Beruflich Dokumente
Kultur Dokumente
Thanks.
******************************************************************************
******************************************************************************
I think that one of the first threads on this new group should be a thank
you to David Bostwick who got sci.techniques.mass-spec going. Thanks Dave!
K. Murray
---------------------------------------------------------------------
Kermit K. Murray Of. 404-727-2254
Emory University Lab 404-727-6534
Department of Chemistry Fax 404-727-6586
Atlanta, GA 30322 http://tswww.cc.emory.edu/~kmurray/
kmurray@emory.edu
---------------------------------------------------------------------
******************************************************************************
******************************************************************************
Greetings to all,
I do not have a background in mass-spec but do get a few samples of
peptides and small proteins analysed by LC/MS to complement analysis by
conventional Edman chemistry in the determination of amino acid
sequenece.I usually carry out proteolytic digestion of proteins and
separate subsequent peptides by microbore LC before sequencing the
peptides.
When I have taken some of the collected peptide for LC/MS or direct
flow/MS analysis I only get about a 50% success rate in forming an ion.
One suggestion has been that I use trifluoroacetic acid(TFA) at 0.08% in
my LC solvents and this may be suppressing the ionisation and that it is
better to use formic acid.
Robin J. Philp
Institute of Molecular and Cell Biology
Singapore.
******************************************************************************
From: jbeale@reed.edu (Jay Beale)
Subject: Is there a digest yet?
Date: 13 Jun 1995 15:49:22 GMT
Organization: Reed College, Portland, Oregon
******************************************************************************
From: jbeale@reed.edu (Jay Beale)
Subject: ?: HP5971 data quality control
Date: 13 Jun 1995 22:04:06 GMT
Organization: Reed College, Portland, Oregon
Jay Beale
jbeale@reed.edu
jbeale@epitope.com
--
-Jay Beale
jbeale@reed.edu
jbeale@epitope.com (not private, limited access)
******************************************************************************
From: Heinrich Luftmann <luftman@uni-muenster.de>
Subject: TOF HV-switch
Date: 14 Jun 1995 11:15:26 GMT
Organization: Organisch Chemisches Institut d. Universitdt
--
Heinrich L.
Muenster -Germany
Heinrich
******************************************************************************
From: jbeale@reed.edu (Jay Beale)
Subject: HP 5971 for quantitation; quality control question
Date: 13 Jun 1995 16:20:31 GMT
Organization: Reed College, Portland, Oregon
I've got some questions about setting up some sort of quality control
program for our Hewlett-Packard 5971 mass spec. We've been using it to
develop methods for quantitation of drugs of abuse and are freqently
performing analyses down near the limit of quantitation. Our method
development process is based on preparing a set of standards, analyzing
them, then making changes in sample prep or data acquisition parameters
and then running another set of standards under the new conditions. We
then compare the results of the two sets of standards to decide whether
the changes produced better results. This assumes that the mass spec was
in the same condition during the two runs, in particular as far as signal
to noise ratio. Lately we've had to run some samples which dirty the
source over the timespan of one week or less, so we can no longer assume
that the machine is performing the same from one run of standards to the
next.
I've been trying to come up with a routine which we can perform which will
give us some kind of quantitative insight into the machine's condition.
We had been obtaining qualitative data by looking at the lens ramps,
particularly the repeller ramp, but this is too subjective an indication
of the source condition for our needs. I've been contemplating making up
an external standard, possibly of PFTBA in some solvent, and running that.
I'd like to be able to extract signal-to-noise information from the external
standard, and have been wondering if baseline=noise and peak height (absolute,
not height above the baseline) is = to signal. Does this make sense?
For our purposes, signal-to-noise is really the only thing we need to keep
an eye on that is not already kept track of through our tuning process.
Thanks,
Jay Beale
jbeale@reed.edu
jbeale@epitope.com
--
-Jay Beale
jbeale@reed.edu
jbeale@epitope.com (not private, limited access)
******************************************************************************
From: jbeale@reed.edu (Jay Beale)
Subject: mailing list digest?
Date: 13 Jun 1995 22:05:43 GMT
Organization: Reed College, Portland, Oregon
Jay Beale
jbeale@reed.edu
jbeale@epitope.com
--
-Jay Beale
jbeale@reed.edu
jbeale@epitope.com (not private, limited access)
******************************************************************************
From: "John Bartmess" <BARTMESS@novell.chem.utk.edu>
Organization: Univ. of Tenn. Dept. of Chemistry
Date: Wed, 14 Jun 1995 17:06:59 EST
Subject: A mailing list for STM-S
Priority: normal
SUB STMSLIST
John
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=-
| John Bartmess | Organic Chem! || my opinions, being antithetical |
| Department of Chemistry || to "big time" football, cannot |
| University of Tennessee || be those of the Univ. of Tennessee|
| Knoxville TN 37996-1600 || "Anions are more fun!" |
| (615) 974-6578 Fax: 974-3454 || |
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=--=-
******************************************************************************
From: topaz56@cyberg8t.com (BlueShift)
Subject: MALDI
Date: Wed, 14 Jun 1995 22:21:55
Organization: Cyberg8t
******************************************************************************
******************************************************************************
******************************************************************************
From: mcope@ix.netcom.com (Michael Cope)
Subject: Portable Gas Chromatograph Mass Spectrometer
Date: 14 Jun 1995 15:49:41 GMT
Organization: Netcom
NNTP-Posting-Host: ix-dfw10-28.ix.netcom.com
******************************************************************************
From: pmayer@email.unc.edu (Paul Mayer)
Subject: this years ASMS meeting
Date: 15 Jun 1995 20:05:32 GMT
Organization: The University of North Carolina at Chapel Hill
******************************************************************************
From: "Kermit K. Murray" <kmurray@emory.edu>
Subject: WWW Site for Mass Spectrometry
Date: 15 Jun 1995 23:02:37 GMT
Organization: Emory University Chemistry
http://tswww.cc.emory.edu/~kmurray/mslist.html
Kermit K. Murray
kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
From: depauw@gw.unipc.ulg.ac.be (De Pauw Edwin)
Subject: Electrospray for the monitoring of photochemical reactions
Date: Mon, 19 Jun 1995 18:50:51 +0200
Organization: Liege University
******************************************************************************
From: "kasi V. Somayajula" <kasi@speedy.cs.pitt.edu>
Subject: Long due
Date: 16 Jun 1995 19:25:32 GMT
Organization: University of Pittsburgh
Welcome to the mass spec news group. I thank all the folks at
Georgia Tech for the efforts in bringing this news group. Let us
do some PEEKING.
Kasi
--
David E. Bostwick
Georgia Institute of Technology, Atlanta, GA, 30332
david.bostwick@chemistry.gatech.edu
******************************************************************************
******************************************************************************
[Snip...]
>static, stirred reactor. The photosubstitution of chlorine in
>chlorpromazine has been choosen as a test reaction. The reaction has been
[Snip...]
>then been used to follow the addition reaction of methoxypsoralene with
>thymine and oligonucleotides.
Err, I'm guessing here, but I was under the impression that
pharmaceuticals, injested, never saw the light of day. What is the
driving force behind this research (who funded it)?
Mark gmt1810@msu.oscs.montana.edu
******************************************************************************
From: gmt1810@trex.oscs.montana.edu (Mark Tarka)
Subject: Re: no subject (file transmission)
Date: Mon, 19 Jun 1995 22:54:50
Organization: Montana State University
Gee, I hope I don't generate a lot of static about this, but wouldn't
it be a good idea to limit one's line length to 70 charaters or less,
so quotations would be readable. Folks could set that limit for their
editors (that is, the software that allows them to write messages),
using some sort of "set" command (e.g. in VMS, "set right margin 70").
Mark
Mark gmt1810@msu.oscs.montana.edu
******************************************************************************
From: jbeale@reed.edu (Jay Beale)
Subject: Digest functioning?
Date: 20 Jun 1995 21:05:20 GMT
Organization: Reed College, Portland, Oregon
-Jay Beale
jbeale@reed.edu
jbeale@epitope.com
--
-Jay Beale
jbeale@reed.edu
jbeale@epitope.com (not private, limited access)
******************************************************************************
From: "Terry L. Kaduce" <tkaduce@blue.weeg.uiowa.edu>
Subject: On Line Databases
Date: Tue, 20 Jun 1995 16:49:33 -0500
Organization: University of Iowa, Iowa City, IA, USA
Thank you
Terry L. Kaduce
University of Iowa
Dept of Biochemistry
4-555 BSB
Iowa City, IA 52242
319/335-7914
******************************************************************************
From: "Rob O'Brien" <ro@iecems.lan.nrc.ca>
Subject: Negative Chemical Ionization - Discussion/Reference text
Date: 21 Jun 1995 01:16:18 GMT
Organization: National Research Council, Canada
++++++++++++++++++++++++++++++++++++
Rob O'Brien
PHD Candidate, Carleton University
========================
Table of Contents
2. Fundamentals
2A Thermodynamics
2A.1 Electron affinity
2B Kinetics
2C Reaction Mechanisms
3. Instrumentation
3A Ion Source requirements
3A.1 Measurement issues
3A.1A Pressure
3A.1B Temperature
3A.1C Electron density
3A.1D Ventilation rate
3B Instrument comparisons
3C Calibration methods
3D Sample introduction
3E Reagent systems
3E.1 Methane
3E.2 Ammonia
3E.3 Mixed gas systems
4. Analytical Applications
4A Detection limit improvement
4B Molecular weight determination
4C Structure determination
4D Isomer discrimination
5. Reviewed References
5A Journal Articles
5B Books
5C Electronic Information
******************************************************************************
From: ihogben@tartarus.uwa.edu.au (Ian Hewlett Hogben)
Subject: Lamer Question: AMS and Archaeology
Date: 21 Jun 1995 03:39:15 GMT
Organization: The University of Western Australia
******************************************************************************
From: depauw@gw.unipc.ulg.ac.be (De Pauw Edwin)
Subject: www home page for mass spectrometry at liege university
Date: Wed, 21 Jun 1995 09:19:36 +0200
Organization: Liege University
http://www.pne.ulg.ac.be/mslab/mslab.html
We start a collection of hints and tricks to help new (and others) users of mass
spectrometry to better use and understand this fascinating method. send me yours
and I'll put them in the records.
De Pauw Edwin
depauw@gw.unipc.ulg.ac.be
--
De Pauw Edwin
Mass Spectrometry Laboratory, B6
Chemistry Institute, Liege University
B4000-Liege Belgium
depauw@gw.unipc.ulg.ac.be
******************************************************************************
From: Heinrich Luftmann <luftman@uni-muenster.de>
Subject: High Voltage Switch
Date: 21 Jun 1995 08:23:35 GMT
Organization: Organisch Chemisches Institut d. Universitdt
******************************************************************************
From: kore@cityscape.co.uk (Steve Mullock)
Subject: Re: TOF HV-switch
Date: Wed, 21 Jun 1995 08:05:42 GMT
Organization: CityScape Internet Sevices
Steve
******************************************************************************
From: "Kermit K. Murray" <kmurray@emory.edu>
Subject: Re: TOF HV-switch
Date: 21 Jun 1995 14:24:10 GMT
Organization: Emory University Chemistry
There's a company in Ft. Collins, Colorado that sells high voltage switches
and pulsed power supplies:
I have one of their pulsers that will switch +/- 3kV with < 45 ns rise and
fall to > 10 kHz rep rate. It's not floatable, but you could put it in a
plexiglass box on an isolation transformer and trigger it with an optical
isolator. I am thinking of doing this myself, so if anyone knows where I can
get an isolation transformer that can hold off 20 to 30 kV, please let me
know.
Kermit
Kermit K. Murray
kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
From: "Kermit K. Murray" <kmurray@emory.edu>
Subject: Re: mailing list digest?
Date: 21 Jun 1995 14:51:07 GMT
Organization: Emory University Chemistry
I have been archiving the listserver posts for the the discussion group and
STMS in a searchable database available on WWW. The URL is reachable from the
MS page I have at http://tswww.cc.emory.edu/~kmurray/mslist.html (the one I
plugged in an earlier post). The search engine is a nice add-on to MacHTTP
and it is running on one of my lab Macintosh computers. I'll keep on
archiving server posts as much as time an disk space permits.
Kermit
Kermit K. Murray
kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
From: "John Bartmess" <BARTMESS@novell.chem.utk.edu>
Organization: Univ. of Tenn. Dept. of Chemistry
Date: Wed, 21 Jun 1995 11:11:54 EST
Subject: Re: Negative Chemical Ionization - Discussion/Reference text
Priority: normal
>2. Fundamentals
> 2A Thermodynamics
> 2A.1 Electron affinity
******************************************************************************
From: dpvw@iastate.edu (Dave P VanderWiel)
Subject: Anyone using SSITKA techniques?
Date: 21 Jun 1995 19:33:43 GMT
Organization: Iowa State University, Ames, Iowa USA
Originator: dpvw@eng3.iastate.edu
Thanks!
Dave VanderWiel
Dept. Chemical Engineering
Iowa State University
******************************************************************************
From: schiller@prl.philips.nl (schiller c)
Subject: Can mass spect. resolve different bond types?
Organization: Philips Research Laboratories Eindhoven, Netherlands
Date: Thu, 22 Jun 1995 08:47:08 GMT
More simply, measuring the masses of H2, O2 (or better, H and 0) and
H20, one could determine their binding energy.
Thanks
Christoph Schiller
******************************************************************************
From: jesnow@geobar.mpch-mainz.mpg.de (Jonathan E. Snow)
Subject: Hello, mass spectrometric world.
Date: Thu, 22 Jun 1995 11:08:27 GMT
Organization: Max-Planck Institut fuer Chemie
I'm very happy the CFV went through and I'm grateful to whoever had
the initiative to put it through.
I'm now going to sit down and email as many people as I can think of
about the existence of this group.
Cheers,
jon.
----------------------------------------------------
Jonathan E. Snow
Max-Planck Institut fuer Chemie, Abt. Geochemie
Postfach 3060, D-55020 Mainz, Germany
jesnow@geobar.mpch-mainz.mpg.de
TEL:(01149) 6131 305 202 (or 281 to lv. msg.)
FAX:(01149) 6131 371 051
----------------------------------------------------
******************************************************************************
From: kore@cityscape.co.uk (Steve Mullock)
Subject: Re: Portable Gas Chromatograph Mass Spectrometer
Date: Thu, 22 Jun 1995 10:40:02 GMT
Organization: CityScape Internet Sevices
>I am involved in the selection process for purchasing a GCMS which will
>be used for Environmental and Materials sample analysis. It needs to
>be portable and have high resolution. Currently we are looking at a
>Viking Instruments model which is portable (if you are a gorilla), but
>I want to insure that we are considering our alternatives. This is for
>the Dallas Environmental Health Center.
Dear Michael
I saw on the mass spec newsgroup that you were in the process of
selecting a portable GCMS. You may not be aware that we are developing
portable time-of-flight mass spectrometers here at Kore. We will have
prototypes ready for field trials around late August this year. These
will not have GC interfaces fitted however as they fit into suitcases
suitable for in cabin flight storage you do not need gorilla-like
strength to carry them.If you would like more information or even
perhaps to participate in these trials can you give us your telephone
number and postal address so that we can contact you.
Barrie Griffiths
tel +44 1223 420840
Kore Technology Ltd, Cambridge Science Park, Cambridge CB4 4WF,UK.
--
Dr S.J. Mullock
Kore Technology Ltd.
291, Cambridge Science Park
Milton Road
Cambridge CB4 4WF
UK
Tel: 44 (0) 1223 420840
Fax: 44 (0) 1223 426041
******************************************************************************
From: "Margaret P. Ricci" <isotopes@indiana.edu>
Subject: WWW page for isotope ratio monitoring-GCMS
Date: 22 Jun 1995 14:53:29 GMT
Organization: Indiana University, Bloomington
http://silver.ucs.indiana.edu/~isotopes/home.html
Margaret P. Ricci
isotopes@indiana.edu
******************************************************************************
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: ICP-MS Analyses Service?
Followup-To: sci.techniques.mass-spec
Date: Thu, 22 Jun 95 15:26:57 GMT
Organization: Caltech (Environmental Engineering Science)
Howdy,
Thanks in advance,
-Peter Green
^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
Peter G. Green, Ph. D. Senior Scientist
Keck 201 <= on foot (818) 395-3787
Caltech 138-78 <= mail/UPS fax: -3170
Pasadena, CA 91125 USA or -2940
pggreen@cco.caltech.edu Environmental Eng. Sci.
^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
******************************************************************************
Date: Tue, 20 Jun 95 16:40:56 0400
From: "Kermit K. Murray" <kmurray@emory.edu>
Organization: Emory University Chemistry
Subject: Re: Can the chemical mass defect be measured by weighing ?
Kermit K. Murray
kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
Date: Tue, 20 Jun 95 16:40:56 0400
From: "Kermit K. Murray" <kmurray@emory.edu>
Organization: Emory University Chemistry
Subject: Re: Can the chemical mass defect be measured by weighing ?
Kermit K. Murray
kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
Date: Tue, 20 Jun 1995 17:42:35 +0200
From: depauw@gw.unipc.ulg.ac.be (Edwin De Pauw)
Subject: Re: Electrospray for the monitoring of photochemical reactions
De Pauw Edwin
Laboratoire de Spectrom=E9trie de Masse
Universit=E9 de Liege B4000-Liege Belgium
Tel 00.32.41.663435 FAX 00.32.41.663413
email depauw@gw.unipc.ulg.ac.be
www:http://www.pne.ulg.ac.be/mslab/mslab.html
******************************************************************************
Date: Tue, 20 Jun 95 16:40:56 0400
From: "Kermit K. Murray" <kmurray@emory.edu>
Organization: Emory University Chemistry
Subject: Re: Can the chemical mass defect be measured by weighing ?
Kermit K. Murray
kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
Date: Thu, 22 Jun 1995 23:31:15 +0000 (GMT)
From: ddxdd@IMAP1.ASU.EDU
Subject: Re: TOF HV-switch
Organization: daves not here
: --
: Heinrich L.
: Muenster -Germany
: Heinrich
-d^2
******************************************************************************
From: rjnemery@uniwa.uwa.edu.au (Neil Emery)
Subject: MS for ureides?
Date: 23 Jun 1995 07:47:49 GMT
Organization: The University of Western Australia
We've noticed that some medical labs have done so, but in the methods
of published works, the details of the mass spec work are not mentioned.
******************************************************************************
From: pzadoroz@wimsey.com (Peter Zadorozny)
Subject: Re: ICP-MS Analyses Service?
Date: Fri, 23 Jun 1995 07:55:43 -0800
Organization: GVRD
In article <3sc6ip$t0r@acmex.gatech.edu>, pggreen@cco.caltech.edu (Peter
G. Green) wrote:
> Howdy,
>
> I'm looking for recommendations of commercial services that will do
> ICP-MS analyses. US and/or Canada preferred. Needing pbb and ppt
> performance.
I know they have been around for year doing ICP-MS , never used them but
have been through their lab, very nice set up.
Peter
******************************************************************************
From: Kevin.R.Boyce@gsfc.nasa.gov (Kevin R. Boyce)
Subject: Re: Can mass spect. resolve different bond types?
Date: Fri, 23 Jun 1995 13:19:47 -0400
Organization: NASA Goddard Space Flight Center -- Greenbelt, Maryland USA
In article <3sbpml$d5t@acmex.gatech.edu>,
schiller@prl.philips.nl (schiller c) wrote:
But you need to do better than that to measure bond energies with any
accuracy. Rest assured that the ICR folks are working toward just that
goal. It's not exactly off-the-shelf equipment, though... :-)
--
Kevin Kevin.R.Boyce@gsfc.nasa.gov
"Well I'm not really familiar with that study." --Paul Brodeur
******************************************************************************
From: jbeale@reed.edu (Jay Beale)
Subject: Re: mailing list digest?
