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a b s t r a c t
Keywords: Purpose: The purpose of our study was to investigate the effects of Kinesio Taping® Application with
Kinesio Taping® application Complex Decongestive Therapy (CDT) in patients with lymphedema.
Lymphedema
Materials and Methods: 45 patients were randomly divided into 3 groups (CDT including Bandage, CDT
Complex decongestive therapy
Breast cancer
including Bandage þ Kinesio Tape®, CDT including Kinesio Tape® without bandage). Assessments
Exercise included the severity of the symptoms such as pain, discomfort, heaviness, tension, stiffness and
weakness. Bilateral circumference measurements were done for evaluation of the edema.
Results: Symptoms were decreased in all three groups (p < 0.05). CDT was found effective only during
treatment in arm volume (p < 0.05). Kinesio Taping® applied with CDT had effect of decreasing edema
after 10 days of treatment period (p < 0.05) and for control period (p < 0.05). Only the application of
Kinesio Taping® group also had significant decrease at edema (p < 0.05).
Conclusion: Kinesio Taping® Application along with CDT may have a better effect on decreasing lym-
phedema which can stimulate the reduction of edema for long term effects.
© 2014 Elsevier Ltd. All rights reserved.
http://dx.doi.org/10.1016/j.ejon.2014.06.010
1462-3889/© 2014 Elsevier Ltd. All rights reserved.
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suitable bland emollient. General advice should be given to patients to all patients. Patients were also instructed to continue their ex-
on observing their skin (Williams, 2006). ercises at home. All patients were assessed by an experienced
Exercise is the other important component of the CDT. Lymph physiotherapist and the treatments were done by another educated
flow can be enhanced by activities such as walking, arterial pulsa- lymphedema therapist in order to provide single blind structure of
tion, arteriolar vasomotion, intestinal peristalsis, muscle move- the study.
ment, exercise, massage or respiration. Exercise is a general The patients were randomly assigned to the one of the three
provider of all enhancing activities (Shim et al., 2003) and exercises groups using an online random allocation software program
may facilitate venous and lymphatic flow (Hayes et al., 2009; Ya- (GraphPad Software QuickCalcs, GraphPad Software Inc., La Jolla,
Hui et al., 2012). Kim et al. (2010) stated that for the treatment of California, USA).
patients with breast cancererelated lymphedema, active resistive
exercise with complex decongestive therapy did not cause addi-
Participants
tional swelling, and it significantly reduced proximal arm volume
and helped improve quality of life (Kim et al., 2010).
Forty five patients who admitted to Başkent University Hospital,
Compression bandaging made with short stretch bandages is
Ankara, Turkey with the complaints of edema, pain, limitations in
also one of the major components of CDT. King et al. (2012) re-
daily living activities, discomfort, heaviness, tension, stiffness,
ported that within the initial treatment phase of a CDT protocol for
numbness and were diagnosed with grade 2 and 3 lymphedema
acquired, breast cancer-related lymphedema, compression
participated in the study. Participants were included if they had
bandaging may lead to greater volume reduction but worse upper
post-mastectomy upper extremity lymphedema. All participants
extremity functional status (higher Disability of Arm and Shoulder
had infiltrating ductal carcinoma as cancer type. None of the pa-
Questionnaire scores) as compared to compression garments (King
tients had limited shoulder range of motion. 45 patients were
et al., 2012). A multilayer bandage can only be stretched a little
divided into 3 groups randomly but the groups did not show ho-
and is usually used to maintain the volume reduction from manual
mogeneity according to the sociodemographic characteristics
lymphatic drainage by the help of exercise. It provides mild
except Body Mass Index (BMI) and time since surgery. Time since
pressure during resting and creates higher pressure during muscle
surgery was between 6 and 8 years and statistically homogeny
contraction to prevent skin extension. The lymphatics are com-
between groups (p ¼ 0.483). All patients had received a pharma-
pressed between the muscle and the bandage, causing them to be
cologic treatment of Chemotherapy or Chemotherapy þ
manually pumped. The variable pressure over the skin created by
Radiotherapy but had developed lymphedema in 6e8 years.
muscle contraction is identical to the effect obtained after a
Exclusion criteria for this study were if subject; a) had grade 1 or 4
massage, which increases the lymph flow. The bandage should be
lympedema, b) had cardiac and kidney problems, c) had an allergy
kept on as long as possible, even during the night (Tsai et al.,
to adhesive tape, d) had acute infection in any part of their body, e)
2009).
had malign metastasis to any organs, f) orthopedic problems
In lymphedema management, Kinesio Taping® Lymphatic
affecting upper extremity.
