Index
A cG~P
Acetylcholine (ACh) 104, 109, 110, 137, 138
Actin 1-12,23,24,34,37,39,56-58,67-70,
83-85,90,95,97,98,138,139,148
Actin filaments and associated proteins 2
Adhesion 5, 10, 17,36,38-40,44,45, 55-57,
59,68,69,75,95-98,100,134,136,
144,146-149,151-153,160
Astroeytic gliosis 44
Axon growth 5, 11, 12,23,36,40,42, 50,
58,81,83,84,87,88,90,95-98,100,
101, 123-125
Axon guidance 17-19,21,22,25,26,32,
38-40,43,44,50,52,58,68,72,73,75,
76,81,83,85-87,90,95,99,100,106,
10~ 116, 117, 120, 123, 125, 126, 128,
130, 131, 134, 136, 138, 139, 141, 142,
144, 149, 152, 153, 156, 157, 159-164
Axonalpathfinding 7, 108, 116
Axonal regeneration 6,9-12,75,164
B 135, 137, 139, 141, 142, 144, 146, 153,
Brain-derived neurotrophic factor (BDNF)
82-87,89,90,137,138,148,150,151
Bone morphogenic protein 116, 117
Branching 4,9,12,21,37,41,43,44,65,73,
81,82, 87-90
c 121, 123, 126, 129, 131, 138, 157,
Caenorhabditis elegans (C elegans) 17-19,
21-24,32,67,69,72,74,96,123,125,
157, 163
~p 7,11,25,26,70,71,85,86,99,109,
112, 123, 124, 134-142
Cell adhesion molecule 68, 95, 148, 160
Cell migration 17,26,32,35,37-39,44, 50,
52, 58,69,74,95, 104, 107, 111, 148,
151-153,162
Central nervoussystem (CNS) 10,11,17,18,
21,22,26,36,40,44,65,72-75,82,
107, 123, 126, 142, 156, 159-163
Cerebralcortex 22, 100, 107, 109
59,71,112,123,134-138,140-142
cG~P-dependentprotein kinase 136, 137
Chemoaffinityhypothesis 40
Cholesterol 144, 145, 146, 149, 150
Ciliary neurotrophic factor (CNTF) 83
cis-interaction 36
Clutch 97, 98
Commissuralneuron 17,18,25,71,85,118,
120, 121, 123, 125-127, 138
Commissure 22,23,40,71-73, 120, 123,
126, 127, 130, 161, 162
Cross-talk 1, 12,99, 149
Cyclicnucleotide 7,25,71,86, 109, 112,
123, 124, 134-138, 140-142
Cytoskeletonreorganization 10, 58
D
Development 1,4-6,10-12,17-19,22,25,
26,32,38-45, 50- 52, 67, 73-75, 81-83,
95,96,100,104,104-109,112,116,
117, 120, 121, 123, 125, 126, 128, 134,
157, 159, 164
Differentiation 44,45,74,75,82,84, 85,
104,111,117,123,146,157,159,160,
163, 164
Directionalsteering 152, 153
Dopamine 22,52,82,104, 106, 107
Drosophila 19,38, 56,58,65-69,71-75,96,
159-161, 163, 164
E
EGFR 159, 160, 163
Endocytosis 25,35,36,39,72,96,145,147
Ephrin 7,32,33-45,58,81,88, 106, 116,
129-131, 134, 149
Extracellular cues 1,5,7-9,11, 144, 149
F
Floor plate 17-19,22,72,75,99,117,118,
120, 121, 123, 130
Forwardsignalling 35
168
G N
G-aminobutyric acid (GABA) 104, 107,
110-112
Glial cellline-derived neurotrophic factor
(GDNF) 82,83,85,87-90, 146, 147
Glia 10, 18,22,26,40,44, 52,65,72-75,82,
83,87,96,104,108,111,146,156,157,
159-164
Glutamate 104,107,108,110,111,150,151
Growth cone 1-12,23,25,34-36,39,40,42,
44,50-52,57-59,65,70,71,83-87,90,
97-100, 104-112, 121, 123-127, 130,
131, 134, 135, 137, 138, 140-142, 144,
148-153,156,157,159-162
Guidance 1,4,6,7,9,11,12,17-19,21-23,
25,26,32,38-44,50,52,58,59,68,
71-73,75,76,81,83,85-88,90,95,96,
99-101,104-109, 111, 112, 116-118,
120,121, 123-131, 134-139, 141, 142,
144,149-153, 156, 157, 159-164
Guidance signal 106,108,109,111,123,
128,141,144,149,151,153
H o
rIedgehog 116,117,120,123,157,162,163
Homology 19,25,52,53,56,65,69, 110,
149
I
Interstitial branching 41
L Peripheral nervous system 10, 36, 51, 142,
Ll 55,5~95-100, 148, 151, 160
Lipid raft 44,97, 144-153
M 125, 136-142
Membrane microdomain 36,97,144-147,
153
Microtubule 1,2,4-9, 12,34, 58, 83, 84, 90,
139, 147, 148, 160
Midline 17-19,22,23,40,99,100,117,118,
120-128, 157, 159, 161-163
Migration 32,35,37-39,44, 50, 52, 58, 95,
99,100,104,107,111,123,124,148,
151-153,156,157,159-164
Molecular motor 2, 5, 9
Morphogen 116-121,130, 131, 157
Axon Growth and Guidance
N-CAM 160
Nervegrowth factor (NGF) 73,81-90,147
Nervoussystem 17,22,25,32,36,39,40,
44,104,107,109-112,116,117,126,
134, 135, 137, 142, 146, 156, 157, 164
Netrin 17-26, 106, 116, 118, 120, 121, 124,
125, 131, 134, 137, 138, 140, 141, 150,
151, 157, 161, 163
Neural tube 17,117,120,125,127
Neuregulin 148, 159, 160, 163, 164
Neurobiology 18
Neuroepithelium 17,19,112
Neuron 32,34,35,36,39-44,104-109,111,
112, 136-142, 144, 146, 148, 149
Neurotransmitter 104-107,109, 112, 148
Neurotrophic factor 81-90, 137, 144, 146,
148
Neurotrophin 7,56,81,82,84-90, 137, 146,
147
Neurotrophin-3 (NT-3) 82, 137, 138
Neurotrophin-4/5 (NT-4/5) 82
Oligodendrocyte 26, 52, 159
Ortholog 17,19,65,69
p
Pathfinding 5-7,72,73,81,88,90,99,100,
10~ 116, 125, 128, 134, 13~ 139, 141,
148, 156, 159, 160, 164
156
PKG 136-142
PNS 10,11,22,26,36,52,74,75,159-163
Protein kinaseA (PKA) 7, 11,25,71,84,85,
R
Raft 145-148, 150-153
Recycling 39, 58, 98
Regeneration 1,4-7,9-12,26,39,44,75,89,
104, 112, 142, 153, 164
Retina 18,22,26,35,36,40,41,58,70-72,
75,83,88,89,100,104,123,124,129,
130, 138, 141, 159, 161, 162
Retinalganglioncell 18,22,36,40, 123, 124
Reverse signaling 34, 38, 39, 42, 44
Index 169