Date: 23 Jun 1995 17:35:43 GMT
Organization: Reed College, Portland, Oregon
In article <3s9c0a$3mt@acmex.gatech.edu>,
Kermit K. Murray <kmurray@emory.edu> wrote:
>
>I have been archiving the listserver posts for the the discussion group and
>STMS in a searchable database available on WWW. The URL is reachable from the
>MS page I have at http://tswww.cc.emory.edu/~kmurray/mslist.html (the one I
>plugged in an earlier post). The search engine is a nice add-on to MacHTTP
>and it is running on one of my lab Macintosh computers. I'll keep on
>archiving server posts as much as time an disk space permits.
Thanks-
Been there once and it looks good!
-Jay Beale
jbeale@reed.edu
--
-Jay Beale
jbeale@reed.edu
jbeale@epitope.com (not private, limited access)
******************************************************************************
From: dhachey@bcm.tmc.edu
Subject: Re: Hello, mass spectrometric world.
Date: 23 Jun 1995 20:17:11 GMT
Organization: Baylor College of Medicine
[Snip, snip]
>>>>
Jon;
******************************************************************************
From: "Thomas A. Lehman" <tal001@acpub.duke.edu>
Subject: Re: Can the chemical mass defect be measured by weighing ?
Date: Fri, 23 Jun 1995 18:52:44 -0400
Organization: Duke University, Durham, NC, USA
In-Reply-To: <3scica$kje@acmex.gatech.edu>
Thomas Lehman
Duke University Med Center Mass Spectrometry Lab
******************************************************************************
From: mcbrp@leonis.nus.sg (Philp Robin John)
Subject: Peptide/Protein ionisation?
Date: 24 Jun 1995 03:08:12 GMT
Organization: National University of Singapore
Summary:
Keywords:
Greetings,
Good to see this digest up and running, great job.
As a non MS user but one that has samples analysed by this technique
(electrospray/API/LC/MS) I would like to seek info.
Does anybody have any thoughts or comments on this effect that would be
happy to post? It would be very useful to obtain mass data on the
peptides before sequencing so as to help in full analysis.
Many thanks.
Robin J. Philp
Institute for Molecular and Cell Biology
Singapore.
******************************************************************************
From: gmt1810@trex.oscs.montana.edu (Mark Tarka)
Subject: Re: Anybody out there?
Date: Sat, 24 Jun 1995 22:40:18
Organization: Montana State University
In article <3s3v2o$pnt@acmex.gatech.edu>, "A.L. McCormack"
<alm7203@u.washington.edu> writes:
[Snip...]
>I am getting ready to do H-D exchange of a protein followed by
>micro-LC-ESI. Anyone have any general hints or suggestions?
[Snip...]
Hove you talked with the NMR people (H-D exchange is a routine deal)?
Mark gmt1810@msu.oscs.montana.edu
******************************************************************************
From: depauw@gw.unipc.ulg.ac.be (De Pauw Edwin)
Subject: peptides sequencing
Date: Mon, 26 Jun 1995 15:09:04 +0200
Organization: Liege University
--
De Pauw Edwin
Mass Spectrometry Laboratory, B6
Chemistry Institute, Liege University
B4000-Liege Belgium
depauw@gw.unipc.ulg.ac.be
******************************************************************************
From: jts@sage.cc.purdue.edu (Jon Schwedler)
Subject: Re: Peptide/Protein ionisation?
Date: 26 Jun 1995 11:42:55 -0500
>Greetings,
>Good to see this digest up and running, great job.
>As a non MS user but one that has samples analysed by this technique
>(electrospray/API/LC/MS) I would like to seek info.
>My work involves the isolation of peptides and proteins for sequence
>analysis using chemical degredation techniques. Most proteins are
>digested in-gel and peptides separated using micro-reversed phase HPLC. I
>almost always use Trifluoroacetic acid as an ion pair reagent in the
>eluting solvents (water for A and acetonitrile for B) as this gives an
>excellent separation. However, I don't get much success when I submit a
>small amount of each fraction for MS analysis. If I have already carried
>out a separation the samples are usually applied by flow injection in 60%
>ACN. One reason offered is that TFA suppreses ionization of the peptide
>and formic acid would be better. I can switch to this but have read many
>references for this work being carried out perfectly well in TFA.
>Does anybody have any thoughts or comments on this effect that would be
>happy to post? It would be very useful to obtain mass data on the
>peptides before sequencing so as to help in full analysis.
>Many thanks.
>Robin J. Philp
>Institute for Molecular and Cell Biology
>Singapore.
JT
******************************************************************************
From: jts@sage.cc.purdue.edu (Jon Schwedler)
Subject: Re: Peptide/Protein ionisation?
Date: 26 Jun 1995 11:42:55 -0500
>Greetings,
>Good to see this digest up and running, great job.
>As a non MS user but one that has samples analysed by this technique
>(electrospray/API/LC/MS) I would like to seek info.
>My work involves the isolation of peptides and proteins for sequence
>analysis using chemical degredation techniques. Most proteins are
>digested in-gel and peptides separated using micro-reversed phase HPLC. I
>almost always use Trifluoroacetic acid as an ion pair reagent in the
>eluting solvents (water for A and acetonitrile for B) as this gives an
>excellent separation. However, I don't get much success when I submit a
>small amount of each fraction for MS analysis. If I have already carried
>out a separation the samples are usually applied by flow injection in 60%
>ACN. One reason offered is that TFA suppreses ionization of the peptide
>and formic acid would be better. I can switch to this but have read many
>references for this work being carried out perfectly well in TFA.
>Does anybody have any thoughts or comments on this effect that would be
>happy to post? It would be very useful to obtain mass data on the
>peptides before sequencing so as to help in full analysis.
>Many thanks.
>Robin J. Philp
>Institute for Molecular and Cell Biology
>Singapore.
JT
******************************************************************************
From: "kasi V. Somayajula" <kasi@speedy.cs.pitt.edu>
Subject: Re: ICP-MS Analyses Service?
Date: 26 Jun 1995 20:37:14 GMT
Organization: University of Pittsburgh
1-800-78-EARTH
Good Luck
Kasi
******************************************************************************
From: raj@alumni.caltech.edu (Roger Moore)
Subject: Re: Peptide/Protein ionisation?
Date: 26 Jun 1995 22:01:39 GMT
Organization: California Institute of Technology, Pasadena
>As a non MS user but one that has samples analysed by this technique
>(electrospray/API/LC/MS) I would like to seek info.
>My work involves the isolation of peptides and proteins for sequence
>analysis using chemical degredation techniques. Most proteins are
>digested in-gel and peptides separated using micro-reversed phase HPLC. I
>almost always use Trifluoroacetic acid as an ion pair reagent in the
>eluting solvents (water for A and acetonitrile for B) as this gives an
>excellent separation. However, I don't get much success when I submit a
>small amount of each fraction for MS analysis. If I have already carried
>out a separation the samples are usually applied by flow injection in 60%
>ACN. One reason offered is that TFA suppreses ionization of the peptide
>and formic acid would be better. I can switch to this but have read many
>references for this work being carried out perfectly well in TFA.
The MS lab where I work does just fine using TFA sltns. In fact, they do
quite well with a capillary column HPLC feeding directly into the ESI for
our triple quads, and that uses TFA as an ion pair reagent. I wouldn't
think that the TFA would be a problem.
--
Raj
Master of Meaningless Trivia
******************************************************************************
From: wendyab@mail.utexas.edu
Subject: HELP!! Arachidonic Acid and Deuterium
Date: 27 Jun 1995 01:11:48 GMT
Organization: The University of Texas at Austin
******************************************************************************
From: mroz@Lanl.GOV (Eugene Mroz)
Subject: Slurry Analysis by ICP/MS or ICP/AES
Date: Tue, 27 Jun 1995 08:14:09 -0700
Organization: Los Alamos National Laboratory
Does anyone have experience with analzying aqueous slurries of NIST SRM
1648 (Urban Particulate) by ICP/MS or ICP/AES methods? I'd like to hear
about your experiences and results. I've been trying-but with little
success. Thanks!
--
Gene Mroz + Voice: 505-667-7758
Chemical Science and Technology Division + Fax: 505-665-4955
Mail Stop: J514 + E-Mail: mroz@lanl.gov
Los Alamos National Laboratory
Los Alamos, NM 87545
"There is something fascinating about science. One gets such wholesale returns of
conjecture out of such a trifling investment of fact"--Mark Twain from Life on the
Mississippi
******************************************************************************
From: dip@hubcap.clemson.edu
Subject: Selected Ion Monitoring v. Extracted Ion
Date: 27 Jun 1995 14:49:38 GMT
Organization: bizzzarro rancho
My problem is this: when using SIM to monitor alkylated three and four ring
compounds, I find that as the amount of alkylation increases(ie from C1 to C2,
etc.) that I'm getting each new peak in addition to those already being monitored.
This mixture is extremely complex, with many isomers of each and up to
C11-carbazoles and C8-benzocarbazoles present above my current detection
limits. These compounds do not all elute in order of alkylation/mass
(seems obvious you say), so I can't "turn one ion off" while "turning another ion
on". Basically, I need to monitor for all of the various alkylated ions of
carbazole(181,195,209,223,etc.) over a 12 minute window and then all of the
alkylated isomers of benzocarbazole over a diffent, later 15 minute window of
elution. But this doesn't allow me to determine if the peaks are one compound
or two different alkylated species(eg C3 and C4).
My question: What is the difference between Extracted ion monitoring from the
TIC and SIM in terms of data quality? Is Extracted Ion as "good" as SIM? If I use
Extracted Ion on my standards, shouldn't that behave the same as SIM of the
standards?
sorry this is rather jumbled and not all that clear(late night last night, but
aren't
they all?) I'd be more than willing to reference any help given in my thesis. also
any good references would be appreciated. admittedly, I'm still in the process
of searching the literature on this subject, so try not to flame me for missing
something obvious. I'm really looking mostly for personal experiences here.
Gracias,
dip
"Help! Help! I'm being repressed! / Come and see the violence inherent in the
system!!"
******************************************************************************
From: KKM <kmurray@emory.edu>
Subject: Re: this years ASMS meeting
Date: 27 Jun 1995 21:42:11 GMT
Organization: Emory University Chemistry
This was posted in sci.chem a few weeks ago. Somewhat off-topic, but
it was part of an ASMS plenary talk.
[begin paste]
Subject: (fwd) Top Ten reasons Network Producers don't give science
more air time!
FROM THE HOME OFFICE IN LOS ALAMOS, NEW MEXICO, THE TOP
TEN REASONS NETWORK NEWS PRODUCERS DON'T GIVE SCIENCE MORE AIR
TIME.
AND THE NUMBER ONE REASON NETWORK NEWS PRODUCERS DON'T GIVE
SCIENCE MORE AIR TIME: "JOURNALISTS ARE FROM MARS...SCIENTISTS FROM
VENUS."
Miles O'Brien
Anders Lund
--
><> Anders Lund <><
alund@unl.edu
<><
[end paste]
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
From: douglas@chem.ubc.ca (don douglas)
Subject: ASMS 1996
Date: 27 Jun 1995 20:21:31 GMT
Organization: University of British Columbia
--
Don Douglas
Chemistry
University of British Columbia
2036 Main Mall
Vancouver,B.C.
V6T 1Z1
******************************************************************************
From: jbeale@reed.edu (Jay Beale)
Subject: Re: Selected Ion Monitoring v. Extracted Ion
Date: 27 Jun 1995 23:31:10 GMT
Organization: Reed College, Portland, Oregon
The essence of the difference is that in scan mode you are looking at all
the ions in the scan range, whether they yield valuble information or not,
while in SIM mode you only look at predetermined ions. I'm sure you know
that already, but what it boils down to is the machine performs more measure-
ments per ion per minute in SIM mode than it does in scan mode. As far as
data quality, I've heard that quantitation suffers if one has less than 11
(I've also heard 13) data points across the width of the peak being measured.
The HP manual has a section on how to figure out the number of data points
your method will collect, so that's a good place to start.
Your standard curve data must be collected using the same method as used
for the unknowns.
>My question: What is the difference between Extracted ion monitoring from the
>TIC and SIM in terms of data quality? Is Extracted Ion as "good" as SIM? If I use
>Extracted Ion on my standards, shouldn't that behave the same as SIM of the
>standards?
>Gracias,
>dip
>"Help! Help! I'm being repressed! / Come and see the violence inherent in the
>system!!"
>
>
>
--
-Jay Beale
jbeale@reed.edu
jbeale@epitope.com (not private, limited access)
******************************************************************************
From: dfettero@pipeline.com (Dean Fetterolf)
Subject: Re: Selected Ion Monitoring v. Extracted Ion
Date: 27 Jun 1995 21:31:18 -0400
Organization: The Pipeline
As you have noticed Extracted ion profiles are useful for "profile"
comparison and compound class feature extraction. SIM however will improve
your S/N ratio but at the loss of full spectral data.
******************************************************************************
******************************************************************************
Could you elaborate a bit about MS/MS and its connection to MRM, and
about the MRM process itself; a citation or two to a major journal
would suffice. I'd like to get a feel for what you mean by
quantitation (e.g. reproducibility and accuracy) using the
electrospray method. Right now I have the impression that short term
analyses are doable, while long term, repetitive work is not.
TIA
Mark gmt1810@msu.oscs.montana.edu
******************************************************************************
From: URWFOSTER@MSUVX1.MEMPHIS.EDU
Date: Tue, 27 Jun 1995 22:02:06 -0500 (CDT)
Subject: Balzers Help Needed for Quad Mass Sp.
From: urwfoster@cc.memphis.edu
Subject: Balzers Help Needed for Quad Mass Sp.
Date: 27 Jun 95 22:00:51 -0500
Followup-To: sci. techiques.
Keywords: Balzers
Organization: The University of Memphis
News-Moderator: Approval required for posting to sci.techniques.mass-spec
I have a Balzers QMG 112 powersupply, rga, preamp. and have lost the manual,
can anyone lend some assistance to me? All respondents would be greatly
appreciated.
******************************************************************************
From: macht@chclu.chemie.uni-konstanz.de (Marcus Macht)
Subject: Re: Anybody out there?
Date: 28 Jun 1995 07:52:47 GMT
Organization: Univ.Konstanz,Germany
I think you should try H-D exchange without LC-ESI first, because you
shurely will have a remarkable back-exchange in the LC. We use for our
exchange experiments solutions of proteins in deuterated solvents (D2O,
D4-acetic acid, ND4OD etc.) with flow injection on a vestec instrument.
Before making your LC-ESI experiments, you should investigate , how much
protons exchange fast or very fast 'cause I would expect that these will
back-exchange in your chromatography prior to MS.
Marcus Macht
Faculty of chemistry
University of Constance
Germany
******************************************************************************
From: cepas@randb.pprd.abbott.com
Subject: Vestec electrospray
Date: 28 Jun 95 07:16:10 CST
Organization: Abbott Laboratories
I'm happy to see this group up and running finally! Thanks Dave.
I'm having trouble running LC/MS with a Vestec ESI interface. Using the
interface in infusion mode with a syringe pump, things seem pretty good --
picomole sensitivity for small peptides (under 2000 da), usually just the
single and doubly charged ions. However when I switch to LC/MS using an
Acurate flow splitter, the sensitivity goes out the window, losing maybe a
factor of 1000.
Can anyone offer any tips? On the Vestec ESI interface, or the Acurate
splitter?
Details:
Extrel triple quad
Waters 600MS series HPLC
Acurate splitter @ the 1:50 or 1:150 splits
column flow of 250 uL/min 25:75 ACN:25mM NH4OAc
post-column flow of 400 uL/min of 5% HOAc in MeOH
flow into ESI @ 1:50 split = 13 uL/min
flow into ESI @ 1:150 split = 4.3 uL/min
HPLC backpressure about 1500psi with 2mm column
--
*****************************************************************************
Steve Cepa ++Just a thought++
Abbott Labs *** These are my opinions only. So blame me. ***
(midway between Chicago and Milwaukee)
cepa.steven@igate.abbott.com
******************************************************************************
From: URWFOSTER@MSUVX1.MEMPHIS.EDU
Date: Tue, 27 Jun 1995 22:02:06 -0500 (CDT)
Subject: Balzers Help Needed for Quad Mass Sp.
From: urwfoster@cc.memphis.edu
Subject: Balzers Help Needed for Quad Mass Sp.
Date: 27 Jun 95 22:00:51 -0500
Followup-To: sci. techiques.
Keywords: Balzers
Organization: The University of Memphis
News-Moderator: Approval required for posting to sci.techniques.mass-spec
I have a Balzers QMG 112 powersupply, rga, preamp. and have lost the manual,
can anyone lend some assistance to me? All respondents would be greatly
appreciated.
******************************************************************************
From: Erich Loew <eel@org.chemie.uni-muenchen.de>
Subject: pc-utilities for interpretation of mass spectra available?
Date: 27 Jun 1995 12:50:23 GMT
Organization: Leibniz-Rechenzentrum, Muenchen (Germany)
NNTP-Posting-Host: 141.84.241.24
For example:
email: eel@org.chemie.uni-muenchen.de
******************************************************************************
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Re: ASMS 1996
Date: Wed, 28 Jun 95 22:15:25 GMT
Organization: Caltech (Environmental Engineering Science)
-Peter Green
******************************************************************************
From: Fred Schwarzer <fred1330@mailszrz.zrz.tu-berlin.de>
Subject: Re: pc-utilities for interpretation of mass spectra available?
Date: 29 Jun 1995 07:37:17 GMT
Organization: Institute of Food Chemistry / Technical University of Berlin
There is a publication that may help you. The programs can be obtained from the
authors.
I4m also interested in that programs. So i would be pleased if you can send me a
note when you
get these programs.
Abstract[
--
Fred Schwarzer
Institute of Food Chemistry / TU Berlin
see also
http://kojak.lb.tu-berlin.de/lc/fred.htm
******************************************************************************
From: wenthold@dante.colorado.edu
Subject: Re: ASMS 1996
Date: 29 Jun 1995 15:44:44 GMT
Organization: University of Colorado at Boulder
In-Reply-To: pggreen@cco.caltech.edu's message of 29 Jun 1995 08:27:55 -0400
How does everyone feel about the fact that the Portland meeting
will be at the convention center and not a hotel? What effect
will this have on the meeting? What about conference fees?
Will they go up? Will this turn people off and end up making the
meeting smaller? What will happen to the format? Can we handle
extra oral sessions going on at the same time? I'm sure the poster
sessions can handle getting bigger...
paul
I was told that the best option was to use a convention center. The meeting
has grown so large that only a few hotels are large enough to hold it, and
splitting up into separate hotels was a worse choice.
As for fees and hospitality suites, any changes will obviously depend on what
the cost of the convention center is.
I know there are people who read this who are on the Board, or who have
regular contact with them, as well as company reps. Any word from y'all?
--
David E. Bostwick
Georgia Institute of Technology, Atlanta, GA, 30332
david.bostwick@chemistry.gatech.edu
******************************************************************************
From: nomad01@aol.com (Nomad01)
Subject: Re: Selected Ion Monitoring v. Extracted Ion
Date: 29 Jun 1995 18:22:46 -0400
Organization: America Online, Inc. (1-800-827-6364)
Your Question:
My question: What is the difference between Extracted ion monitoring from
the
TIC and SIM in terms of data quality? Is Extracted Ion as "good" as SIM?
If I use
Extracted Ion on my standards, shouldn't that behave the same as SIM of
the
standards?