Correction Method is also used to assist the removal of edema by
directing fluid towards a less congested lymphatic pathway and
lymph node. This is accomplished by the lift effect and elasticity of Assessments
Kinesio Taping® material. The lifting of superficial skin decreases
pressure and opens initial lymphatics, while the tape also creates a Patients were assessed before, at the end of the treatment
massaging action during active motion. This effect is very impor- (10th day) and at control period (1 month after the end of
tant especially in patients with sensitive skin to pressure. The effect treatment). Assessments included the severity of the
of Kinesio Taping® on muscle also improves the efficiency of the lymphedema-related symptoms such as pain, limitations in daily
deeper lymphatics by allowing maximum contraction and relaxa- living activities, discomfort, heaviness, tension, stiffness and
tion of a muscle (Kase et al., 2003). numbness which were evaluated by Visual Analog Scale (VAS).
According to the literature there are lots of studies those VAS is a 10 cm line with no marks along them, anchored with the
investigating the effects of CDT in lympedema treatment (Shim words “no pain” on one hand, and “the most severe pain” on the
et al., 2003; Szuba et al., 2000; Tsai et al., 2009; Ya-Hui et al., other. Participants were simply instructed to place a mark along
2012) however there is no randomized controlled study compared the line at a level representing the intensity of their pain,
the effects of CDT, CDT plus Kinesio Tape® and CDT without discomfort, heaviness, tension, stiffness and numbness, limita-
bandage (skin care þ MLD þ exercise) plus Kinesio Tape® in lym- tions of daily living activities. Also patient satisfaction during
pedema treatment after mastectomy. night and daily living from the treatment, itching and wound
formation caused by treatment were assessed with VAS at the
Materials and methods end of treatment (Tsai et al., 2009).
For the evaluation of volume reduction, circumferential mea-
Research design surements in centimeters on bilateral upper extremities at 5 cm
intervals from wrist to axilla were used. These circumference
The study protocol was approved by the Hacettepe University measurements were then used to calculate the volume of the arms
Ethics Committee (HEK 12/227-16), and all participants provided with Frustum Formula (Kaulesar Sukul et al., 1993).
written consent. 45 patients with grade 2 and 3 lymphedema were In addition, quality of life was evaluated by Short-Form 36 (SF-
randomly divided into 3 groups. The CDT including MLD, 36). The SF-36, developed by Ware and Sherbourne (1992), consists
compression bandage skin care and theurapeutic exercises were of a multi-item scale which assesses eight health concepts each
applied to the first group. In the second group, CDT was combined between 2 and 10 questions: physical functioning (PF), role limi-
with Kinesio Taping® Lymphatic Correction Technique. This lymph tations due to physical problems (RP), bodily pain (BP), general
technique was applied to the skin under the compression health perception (GH), vitality (VT), social functioning (SF), role
bandaging. In the third group CDT without bandaging was com- limitations due to emotional problems (RE), and mental health
bined with and Kinesio Taping® Lymphatic Correction Technique. (MH). Lower scores describe limitations in quality of life (Ware and
After 10 treatment sessions, compression garments were provided Sherbourne, 1992).
€ Pekyavaş et al. / European Journal of Oncology Nursing 18 (2014) 585e590
N.O. 587
Treatments
Table 1
Sociodemographic characteristics of participants.
*p < 0.05.
BMI: Body Mass Index.
MRM: Modified Radical Mastectomy.
AD: Axillary Dissection.
PM: Partial Mastectomy.
RM: Radical Mastectomy.
*p < 0.05.
a
Kruskal Wallis Test.
b
ChieSquare Test.
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Table 2
The mean differences in arm volume. pain. lymphedema-related symptoms and SF-36 score parameters between three groups.
