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Pathophysiology of Schizophrenia

Modifiable Risk Non-modifiable Risk


Factor Factor
- Environment - Age

- Stress - Sex

- Substance Abuse - Biological

- Complications of Pregnancy and Birth - Genetics

Dopamin Serotoni Glutamat


e n e
Activity in Activity in Mediates Level
the the dopamine
mesolimbic mesocortica level
Regulation of Cognitive
pathway l pathway
Positive N-methy-D- Symptom
s
Positive Negativ Sympto Aspartate Mood
Sympto e ms (NMDA) Symptom
ms Sympto s

Cognitive Perceptu
Disturban al Thought Mood Motor
ces Disturban and disturbanc behavior
v language es disturban
Alteration Alteration Hallucinati
alterations Reduced ce
ons
s in s in form emotional Physica
thought of thought Impair disturbance
l
s
content ed Anergi
Loose Poor
Bizarre Delusio sensor Blunt
associati Eye
Behavio ns affec Physic
on Contact
r Avolitio t al
Agitated Flight
n Anergia
unpredic of Anhedonia
Ideas Poverty
t-able
Poverty of
behavior Social
of speech
withdraw
content
Repetitiv al
v
e/
stereotyp Social
ed Isolation

Religiou Persecuto Grandios Nihilisti Ideas of Somatic


ryDelusio eDelusio
s cDelusi referen Delusio
ns ns