1st Part:
The quality of the TIC versus SIM monitoring is mostly dependant upon the
relative sensitivity of the MSD to the analyte(s). In general, I prefer to
use SIM for routine analytical use because of sensitivity issues but if
you have adequate sensitivity to perform your analysis in TIC mode you
have more reliable data upon which to establish compound identity.
2nd part
The quality of the ion, be it extracted or SIM, is mostly related to how
well the inital paramenters have been established. Dwell time is very
important to prevent biasing of the spectra. (This is most apparent when
your isotopic ratios are incorrect.) If you do go with SIM mode it is VERY
important to perform a Dynamic Mass Calibration for the SIM ions of
interest.
3rd Part
I would not reccomend that approach because of relative sensitivity
differences between the two modes. An exception might be if you are using
an internal standard for correction of injection variation.
I have been using and developing analytical methods for pesticides using
the 5971 for about five years now. It's a tough instrument.
Mike
Hope this helps,
******************************************************************************
From: deline@netcom.com (James Deline)
Subject: Re: pc-utilities for interpretation of mass spectra available?
Organization: NETCOM On-line Communication Services (408 261-4700 guest)
Date: Thu, 29 Jun 1995 22:31:54 GMT
: For example:
I've written a program that does exactly that, but it is currently only
available on the Macintosh. However, someone is porting it over to
Windows and we hope it will be done with the next month or two. Both
versions will be freeware.
jd
******************************************************************************
Date: Thu, 29 Jun 1995 15:05:17 -0700 (PDT)
From: Lorne Isabelle <isabelle@ese.ogi.edu>
Subject: ASMS Portland
It turns out the daughter of the Chemistry Dept secretary here at OGI
is the representative for the Portland Convention Center. From what I
can figure out, they are going to use 3 to 4 hotels near the convention
center. The hospitality suites will be at the convention center, or at
least that option is available. I think that by the time the convention
rolls around, the Portland light rail will be free in the downtown area
so getting from hotels to the convention center will be no problem.
Some are within walking distance. I think this will all workout O.K.
Lorne Isabelle
Oregon Graduate Institute
******************************************************************************
From: G.Spierings@fys.ruu.nl (Geert Spierings)
Subject: H/Cu pair potentials wanted.
Organization: Physics and Astronomy, University of Utrecht, The Netherlands
Date: Fri, 30 Jun 1995 12:31:19 GMT
Geert.
-----------------------------------------------------------------------
Geert Spierings Debye Institute
Princetonplein 5
spiering@fys.ruu.nl 3584 CC Utrecht, NL
-----------------------------------------------------------------------
--
-----------------------------------------------------------------------
Geert Spierings Debye Institute
Princetonplein 5
spiering@fys.ruu.nl 3584 CC Utrecht, NL
-----------------------------------------------------------------------
******************************************************************************
From: dpvw@iastate.edu (Dave P VanderWiel)
Subject: Re: ASMS 1996
Date: 30 Jun 1995 14:40:18 GMT
Organization: Iowa State University, Ames, Iowa USA
Originator: dpvw@eng3.iastate.edu
<lines deleted>
|> extra oral sessions going on at the same time? I'm sure the poster
|> sessions can handle getting bigger...
|>
|> paul
|>
|> PS What's gong to happen to the hospitality suites?
Dave
******************************************************************************
From: Ashley McCormack <alm7203@u.washington.edu>
Subject: Re: Peptide/Protein ionisation?
Date: Fri, 30 Jun 1995 08:38:24 -0700
Organization: University of Washington
Nntp-Posting-User: alm7203
In-Reply-To: <3smcjb$4hb@acmex.gatech.edu>
Finally a newsgroup!!!!
Anyway I have several questions to clarify: if you separate peptides by
HPLC then you use direct injection in 60% MeCN to introduce sample into
MS? Do you lyophylize (sp?) your sample to dryness?? Is the instrument
tuned properly for TFA/MeCN?
-Ashley
**********************************
Ashley L. McCormack
Research Scientist III
Dept. of Molecular Biotechnology
FJ-20, University of Washington
Seattle, WA 98195
206-685-7335
alm7203@u.washington.edu
http://thompson.mbt.washington.edu
**********************************
> Greetings,
> Good to see this digest up and running, great job.
>
> As a non MS user but one that has samples analysed by this technique
> (electrospray/API/LC/MS) I would like to seek info.
>
> My work involves the isolation of peptides and proteins for sequence
> analysis using chemical degredation techniques. Most proteins are
> digested in-gel and peptides separated using micro-reversed phase HPLC. I
> almost always use Trifluoroacetic acid as an ion pair reagent in the
> eluting solvents (water for A and acetonitrile for B) as this gives an
> excellent separation. However, I don't get much success when I submit a
> small amount of each fraction for MS analysis. If I have already carried
> out a separation the samples are usually applied by flow injection in 60%
> ACN. One reason offered is that TFA suppreses ionization of the peptide
> and formic acid would be better. I can switch to this but have read many
> references for this work being carried out perfectly well in TFA.
>
> Does anybody have any thoughts or comments on this effect that would be
> happy to post? It would be very useful to obtain mass data on the
> peptides before sequencing so as to help in full analysis.
>
> Apologies if this has appeared before but I posted a similar message
> before this link was fully up and running and I think it may have got lost!
>
> Many thanks.
>
> Robin J. Philp
> Institute for Molecular and Cell Biology
> Singapore.
>
>
>
>
******************************************************************************
From: David Wheeler <wheeler@elementl.demon.co.uk>
Subject: Job Wanted. ICP-MS, LA-ICP-MS, GDMS
Date: Fri, 30 Jun 1995 15:10:24 GMT
Job Wanted
----------
A micro CV follows.
GDMS development, both RF and DC for high resolution (VG9000) and quadrupole
(GloQuad) GDMS
instruments.
* Involvment in sales, marketing and customer care for ICP-MS and GDMS
instruments.
1984 to 1986 G.E.C. Avionics - Applied Physics Division.
Experience:
******************************************************************************
From: Ashley McCormack <alm7203@u.washington.edu>
Subject: Re: ASMS 1996
Date: Fri, 30 Jun 1995 09:06:49 -0700
Organization: University of Washington
Nntp-Posting-User: alm7203
In-Reply-To: <3suqis$pv4@acmex.gatech.edu>
Ashley
**********************************
Ashley L. McCormack, PhD
Research Scientist III
Dept. of Molecular Biotechnology
FJ-20, University of Washington
Seattle, WA 98195
206-685-7335
alm7203@u.washington.edu
http://thompson.mbt.washington.edu
**********************************
>
>
> >When is the ASMS 1996 meeting?
> >
> >[The 1996 ASMS conference will be in Portland, Oregon, from May
> 12-17. - db]
>
>
> How does everyone feel about the fact that the Portland meeting
> will be at the convention center and not a hotel? What effect
> will this have on the meeting? What about conference fees?
> Will they go up? Will this turn people off and end up making the
> meeting smaller? What will happen to the format? Can we handle
> extra oral sessions going on at the same time? I'm sure the poster
> sessions can handle getting bigger...
>
> paul
>
> PS What's gong to happen to the hospitality suites?
> --
> ***********************************************************************
> * * *
> * Dr. Paul G. Wenthold * "Not many girls in contemporary *
> * JILA * society would give their underwear *
> * University of Colorado * to help a geek like me." *
> * Boulder, CO 80309 * Farmer Ted *
> * (303)492-7768 * *
> * * *
> ***********************************************************************
> * I don't speak for JILA. In fact, I doubt they even agree with me! *
> ***********************************************************************
>
>
>
>
******************************************************************************
From: dejohnde@aol.com (DeJohnDE)
Subject: Re: Peptide/Protein ionisation?
Date: 1 Jul 1995 14:12:07 -0400
Organization: America Online, Inc. (1-800-827-6364)
******************************************************************************
From: jwindak@umich.edu (Jim Windak)
Subject: Isotope pattern software
Followup-To: sci.techniques.mass-spec
Date: 5 Jul 1995 15:13:10 GMT
Organization: University of Michigan, Chemistry
Does anyone know of any software for Dos or Windows which will generate a
theoretical isotope pattern from an entered formula? I have seen such
programs for the Macintosh, but I would like to have a Dos or Windows
version for one of our PC's which is interfaced to a GC/MS. Any
suggestions would be appreciated.
Jim Windak
University of Michigan
Chemistry Dept.
jwindak@umich.edu
******************************************************************************
From: jwindak@umich.edu (Jim Windak)
Subject: Isotope pattern software
Date: 5 Jul 1995 15:13:10 GMT
Organization: University of Michigan, Chemistry
Does anyone know of any software for Dos or Windows which will generate a
theoretical isotope pattern from an entered formula? I have seen such
programs for the Macintosh, but I would like to have a Dos or Windows
version for one of our PC's which is interfaced to a GC/MS. Any
suggestions would be appreciated.
Jim Windak
University of Michigan
Chemistry Dept.
jwindak@umich.edu
******************************************************************************
Date: Wed, 05 Jul 1995 18:38:29 +0000 (GMT)
From: ddxdd@IMAP1.ASU.EDU
Subject: Re: Isotope pattern software
Organization: daves not here
the program is a dos program, but phil may be working on a windows version.
oh, he requests that you write him for the program, NOT call him.
hope this helps.
-d^2
******************************************************************************
From: Norbert Nieth <noobi@odin.oci.uni-heidelberg.de>
Subject: Re: Isotope pattern software
Date: 6 Jul 1995 13:28:21 GMT
Organization: Organisch-Chemisches Institut
boundary="-------------------------------28615894515740"
---------------------------------28615894515740
Norbert Nieth
---------------------------------28615894515740
---------------------------------28615894515740--
******************************************************************************
From: db32@prism.gatech.edu (David E. Bostwick)
Subject: no subject (file transmission)
Date: Thu, 6 Jul 1995 09:51:27 -0400 (EDT)
Thanks in advance,
Ilse
******************************************************************************
From: Rachel Ogorzalek Looo <loo@brcf.med.umich.edu>
Subject: re:re:isotope pattern software and protein software
Date: 6 Jul 1995 17:18:10 GMT
Organization: University of Michigan
--------------
Rachel Ogorzalek Loo
Protein and Carbohydrate Structure Facility
University of Michigan
2560 MSRB II
1150 W. Meddical Center Dr.
Ann Arbor, MI 48109-0674
******************************************************************************
From: "Rob O'Brien" <ro@iecems.lan.nrc.ca>
Subject: Re: Isotope pattern software
Date: 6 Jul 1995 18:08:46 GMT
Organization: National Research Council, Canada
<http://www-mac.shef.ac.uk/chemistry/web-elements/isotope.script>
This will only give you the mass/intensity values and not
a spectra.
A more difficult problem is finding a program to calculate a
pattern for an isotopically enriched species such as (37Cl)Cl5C12H4
where the 37Cl label is not 100%. If anyone has or knows of a
program that can do that please let me know.
regards,
R.O'B
******************************************************************************
From: kkm <kmurray@emory.edu>
Subject: Re: Isotope pattern software
Date: 6 Jul 1995 20:24:01 GMT
Organization: Emory University
Abstract:
http://hyperarchive.lcs.mit.edu/HyperArchive/Abstracts/sci/isotope-patter
n-calculator-165.hqx.abs
Download:
http://hyperarchive.lcs.mit.edu/HyperArchive/Archive/sci/isotope-pattern-
calculator-165.hqx
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
From: senko@magnet.fsu.edu (Mike Senko)
Subject: Re: Isotope pattern software
Date: 7 Jul 1995 00:36:22 GMT
Organization: NHMFL
Mike Senko
senko@magnet.fsu.edu
******************************************************************************
From: a1619195@smail1.rrz.Uni-Koeln.DE (Werner Spahl)
Subject: Re: NEED HELP ON HPLC-MS
Date: 7 Jul 1995 12:10:55 GMT
Organization: Regional Computing Center, University of Cologne
--
Werner Spahl (a1619195@smail.rrz.uni-koeln.de)
"The meaning of my life is to make me crazy"
******************************************************************************
From: Rob Levine <rlevine@noriko.demon.co.uk>
Subject: Wanted: Comprehensive Mass List for Quadrupole Gas Analyser
Date: Fri, 07 Jul 1995 07:56:52 GMT
Organization: Raychem Ltd
Dear All,
I routinely use quadrupole gas analysers and am after a comprehensive
list of which species each mass is likely to represent. I already have
various (incomplete) lists but was wondering if anyone new of a
'definitive' list.
Thanks for any help,
Rob
--
Robert J. Levine.
Corporate Technology Europe, Raychem Ltd, Faraday Road,
Dorcan, Swindon, Wiltshire SN3 5HH, UK.
-------------------------------------------------------
E-mail: rlevine@thinfilm.demon.co.uk OR
rlevine@raukcte.ccmail.compuserve.com
******************************************************************************
From: strecker@chemie.fu-berlin.de (Andreas Strecker)
Subject: Re: peptides sequencing
Date: Fri, 07 Jul 95 20:09:04 GMT
Organization: FU Berlin
In article <3smd65$8bn@acmex.gatech.edu>,
depauw@gw.unipc.ulg.ac.be (De Pauw Edwin) wrote:
>Oligopeptides sequencing can be performed using liquid SIMS or
>electrospray ionization. If the interpretation of spectra of known
>compounds is easy, structure determination of unknowns is however
>not so direct. Fragmentation does not often give all the structural
>information needed. Two methods can then be used: the brutal force
>or MS/MS. The brutal force means fitting the spectra on the basis of
>the amino acids combinations. If their nature can be deduced from the
>low mass iminium fragments, the task is simplified. The other way is
>the use of MS/MS. Daughter ion spectra are usually employed. We used
>in addition the fact that b-a ions are often present to selectively
>pick the b-a transition by constant neutral loss of CO. This scan
>labels the fragments as b ones. In electrospray, multiply charged ions
>are the source of most fragments. We recently observed the loss of CO
>and water from doubly charged ions on a triple quadrupole instrument,
>resulting, as expected, from the apparent loss of half the mass monitored
>(double charge). In sector instruments, the same sample gaves not
>the same results. We think that calibration of linked scans do not work
>for losses from multiply charged ions. Before to start ourselves
>the scans calculation, we would like to know if someone already made
>the job.
>Thanks
>
There is also now the posiibility to sequence with MALDI-MS and
post-source-decay (PSD) technique. The first machines are already on the
market. The technique uses the "natural" fragmentation that occurs subsequent
to acceleration of the ions after MALDI. The fragments get a secondary
acceleration and are detectable as a fragmentation series of the original
molecule. This makes peptide sequencing possible. Major advantages: Little
sample amount required; low purity of sample required (peptide mixtures or
even complete digest probes are sequencable); ions differing in less than 50
masses may be separated prior to sequencing within the MS by way of an
electronic switch. Major disadvantage: Only few machines installed yet (but
numbers are rapidly growing!)
Andreas
******************************************************************************
From: brevardlab@aol.com (BrevardLab)
Subject: Re: ICP-MS Analyses Service?
Date: 7 Jul 1995 17:02:51 -0400
Organization: America Online, Inc. (1-800-827-6364)
My lab also performs ICP-MS analysis. We have been using ICP-MS for about
4 years now doing primarily water and wastewater analysis but have had
projects using isotope dilution, hydrothermal vent fluids and all sorts of
solid materials ranging from steel to cement. We have recently started
tissue analysis. Our mailing address is
BTR Labs
250 Grassland Road SE
Palm Bay FL 32909
******************************************************************************
From: sismspec@aol.com (Sismspec)
Subject: Increasing Sensitivity of the HP MSD
Date: 8 Jul 1995 12:19:39 -0400
Organization: America Online, Inc. (1-800-827-6364)
Part 1 of this article addresses the improvements that can be made in the
MSD to improve its sensitivity (increasing signal-to-noise level). This
can be accomplished by reducing the background originating in the MSD
itself. The new high sensitivity multipliers available from several
manufacturers were evaluated and provided a four to five fold increase in
sensitivity over the original multipliers supplied with the MSD when it
was first manufactured. Further improvements can be achieved by improving
the vacuum level by using larger vacuum pumps and new higher grade rough
pump and diffusion pump oils. A direct capillary transfer line was also
used to permit the direct introduction of the column effluent into the GC
source.
Part 2 of this article describes the changes that can be made to the GC to
improve performance. GC bleed is the major reasons for loss in MS
sensitivity because any bleed from the column or injection port
contributes to the background noise level in the MSD. GC septa from
various manufacturers were studied and it was determined that the Supelco
Thermogreen septa produce the lowest bleed for use in GC/MS applications.
A new injection port liner and Vespel injection port liner seal were
developed. A method is described for the high temperature flow
conditioning of the GC injection port. In addition the new low bleed -MS
bonded phase columns available from several manufacturers help reduct the
noise level in the MSD.
The combined improvements in the MSD and GC improved the overall MSD
signal-to-noise level bewteen 5 to 10 fold.
I am sure that there are more techniques and design changes that can be
made to improve the performance in MSD's and other mass spectrometers. I
seems that no matter what the level of sensitivity the mass spec spec was
designed for, you can always use a little more sensitivity to detect that
problem compound. I would like to hear from anyone who has any new
tested or untested ideas or any other suggestion for improving the
performance of the mass spectrometer.
John J. Manura
Scientific Instrument Services
Supplier of Parts and Services for Mass Spectrometers and Other Scientific
Instruments.
Phone: (908) 788-5550
FAX: (908) 806-6631
e-Mail: sismspec@aol.com
******************************************************************************
From: vilboisf@iprolink.ch (Francis Vilbois)
Subject: Re: peptides sequencing
Date: Sat, 08 Jul 1995 23:55:07 +0100
Organization: Internet ProLink
> There is also now the posiibility to sequence with MALDI-MS and
> post-source-decay (PSD) technique. The first machines are already on the
> market. The technique uses the "natural" fragmentation that occurs subsequent
> to acceleration of the ions after MALDI. The fragments get a secondary
> acceleration and are detectable as a fragmentation series of the original
> molecule. This makes peptide sequencing possible. Major advantages: Little
> sample amount required; low purity of sample required (peptide mixtures or
> even complete digest probes are sequencable); ions differing in less than 50
> masses may be separated prior to sequencing within the MS by way of an
> electronic switch. Major disadvantage: Only few machines installed yet (but
> numbers are rapidly growing!)
>
> Andreas
I have never seen any good data from these MALDI-MS PSD techniques. The
mass spectrometers on the market are absolutely useless.
Francis
--
Francis Vilbois
e-mail: vilboisf@iprolink.ch
******************************************************************************
From: topaz56@cyberg8t.com (BlueShift)
Subject: MALDI-TOF
Date: Sun, 9 Jul 1995 10:12:10
Organization: Cyberg8t
BlueShift
******************************************************************************
From: db32@prism.gatech.edu (David E. Bostwick)
Subject: Reception problems
Date: 10 Jul 1995 10:16:03 -0400
Organization: Georgia Institute of Technology
I have heard from a couple of people that all of the postings aren't
making it to every site. There should be more than 90 postings by now. If
you have not received all of the messages, let me know via e-mail, not a
posting here. Send the mail to me at db32@prism.gatech.edu (a reply to
this message should do that), to Sarah Shealy at ss17@prism.gatech.edu, or
to the group contact address at mass.spec-request@chemistry.gatech.edu.
--
David E. Bostwick
Georgia Institute of Technology, Atlanta, GA, 30332
david.bostwick@chemistry.gatech.edu
******************************************************************************
From: Ashley McCormack <alm7203@u.washington.edu>
Subject: Re: peptides sequencing
Date: Mon, 10 Jul 1995 17:12:51 -0700
Organization: University of Washington
Nntp-Posting-User: alm7203
In-Reply-To: <3tm6ch$dhs@acmex.gatech.edu>
While MALDI TOF instruments capable of PSD are a welcome addition to the
techniques available, metastable fragmentation has been available to
biological mass specrometrists for some years. It may produce
different ion series that low- or high-energy CID but the ion series
produced by those methods usually provide the information necessary to
sequence peptides. And some peptides just won't fall apart the right
way, no matter what you do to them.
