SURFACE proteoglycans
Attached to the surface of many types of cells,
particularly epithelial cells.
Ex. syndecan and fibroglycan
GLYCOPROTEIN
Medical significance:
KELOID – abnormal amount of collagen fibers
formed in the scars of the skin.
Systemic SCLEROSIS – excessive accumulation of
collagen in skin, digestive tract, kidneys – hardened
and dysfunctional impairment of organs affected
(fibrosis).
Vitamin C deficiency (SCURVY) – hydroxylation of
prolyl and lysyl residues (AAs) in the endoplasmic
reticulum can be inhibited, producing defective
collagen (non-reversible) – DEGENERATION of
connective tissue.
Vit. C is a COFACTOR of proline hydroxylase.