Pathophysiology of Schizophrenia

Modifiable Risk Factor Non-modifiable Risk Factor

- Environment - Age
- Stress - Sex
- Substance Abuse - Biological
- Complications of Pregnancy and Birth - Genetics

Dopamine Serotonin Glutamate

Activity in the Activity in the Mediates Level

mesolimbic mesocortical dopamine level
pathway pathway Cognitive
Regulation of N- Symptoms
Positive methy-D-Aspartate
Positive Negative Symptom (NMDA) Mood
Symptom Symptom s Symptoms
s s
Cognitive Perceptual
Thought and Mood Motor
Disturbance Disturbance
language disturbances behavior
v alterations disturbance
Alterations Alterations Hallucinations
Reduced
in thought in form of emotional Physical
content thought Impaired disturbances
Anergia
sensory
Loose Poor Eye
Bizarre Delusions Contact Blunt
association Physical
Behavior affect
Avolition Anergia
Agitated Flight of
unpredict- Ideas Anhedonia
Poverty of
able
Poverty speech
behavior Social
of
withdrawal
Repetitive/ content
v
stereotyped
behavior Social
Isolation

Religious Persecutory Grandiose NihilisticD Ideas of Somatic

Delusions Delusions
Delusions elusions reference Delusions