Ashley L. McCormack
UW
******************************************************************************
From: Ecuvac <pmarston@vacgen.fisons.co.uk>
Subject: On-line catalogues ?
Date: Tue, 11 Jul 1995 01:45:13 -0400
Organization: Vac Gen
Thanks
Phil
******************************************************************************
Date: Tue, 11 Jul 1995 07:37:00 -0500 (CDT)
From: "Steven P. Cepa 708-937-7539" <CEPA.STEVEN@igate.pprd.abbott.com>
Subject: Chicago area meeting
PLEASE POST
Dale Scholler
University of Chicago
"Diet and Metabolism using Radioactive Tracers with MS"
Robert Ludicky
Morton International
"Analysis of Polyesters and Other Polymers by LD-FTMS"
Bryan Winger
Extrel FTMS
"Interfacing ESI with FTMS"
Cost $25
Call 708-245-3403 by July 17 to register.
******************************************************************************
Subject: Alternative Analytical Methods for ng/L
Date: Mon, 10 Jul 1995 11:15:42 -0600
From: "David A. Bender, ECO contract person, Rapid City, SD
"<dabender@wrdmail.er.usgs.gov>
Organization: US Geological Survey
NAWQA's present VOC schedule has a reporting level of 0.2 ug/L. This
reporting level is adequate for making observations about VOCs detected
in ground water or surface water to federal regulatory standards or
criteria. This reporting level, however, is not adequate for many other
aspects of scientific investigations including for example
characterization
of the frequency of occurrence of contaminants, and understanding their
transformation, transport, and fate. A reporting level of 1 - 10 ng/L is
needed if quantitative assessments of VOCs in surface water are to be
achieved.
Currently the NWQL is using full scan purge and trap gas
chromatography/mass
spectrometry (P+T GC/MS), but by switching to selective ion
monitoring a reporting level of 10 - 20 ng/L can be achieved. This latter
method, however, does not allow for non-target VOCs to be identified and
also only a select number of targets can be quantified.
--------------------------------------------------------------------------
---
--------------------------------------------------------------------------
---
******************************************************************************
Date: Wed, 12 Jul 1995 15:55:57 +0000 (GMT)
From: fan@pangea.usask.ca (Jhianzong Fan)
Subject: Stability of ICPMS
Organization: University of Saskatchewan
******************************************************************************
From: proulxp@ere.umontreal.ca (Proulx Pascal)
Subject: Identifying doubly charge ions in ESI/MS/MS
Organization: Universite de Montreal
Date: Thu, 13 Jul 1995 00:45:45 GMT
Hi,
I am looking for suggestion for the identification of doubly
charge ions in ESI/MS/MS of peptides.
Any suggestions?
Pascal Proulx
PhD student
Universite de Montreal
proulxp@ere.umontreal.ca
******************************************************************************
From: greg@sciex.com (Greg King)
Subject: Re: Stability of ICPMS
Date: Thu, 13 Jul 1995 12:04:50 -0400
Organization: SCIEX
Greg
--
Greg King
SCIEX
71 Four Valley Drive
Concord, Ontario, Canada
(905) 660-9005
greg@sciex.com
******************************************************************************
From: "Dr. S. K. Singhal" <ksinghal@mni.uwo.ca>
Subject: Question: Tandem MS of amino acids?
Date: 14 Jul 1995 18:47:50 GMT
Organization: The University of Western Ontario
ksinghal@mni.uwo.ca
Thanks!
******************************************************************************
From: dhchace@acpub.duke.edu (Donald H. Chace)
Subject: Re: Question: Tandem MS of amino acids?
Date: 15 Jul 1995 02:10:58 GMT
Organization: Duke University Medical Center
******************************************************************************
From: dhchace@acpub.duke.edu (Donald H. Chace)
Subject: Re: Question: Tandem MS of amino acids?
Date: 15 Jul 1995 02:16:25 GMT
Organization: Duke University Medical Center
******************************************************************************
From: Nahum Gat <oksi@cerfnet.com>
Subject: TechExpo WWW site for hi-tech users
Date: 15 Jul 1995 19:13:29 GMT
Organization: Opto-Knowledge Systems, Inc.
Dear Colleague
Regards,
Hi,
I'm one of a group of undergraduates looking at the quantitative abilities
of our Universitys newly acquired Electrospray Mass Spectrometry device.
We are tasked to look at anabolic steriods in this assignment, and to
design and test a basic protocol to achieve the main goal. (ie to see
whether this beast can do quantitative analysis, and tell us the concentr-
ations of the standard steriod solutions we send thru it.)
We would greatly appreaciate any wisdom you could pass on; things like
experimental hints, good articles on the subject, fore warning of any pit falls
etc this sort of thing would be really helpful to us.
R D Winefield
******************************************************************************
Date: Mon, 17 Jul 1995 11:01:35 +0500 (GMT+0500)
From: Prof A G Menon <agmenon@hamsadvani.serc.iisc.ernet.in>
Subject: Interpretation of Mass Spectra.
________________________________________________________________________
< A. G. Menon | P. S. Sastry >
< Instrumentation and Services Unit | Department of >
< Indian Institute of Science | Electrical Engineering >
< Bangalore 560 012 | IISc, Bangalore >
< INDIA | >
< e-mail: | e-mail: >
< agmenon@vigyan.iisc.ernet.in | sastry@ee.iisc.ernet.in >
< agmenon@isu.iisc.ernet.in | >
< agmenon@mass.isu.iisc.ernet.in | >
------------------------------------------------------------------------
******************************************************************************
Date: Mon, 17 Jul 1995 11:01:35 +0500 (GMT+0500)
From: Prof A G Menon <agmenon@hamsadvani.serc.iisc.ernet.in>
Subject: Interpretation of Mass Spectra.
________________________________________________________________________
< A. G. Menon | P. S. Sastry >
< Instrumentation and Services Unit | Department of >
< Indian Institute of Science | Electrical Engineering >
< Bangalore 560 012 | IISc, Bangalore >
< INDIA | >
< e-mail: | e-mail: >
< agmenon@vigyan.iisc.ernet.in | sastry@ee.iisc.ernet.in >
< agmenon@isu.iisc.ernet.in | >
< agmenon@mass.isu.iisc.ernet.in | >
------------------------------------------------------------------------
******************************************************************************
From: rdw@waikato.ac.nz
Subject: Quantitative work with ESMS
Date: 17 Jul 95 17:27:55 +1200
Organization: University of Waikato, Hamilton, New Zealand
Hi,
I'm one of a group of undergraduates looking at the quantitative abilities
of our Universitys newly acquired Electrospray Mass Spectrometry device.
We are tasked to look at anabolic steriods in this assignment, and to
design and test a basic protocol to achieve the main goal. (ie to see
whether this beast can do quantitative analysis, and tell us the concentr-
ations of the standard steriod solutions we send thru it.)
We would greatly appreaciate any wisdom you could pass on; things like
experimental hints, good articles on the subject, fore warning of any pit falls
etc this sort of thing would be really helpful to us.
R D Winefield
******************************************************************************
From: rdw@waikato.ac.nz
Subject: Quantitative work with ESMS
Date: 17 Jul 95 17:27:55 +1200
Organization: University of Waikato, Hamilton, New Zealand
Hi,
I'm one of a group of undergraduates looking at the quantitative abilities
of our Universitys newly acquired Electrospray Mass Spectrometry device.
We are tasked to look at anabolic steriods in this assignment, and to
design and test a basic protocol to achieve the main goal. (ie to see
whether this beast can do quantitative analysis, and tell us the concentr-
ations of the standard steriod solutions we send thru it.)
We would greatly appreaciate any wisdom you could pass on; things like
experimental hints, good articles on the subject, fore warning of any pit falls
etc this sort of thing would be really helpful to us.
R D Winefield
******************************************************************************
From: rdw@waikato.ac.nz
Subject: Quantitative work with ESMS
Date: 17 Jul 95 17:27:55 +1200
Organization: University of Waikato, Hamilton, New Zealand
Hi,
I'm one of a group of undergraduates looking at the quantitative abilities
of our Universitys newly acquired Electrospray Mass Spectrometry device.
We are tasked to look at anabolic steriods in this assignment, and to
design and test a basic protocol to achieve the main goal. (ie to see
whether this beast can do quantitative analysis, and tell us the concentr-
ations of the standard steriod solutions we send thru it.)
We would greatly appreaciate any wisdom you could pass on; things like
experimental hints, good articles on the subject, fore warning of any pit falls
etc this sort of thing would be really helpful to us.
R D Winefield
******************************************************************************
From: rdw@waikato.ac.nz
Subject: Quantitative work with ESMS
Date: 17 Jul 95 17:27:55 +1200
Organization: University of Waikato, Hamilton, New Zealand
Hi,
I'm one of a group of undergraduates looking at the quantitative abilities
of our Universitys newly acquired Electrospray Mass Spectrometry device.
We are tasked to look at anabolic steriods in this assignment, and to
design and test a basic protocol to achieve the main goal. (ie to see
whether this beast can do quantitative analysis, and tell us the concentr-
ations of the standard steriod solutions we send thru it.)
We would greatly appreaciate any wisdom you could pass on; things like
experimental hints, good articles on the subject, fore warning of any pit falls
etc this sort of thing would be really helpful to us.
R D Winefield
******************************************************************************
From: ERI@mindlink.bc.ca (Bill Trembath)
Subject: Organic Analytical Chemist Required
Date: Mon, 17 Jul 1995 18:20:57 GMT
Organization: MIND LINK! - British Columbia, Canada
Interested candidates should submit CVs with contact address and phone number
immediately
to fax: (604) 986-0071. Short-listed applicants will be contacted before August 1,
1995 for
interview.
******************************************************************************
From: anbar_a@caltech.edu (A. D. Anbar)
Subject: Re: Stability of ICPMS
Date: Mon, 17 Jul 1995 12:23:25 -0800
Organization: The Lunatic Asylum, California Institute of Technology
However, if problems persist, look closely at the data. I saw some similar
results with Os, _using an internal standard_. The behavior was quite
bizzare, with one isotope behaving "normally", while the other grew in
intensity continuously during the run, and took a long time to wash out.
As best I can figure it, the standard and the normal I used must have been
different species, which did not equilibrate when mixed. The "misbehaving"
isotope must have been in a form which adhered to the Tygon sampling tube,
and therefore did not rinse efficiently into the plasma. Think of it as
Tygon chromatography... :)
This actually makes sense for Os, which is known to form very strong
complexes which equilibrate very slowly under benchtop conditions. I'd be
surprised if Zr shows any similarity, but you never know...
Ariel
--
_____________________________________________________________________
A. D. Anbar anbar_a@caltech.edu
Mail Stop 170-25 Tel: (818) 395-6982
Division of Geological and Planetary Sciences Fax: (818) 796-9823
California Institute of Technology
Pasadena, CA 91125
_____________________________________________________________________
******************************************************************************
From: cmcgandy@TRENTU.CA
Subject: Iodine analysis via ICP-MS
Organization: Trent University, Peterborough
Date: Tue, 18 Jul 1995 14:49:26 GMT
Colin
******************************************************************************
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Re: Iodine analysis via ICP-MS
Date: Tue, 18 Jul 95 16:23:30 GMT
Organization: Caltech (Environmental Engineering Science)
Unaffiliatedly,
-Peter Green
******************************************************************************
From: anbar_a@caltech.edu (A. D. Anbar)
Subject: Re: Iodine analysis via ICP-MS
Date: Tue, 18 Jul 1995 11:03:05 -0800
Organization: The Lunatic Asylum, California Institute of Technology
Can you give more details on this background? Is it present in all your
solutions (reagents, pure H2O, etc.)? Are you sure it is really Iodine
(you see only mass 127)?
Of course, since we use alot of HCl generally in the lab, and specifically
in my chem. procedures, Cl contamination is not a surprise. I suspect the
other halogens are present as impurities in the HCl. Since Cl, Br and I
all form volatile species, this contamination can be hard to control.
Ariel
--
_____________________________________________________________________
A. D. Anbar anbar_a@caltech.edu
Mail Stop 170-25 Tel: (818) 395-6982
Division of Geological and Planetary Sciences Fax: (818) 796-9823
California Institute of Technology
Pasadena, CA 91125
_____________________________________________________________________
******************************************************************************
From: kull@leland.stanford.edu (Alan Kull)
Subject: Hiden Analytical Mass Specs
Date: Tue, 18 Jul 1995 16:14:38 -0800
Organization: Stanford University
Does anyone out there have any experience with Hiden Analytical Ltd.'s mass
spectrometers, in particular the EQP system? We are evaluating equipment
for detection of radicals in a plasma CVD environment using a molecular
beam mass spectrometer. We have narrowed our choices down to the Hiden
equipment, but I would really like to hear from a few other users before we
start hemorrhaging cash.
Thanks,
Alan
--
Alan Kull
High Temperature Gasdynamics Laboratory
Stanford University
Stanford, CA 94305-3032
415-723-4182
kull@leland.stanford.edu
******************************************************************************
From: verberck@ruca.ua.ac.be (Filip Verberckmoes)
Subject: Ribermag 10-10b : who has one for sale ?
Date: 19 Jul 1995 14:43:21 GMT
Organization: RUCA , Universiteit Antwerpen
Hi,
Dr. F. Verberckmoes
Department of Chemistry
University of Antwerp (RUCA)
Groenenborgerlaan 171
2020 Antwerp
Belgium
e-mail : verberck@ruca.ua.ac.be
******************************************************************************
From: mlgay@ix.netcom.com (Martha L. Gay)
Subject: FDA Symposium on Mass Spectrometry
Date: 19 Jul 1995 23:08:16 GMT
Organization: Netcom
FDA SYMPOSIUM
The FDA will host a two-day symposium entitled "FDA Mass Spectrometry
Symposium: New Challenges, New Techniques", September 12-13, 1995, in
the Voice of America Building, 330 Independence Ave SW, Washington, DC.
Twenty-tw
o lectures will be presented by speakers from academia, industry, and
government. Although there will be no registration fee, participants
are asked to contact either Jack Lay or Jim Sphon to ensure adequate
seating. A bl
ock of rooms has been reserved at the Holiday Inn Capitol(550 C St. SW)
at the government rate of $114. To obtain this rate, reservations must
be made with the Holiday Inn for the FDA symposium by August 9; phone
202-479-
4000.
K. Qian, Ph.D
qian@wrc.wrgrace.com
******************************************************************************
From: knaack@wsu.edu (Charles Knaack)
Subject: Re: Stability of ICPMS
Date: Thu, 20 Jul 1995 23:03:16 GMT
Organization: W.S.U. Geology Dept.
Good luck,
Charles
--
Charles Knaack
Geoanalytical Laboratory
Washington State University
Pullman, WA 99164
Knaack@wsu.edu
******************************************************************************
From: rshouk@iastate.edu (Robert S Houk)
Subject: Re: Iodine analysis via ICP-MS
Date: 21 Jul 1995 14:33:08 GMT
Organization: Iowa State University, Ames, Iowa USA
******************************************************************************
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Help! Inexplicable background problem.
Date: Fri, 21 Jul 95 17:05:54 GMT
Organization: Caltech (Environmental Engineering Science)
Some specifics:
Astoundingly, it is present even when the ion source is off. Even when it
has been off overnight, or even for days. (At the moment it roughly
doubles in size when the source is on, but previously one could hardly see
an increase at all.)
It scales with the mass selected (thus the voltages on the rods) roughly
to the first or second power.
Well, that's what I see. Luckily it has so far always stayed small enough
that it only interferes a little with some experiments, or badly with a few
specialized measurements. But, it is a definite annoyance, and complete
baffler to date.
Any and all suggestions (posted here or by email) are deeply appreciated!
-Peter Green
^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
Peter G. Green, Ph. D. Senior Scientist
Keck 201 <= on foot (818) 395-3787
Caltech 138-78 <= mail/UPS fax: -3170
Pasadena, CA 91125 USA or -2940
pggreen@cco.caltech.edu Environmental Eng. Sci.
^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
Man, I gotta get me one of them new-fangled key-
boards with all the little smiley face buttons!
******************************************************************************
From: wenthold@dante.colorado.edu
Subject: Re: Help! Inexplicable background problem.
Date: 21 Jul 1995 21:34:43 GMT
Organization: University of Colorado at Boulder
paul
--
***********************************************************************
* * *
* Dr. Paul G. Wenthold * "It is easier to swallow knowledge *
* JILA * than to acquire it laboriously *
* University of Colorado * from books." *
* Boulder, CO 80309 * Prof. H.M. Wogglebug T.E. *
* (303)492-7768 * *
* * *
***********************************************************************
* I don't speak for JILA. In fact, I doubt they even agree with me! *
***********************************************************************
******************************************************************************
From: KGZC01A@prodigy.com (Fran Fargen)
Subject: Mentor wanted for new user of MS
Date: 22 Jul 1995 18:19:56 GMT
Organization: Prodigy Services Company 1-800-PRODIGY
I have worked in an analytical laboratory for nearly five years, and have
been working with GC's for about a year. My company may soon be getting
a GC-MS and I want to be in good position to be the one selected for
training.
I am not a degreed chemist, but have very strong math and science
aptitude (ACT scores of 30,31 in math, science respectively). I have
worked with and am comfortable with split/splitless injection, purge and
trap, FID, PID, Hall detectors and hve used mainly capilary columns.
******************************************************************************
From: David Knapp <david@lace.Colorado.EDU>
Subject: Re: Help! Inexplicable background problem.
Date: 23 Jul 1995 20:05:18 GMT
Organization: University of Colorado at Boulder
This is the clincher. If you have no ionization, then you might think there
is a source of some compound which produces its own ions! The only matarial
I know of that does this is a radioactive source.
BUT, you can get ions from collision alone, especially with large molecules.
>Even when it
>has been off overnight, or even for days. (At the moment it roughly
>doubles in size when the source is on, but previously one could hardly see
>an increase at all.)
>
>It scales with the mass selected (thus the voltages on the rods) roughly
>to the first or second power.
>
Have you put another mass spec on the chamber to see what *it* has to say?
>
>We have also changed an ionization gauge, and had no effect on the
>background problem.
>
>The size of this background varies by factors of two to several on
>timescales of seconds, 10s of seconds, minutes, 10s of minutes, hours,
>days, weeks and months. (Years we'll have to wait and see!) Now
>this strikes us all as really strange.
>
>Well, that's what I see. Luckily it has so far always stayed small enough
>that it only interferes a little with some experiments, or badly with a few
>specialized measurements. But, it is a definite annoyance, and complete
>baffler to date.
>
>Any and all suggestions (posted here or by email) are deeply appreciated!
-put on an entirely different mass spec. same signal? then you have a
contamination problem and your current quad head is not a liar. If not,
your current quad head has problems...
In the past, I've been able to "clean" the head and remove errant signals by
baking and running in an oxidizing atmosphere. I know filaments are expensive,
but if you run at a very low number density, it won't make a diff in the
lifetime.
regards,
david
--
David Knapp
System Administrator, Laser Entrepreneur (303) 492-7113
Department of Geology http://lolita.colorado.edu/david.html
University of Colorado, Boulder david@lolita.colorado.edu
******************************************************************************
From: Dr. Mike Cresswell <100642.2763@CompuServe.COM>
Subject: GC/Mass Spec. odour analysis
Date: 23 Jul 1995 16:29:14 GMT
Organization: MICROBE CONSULTANTS
--
Dr. M.A. Cresswell
******************************************************************************
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Re: general question about mass spectropy
Date: Mon, 24 Jul 95 18:24:06 GMT
Organization: Caltech (Environmental Engineering Science)
>Hello, Netters:
>
>Can anyone out there tell me what mass spectropy can do, and
>what is the basic principle behind it?