Baseline Values BT-AT X ± SE (pb) AT-C X ± SE (pb) BT-C X ± SE (pb) Baseline Values BT-AT X ± SE (pb)
(X ± SE) (X ± SE)
Lymphedema 921.15 ± 629.21 313.90 ± 111.58 (.023*) 44.48 ± 64.76 (1.00) 358.38 ± 108.22 (.052) 1303.67 ± 987.54 373.29 ± 115.79 (.008*)
Volume (ml)
Pain (cm) 1.92 ± 2.26 .78 ± .53 (.449) .64 ± .60 (.884) 1.42 ± .57 (.053) 2.57 ± 3.14 1.00 ± .55 (.237)
Limitations of daily 3.25 ± 2.45 1.14 ± .73 (.387) 1.25 ± .45 (.029*) 2.39 ± .69 (.004*) 2.76 ± 2.71 1.53 ± .76 (.154)
living activities (cm)
Discomfort (cm) 5.35 ± 4.04 2.03 ± .70 (.018*) 1.82 ± .97 (.209) 3.85 ± 1.00 (.001*) 3.88 ± 3.81 1.50 ± .72 (.137)
Heaviness (cm) 3.64 ± 3.31 1.89 ± .64 (.016*) .60 ± .33 (.228) 2.50 ± .72 (.004*) 3.38 ± 3.42 1.96 ± .66 (.017*)
Tension (cm) 3.21 ± 3.36 1.85 ± .72 (.045*) .35 ± .28 (.670) 2.21 ± .77 (.022*) 3.00 ± 3.72 1.34 ± .75 (.249)
Stiffness (cm) 3.68 ± 3.51 1.86 ± .86 (.110) .35 ± .28 (.641) 2.22 ± .92 (.063) 3.80 ± 3.77 2.34 ± .89 (.037*)
Numbness (cm) 1.60 ± 2.58 .57 ± .34 (.328) .89 ± .47 (.195) .32 ± .36 (1.00) 1.46 ± 1.94 .42 ± .36 (.748)
SF-36.p 48.11 ± 9.78 2.54 ± 1.05 (.062) .00 ± .00 2.54 ± 1.05 (.062) 44.54 ± 9.20 .05 ± 1.09 (1.00)
SF-36.m 41.23 ± 11.66 3.71 ± 1.41 (.037*) .00 ± .00 3.71 ± 1.41 (.037*) 48.15 ± 9.13 3.80 ± 1.46 (.040*)
Results It could be said that CDT plus Kinesio Tape® application brings
longevity to the effect of lymphedema treatment. The reason for
The power analysis indicated that 15 participants for each group this may be that Kinesio Taping® Lymphatic Correction Method
were needed with 80% power and a 5% type 1 error. The power creates channeling at lymphatic circulation by lifting the epidermis
analysis of our study showed a power of 80% with discomfort as the and increasing the volume of dermis which contains lymphatic
primary outcome. vessels and compression of bandage creates press effect on the
Forty five patients with the mean age of 49.6 ± 10.5 years and extracellular fluid (Kase et al., 2003). Tsai et al. (2009) studied about
the mean body mass index of 29.9 ± 4.7 kg/m2 participated in this Kinesio Taping® in patients with lymphedema and has recruited
study. Sociodemographic characteristics of participants are shown forty-one patients with unilateral breast-cancer-related lymphe-
in Table 1. The flow-chart in Fig. 2 shows allocation of patients to dema who were randomly into two groups as CDT and modified
treatment groups. The differences between the bilateral arm vol- CDT. Skin care, 30-min manual lymphatic drainage, 1-h pneumatic
ume estimates based on Frustum model and pain, lymphedema- compression therapy, application of a short-stretch bandage or
related symptoms and quality of life scores of three groups are Kinesio Tape® for each group, and a 20-min physical therapy ex-
presented in Table 2. No significant difference was found between ercise were given during every treatment session. Patient evalua-
three groups in all measurement parameters as pain, limitations in tion items included physical therapy assessment, limb size, and
daily living activities, discomfort, heaviness, stiffness and numb- water composition of the upper extremity, lymphedema-related
ness, quality of life (p > 0.05), but significant difference was found symptoms, quality of life, and patients' acceptance to the bandage
between time factors in all groups (p < 0.05). Participants' re- or tape. They stated that Kinesio Tape® could replace the bandage in
sponses to the bandage or Kinesio Tape® after treatment are shown CDT and could be an alternative for patients with breast-cancer-
in Table 3. No significant difference was found between three related lymphedema who had poor compliance with the bandage.
