they compress, which could be
abrasive, corrosive or s9cky in nature that need to be cleaned Thoroughly & Regularly

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Impact of Unclean
Equipment ?

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Impact of Unclean Tooling

Compression tools are the most critical link in


tablet manufacturing. They can determine
•  Tablet Quality
•  Tablet Appearance
•  Tablet Size
•  Tablet Press Performance

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Impact of Unclean Tool?

Leaving product on tooling for a


period of time can lead to …

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Impact of Unclean Tool?

Corrosion & Discoloration


of tool, resulting in …

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Impact of Unclean Tool?


Defec1ve Tablet

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Impact of Unclean Tablet Press?

Tablet Press Parts in contact with product need to be


cleaned after every batch.

Parts clogged up with product for a prolonged period


of time will cause…
Contamination between Punch & Turret guides , creating
excessive heat & friction that can lead to…

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Impact of Unclean Tablet Press?

Punch tightening causing tooling and press
wear
Regular disruptions to press operation resulting
in loss of output

Tablet Defects

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Cleaning helps …

Improve equipment efficiency

Enhance equipment life

Achieve desired product quality

Minimal disrup:ons, resul:ng in op:mal
produc:on


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Cleaning Options

Understanding cleaning methods

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Cleaning OpJons & Overview
Most commonly used cleaning method at
majority tablet manufacturing facilities around
the world is…

Manual Cleaning

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Cleaning OpJons & Overview

Advantages of Manual Cleaning

Quick Fix

Low / No Cost

Minimal Training Required

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Cleaning OpJons & Overview

Disadvantages of Manual Cleaning

Inconsistency

limited access to many nooks and


crevices

Undetected product deposits continue


to cause contamination

Process that is difficult to validate

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Cleaning OpJons & Overview
age old practice cannot be changed overnight…

Adopt right process & right tools for cleaning

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Cleaning OpJons & Overview
Adopt right process & tools for cleaning

Tooling (Punch) surface could have letters or numbers


engraved that could attract product deposits.

It is recommended to clean the punch surface using


Phenolic Embossing Pick safely removes product from
punch face

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Cleaning OpJons & Overview - Solutions recommended

Alkaline Solutions: Natoli Alkaline Wash

Removes oils, greases, carbon residues,


various oxides, particulate matter, and
various other contaminants from…
•  Steels
•  Ceramics,
•  Glasses,
•  other compatible materials.

• USDA Category A1
• Ideal for cleaning tablet presses and
tooling

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Cleaning OpJons & Overview - Solutions recommended

Alkaline Solutions : CHEM-CREST® 211

Heavy-duty, biodegradable, phosphate free,


concentrated alkaline cleaner.

Effectively removes airborne contaminants, heavy oils,


greases, fingerprints, lubricants, ceramic dust, light
buffing and lapping compounds, light silicone oils and
ink

Safe on cast-iron, steel, brass, aluminum, copper,


beryllium, stainless steel, glass, plastics and ceramics

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Cleaning OpJons & Overview - Solutions recommended

Caustic Solutions:
Contain hydroxides- Great for heavy
greases.

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Cleaning OpJons & Overview - Solutions recommended

Isopropyl Alcohol:

Commonly accepted & used- Greater than 90%


Low / No Risk on any metal
Can be used on Coated or Anodized surfaces

Disadvantage : Flash Point

Alcohol can cause corrosion

Spray Alcohol on tooling/parts when


at warmer/higher temperature

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Time to Change

Why Should We Adopt Advanced Cleaning Technology?

Validate Cleaning – Validation is becoming a requirement with almost


every regulatory authority

Investment on High Priced Machinery & Components Need to be


protected

Contaminated parts cannot be allowed to impact production outputs

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Adopting to Advanced Cleaning Technology

Ultrasonic Cleaners will ensure most efficient cleaning routine for compression tooling

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Adopting to Advanced Cleaning Technology

What are Ultrasonic Cleaners?


They are stainless Steel built advanced solution, designed to clean product in 3 stages
Drying Wand

Washing Station Rinse Station Drying Station

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AdopJng to Advanced Cleaning Technology - Understanding Ultrasonic Cleaners
First Stage : Washing Station

Individual Punch & Die baskets provide ease of cleaning, handling & prevent any tool
damage

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AdopJng to Advanced Cleaning Technology - Understanding Ultrasonic Cleaners
First Stage : Washing Station

De-ionized or Purified Water is used in washing station, temperature is set at 140 F


(60C) for 10 minutes cycle, with one cup of cleaning detergent

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AdopJng to Advanced Cleaning Technology - Understanding Ultrasonic Cleaners
First Stage : Washing Station

De-ionized water has ions such as calcium & fluoride removed and replaced with
hydrogen or hydroxyl ions that reform to make pure water molecules

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AdopJng to Advanced Cleaning Technology - Understanding Ultrasonic Cleaners

First Stage : Washing Principle

Transducers produce high frequency pressure (Sound)


waves that create cavitation bubbles to agitate liquid. The
agitation produces high forces on contaminants that are
adhering to Metal, Glass, Ceramic…

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AdopJng to Advanced Cleaning Technology - Understanding Ultrasonic Cleaners
Second Stage : Rinse Station

Recommended to add rinse additive for protecting against corrosion.

Caution: Rinse additive is not recommended on Aluminum, Zinc and parts that are
coated and anodized

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AdopJng to Advanced Cleaning Technology - Understanding Ultrasonic Cleaners
Third Stage : Drying Station

Drying Unit blows hot air in to the Punch Cups

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AdopJng to Advanced Cleaning Technology - Understanding Ultrasonic Cleaners
Drying Wand
Drying wand blows air on Punch Cups and will ensure blowing off water particles from
undetected areas, with limited access for cleaning, such as Keys & innovative designs

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AdopJng to Advanced Cleaning Technology – Benefits of Ultrasonic Cleaners
Process that can be conveniently VALIDATED
Controlled Cleaning Process – Time & Temperature
Prevents Tool Damage
Ensures thorough Cleaning
Regulation Complaint … FCC / CE / CSA
Before After

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AdopJng to Advanced Cleaning Technology – Benefits of Ultrasonic Cleaners

Before After

Caution : Use of wrong solution can cause Discoloration to cloudy dark grey

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AdopJng to Advanced Cleaning Technology - Understanding Ultrasonic Cleaners
Ultrasonic Table top is a single stage solution, working on same principle

•  Uses same cleaning medium as 3


stage cleaner

•  Provides Temperature Control

•  Can set operating time

•  Cleans limited quantity of tools

•  Rinse and Drying stations excluded

•  Drying has be done manually

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AdopJng to Advanced Cleaning Technology

Irrespective of the cleaning method used,

It is important to lubricate tooling after


cleaning…

&
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AdopJng to Advanced Cleaning Technology

And before storage…

following correct storage procedure

Use Antioxidize Lubricant before storing for a


prolonged period of time

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QUESTIONS

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Thank You!

Natoli Engineering Company Inc.


28 Research Park Circle • St. Charles, MO 63304 • 636-926-8900
www.natoli.com • sales@natoli.com

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