See below.
>
>Suppose I have a mixture of octant, octene, hexane, hexene
>and squalane, can I use mass spectropy, to analyze it and to
>find out the mass percentage of each compound?
>
Yes, though like most analytical techniques you'll need
standards (known samples) to quantify.
******************************************************************************
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Re: Mentor wanted for new user of MS
Date: Mon, 24 Jul 95 19:26:05 GMT
Organization: Caltech (Environmental Engineering Science)
> I have
>worked with and am comfortable with split/splitless injection, purge and
>trap, FID, PID, Hall detectors and hve used mainly capilary columns.
>
>I don't yet know the model GC-MS that we are getting.
>
>How about it. Anyone have any suggestions?
>
I suggest at least that the GC model be one you are already familiar with,
that way there's less new to learn. H-P has lots of well-established
products and training courses taught all over the US (and beyond?). Call
800-227-9770 for info on both. They also have good tutorial books/primers.
******************************************************************************
From: cody@jeol.com (Chip Cody)
Subject: Re: Quantitative work with ESMS
Organization: JEOL USA, Inc.
Date: Mon, 17 Jul 1995 16:33:47 GMT
>Hi,
>I'm one of a group of undergraduates looking at the quantitative abilities
>of our Universitys newly acquired Electrospray Mass Spectrometry device.
>We are tasked to look at anabolic steriods in this assignment, and to
>design and test a basic protocol to achieve the main goal. (ie to see
>whether this beast can do quantitative analysis, and tell us the concentr-
>ations of the standard steriod solutions we send thru it.)
Electrospray will probably not work very well for analyzing anabolic
steroids. If your mass spectrometer has atmospheric pressure CI, that would
be a much better way to ionize the sample. In general, use electrospray for
polar compounds that can undergo proton or cation attachment (in positive-ion
mode, anyway) and use APCI for the less polar materials. Of course, GC/MS and
EI or CI are still perfectly good ways to analyze steroids.
Robert B. Cody
JEOL USA, Inc.
******************************************************************************
From: deline@netcom.com (James Deline)
Subject: Free Mass Spec Software
Organization: NETCOM On-line Communication Services (408 261-4700 guest)
Date: Mon, 24 Jul 1995 23:05:15 GMT
Within the next few days I will be posting the Windows (tm) version of my
program "Mass Fragment Calculator" (tm) to my anonymous ftp site at:
ftp.netcom.com/pub/de/deline/
WHAT IT DOES
The user enters a fragment mass and tolerance, and selects the elements
and ranges of the elements to include in the calculation. The program
will then generate all M+ and M+1 formulae that correspond to the
inputted values. The results are presented in an easy to view,
scrollable list, which can also be sent to the printer. The user can
also edit the atomic masses of the elements used in the calculations.
Jim Deline
******************************************************************************
From: A.TREUMANN@dundee.ac.uk (H.J. Treumann Biochemistry ext 4301)
Subject: Re: Quantitative work with ESMS
Date: 25 Jul 1995 10:49:28 +0100
Organization: The University, Dundee, DD1 4HN, Scotland, UK.
: Electrospray will probably not work very well for analyzing anabolic
: steroids. If your mass spectrometer has atmospheric pressure CI, that would
: be a much better way to ionize the sample. In general, use electrospray for
: polar compounds that can undergo proton or cation attachment (in positive-ion
: mode, anyway) and use APCI for the less polar materials. Of course, GC/MS and
: EI or CI are still perfectly good ways to analyze steroids.
I do not agree with this opinion. We had very good responses analysing
phosphatidylinositols in a CHCl3/MeOH mixture on an electrospray mass
spectrometer, both via direct injection and through LCMS with a SiO2 column.
Achim
--
Achim Treumann tel. +44-1382-344301
Carbohydrate Research Centre fax +44-1382-322583
Department of Biochemistry
Dundee DD1 4HN, Scotland, UK email a.treumann@dundee.ac.uk
******************************************************************************
From: rskinner@cycor.ca (Ron Skinner)
Subject: Anybody out there want to talk about ion trap ms/ms ect
Date: Tue, 25 Jul 1995 08:42:42 LOCAL
Organization: PEI Food Technology Centre
I am just starting to use the Varian Saturn MS/MS and have been extremely
impressed with the future direction toward ms/ms/ms as well as selected ion
storage. This instrument is becoming an unbelievably powerful tool. In past
full scan capability was a blessing and a curse when severe background was
present but with the SIS and EI/CI- MS/MS.
Maybe we can get a good discussion going as well as a discussion group through
which we can help each other solve interesting problems.
Ron
******************************************************************************
From: fletcher@osprey.csrv.uidaho.edu (Fletcher Rick)
Subject: Re: GC/Mass Spec. odour analysis
Date: 25 Jul 1995 18:27:44 GMT
Organization: University of Idaho, Moscow, Idaho
I'm not trying to be goofy here, but I'm seriously wondering if it might
not be more efficient to invite a sulfur chemist in to simply have a
smell. Like wine makers, their noses usually knowses.
Rick
--
T. Rick Fletcher - http://www.chem.uidaho.edu/~fletcher/
Assistant professor of chemistry | That's Idaho, not Iowa. | These
University of Idaho | Upper Left Hand Corner. | opinions
Moscow, ID 83844-2343 | No, I don't grow potatoes. | are mine.
******************************************************************************
From: cmd4973@gold.acns.fsu.edu
Subject: Help! Need resources.
Date: 26 Jul 1995 05:24:21 GMT
Organization: Florida State University
Hi Kids,
I would like to get some suggestions on book resources for reading the MS, IR, and
nmr. I have taken a course in Organics and was never able to fully comprehend
the spectroscopy section. Any additional tricks or suggestions would be
apprieciated.
Your Buddy,
C. Dulay
Senior Bio-Chemistry
******************************************************************************
From: "Chip Cody" <cody@titian.jeol.com>
Date: Wed, 26 Jul 1995 12:45:58 -0400
Subject: Follow-up mail for sci.techniques.mass-spec
Cc: cody@seurat.jeol.com
I've had some trouble automatically posting a follow-up via our news
program, so I'm mailing this directly to mass.spec@gatech.edu. Here's the
message :
----------------------------------------------------------------------------
Re: Quantitative work with ESMS
>: Electrospray will probably not work very well for analyzing anabolic
>: steroids. If your mass spectrometer has atmospheric pressure CI, that
would
>: be a much better way to ionize the sample. In general, use electrospray
for
>: polar compounds that can undergo proton or cation attachment (in
positive-ion
>: mode, anyway) and use APCI for the less polar materials. Of course,
GC/MS and
>: EI or CI are still perfectly good ways to analyze steroids.
>I do not agree with this opinion. We had very good responses analysing
>phosphatidylinositols in a CHCl3/MeOH mixture on an electrospray mass
>spectrometer, both via direct injection and through LCMS with a SiO2
column.
>On the other hand there is an inherent negative charge on the phosphate
>in these molecules. What, anyway, would be the difference between APCI
>and ESI that would make anabolic steroids more amenable to APC ionisation?
>Achim
>--
>Achim Treumann tel. +44-1382-344301
>Carbohydrate Research Centre fax +44-1382-322583
>Department of Biochemistry
>Dundee DD1 4HN, Scotland, UK email a.treumann@dundee.ac.uk
It all depends on what you are trying to analyze. If you have a
charged site (as in your example or something like boldenone sulfate),
then ESI will work very well. If, however, you are trying to ionize
an unmodified steroid such as boldenone or testosterone, there is
no site that is easily ionized in electrospray. You are going to have a
hard time getting an M+H -- the best you can hope
to do is add some sodium or potassium and look for a (relatively weak)
cation-attachment peak. I don't believe that there will be a strong
[M-H]- in negative-ion ESI, either, but I haven't tried that myself for
these compounds.
On the other hand, APCI will readily ionize the unmodified steroids
because the ionization occurs in the gas phase.
Robert Cody
JEOL USA, Inc.
--
******************************************************************************
From: tedd@netcom.com (Ted Johnson)
Subject: Any ideas ?
Organization: NETCOM On-line Communication Services (408 261-4700 guest)
Date: Thu, 27 Jul 1995 04:17:56 GMT
Using and Icos 50B GC/MS doing stat human toxicology had a nice peak
(oven program 115 to 297, ramp 11/min.) RT 10 minutes dominantly mass
282; library best match is a Fentanyl analog (don't think so).
Metabolite or parent or breakdown product 1.5 minutes later (also a nice
peak) 282 (100%) 251 (55%) 223 (24%). Doctor suspects tricyclic
antidepressant among several other compounds (Might be a newer tetracyclic).
Got any ideas?
Thanks,
--
********************************************************
******************************************************************************
From: singley@clinpharm.niaaa.nih.gov (Erick Singley)
Subject: Humidity and derivitization
Organization: (National Institutes of Health, Bethesda, MD)
Date: Thu, 27 Jul 1995 15:44:42 GMT
Background: I've got a HP 5970 with a Phasor HED running Chemstation (windows)
and a 5890 GC with a J&W Scientific DB-225 (50% Cyanopropylophenyl) Methyl-
polysiloxane.
I've replaced all my reagents with new (blew nitrogen into bottles to displace
moisture laden air); retuned the MS; and tried running the same samples on
someone else's GC/MS (similar set up) - same results (so I don't think it's
my instrument. no air leaks)
I can always try doing a prep in a cold room here and then trying it, say,
outisde where it's really rotten :) but I' thought I'd ask around to see before
I start wrecking any more samples (bit hard to ask for more CSF after the study
is done...)
Thanks
Erick
--
singley@clinpharm.niaaa.nih.gov
******************************************************************************
From: "75317.1047@compuserve.com (Gary Astle)" <75317.1047@CompuServe.COM>
Subject: Re: Quantitative work with ESMS
Date: 28 Jul 1995 02:14:58 GMT
Organization: ABB Extrel
******************************************************************************
From: mlgay@ix.netcom.com (Martha L. Gay)
Subject: Re: Help! Need resources.
Date: 29 Jul 1995 03:06:40 GMT
Organization: Netcom
******************************************************************************
From: mlgay@ix.netcom.com (Martha L. Gay)
Subject: Re: Mentor wanted for new user of MS
Date: 29 Jul 1995 03:13:25 GMT
Organization: Netcom
But, you are interested in getting to use the mass spec., so - do you
know anyone who has one? Any local universities or discussion groups?
By all means let everybody know you are interested. Good luck. Martha
Gay
******************************************************************************
From: "K.R. Jonscher" <krj@u.washington.edu>
Subject: Re: Anybody out there want to talk about ion trap ms/ms ect
Date: 29 Jul 1995 19:52:41 GMT
Organization: UW
******************************************************************************
From: "K. Murray" <kmurray@emory.edu>
Subject: Re: Help! Need resources.
Date: 31 Jul 1995 14:49:01 GMT
Organization: Emory University
>>Hi Kids,
>>I would like to get some suggestions on book resources for reading the MS,
>>IR, and nmr. I have taken a course in Organics and was never able to
>fully comprehend the spectroscopy section. Any additional tricks or
>suggestions would be apprieciated.
Kermit Murray
kmurray@emory.edu
******************************************************************************
From: mdziewat@postbox.acs.ohio-state.edu (Mike Dziewatkoski)
Subject: Simion Time of Flight Modeling
Date: Mon, 31 Jul 1995 23:46:00 GMT
Organization: The Ohio State University
Thanks in advance,
Mike Dziewatkoski
Ohio State University
******************************************************************************
From: heinen@rulg18.leidenuniv.nl (Wouter Heinen)
Subject: Mass Spectrometry Anhydrides
Date: 1 Aug 1995 07:30:31 GMT
Organization: Leiden University, The Netherlands
L.S.!
--
__________________________________________________
Wouter Heinen
Gorlaeus Laboratories
Rijksuniversiteit Leiden
P.O.Box 9502
2300 RA Leiden
The Netherlands
tel ++ 31 71 274472
fax ++ 31 71 274488 :-)
__________________________________________________
#######################################################
From: rjnemery@uniwa.uwa.edu.au (Neil Emery)
Subject: Re: Humidity and derivitization
Date: 2 Aug 1995 09:36:29 GMT
Organization: The University of Western Australia
I've had problems getting rid of water when I make TMS derivatives, and try to
get around this by adding methylene chloride as an azeotrope and evaporating under
a stream of N2
I don't have any experience with TFAA/TFE, but perhaps my comments might help, as
noone else appears
to be answering. If they are I'd appreciate seeing the responses posted, since I
think the problem
is of general appeal.
Neil
>
#######################################################
From: cato.brede@kjemi.uio.no (Cato Brede)
Subject: Electron background in quadropoles?
Date: 2 Aug 1995 10:20:50 GMT
Organization: Universitet i Oslo
"Altough there are significant populations of negative ions available for sampling
form
the argon ICP, the detection limits obtained with negative ion operation are
generally
higher as a result of elevated background signals. Background count rates,
presumably from
electrons, are of the order of 1000 counts/s, which is not unusual with negative
ion
operation."
Question:
How do the electrons pass the quadropole analyzer and reach the detector?
Possible answer:
Is it possible that some electrons gain enough energy (and velocity) to pass the
quadropole
without beeing deflected.
Cato Brede
Dept. of Chemistry
University of Oslo, NORWAY
#######################################################
From: David West <west@oxy.edu>
Subject: any ideas
Date: 2 Aug 1995 17:20:25 GMT
Organization: Occidental College
Ted: I'm not a REAL mass spectroscopist, but your spectrum rings a bell. I think
I got the same one on my HP GC-MS last year and, even though it showed a nice GC
peak at about 10 min., it was actually silicone contamination! I would like a
real mass spectroscopist to tell me how contamination can show up as a nice G.C.
peak. Thank you all.
Dave West
#######################################################
From: Heinrich Luftmann <luftman@uni-muenster.de>
Subject: Re: Simion Time of Flight Modeling
Date: 3 Aug 1995 07:53:01 GMT
Organization: Org.Chem.Inst. Uni. Muenster
Heinrich Luftman ,
Univ. of Muenster
#######################################################
From: karr@well.com (Dane Karr)
Subject: Re: any ideas
Date: 3 Aug 1995 14:15:19 GMT
Organization: TET
> Ted: I'm not a REAL mass spectroscopist, but your spectrum rings a
bell.I >think I got the same one on my HP GC-MS last year and, even though
it showed a >nice GC peak at about 10 min., it was actually silicone
contamination! I would >like a real mass spectroscopist to tell me how
contamination can show up as a >nice G.C. peak. Thank you all.
I didn't catch the original post but your description sounds like septum
bleed to me. When the oven cools down, silicone decomposition products
from the septum can focus at the head of the column. When you do your next
GC run, a nice sharp GC peak (or a series of them) show up with ions
characterisic of silicone. This can be reduced by using low bleed septa
and changing septa frequently.
Dane
--
Dane Karr
karr@well.com
#######################################################
Date: Thu, 03 Aug 1995 18:58:13 +0000 (GMT)
From: ddxdd@IMAP1.ASU.EDU
Subject: Re: Simion Time of Flight Modeling
Organization: daves not here
Mike Dziewatkoski (mdziewat@postbox.acs.ohio-state.edu) wrote:
: I am a user of the PC version of Simion. I would like to hear from anyone
: out there who is familiar with using the PC version of Simion and knows how to
: extract ion flight time information from the program. Specifically, I am
: interested in knowing how long it takes an ion of given mass and kinetic
: energy to travel a certain distance through the ion lens system and
: quadrupoles and how this time varies with trajectory.
: Thanks in advance,
: Mike Dziewatkoski
: Ohio State University
-d^2
#######################################################
From: HAIGH@frost.oit.umass.edu (Paul E Haigh)
Subject: Re: any ideas
Date: 4 Aug 1995 14:06:44 GMT
Organization: University of Massachusetts, Amherst
: > Ted: I'm not a REAL mass spectroscopist, but your spectrum rings a
: bell.I >think I got the same one on my HP GC-MS last year and, even though
: it showed a >nice GC peak at about 10 min., it was actually silicone
: contamination! I would >like a real mass spectroscopist to tell me how
: contamination can show up as a >nice G.C. peak. Thank you all.
: I didn't catch the original post but your description sounds like septum
: bleed to me. When the oven cools down, silicone decomposition products
: from the septum can focus at the head of the column. When you do your next
: GC run, a nice sharp GC peak (or a series of them) show up with ions
: characterisic of silicone. This can be reduced by using low bleed septa
: and changing septa frequently.
I didn't see the original post either, but we have run into silicon
problems in ICP-MS because of latex glove powder. You may have done a
minor extraction upon your gloves, or had some of the dust flying
about in the lab.
Maybe??
good luck
pbh
#######################################################
From: Martin Mach <Martin.Mach@trw.com>
Subject: Plasma Chromatography
Date: 4 Aug 1995 16:00:57 GMT
Organization: TRW Space & Electronics Group, Redondo Beach, CA
#######################################################
Date: 4 Aug 1995 19:21:22 -0700
From: "Bud Buttrill" <bud.buttrill@grc.varian.com>
Subject: Bay Area MS Discussion Grou
The next meeting of the Bay Area Mass Spectrometry discussion group will be at
the Sheraton Inn in Sunnyvale, CA.
Reservations for dinner required by Aug. 23. Contact Carolyn Koester, BAMS
Secretary at koester1@llnl.gov
#######################################################
Date: 4 Aug 1995 19:21:22 -0700
From: "Bud Buttrill" <bud.buttrill@grc.varian.com>
Subject: Bay Area MS Discussion Grou
The next meeting of the Bay Area Mass Spectrometry discussion group will be at
the Sheraton Inn in Sunnyvale, CA.
Reservations for dinner required by Aug. 23. Contact Carolyn Koester, BAMS
Secretary at koester1@llnl.gov
#######################################################
From: tedd@netcom.com (Ted Johnson)
Subject: Any ideas ?
Organization: NETCOM On-line Communication Services (408 261-4700 guest)
Date: Sun, 6 Aug 1995 15:39:56 GMT
Not to discount the septa bleed theory but, we run 7 MSD's, an INCOS 50
and a TSQ 7000, use low bleed septa and this peak was also present in
repeat injections and different instruments and new extractions. I just
hate it when you know it's something and the MD's say "are you sure the
Tox. report was negative?". Thanks for the help.
--
********************************************************
#######################################################
From: stoeri@eapv38.tuwien.ac.at (Herbert Stoeri)
Subject: Re: Electron background in quadropoles?
Date: 7 Aug 1995 14:47:39 GMT
Organization: Institut fuer Allgemeine Physik, TU Wien
Another type of mass spectrometer would solve the first problem, but not
the second one.
Herbert Stoeri
Institut fuer Allgemeine Physik
Arbeitsgruppe Plasmatechnik
Technische Universitaet Wien
AUSTRIA
#######################################################
From: "K. Murray" <kmurray@emory.edu>
Subject: STMS through the WWW
Date: 9 Aug 1995 00:32:46 GMT
Organization: Emory University
I have the STMS posts from the listserver mailings archived under
http://tswww.cc.emory.edu/~kmurray/stms.html
It's searchable as are some pages of MS links at
http://tswww.cc.emory.edu/~kmurray/mslist.html
Many thanks to all who have submitted pages and linked my page
and others. Mass spec on the WWW is much more of a web now than it
was even six months ago.
Kermit Murray
kmurray@emory.edu
#######################################################
Date: Wed, 9 Aug 1995 15:31:45 +0000
From: Peter.Davies@mrc-dunn.cam.ac.uk (PSW Davies)
Subject: Stable isotope equipment information wanted
Bill Park
=========
#######################################################
From: deline@netcom.com (James Deline)
Subject: Free Mass Spec Software
Organization: NETCOM On-line Communication Services (408 261-4700 guest)
Date: Thu, 10 Aug 1995 02:44:40 GMT
http://www.camsci.com/others/shareware/mfcalc.html
The program is available for both the Macintosh and Windows platforms.