groups in all measurement parameters as patient satisfaction from They also stated that within the groups, patients in both groups
the treatment at night and daily activities, itching and wound for- experienced improvement in some of the outcome variables which
mation at the end of treatment (p > 0.05). is parallel to our findings (Tsai et al., 2009). As we investigate the
mean differences between the volumes of bilateral arms, Kinesio
Tape® application along with CDT has made the highest improve-
Discussion ment compared to other groups. This could be explained as Kinesio
Tape® Lymphatic Correction Method Application has made the
In this study we investigated the effects of CDT, CDT plus Kinesio channeling and compression bandaging had the extra effect of
Tape® and CDT without bandage (skin care þ MLD þ exercise) plus pumping the fluid away from the affected area.
Kinesio Tape® in lymphedema treatment after mastectomy and The abnormal sensation of heaviness is also found to be
found similar effects on decreasing lymphedema and symptoms decreased in all groups with treatment and at control period
and increasing quality of life. because of the decreased amount of fluid at subcutaneous tissue.
In comparison of the three application methods at the param- There are many studies investigating the effects of CDT and
eter of arm volume, compression bandaging along CDT and CDT treatment sessions are at the range of 3e26 days long (Holtgrefe,
without bandage plus Kinesio Tape® groups only had a decreasing 2006; Liao et al., 2004; Szuba et al., 2000; Yamamoto and
effect during treatment period but Kinesio Taping® applied under Yamamoto, 2000). In our study, the treatment period was chosen
compression bandaging had a decreasing effect both during the as 10 days because the patients could visit the clinic for 10 days paid
treatment and at the control period of 4 weeks. by social insurance. Having treatment for only 10 days could be a
€ Pekyavaş et al. / European Journal of Oncology Nursing 18 (2014) 585e590
N.O. 589
AT-C X ± SE (pb) BT-C X ± SE (pb) Baseline Values BT-AT X ± SE (pb) AT-C X ± SE (pb) BT-C X ± SE (pb)
(X ± SE)
174.64 ± 67.21 (.040*) 547.94 ± 112.31 (.000*) 983.72 ± 821.06 358.21 ± 111.58 (.008*) 20.83 ± 64.76 (1.00) 379.04 ± 108.22 (.010*) .308
.84 ± .62 (.557) 1.84 ± .59 (.011*) 3.28 ± 2.46 1.42 ± .53 (.033*) 1.14 ± .60 (.199) 2.57 ± .57 (.000*) .723
.46 ± .47 (1.00) 2.00 ± .72 (.026*) 5.03 ± 3.05 2.64 ± .73 (.003*) 1.21 ± .45 (.035*) 3.85 ± .69 (.000*) .252
1.03 ± 1.01 (.934) 2.53 ± 1.03 (.058) 6.75 ± 3.16 3.42 ± .70 (.000*) 1.92 ± .97 (.166) 5.35 ± 1.00 (.000*) .291
.65 ± .34 (.198) 2.61 ± .75 (.004*) 5.46 ± 2.89 3.64 ± .64 (.000*) .35 ± .33 (.871) 4.00 ± .72 (.000*) .202
.46 ± .29 (.394) 1.80 ± .80 (.094) 4.57 ± 3.90 2.96 ± .72 (.001*) .32 ± .28 (.816) 3.28 ± .77 (.000*) .383
.84 ± .29 (.019*) 3.19 ± .95 (.006*) 5.87 ± 3.73 3.95 ± .86 (.000*) .50 ± .28 (.254) 4.45 ± .92 (.000*) .234
.57 ± .48 (.732) 1.00 ± .37 (.034*) 3.64 ± 3.41 .14 ± .34 (1.00) .92 ± .36 (.043*) .78 ± .47 (.308) .466
.00 ± .00 .05 ± 1.09 (1.00) 41.01 ± 10.67 .55 ± 1.05 (1.00) .00 ± .00 .55 ± 1.05 (1.00) .230
.00 ± .00 3.80 ± 1.46 (.040*) 47.77 ± 10.27 .80 ± 1.41 (1.00) .00 ± .00 .80 ± 1.41 (1.00) .249
Table 3
Participants' responses to the bandage or Kinesio tape after treatment.
