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Damaged beta cells = decrease insulin insulin less effective to stimulate glucose uptake
by the tissue
Unchecked glucose Glucose from food cannot be stored in Inability of glucose to cross cellular membrane to
production in the liver the liver be use for energy
Increase glucose in the blood stream = hyperglycemia Stimulation of hunger center due to
less glucose. = polyphagia
Increase blood viscosity leading to arthrosclerosis of the
vessels Fat breakdown for energy = wasting of
lean body mass leading to wt. loss
EYES HEART
Damage to the decrease blood supply = base Fat metabolism in the liver = ketone formation
membrane of the retina ISCHEMIA and accumulation in the blood leading to
Diabetic Ketoacidosis
Decrease blood supply
Respiratory system compensates to metabolic acidosis = kausmaull’s
= DIABETIC RETINOPHATY BLINDNESS
breathing and acetone breathe
Kidneys cannot reabsorb all the filtered glucose in the
blood
Glycoprotein cell wall deposits
Increase osmotic pressure = execration of large
amount of body fluids leading to POLYURIA and
GLYCOSURIA
Dehydration occurs
Diabetic neuropathy Small vessel disease Accelerated atherosclerosis Impaired immune function