#######################################################
From: park@netcom.com (Bill Park)
Subject: Re: Free Mass Spec Software
Organization: Netcom Online Communications Services (408-241-9760 login: guest)
Date: Thu, 10 Aug 1995 19:55:15 GMT
Hmmmmm ....
403
Forbidden
403 FORBIDDEN
#######################################################
From: Ian Michael <ian-michael@impub.demon.co.uk>
Subject: European Mass Spectrometry 1/3 Abstracts
Date: Thu, 10 Aug 95 14:47:47 GMT
Organization: IM Publications
The abstracts for the next issue of European Mass Spectrometry, due for
publication on 28 August are detailed below.
--
Ian Michael
============================================
VOLUME 1 ISSUE 3 1995 Abstracts and Contents
============================================
Free sample copies of the journal are available; please send e-mail to
ian-michael@impub.demon.co.uk, fax on +44-1243-811711 or write to
IM Publications, 6 Charlton Mill, Charlton, Chichester, West Sussex PO18 0HY,
United Kingdom. Please include the following information:
Copies of Instructions for Authors are also available from the same source
and an e-mail version can be sent to you quickly.
MANAGING BOARD
Professor Allan Maccoll (London)
Professor Hans-Friedrich Gruetzmacher (Bielefeld)
Professor J.H. Bowie (Adelaide)
Professor L. Ceraulo (Palermo)
Professor Oleg S. Chizhov (Moscow)
Professor Peter J. Derrick (Warwick)
Professor Juergen Grotemeyer (Wurzburg)
Professor John L. Holmes (Ottawa)
Professor Keith R. Jennings (Warwick)
Professor Mamoru Ohashi (Tokyo)
Professor Jean-Claude Prome (Toulouse)
Professor Douglas P. Ridge (Newark)
Professor Einar Uggerud (Oslo)
-----------------
Table of Contents
-----------------
Allan Maccoll
-----------------
ABSTRACT:
A procedure for extraction of the kinetic energy release distribution
from the metastable fragment ion peak shape in an ion trap reflectron
time-of-flight mass spectrometer is presented. Peak shapes for a set
of discrete values of kinetic energy releases are calculated and their
contributions to the measured peak shape determined. Information about
the temporal evolution of each component is required in order to get
the correct kinetic energy release distribution. This is obtained by
carrying out the measurements at different times following ion formation.
The method is demonstrated for the metastable decay of aniline ions
formed by multiphoton ionization.
-----------------
ABSTRACT:
Quantum chemistry calculations and experimental investigations
of the unimolecular dissociation step of the molecular radical cation
of tetramethylsilane losing a methyl radical to give the m/z 73 trimethyl
silyl cation have been carried out. There is an apparent lack of an
ion/neutral complex in the minimum energy reaction pathway, where in
quaternary carbon compounds there is evidence of such complexes.
It is suggested that at interfragment separation distances at which
an ion/neutral complex would be expected the electrostatic interactions
are swamped by the strength of the conventional covalent bonding
interactions which are an order of magnitude greater than
in the quaternary carbon systems at similar separations.
-----------------
ABSTRACT:
The fragmentation pattern of C70+* in its collision with He has been
studied in order to derive an explanation for recent observations on
tremendous differences in relative intensities and extent of
fragmentation upon variation of the centre-of-mass collision energy.
-----------------
ABSTRACT:
The addition of metal salts to proteins produces metal adduct ions,
as well as multiply protonated species, in electrospray mass spectra.
These adducts can be used for charge state determination of both intact
and fragment ions using low resolution mass analyzers. In this study,
the effectiveness of MeHg+, Ag+, PhHg+, Zn2+, Cd2+, Pb2+, La3+ and Tb3+
as adducts with myoglobin and ubiquitin, and their resistance to loss
during collisional activation experiments, are investigated. Due to the
large m/z separations, high MeHg+, PhHg+ and Pb2+ concentrations produce
mass spectra with overlapping charge state series. The adduction of Ag+,
Cd2+ and Zn2+ results in smaller separations, with no interference from
adjacent charge states. However, higher concentrations of these cations
are required to form reasonably intense adduct ion peaks. For La3+ and
Tb3+ cations, significant adduction is only observed at very high metal
salt concentrations. The small m/z separations for the zinc adducts cause
problems with resolution, resulting in charge state assignment errors.
Unlike their singly charged silver and mercury-containing counterparts,
lead, cadmium and zinc adduct precursors do not readily form metal adduct
fragment ions during collisional activation experiments, making them
less suited to accurate charge state assignment for fragments.
-----------------
253 The effects of stearyl and cetyl alcohol on the electrospray mass
spectrometry of proteins and their implications on the electrospray
mechanism
Fu Ke, J.C. Yves Le Blanc, Roger Guevremont and K.W. Michael Siu
ABSTRACT:
The presence of a low percentage of a long-chained n-alkanol, such as
stearyl or cetyl alcohol, in a micrometer-size water droplet is known
to retard significantly the droplet's evaporation rate due to formation
of a layer of the alcohol on its surface. If solvent evaporation from
electrospray-generated droplets played a crucial role in the electrospray
mechanism, the presence of a long-chained n-alkanol would interfere with
the gas-phase ion formation and cause a drastic decrease in analyte
response. As it turned out, the electrospray responses of proteins tested
with and without the presence of n-alkanols were comparable. In these
experiments, the n-alkanols were added either as solutes in water/methanol
solutions of proteins or in hexane solutions delivered coaxially to
aqueous protein solutions during their electrospray. These results lend
further support to our hypothesis that solvent evaporation is not a
necessary prerequisite to ion formation in electrospray, and that ions
are formed early rather than late during the electrospray process; the
earliest point that this can occur is at the Taylor cone.
-----------------
ABSTRACT:
The unimolecular chemistry of the N-methyl-O-methyl carbamate radical
cation CH3N(H)COOCH3+*, has been studied by a variety of mass spectrometry
based techniques [metastable ion (MI), collisional activation (CA) and
neutralisation-reionisation (NR) mass spectrometry and multiple collision
(MS/MS/MS) experiments] in combination with D, 13C and 18O labelling
experiments. The loss of a methyl radical is not a simple bond cleavage
process; rather, at high internal energies, the reaction proceeds via
a 1,4-hydrogen shift to produce the distonic ion CH2=N(H)-C(OH)OCH3+*
which then sheds the O-CH3 methyl group to produce the N-carboxyliminium
ion CH2=N(H)-COOH+, a putatively destabilized iminium ion. The latter step
is exothermic (by c.15 kcal mol-1) and moreover involves a significant
barrier for the forward reaction, characteristic of O-C bond cleavages
in (distonic) radical cations, rationalizing the large kinetic energy
release observed for this dissociation. At low internal energies, the
hydrogen atoms of the methyl groups, but not that of the N-H group,
exchange to the statistical limit. This is rationalized in terms of the
equilibria CH3N(H)COOCH3+* # CH2=N(H)-C(OH)OCH3+* # CH3N(H)COOCH3+*
taking place prior to dissociation. The heats of formation of
CH3N(H)COOCH3+* and CH2=N(H)-COOH+* have been estimated as 133 and
82 kcal mol-1, respectively.
-----------------
ABSTRACT:
The mass spectrometric behaviour of four diastereoisomeric
2-hydroxy-4-t-butylcyclopentyl carboxylic acids has been investigated by
means of electron impact ionisation experiments, mass analysed ion
kinetic energy spectroscopy and ion trap mass spectrometry. The comparison
of the data obtained by these different techniques allowed the unambiguous
differentiation of the four compounds.
-----------------
ABSTRACT:
The electron impact mass spectra of eighteen 3-aryloxypropiononitriles and
seventeen immediate precursors, 1-bromo-2-aryloxyethanes, have been
measured. The compounds are readily distinguished by gas chromatography/mass
spectrometry (GC/MS).
-----------------
ABSTRACT:
Barium concentrations in various standards and natural samples are
determined by inductively coupled plasma mass spectrometry (ICP-MS) using
isotope dilution and using external calibration with or without internal
standard. First, the measured Ba isotopic ratios confirm the existence of
a mass bias, which is shown to follow a linear law and which is the same
in unknown natural samples (rocks, river waters, rain waters and sea
waters) and in standards (river water, rock samples and synthetic solutions)
both in matrix-rich samples as well as in diluted samples. As it is not
matrix dependent and it is stable on a daily time-scale, approximate
correction can be made. Second, Ba concentrations obtained with isotope
dilution and with external calibration with an internal standard show
excellent agreement (within +/-2%) for geostandards as well as for unknown
natural samples. This result implies that indium, as an internal standard
for Ba analysis, is very effective for the correction of matrix effects,
whatever the matrix and signal variations. Concentrations calculated
by isotope dilution and by simple external calibration are, however, in
agreement to within +/-6%, which indicates that matrix effects on Ba are
small.
-----------------
ABSTRACT:
A series of poly(methyl methacrylate)s and poly(styrene)s (masses
1000-12,000 Da) with narrow molecular-mass distributions have been
analysed by matrix-assisted laser desorption/ionisation time-of-flight
(MALDI-TOF) mass spectrometry and size exclusion chromatography (SEC).
The resultant number average Mn, mass (weight) average Mw, and z average
Mz molecular masses as determined from the two techniques are presented
and compared. These data show MALDI-TOF mass spectrometry and size
exclusion chromatography (SEC) to be in good agreement, typically to
within 10% for the analyses of these types of polymers.
-----------------
ABSTRACT:
The technique of electrospray ionisation mass spectrometry has been used
to study the hydrogen/deuterium exchange of bisMSH-DTPA, a derivative of
.alpha.-melanocyte stimulating hormone (MSH) in which two complete MSH
peptide chains are covalently bound to a single molecule of
diethylenetriamine pentaacetic acid (DTPA). The results show different
levels of exchange between the metal-chelated and the unchelated peptide.
We suggest that the unchelated peptide is able to form a hydrogen-bonded
structure between the carboxyl groups of DTPA and the amino nitrogen of
the N'-terminal serine of MSH.
-----------------
ABSTRACT:
Four samples of natural melanin extracted from red, fair, black and brown
human head hair were studied by both laser desorption/ionisation (LDI)
and matrix-assisted laser desorption/ionisation (MALDI) methods. Clear
differences were found among the LDI and MALDI mass spectra of the four
melanins. In red hair melanin, there was a major peak at m/z 842
attributed to an oligomeric cluster, together with lower-intensity peaks
in the range 4000-5000 Da. In fair hair melanin, only species with
molecular masses from 300 to 600 Da were evidenced. In black hair melanin,
clusters up to 25,000 Da were detectable, and in brown hair melanin,
there were two main oligomeric clusters in the ranges 600-900 Da and
3000-5000 Da, respectively, and a large oligomer distribution from
11,000 to 16,000 Da. It is concluded that there is an increase in relative
molecular masses of melanins on passing from fair to black hair,
suggesting that in dark hair the colour is related to melanins with a
higher degree of polymerisation.
-----------------
ABSTRACT:
In an attempt to probe the molecular topology of the ion gate in the
nicotinic AChR protein, the high affinity Kd >> 10-11 molar) ligand
neurotoxin II (NT II), a 61 residue peptide from the venom of Naja
naja oxiana, was photocrosslinked to the nAChR of Torpedo californica.
The photoactivatable group was a 125I-p-azidosalicylamidoethyl-1,3-
dithiopropyl (ASED) moiety located at the K25 residue of NT II. Specific
labeling occurred at the delta-subunit which, after SDS-PAGE, was
subjected to tryptic digestion and reverse phase high performance
liquid chromatography (rpHPLC) separation. Although the radioactivity
profile of the collected HPLC fractions exhibited two sharp maxima
suggesting rather specific crosslinking site(s), attempts to localize these
sites by Edman degradation failed. Thus, matrix-assisted laser desorption
ionization (MALDI) mass spectrometry was employed in the hope of
circumventing the difficulties encountered with the conventional protocols.
This technique, in conjunction with the option to perform mass
spectrometric peptide sequencing by so-called post-source decay (PSD)
product ion analysis, (even with subpicomoles of analyte loads in
heterogeneous samples) allowed us not only to determine the labeled tryptic
peptide but also to localize the site of the crosslink down to the A268
position of the delta-subunit. It is felt that these results demonstrate
the capability of the MALDI technique to overcome some of the constraints
inherent in the analytical tool of photolabeling, especially in cases where
large molecular probes (such as NT II) are employed.
-----------------
Allan Maccoll
-----------------
ABSTRACT:
The molecule D2SiCH2 has been generated and identified for the first
time in the gas phase by the neutralization of an 8 keV beam of
[D2SiCH2]+* ions.
-----------------
#######################################################
From: brecher@terminator.rs.itd.umich.edu (Jonathan Brecher)
Subject: Re: Free Mass Spec Software
Date: 12 Aug 1995 16:10:30 GMT
Organization: CambridgeSoft Corporation
Jonathan Brecher
CambridgeSoft Corporation
#######################################################
From: rbaker@ds16.modicon.com (Richard Baker)
Subject: Re: Any ideas ?
Date: 14 Aug 1995 00:04:39 GMT
Organization: Modicon Division of AEG Schneider Automation
This leads to the question of the type of sample. Was this a urine
sample?
Leisa Mingo
West Newbury, MA
#######################################################
From: rbaker@ds16.modicon.com (Richard Baker)
Subject: Med Tech - Toxicology - MA
Date: 14 Aug 1995 00:15:31 GMT
Organization: Modicon Division of AEG Schneider Automation
TOXICOLOGY
#######################################################
From: hall_lab@tikal.biosci.arizona.edu (Robert Baker)
Subject: Help: ICP-MS
Date: Fri, 18 Aug 1995 11:58:55 +1000
Organization: The University of Arizona
Robert Baker
Dept. of Molecular and Cellular Biology
University of Arizona
(520) 621-7522
e-mail: hall_lab@tikal.biosci.arizona.edu
or: rbaker@gas.uug.arizona.edu
#######################################################
Date: Fri, 18 Aug 1995 13:24:00 -0500 (CDT)
From: "Steven P. Cepa 708-937-7539" <CEPA.STEVEN@igate.pprd.abbott.com>
Subject: Deconvolution software
Many of the mass spec vendors offer software to deconvolute multiply charged
mass spectra.
cepa.steven@igate.abbott.com
#######################################################
From: Nahum Gat <oksi@cerfnet.com>
From: ciads@sivax.unisi.it
Subject: The Italian Home Page on Mass Spectrometry
Date: 21 Aug 1995 08:01:15 GMT
Organization: Universita' di SIENA
is a WWW site devoted to mass spectrometry in Italy, but open over the world.
URL: http://www.cineca.it/mass_spectrom/
http://www.cineca.it/mass_spectrom/massa96/
Sincerely yours
Gianluca
-------------------------------------------------------
Dr. Gianluca Giorgi
Centro Interdipartimentale di Analisi e Determinazioni
Struttturali della Universita' di Siena
via P.A. Mattioli, 10
53100 Siena (Italy)
tel. 0039-577-298925 fax. 0039-577-298927
E-mail: CIADS@UNISI.IT
#######################################################
From: ciads@sivax.unisi.it
Subject: MASSA 96-2nd MS-PHARMADAY Meeting
Date: 21 Aug 1995 08:02:37 GMT
Organization: Universita' di SIENA
http://www.cineca.it/mass_spectrom/massa96/
Sincerely yours
Gianluca
-------------------------------------------------------
Dr. Gianluca Giorgi
Centro Interdipartimentale di Analisi e Determinazioni
Struttturali della Universita' di Siena
via P.A. Mattioli, 10
53100 Siena (Italy)
tel. 0039-577-298925 fax. 0039-577-298927
E-mail: CIADS@UNISI.IT
#######################################################
From: pmarston@vacgen.fisons.co.uk (pmarston)
Subject: Download Free LEED Demo Software
Date: 21 Aug 1995 15:27:04 GMT
Organization: Fisons Instruments Surface Systems
Features.
+ Windows. compatible.
+ 256 levels / 8-bit resolution.
+ Contrast/ brightness adjustment by input look up table.
+ Image alignment using Pendry R-Factor analysis.
+ Automatic spot tracking.
+ Diffuse tracking (tracking from stored template).
+ Target current normalisation.
+ Compatible with VG and most other LEED optics.
http://www.surface.fisons.co.uk/vacgen/
The software can be found on the 'Download Demo Software' page.
Phil Marston
Vacuum Generators
#######################################################
From: Howard Berg <berg@magic.geol.ucsb.edu>
Subject: electron multiplier detectors
Date: 22 Aug 1995 00:56:49 GMT
Organization: University of California, Santa Barbara
Does anyone have experience using discreet dynode, active film electron
multipliers for ICPMS work as opposed to the continuous channel type?
We have a VQ Plasmaquad, fitted with a Galileo dual-mode (ion/analog)
detector. We are interested in trying a discreet dynode, dual-mode
replacement by ETP. The promises of the ETP unit are flatter
ion-counting/bias plateau for improved stability, greater counting rate
limit for increased dynamic range, lower background noise, and improved
shelf life. The ETP units can also be rebuilt at a fraction of the cost
of a new one. My information is that VG now uses the ETP discreet
dynode units in production intruments.
Howard Berg
UCSB
berg@magic.geol.ucsb.edu
#######################################################
From: spectrscpy@aol.com (Spectrscpy)
Subject: MS Survey
Date: 22 Aug 1995 19:27:53 -0400
Organization: America Online, Inc. (1-800-827-6364)
No names will be published, but be sure to include your name and contact
information in case we have questions.
We welcome your participation and hope you'll enjoy this special issue.
Michael MacRae
Editor
#######################################################
Subject: Help: free iso cluster calculation program for PC?
Date: 23 Aug 1995 20:29:43 GMT
Organization: Your Organization
From: News Owner <news@waage.rz.uni-ulm.de>
Does anybody here know if there is some free- or shareware available on the net
for calculating isotopic cluster abundances, e.g. for halogenated compounds?
Karlheinz Hauff
#######################################################
From: Nahum Gat <oksi@cerfnet.com>
Subject: LC/GC Magazine TOC now at TechExpo WWW
Date: 24 Aug 1995 06:40:23 GMT
Organization: Opto-Knowledge Systems, Inc.
Dear Colleague,
NEW:
The TOC will be updated monthly, prioiur to the issue of the printed
version.
Cheers
:-)
Nahum Gat, Ph.D.
nahum@techexpo
or
oksi@cerfnet.com
#######################################################
Date: Thu, 24 Aug 1995 06:38:51 -0400 (EDT)
From: "Dana DeJohn (313)996-7135" <dejohn@aa.wl.com>
Subject: Mich. Mass Spec. Disc. Grp. Meeting 9/13
The next meeting of the Michigan Mass Spectrometry Discussion Group will be
held on ***WEDNESDAY SEPTEMBER 13, 1995*** at the University of Michigan, Ann
Arbor Campus. ***THE MEETING WILL BEGIN AT 5:30PM IN FURSTENBURG 2747, WHICH
IS PART OF THE MEDICAL SCIENCE II COMPLEX.*** Dinner will follow at a local
restaurant. The scheduled speakers are:
Dr. Schey is a 1992 American Society for Mass Spectrometry Research Awardee
and is being sponsored by the ASMS speaker program. Kevin is currently in the
Pharmacology Department at the Medical University of South Carolina. Dr.
Ogorzalek Loo is currently a research associate at the University of Michigan
Protein & Carbohydrate Structure Facility directed by Dr. Phil Andrews.