Patient satisfaction from the treatment at night (cm) 6.66 ± 4.35 3.33 ± 4.74 7.06 ± 4.44 .139 3.946
Patient satisfaction from the treatment at daily living (cm) 6.33 ± 4.16 4.50 ± 4.88 6.90 ± 3.71 .716 .668
Itching (cm) 5.80 ± 4.07 5.66 ± 3.35 5.13 ± 3.20 .831 .369
Wound formation caused by treatment (cm) 3.80 ± 4.26 2.90 ± 2.30 3.83 ± 4.03 .978 .045
stimulant for the lymphatic circulation as the treatment could be The cost of materials of the bandage application (group 1) and
longer to see better effects. Kinesio Tape® application (group 3) were similar in 10 days treat-
Many researchers discussed the various physiological symptoms ment period. The treatment of Kinesio Tape® application along with
of lymphedema. Williams et al. (2002) used 11 lymphedema- compression bandaging doubles the cost of the materials. If the
related symptoms such as sensations of pain, discomfort, heavi- treatment period was extended to more than 10 days, the cost of
ness, fullness, bursting, hardness, heat, cold, numbness, weakness Kinesio Tape® would be higher than bandage application because
and tingling to evaluate the effects of intervention (Williams et al., Kinesio Tape® is a one-time use product, but the bandage can be
2002). In our findings the intensity of pain at the effected arm had reused. A cost effectiveness analysis might be considered in clinical
significant decrease with Kinesio Tape® applications in Group 2 and practice. The time-cost of Kinesio Tape® application is better than
3, Kinesio Tape® has the effect of lifting the skin with creating compression bandaging treatment. Kinesio Tape® application is
convolutions which enlarges the area of dermis and inhibits the faster and pre-cut tapes can be found in order to decrease the time
free nerve endings (Kase et al., 2003; Tsai et al., 2009). spent. However we have to remain in mind that Kinesio Tape® can
Different application techniques of Kinesio Tape® is said to have make an allergic reactions in sensitive skins.
physiological effects including decreasing pain or abnormal The limitation of the study is that patients may not have done
sensation, supporting the movement of muscles, removing the exercises at home or may not have worn the compression
congestion of lymphatic fluid or hemorrhages under the skin, and garments properly during the control period and this could effect
correcting misalignment of joints (Tsai et al., 2009). our findings.
According to Tsai et al. (2009), during the intervention period,
participants in the bandage group frequently complained that
wearing a bandage was very inconvenient, and it served as a Conclusion
reminder to them that they were sick and handicapped. After
substituting a compression garment for the bandage in the follow- Kinesio Taping® applied with CDT (skin care þ MLD þ
up period, they might feel much better. On the contrary, for patients compression bandaging þ exercise) may have positive effect on
in the tape group, they had to wear a compression garment instead decreasing the symptoms related to lymphedema. Also It might be
of the relatively more comfortable Kinesio Tape®. This might cause said that CDT plus Kinesio Tape® application brings longevity to the
them to feel uncomfortable (Tsai et al., 2009). In contrast in our effect of lymphedema treatment. We may recommend this method
study, we have seen that all treatment groups have a very positive as an alternative technique in the treatment of suitable lymphe-
effect on lymphedema-related limitations in daily living activities. dema patients. Further research may be needed with larger sample
SF-36 scoring is divided into two parameters including SF-36.p sizes.
for physical parameters such as physical functioning (PF), role limi-
tations due to physical problems (RP), bodily pain (BP), general Conflict of interest
health perception (GH) and SF-36.m for mental parameters such as
vitality (VT), social functioning (SF), role limitations due to emotional None declared.
problems (RE), and mental health (MH) (http://www.sf-36.org/
demos/SF-36.html) (last accessed: 11.02.2014). SF-36.m scores of
group 1 and 2 are found to be increased at treatment and control Role of the funding source
periods. This could mean that compression bandage used in CDT has
a positive effect on patient mentality for the effect of treatment. None declared.
590 € Pekyavaş et al. / European Journal of Oncology Nursing 18 (2014) 585e590
N.O.
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