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S1212 Bendamustine Hydrochloride (877)796-6397
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+1-713-796-9816
Technical Data:
O
Orders
M.Wt: 394.72 OH +1-713-922-4115
Formula: C16H21Cl2N3O2.HCl N
enquiry@selleckchem.com
Solubility: Unknown Cl
N N
Purity: 99% Tech Support
HCl tech@selleckchem.com
Storage: at -20℃ 2 years Cl
(chemistry support)
CAS No.: 3543-75-7 Synonyms: Ribomustin, Treanda, SDX-105 techbio@selleckchem.com
(bio support)

Web
Biological Activity
www.selleckchem.com
Bendamustine is a nitrogen mustard used in the treatment of chronic lymphocytic leukemias (CLL) and
lymphomas. It is also being studied for the treatment of sarcoma.[1] Betamustine acts as an alkylating
agent causing intra-strand and inter-strand cross-links between DNA bases. Bendamustine may differ
from other alkylators in that it may be more potent in activating p53-dependent stress pathways and
inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair
pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more
Selleck Overnight Delivery Service
efficacious and less susceptible to drug resistance than other alkylators.[2] This agent inhibited SU-DHL-1
cell proliferation with IC50 at 50 μm. [3]

References
Return Policy
[1] http://en.wikipedia.org/wiki/Bendamustine
Please inspect packages immediately upon
[2] http://www.cancer.gov/drugdictionary/?CdrID=350251 receipt and notify customer service within

[3] Lorenzo M. Leoni et al. Clin Cancer Res.2008 January 1;14:309-317 3 days of delivery of any damage or

discrepancies.Our team will take quick and

[4] http://www.rxlist.com/treanda-drug.htm
appropriate action to correct any problem.

MSDS & CoA Goods ordered in error can only be accepted

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are in good condition. Should you wish to

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Notes be received from our customer service team.

Returns accepted will be subject to a 30%

restocking charge.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.

NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. For all product returns and product replace-

ments,please contact Selleck directly by

Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under info@selleckchem.com or
the recommended conditions, are stable for two year. Products are sometimes shipped at a temperature that differs from the recommended +1-713-922-4115.
storage temperature,most are recommended stored at -20℃.Many products are stable in the short-term at temperatures that differ from that Please have on hand, the invoice number,
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save purchase order number,air bill number and
you shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage approximate date of shipment/receipt.
recommendations on the product data sheet.

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