PerSeptive Biosystems will be our corporate sponsor for this meeting. They
have graciously agreed to cover the cost of parking for meeting attendees.
Please be sure to thank Dave Painter for their generosity. Because parking
passes have to be obtained, you must ***CONTACT RACHEL OGORZALEK LOO, 2560
MSRB II, 1150 W. MEDICAL CENTER DR., ANN ARBOR, MI 48109-0674 (E-MAIL:
LOO@BRCF.MED.UMICH.EDU; PHONE: 313-936-1137 OFFICE, 313-936-2638 FAX) BY SEPT.
8 TO ARRANGE TO HAVE A PARKING PASS MAILED.*** Parking will be in the parking
ramps at Glen and Catherine Streets. Park in one of the 2 parking ramps and
walk up Catherine Street to the meeting site.
For those of you being notified through e-mail and aren't sure where the
building and parking ramps are, I have maps available that I can FAX (or
mail) to you on request. E-mail (or call) me with your preference and I'll
get them to you right after the Labor Day holiday.
Pass the word about the meeting to any of your colleagues. Hope to see you at
the University of Michigan.
Best Regards,
Dana DeJohn
Parke-Davis Pharmaceutical Research
2800 Plymouth Rd.
Ann Arbor, MI 48105
TEL: 313-996-7135
FAX: 313-998-2716
INTERNET: dejohn@aa.wl.com
#######################################################
Date: Thu, 24 Aug 1995 06:38:51 -0400 (EDT)
From: "Dana DeJohn (313)996-7135" <dejohn@aa.wl.com>
Subject: Mich. Mass Spec. Disc. Grp. Meeting 9/13
The next meeting of the Michigan Mass Spectrometry Discussion Group will be
held on ***WEDNESDAY SEPTEMBER 13, 1995*** at the University of Michigan, Ann
Arbor Campus. ***THE MEETING WILL BEGIN AT 5:30PM IN FURSTENBURG 2747, WHICH
IS PART OF THE MEDICAL SCIENCE II COMPLEX.*** Dinner will follow at a local
restaurant. The scheduled speakers are:
Dr. Schey is a 1992 American Society for Mass Spectrometry Research Awardee
and is being sponsored by the ASMS speaker program. Kevin is currently in the
Pharmacology Department at the Medical University of South Carolina. Dr.
Ogorzalek Loo is currently a research associate at the University of Michigan
Protein & Carbohydrate Structure Facility directed by Dr. Phil Andrews.
PerSeptive Biosystems will be our corporate sponsor for this meeting. They
have graciously agreed to cover the cost of parking for meeting attendees.
Please be sure to thank Dave Painter for their generosity. Because parking
passes have to be obtained, you must ***CONTACT RACHEL OGORZALEK LOO, 2560
MSRB II, 1150 W. MEDICAL CENTER DR., ANN ARBOR, MI 48109-0674 (E-MAIL:
LOO@BRCF.MED.UMICH.EDU; PHONE: 313-936-1137 OFFICE, 313-936-2638 FAX) BY SEPT.
8 TO ARRANGE TO HAVE A PARKING PASS MAILED.*** Parking will be in the parking
ramps at Glen and Catherine Streets. Park in one of the 2 parking ramps and
walk up Catherine Street to the meeting site.
For those of you being notified through e-mail and aren't sure where the
building and parking ramps are, I have maps available that I can FAX (or
mail) to you on request. E-mail (or call) me with your preference and I'll
get them to you right after the Labor Day holiday.
Pass the word about the meeting to any of your colleagues. Hope to see you at
the University of Michigan.
Best Regards,
Dana DeJohn
Parke-Davis Pharmaceutical Research
2800 Plymouth Rd.
Ann Arbor, MI 48105
TEL: 313-996-7135
FAX: 313-998-2716
INTERNET: dejohn@aa.wl.com
#######################################################
Date: Thu, 24 Aug 1995 06:38:51 -0400 (EDT)
From: "Dana DeJohn (313)996-7135" <dejohn@aa.wl.com>
Subject: Mich. Mass Spec. Disc. Grp. Meeting 9/13
The next meeting of the Michigan Mass Spectrometry Discussion Group will be
held on ***WEDNESDAY SEPTEMBER 13, 1995*** at the University of Michigan, Ann
Arbor Campus. ***THE MEETING WILL BEGIN AT 5:30PM IN FURSTENBURG 2747, WHICH
IS PART OF THE MEDICAL SCIENCE II COMPLEX.*** Dinner will follow at a local
restaurant. The scheduled speakers are:
Dr. Schey is a 1992 American Society for Mass Spectrometry Research Awardee
and is being sponsored by the ASMS speaker program. Kevin is currently in the
Pharmacology Department at the Medical University of South Carolina. Dr.
Ogorzalek Loo is currently a research associate at the University of Michigan
Protein & Carbohydrate Structure Facility directed by Dr. Phil Andrews.
PerSeptive Biosystems will be our corporate sponsor for this meeting. They
have graciously agreed to cover the cost of parking for meeting attendees.
Please be sure to thank Dave Painter for their generosity. Because parking
passes have to be obtained, you must ***CONTACT RACHEL OGORZALEK LOO, 2560
MSRB II, 1150 W. MEDICAL CENTER DR., ANN ARBOR, MI 48109-0674 (E-MAIL:
LOO@BRCF.MED.UMICH.EDU; PHONE: 313-936-1137 OFFICE, 313-936-2638 FAX) BY SEPT.
8 TO ARRANGE TO HAVE A PARKING PASS MAILED.*** Parking will be in the parking
ramps at Glen and Catherine Streets. Park in one of the 2 parking ramps and
walk up Catherine Street to the meeting site.
For those of you being notified through e-mail and aren't sure where the
building and parking ramps are, I have maps available that I can FAX (or
mail) to you on request. E-mail (or call) me with your preference and I'll
get them to you right after the Labor Day holiday.
Pass the word about the meeting to any of your colleagues. Hope to see you at
the University of Michigan.
Best Regards,
Dana DeJohn
Parke-Davis Pharmaceutical Research
2800 Plymouth Rd.
Ann Arbor, MI 48105
TEL: 313-996-7135
FAX: 313-998-2716
INTERNET: dejohn@aa.wl.com
#######################################################
From: Frank Antolasic <rcmfa@bunyip.ph.rmit.edu.au>
Subject: Kratos DS90 software
Date: 25 Aug 1995 05:37:36 GMT
Organization: RMIT Applied Chemistry Dept
Hi
We have a Kratos MS25RF mass spectrometer that is still run by a Data
General Model 30 computer running DS90 software. We are looking at
upgrading this computer to one running MS Windows on a PC. Has anyone out
there upgraded their Kratos system? I would like to hear some comment on
the types of computer upgrades available and what users think of them. I
am especially interested in systems that will control the mass spec as
well as process the data.
#######################################################
From: Preston Korn <iink@primenet.com>
Subject: Need help with a spectroscopy exhibit
Date: 25 Aug 1995 15:19:22 GMT
Organization: Interactive Ink
Preston Korn
Interactive Ink
429 S. San Francisco
Flagstaff, AZ 86001
520-774-0819
iink@primenet.com
#######################################################
From: sismspec@aol.com (Sismspec)
Subject: Local Mass Spec Group Meetings
Date: 25 Aug 1995 12:34:13 -0400
Organization: America Online, Inc. (1-800-827-6364)
Local Mass Spec Group Meetings. - Included in our home page will be a
section for the listing of the local mass spec groups. This listing will
include officers, contact phone numbers, location of meetings, speakers
and schedules. If you would like to have your organization listed free of
charge, please let us know. In addition if your local MS group has a home
page on the internet, we will be glad to hyperlink to it.
If anyone has any suggestions for other mass spec resources, references or
valuable information of interest to the mass spec community that should be
included in our internet home pages, please give me a call or drop me an
e-mail. Your input would be greatly appreciated.
John J. Manura
Scientific Instrument Services
Supplies and Services for Mass Spectrometers, Gas Chromatographs and
related scientific instruments
Phone: (908) 788-5550
FAX: (908) 806-6631
E-Mail: sismspec@aol.com
#######################################################
From: dhachey@bcm.tmc.edu
Subject: Re: Help: free iso cluster calculation program for PC?
Date: 25 Aug 1995 17:38:49 GMT
Organization: Baylor College of Medicine
I obtained a very nice one from Michael Senko at the National High Magnetic
Field Laboratory at
Florida State University. You can contact him at: senko@magnet.fsu.edu
His program calculates isotope patterns for any arbitrary combination of
elements, at any resolution,
and draws spectra in either Gaussian or Lorentzian line shapes. It's a nice piece
of work.
#######################################################
From: JOERG.HAU@01.chlsnr.nestrd.ch
Date: Mon, 28 Aug 1995 15:13:01 +0200
Subject: Data system for sector MS
A question:
We`re using a Finnigan MAT 8430 with HP 5890GC and 7673A Autosampler. The MS
is still in excellent condition, but its SSX data system is nearly "dead".
Joerg Hau
----------------------------------------------------------------------
Dr. Joerg Hau
Nestl'#e Research Center
Vers-chez-les-Blanc
Case postale 44
CH-1000 Lausanne 26
Internet: Joerg.Hau@chlsnr.nestrd.ch
X.400: S=HAU; G=JOERG; OU=CHLSNR; P=NESTRD; A=ARCOM; C=CH
----------------------------------------------------------------------
#######################################################
From: cato.brede@kjemi.uio.no (Cato Brede)
Subject: HP 59970 Chemstation
Date: 28 Aug 1995 15:46:54 GMT
Organization: Universitet i Oslo
The floppy disk drive on the 9133 unit is now broken. We are still able
to use the system, but cannot save data to floppy. So we wonder if
there are people out there who has such a unit. Perhaps with a
broken hard disk and a functionable floppy. Do you want to donate such a
unit to us, please send me an e-mail.
Suggestions on how to fix the floppy will also be appreaciated. It is a
3 1/2", 720KB floppy drive. I think we would need a special kind of
drive, perhaps only delivered from HP.
Cato Brede
e-mail: catob@kjemi.uio.no
#######################################################
From: i.borthwick@strath.ac.uk (Ian Borthwick)
Subject: Mesh or Grids
Date: 29 Aug 1995 08:50:38 GMT
Organization: Strathclyde University
Thanks in advance
ian
#######################################################
From: Gert von Helden <gertvh@sci.kun.nl>
Subject: Simion 5.0 source code
Date: 29 Aug 1995 12:27:27 GMT
Organization: university of Nijmegen
Hi,
I wonder if someone out there could make the Simion 5.0 source code
available to me. We do have the 5.0 binaries as well as the 4.02 source
code. In a recent anouncment from David Dahl (one of the authors) on
Simion 6.0, it said that they do no longer distribute simion 4 or 5 and
that one should try to get it from a collegue. I would appreciate any
help,
Thanks Gert
--
#######################################################
From: "K. Murray" <kmurray@emory.edu>
Subject: Re: Mesh or Grids
Date: 29 Aug 1995 13:47:06 GMT
Organization: Emory University
Buckbee Mears
St. Paul, MN
612-228-6400
Fax 612-228-6572
-----
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
#######################################################
Date: Tue, 29 Aug 1995 22:38:16 +0000 (GMT)
From: stuart.thomson@vcp.monash.edu.au (Stuart Thomson)
Subject: Re: Data system for sector MS
Organization: Victorian College of Pharmacy
G'Day Joerg,
I have attached an MSS data system to a Jeol DX-300 with the high-res option.
It works fine, but I don't know how you will go with the GC/Autosampler, but I
seem to remember that the data system has some extra outputs, which could be
used for control of external devices. I have found the data system to be
reliable and quite good for high res ms work.
Cheers,
Stuart Thomson.
#######################################################
From: kore@cityscape.co.uk (Steve Mullock)
Subject: Re: Mesh or Grids
Date: Wed, 30 Aug 1995 08:30:25 GMT
Organization: Kore Technology Ltd.
i.borthwick@strath.ac.uk (Ian Borthwick) wrote:
>I am looking for a low cost source, preferably in the UK, of fine
>meshes or grids, >100 wires per inch, >75% open area, for
>defining electrostatic fields, any metal should be okay.
>Thanks in advance
>ian
regards Steve
--
Dr S.J. Mullock
Kore Technology Ltd.
291, Cambridge Science Park
Milton Road
Cambridge CB4 4WF
UK
Tel: 44 (0) 1223 420840
Fax: 44 (0) 1223 426041
#######################################################
From: kore@cityscape.co.uk (Steve Mullock)
Subject: Re: HP 59970 Chemstation
Date: Wed, 30 Aug 1995 08:30:22 GMT
Organization: Kore Technology Ltd.
<snip>
<snip>
Best of luck
--
Dr S.J. Mullock
Kore Technology Ltd.
291, Cambridge Science Park
Milton Road
Cambridge CB4 4WF
UK
Tel: 44 (0) 1223 420840
Fax: 44 (0) 1223 426041
#######################################################
From: Steve Werness <werness@aa.wl.com>
Subject: What is the current news (rumor) about VG Organic?
Date: 30 Aug 1995 14:24:11 GMT
Organization: Warner-Lambert Parke-Davis Research
#######################################################
From: "K. Murray" <kmurray@emory.edu>
Subject: Re: What is the current news (rumor) about VG Organic?
Date: 30 Aug 1995 16:12:14 GMT
Organization: Emory University
-----
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
#######################################################
From: dfettero@ahoynet.com (Dean D. Fetterolf)
Subject: FBI Lab Position(s)
Date: Wed, 30 Aug 1995 17:42:27 GMT
Organization: Capital Area Internet Service info@cais.com 703-448-4470
#######################################################
From: douglas@chem.ubc.ca (Don Douglas)
Subject: Re: Mesh or Grids
Date: 30 Aug 1995 19:48:13 GMT
Organization: University of British Columbia
Don
#######################################################
Date: Thu, 31 Aug 1995 00:04:38 +0000 (GMT)
From: ddxdd@IMAP1.ASU.EDU
Subject: Re: Mesh or Grids
Organization: daves not here
: Thanks in advance
: ian
-dave
#######################################################
From: park@netcom.com (Bill Park)
Subject: Operating principle of quadrupole mass spectrometer?
Organization: Netcom Online Communications Services (408-241-9760 login: guest)
Date: Thu, 31 Aug 1995 03:34:12 GMT
Thanks,
Bill Park
#######################################################
From: wyattj@nrlfs1.nrl.navy.mil (jrw)
Subject: Re: Operating principle of quadrupole mass spectrometer?
Date: Thu, 31 Aug 1995 09:09:09 LOCAL
Organization: nrl
>Thanks,
>Bill Park
In the simplest terms the answer is that only ions with a certain range
of mass to charge ratios are stable in the rf-dc fields of the quadrupole ms.
Ions of less mass will strike the negative rods, which is sort of intuitive;
and ions of more mass will strike the positive rods, which has never been
intuitive to me. If you wish to study the solutions to the differential
equations reguarding this matter you can see why it is so complicated.
A few years ago I wrote a simple basic program that numerically integrates
the ion trajectories in the x,y planes of the quadrupole and plots the
path. If there is interest I will post it to this newgroup. It is actually
quite a simple program but does a good job of illustrating how a qms works.
#######################################################
From: kanter@anl.gov (Elliot P. Kanter)
Subject: Re: Operating principle of quadrupole mass s
Date: 31 Aug 1995 15:20:18 GMT
Organization: Argonne National Laboratory, Argonne, IL
#######################################################
From: "K. Murray" <kmurray@emory.edu>
Subject: Re: Operating principle of quadrupole mass spectrometer?
Date: 31 Aug 1995 16:19:42 GMT
Organization: Emory University
-----
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
#######################################################
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Re: Operating principle of quadrupole mass spectrometer?
Date: Thu, 31 Aug 95 19:13:20 GMT
Organization: Caltech (Environmental Engineering Science)
-Peter Green
#######################################################
From: douglas@chem.ubc.ca (Don Douglas)
Subject: Re: Operating principle of quadrupole mass s
Date: 31 Aug 1995 23:24:33 GMT
Organization: University of British Columbia
Paul's lecture is great. You might also try "The Quadrupole Mass Filter:
Basic Operating Concepts", P. Miller and M. Denton, J. Chem. ed.
63,617,1986. Not great but some like it.
Don
#######################################################
From: KevinJWK@aol.com
Date: Fri, 1 Sep 1995 00:10:13 -0400
Subject: Molecular formula prediction software
Is there any software available that you could enter the relative abundances
of an isotope cluster and it would predict a molecular formula?
Kevin Wells-Knecht
Rhone-Poulenc Ag
Mass Spectrometry Dept.
#######################################################
From: Axel Boddenberg <boddenbe@wrcd1.urz.uni-wuppertal.de>
Subject: Spikes in GC/MS
Date: 1 Sep 1995 07:26:03 GMT
Organization: BUGH Wuppertal FB 9 Analytical Chemistry
Often TIC measured with GC/MS (range 10 -800 amu) shown spikes at
different times with the Spectrum of air (28, 32, 18,44 amu).
The spikes are in a normal range and their is no problem.
I wonder that spikes with differend times are shown and not an permanent
underground of air.
Thanks
Axel
#######################################################
From: vilboisf@iprolink.ch (Francis Vilbois)
Subject: New Sciex instruments
Date: Fri, 01 Sep 1995 12:09:58 +0100
Organization: Internet ProLink
Does anyone have some experience with the new API 100 and API 300 Sciex
mass spectrometers? I am interested in testing out the API 300 for
sequencing peptides at the low picomole level?
--
Francis Vilbois
e-mail: vilboisf@iprolink.ch
#######################################################
From: KevinJWK@aol.com
Date: Fri, 1 Sep 1995 00:10:13 -0400
Subject: Molecular formula prediction software
Is there any software available that you could enter the relative abundances
of an isotope cluster and it would predict a molecular formula?
Kevin Wells-Knecht
Rhone-Poulenc Ag
Mass Spectrometry Dept.
#######################################################
**************************************************
From: "Gregory G. Dolnikowski" <dolnikows_ms@hnrc.tufts.edu>
Subject: Re: Operating principle of quadrupole mass s
Date: 1 Sep 1995 19:03:39 GMT
Organization: HNRC at Tufts University
********************************************************************************Fro
m news@quartz.MV.COM Sun Sep 3 08:40:53 1995
From: john@wd1v.MV.COM (John Seney)
Subject: Digital Scope.FAQ
Organization: MV Communications, Inc.
Date: Sun, 3 Sep 1995 13:42:29 GMT
\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\
:::::::::::::::::::::::::::::::::::::
::Date/Time | O O ::
:: /\ | ::
:: / \ | O O ::
:: / \ /\ | ::
::__/ \ / \ /`| O O ::
:: \ / \/ | ::
:: \ / | O O ::
::1 GHz BW \/ 2 GS/s |________::
::________________________|A B C D ::
:: rise 1.5 ns | x x x ::
:: fall 4.9 ns | x x x ::
::_________________________________::
::(*) (*) (*) (*) (*) (*) ::
:::::::::::::::::::::::::::::::::::::
::: :::
Dear Technologist(s):
This Digital Storage Scope.FAQ file contains many (but not all) of your
answers to the more "Frequently Asked Questions" re: Digital Storage
Oscilloscopes (DSOs).
The answers and suggestions come from > a decade of my experience as a
DSO sales engineer in Boston, MA. The opinions are mine and represent no
company or service - they are meant simply to be helpful, generic, and easy
to understand.
If you want the next version of this file sent to you automatically, send an
EMAIL where the subject field contains the text "subscribe scope.faq".
\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\
KEY ISSUES REVIEWED IN THIS FAQ (in order of appearance)
* ARCHIVAL & MEMORY (How fast, how deep, and can I get more?)
* DEMOS & PURCHASING (How can I see and get the DSO I really need?)
