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Acute Fatty Liver of Pregnancy
Marshall M. Kaplan, M.D.
N Engl J Med 1985; 313:367370 August 8, 1985 DOI: 10.1056/NEJM198508083130606
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FIGURE 1
ACUTE fatty liver of pregnancy is a potentially fatal, uncommon
disorder that may complicate the third trimester of pregnancy. If
unrecognized or untreated, the disorder may progress to fulminant
hepatic failure with jaundice, encephalopathy, disseminated
intravascular coagulation, uncontrollable gastrointestinal and uterine
bleeding, and death. Until the late 1970s the disease had a dismal
Liver Specimen from a
prognosis, with fetal and maternal mortality rates as high as 85 per Patient with Acute
cent.1 , 2 Early recognition of the disorder, rapid termination of Fatty Liver of
Pregnancy.
pregnancy once the diagnosis has been made, and intensive
FIGURE 2
supportive treatment have brightened the outlook considerably. Fetal
and maternal mortality rates are now as low as . . .
Supported by a Research Grant (AM28490) from the U.S. Public Health Service Oil Red O Staining of a
and a Research Training Grant (AM07024) from the National Institutes of Health. FreshFrozen Liver
Specimen from a
Patient with Acute
Fatty Liver of
SOURCE INFORMATION Pregnancy.
From the Division of Gastroenterology, Department of Medicine, New England
Medical Center Hospitals, 171 Harrison Ave., Boston, MA 02111, where reprint ARTICLE ACTIVITY
requests should be addressed. 95 articles have cited
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