Rho-GTPase 1,7-9,11,57,58 Survival 44,81-85,90,104,134,146,148,

Robo 65-76, 100, 157, 161, 163 156, 159, 163, 164

s T
Semaphorin 7, 50-59,71,73,76,81, 108, Topographicmap 32, 39, 40, 42, 100, 129,
131, 153, 157, 163 149
Seroronin 74,104,106,107 trans-interaction 99
Short-rangeguidance 19 Transforming growth facror (TGF) 116, 117
Signal rransduction 22, 24, 25, 34, 53, 56, TGF-~ 116,117, 119, 121, 124, 130
120,121,131, 134-136, 138, 141, 142,
144-152,157 v
Signaling 1,6-10,12,22,24,26,32,34-45,
50,52-59,67-75,81,83-86,90,95-97, \ferrebrate 10,17,19,21,22,24-26,32,39,
99,111,112,116,117,119,121,124, 50,58,65,66,69,72-75,106,107,109,
125, 127, 128, 130, 131, 136-138, 112,117,121,126,129-131,157,
140-142,144-149,151-153,157,159, 159-161,163
160, 162-164
Slit 40,65-76,81,100,108, 116, 131, 134,
138, 141, 157, 161-163
w
Sonic hedgehog 117, 157 WNT 39,116-121,123,126-131
Sphingolipids 144, 145, 146
Spinalcord 17-19,22,23,26,40,43,44,52,
72-75,83,87-89,99,100,104, 117,
118,120,121,123,125-129,131,142,
156, 161