Best regards,
\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/
John D. Seney, WD1V Internet: john@wd1v.mv.com
144 Pepperidge Drive America On Line: jseney@aol.com
Manchester, NH 03103-6150 AX.25 Pkt: wd1v@wb1dsw.nh.usa.na
(H) 603-668-1096 Ampernet: wd1v@wd1v.ampr.org
\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/
LeCroy Sales Engineering - Maine, New Hampshire, and Northeastern
Massachusetts
(O) 800-553-2769 (F) 603-627-1623 (P) 800-SKYPAGE #5956779
Bill,
I have experience with both techniques and would be glad to answer any
further questions you have by e-mail.
FBH
********************************************************************************Fro
m news@zippo.com Mon Sep 4 03:35:33 1995
From: News Group <news@zippo.com>
Subject: Re: Operating principle of quadrupole mass spectrometer?
Organization: Zippo
Date: Mon, 4 Sep 1995 07:33:08 GMT
Bill,
I have experience with both techniques and would be glad to answer any
further questions you have by e-mail.
FBH
********************************************************************************Fro
m news@zippo.com Mon Sep 4 03:35:33 1995
From: News Group <news@zippo.com>
Subject: Re: Operating principle of quadrupole mass spectrometer?
Organization: Zippo
Date: Mon, 4 Sep 1995 07:33:08 GMT
Bill,
I have experience with both techniques and would be glad to answer any
further questions you have by e-mail.
FBH
********************************************************************************Fro
m Henri.Valeins@rmsb.u-bordeaux2.fr Mon Sep 4 12:13:56 1995
Date: Mon, 4 Sep 1995 18:17:38 +0200
From: Henri.Valeins@rmsb.u-bordeaux2.fr (Henri Valeins)
Subject: isotopomer analysis
I'm very interested by isotopomer analysis of small molecule by GC and with
a quadripole mass spectrometer. What is the routinely limit of carbon
enrichment measure ?
Any info or pointers to sources is greatly appreciated.
Thanks
H. Valeins
RMSB-CNRS
Universite de Bordeaux II
E-Mail : valeins@rmsb.u-bordeaux2.fr
********************************************************************************Fro
m news@sunb.ocs.mq.edu.au Mon Sep 4 17:42:32 1995
From: Daniel Jardine <Daniel.Jardine@mq.edu.au>
Subject: Re: Operating principle of quadrupole mass spectrometer?
Date: 4 Sep 1995 21:42:20 GMT
Organization: Macquarie University
Daniel
********************************************************************************Fro
m CEPA.STEVEN@igate.pprd.abbott.com Tue Sep 5 16:54:27 1995
Date: Tue, 05 Sep 1995 13:13:00 -0500 (CDT)
From: "Steven P. Cepa 708-937-7539" <CEPA.STEVEN@igate.pprd.abbott.com>
Subject: September Meeting
Thursday, September 14
Grand Palace in Gurnee (Illinois)
by Kevin Schey
Medical University of South Carolina
1992 ASMS Research Awardee
Abstract:
SID dissociation efficiencies as high as 13% were measured for the
pentapeptide leucine enkephalin and 20% for the octapeptide VHLTPKVEK (MW
922). CAD dissociation efficiencies averaged only 1% for these two peptides.
SID product ion spectra clearly indicate higher internal energy deposition
compared to high-energy CAD data. These results suggest that utilization of
in-line SID is a high performance instrument is a viable method for structural
analysis.
Call 708-245-3403 to register (by Sept. 11 please).
********************************************************************************Fro
m spectroscopy
From: spectrscpy@aol.com (Spectrscpy)
Subject: MS Survey
Date: 22 Aug 1995 19:27:53 -0400
Organization: America Online, Inc. (1-800-827-6364)
No names will be published, but be sure to include your name and contact
information in case we have questions.
We welcome your participation and hope you'll enjoy this special issue.
Michael MacRae
Editor
********************************************************************************Fro
m News-System@open.ac.uk Thu Sep 7 06:20:52 1995
From: Iain Gilmour <I.Gilmour@open.ac.uk>
Subject: Post Doctoral Fellowship
Date: 7 Sep 1995 10:18:37 GMT
Organization: The Open University, Milton Keynes, UK
The person appointed will be employed by HFL for the duration of this contract, but
seconded to the OU in Milton Keynes. Salary will be commensurate with experience
for a
candidate with a PhD.
********************************************************************************Fro
m callahan@nrlfs1.nrl.navy.mil Thu Sep 7 16:00:36 1995
Date: Thu, 7 Sep 95 15:30:28 -0400
From: callahan@nrlfs1.nrl.navy.mil (John Callahan)
Subject: Washington-Baltimore Mass Spec Discussion Group
eot
John H. Callahan
Code 6113/Chemistry Division
Naval Research Laboratory
Washington, D.C. 20375
202-767-0719
FAX 202-404-8119
John.Callahan@nrl.navy.mil
********************************************************************************Fro
m db32@prism.gatech.edu Thu Sep 7 16:55:59 1995
From: db32@prism.gatech.edu (David E. Bostwick)
Subject: Atlanta/Athens Discussion Group Meeting
Date: 7 Sep 1995 16:42:27 -0400
Organization: Georgia Institute of Technology
--
David E. Bostwick
Georgia Institute of Technology, Atlanta, GA, 30332
david.bostwick@chemistry.gatech.edu
********************************************************************************Fro
m news@dub-news-svc-6.compuserve.com Fri Sep 8 11:59:46 1995
From: <100716.2042@compuserve.com>
Subject: Re:VG Organic's existance
Date: 8 Sep 1995 11:55:41 GMT
Organization: CompuServe Incorporated
VG is still alive and kicking and will remain so for a long time to come.
Whatever happens in the future it looks as though we will remain an
independant company. See this newsgroup for more details in the future
or see our home page on http://www.vgorganic.co.uk
Regards
Jim Speakman
I can also be reached on Jim.Speakman@instruments.fisons.co.uk
********************************************************************************Fro
m 100716.2042@compuserve.com Fri Sep 8 11:28:29 1995
Date: 08 Sep 95 11:18:56 EDT
From: James Speakman <100716.2042@compuserve.com>
Subject: Re: VG,s existance.
I had the same problem with an old Finnigan GC-MS and found that the
spikes were air. I was unable to locate the leak using the usual techniques
and finally concluded that the leak was likely in a defective weld in the
diffusion pump. The episodic nature of the leak strongly suggested bubble
formation in some liquid. These bubbles expand and then burst into the
vacuum, causing spikes in the TIC and on the ion gauge. The most viscous
liquid is found in the cooler parts of the diffusion pump.
********************************************************************************Fro
m nelsone@sibyl.saic.com Fri Sep 8 12:35:13 1995
Date: Fri, 08 Sep 1995 09:33:18 -0700
From: "Eric R. Nelson, Ph.D." <nelsone@sibyl.saic.com>
Subject: PC as Mass Spec
Has anyone ever run across what amounts to turning a PC platform into a mass
spec? I saw a demonstration of a PC-as-mass-spec several years ago, but I
have forgotten the name of the company.
ern
********************************************************************************Fro
m news@vishnu.jussieu.fr Fri Sep 8 14:54:46 1995
From: Kiliulis Rimgaudas <kiliulis@vishnu.jussieu.fr>
Subject: seeking post-doc or researcher position
Date: 8 Sep 1995 18:54:31 GMT
Organization: Universites Paris VI/Paris VII - France
========================================
Rimgaudas
kiliulis@gps.jussieu.fr
========================================
Rimgaudas
kiliulis@gps.jussieu.fr
********************************************************************************Fro
m news@vishnu.jussieu.fr Fri Sep 8 14:57:43 1995
From: Kiliulis Rimgaudas <kiliulis@vishnu.jussieu.fr>
Subject: second hand lasers wanted
Date: 8 Sep 1995 18:57:33 GMT
Organization: Universites Paris VI/Paris VII - France
kiliulis@gps.jussieu.fr
or directly to
saulius.juodkazis@FF.VU.LT
********************************************************************************Fro
m news@sunmail.lrz-muenchen.de Sat Sep 9 07:04:12 1995
From: Werner Spahl <ui22273@sun1.lrz-muenchen.de>
Subject: Mass spectrometry books?
Date: 9 Sep 1995 11:02:00 GMT
Organization: Leibniz-Rechenzentrum, Muenchen (Germany)
Hi, I am looking for a good actual book about organic mass spectrometry.
I own Chapmans Practical Organic Mass Spectrometry and am searching for a
similar book about fragmentations etc. Any recommendations?
********************************************************************************Fro
m news@mhadg.production.compuserve.com Sun Sep 10 04:05:50 1995
From: Andreas Walte <100043.1150@CompuServe.COM>
Subject: GC / Ion trap MS-MS
Date: 10 Sep 1995 08:05:35 GMT
Organization: Techncal University Hamburg-Harbug
(Walte@tu-harburg.de)
********************************************************************************Fro
m news@pipex.net Sun Sep 10 07:19:16 1995
From: Mike Head <aa04@dial.pipex.com>
Subject: Announcement: interLAB Update
Date: 10 Sep 1995 11:19:03 GMT
Organization: The Virtual Networking Company Ltd.
In this section you will find brief descriptions of the latest products,
services and literature available from an extensive range of
Manufacturers and Suppliers.
The infoNET area is updated every month so make sure you've bookmarked
the interLAB URL and keep in touch with the latest news and information.
If you wish to send a direct message to any of the Companies listed
look out for the MAILTO boxes at the end of their entry.
We are constantly on the look out for new facilities to offer interLAB
Visitors and would be glad to receive your suggestions. These may be
e-mailed to our Organisers' Office on da46@cityscape.co.uk.
http://www.interlab.co.uk/interlab
********************************************************************************Fro
m root@newsbf02.news.aol.com Sun Sep 10 12:57:42 1995
From: schtuper@aol.com (Schtuper)
Subject: MS Related Images on the Internet
Date: 10 Sep 1995 12:57:29 -0400
Organization: America Online, Inc. (1-800-827-6364)
Thanks,
Dave M.
********************************************************************************Fro
m news@news.bu.edu Sun Sep 10 21:20:13 1995
From: kacher@bu.edu (Daniel Kacher)
Subject: MRI / DNA
Date: 11 Sep 1995 01:19:59 GMT
Organization: Boston University
********************************************************************************Fro
m root@newsbf02.news.aol.com Mon Sep 11 09:41:22 1995
From: sismspec@aol.com (Sismspec)
Subject: Index of Mass Spectrometer Labs offering Sample Analysis
Date: 11 Sep 1995 09:41:10 -0400
Organization: America Online, Inc. (1-800-827-6364)
As part of our new home page, SIS will be posting a list of mass
spectrometer labs offering sample analysis as a service. This listing is
free. InI this section of our home page called MS-Links we will be listing
laboratories that can be contacted to analyze samples, perform an analysis
on specialized equipment or do specific studies, i.e high resolution, FAB,
dioxin analysis, etc.
If you would like to have your laboratory listed in this index, please
send me an E-Mail message with the name of your lab, address, phone
number, e-mail, fax and contact person. You can also include special
services that you can provide. If you have a home page we can link to
your home page.
Our home page is in the process of being created and will be fully
operational shortly. Our URL is: http://www.sisweb.com
John J. Manura
Scientific Instrument Services
Supplies and Services for mass spectrometers, gas chromatographs and
related scientific equipment.
E-Mail: sismspec@aol.com
Phone: 908-788-5550
Fax: 908-806-6631
********************************************************************************Fro
m news@rover.ucs.ualberta.ca Mon Sep 11 17:23:49 1995
From: alan_hogg@ualberta.ca (Alan Hogg)
Subject: Wanted: Used High-Res. M.S.
Date: 11 Sep 1995 21:23:32 GMT
Organization: University of Alberta
********************************************************************************Fro
m CEPA.STEVEN@igate.pprd.abbott.com Tue Sep 12 11:35:20 1995
Date: Tue, 12 Sep 1995 10:14:00 -0500 (CDT)
From: "Steven P. Cepa 708-937-7539" <CEPA.STEVEN@igate.pprd.abbott.com>
Subject: Meeting
Come 'on guys, there are only 12 registered for the MCM-MSDG meeting on
Thursday (as of Tuesday morning).
**************************************************************************
Thursday, September 14
Grand Palace in Gurnee (Illinois)
by Kevin Schey
Medical University of South Carolina
1992 ASMS Research Awardee
Abstract:
SID dissociation efficiencies as high as 13% were measured for the
pentapeptide leucine enkephalin and 20% for the octapeptide VHLTPKVEK (MW
922). CAD dissociation efficiencies averaged only 1% for these two peptides.
SID product ion spectra clearly indicate higher internal energy deposition
compared to high-energy CAD data. These results suggest that utilization of
in-line SID is a high performance instrument is a viable method for structural
analysis.
********************************************************************************Fro
m news@usenet1.interramp.com Wed Sep 13 09:57:42 1995
From: Ted Morawski <pp000531@interramp.com>
Subject: Technology 2005
Date: Wed, 13 Sep 95 09:55:27 PDT
Organization: PSI Public Usenet Link
TECHNOLOGY 2005
AMERICA'S PREMIER SHOWCASE OF NEW & EMERGING TECHNOLOGY
---------------------------------------------------------------------------
A "who's who" of federal labs, universities, & high-tech firms will
demonstrate an amazing array of inventions & products available for
license, joint development, or sale. See the giant 5000 sq. ft. NASA
pavilion; the "Transportation Tomorrow" pavilion of advanced automotive,
aviation, mass transit, & marine technologies; an expanded SBIR product
showcase; & much, much more. Admission to the exhibits hall is FREE of
charge.
Hands-On Workshops
Learn from the pros how to successfully: license patents ... enter into
cooperative R&D agreements ... obtain SBIR grants ... contract with the GSA
.. find profitable niche markets ... form international partnerships.
These & other valuable workshops are included with your symposia
registration.
Daily training sessions will help you to navigate the net & take full
advantage of on-line engineering & scientific resources. Courses are FREE
for preregistrants & are offered for both beginners & advanced users.
* solve engineering & design problems (& avoid reinventing the wheel)
* create new products & uncover new markets for your current product
line
* improve your manufacturing techniques
* find potential partners & funding sources
* stay ahead of the technology curve - & the competition
E-mail: T2005@interramp.com
********************************************************************************Fro
m Jo Rita Jordan
From: Jo Rita Jordan <76150.2171@CompuServe.COM>
Subject: TOF users?
Date: 13 Sep 1995 13:19:41 GMT
Organization: Analytical Consumer
********************************************************************************Fro
m news@news.iastate.edu Wed Sep 13 17:49:07 1995
From: cebaker@iastate.edu (Charles E Baker)
Subject: Periodic table
Date: 13 Sep 1995 21:48:57 GMT
Organization: Iowa State University, Ames, Iowa USA
I am looking for a periodic table of the most abundent isotopes for our mass spec
lab. My contact with Kratos proved unsuccessful. If anyone knows where I may
find one please let me know.
**********************************************************************************
Charles Baker
Mass Spectrometry Lab
Chemical Instrumentation Facility
Iowa State University
**********************************************************************************
--
Charles E Baker Mass Spectrometrist
2929 Diamond Instrument Services Department
Ames, Iowa 50010 A0101 Gilman
233-0958 294-5544
cebaker@iastate.edu
********************************************************************************Fro
m news@unity.ncsu.edu Thu Sep 14 13:13:07 1995
From: howard@ch9000.chem.ncsu.edu (Howard Sanford)
Subject: Re: Periodic table
Date: Thu, 14 Sep 1995 13:13:41 -0400
Organization: NCSU Chemistry
> I am looking for a periodic table of the most abundent isotopes for our mass
> spec lab. My contact with Kratos proved unsuccessful. If anyone knows
> where I may find one please let me know.
>
I have one posted on the web. It's not so much a periodic table as it is a
list of the most abundent isotope masses. It is at
http://ch9000.chem.ncsu.edu/Exact_Mass.html
If you don't have access I'll be glad to send you (or anyone else) a copy.
I also have a copy of a paper from VG list the exact masses of all of the
isotopes, again not so much a periodic table as a list, but its what we
use in our lab.
Be seeing you...
/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-/-
Howard Sanford / "When I invite a woman to dinner, I
NCSU, Dept. of Chemistry, MS Facility / expect her to look at my face. That's
Raleigh, NC / the price she has to pay."
http://ch9000.chem.ncsu.edu / - Groucho Marx, A night at the Opera
********************************************************************************Fro
m root@globe.indirect.com Fri Sep 15 06:12:42 1995
From: Anne Coburn <coburn@indirect.com>
Subject: BS/MS MASS SPECTROSCOPIST NEEDED NOW! SO.CALIFORNIA
Date: 15 Sep 1995 10:12:35 GMT
Organization: Internet Direct, Inc.
OBJECTIVE/DUTIES:
- Participate in the characterization of proteins using mass spec.
- Act as an in-house liaison between this group and a diverse groups
in-house.
- Conduct and support research projects.
REQUIREMENTS:
- Bachelor's or Master's degree in Chemistry or Biochemistry. (No Ph.D.'s)
- A minimum of 3 years experience in mass spectroscopy, peptide and
protein characterization and mapping.
- Experience in Capillary LC/MS VERY ATTRACTIVE. Expertise in (EI)
electrospray LC/MS,LC/MS, and laser desorption ionization required.
- Proven interpersonal and communication skills, including writing
up results and explaining data inhouse, to diverse individuals
in various area/levels of the company.
- Expertise with protein and peptide mapping and characterization.
- The ability to operated specialized lab equipment & computers.
- Proven skills at the interpretation of mass spectra.
- Strong analytical skills.
********************************************************************************Fro
m news@pfizer.com Fri Sep 15 08:06:39 1995
From: Drew Gibson <Drew_Gibson@sandwich.pfizer.com>
Subject: Re: Periodic table
Date: 15 Sep 1995 12:03:53 GMT
Organization: Pfizer
If you have difficulty finding such a beast, you could compile your own from the
Table of the Isotopes in CRC Handbook of Chemistry =
and Physics (I believe the current edition is the 74th).
********************************************************************************Fro
m news@emory.edu Fri Sep 15 10:13:20 1995
From: "K. Murray" <kmurray@emory.edu>
Subject: Re: Periodic table
Date: 15 Sep 1995 14:11:50 GMT
Organization: Emory University
----------
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
********************************************************************************Fro
m news@saffron.hnrc.tufts.edu Fri Sep 15 11:32:01 1995
From: "Gregory G. Dolnikowski" <dolnikows_ms@hnrc.tufts.edu>
Subject: Wanted: Used HP 5988 GC/MS
Date: 15 Sep 1995 14:32:12 GMT
Organization: HNRC at Tufts University
Our laboratory has an HP 5988 A GC/MS and we would like to acquire another. We
have limited
funds, but would be able to pay $12,0000 for the instrument.It would be nice if the
instrument
had a GC attached but that is not necessary. We would even consider acquiring an
instrument
which was malfunctioning electronically if the vacuum system were intact.
We are also interested in acquiring a used isotope ratio mass spectrometer, with
hydrogen,
or carbon dioxide capabilities. We have more funds for such an instrument, perhaps
$15-20K.
We would prefer a VG instrument but would consider a Finnigan as well.
(617) 556-3298
dolnikows_ms@hnrc.tufts.edu
********************************************************************************Fro
m geblack@cbdcom.apgea.army.mil Fri Sep 15 15:56:46 1995
Date: Fri, 15 Sep 95 15:48:07 EDT
From: "Dr. Gavin E. Black" <geblack@cbdcom.apgea.army.mil>
Subject: Looking for Finnigan MAT on the net
I've done the Infoseeking, the crawling, and even the begging (at K.Murray's
Web page), but I STILL have not found a net site for Finnigan MAT. Anyone
have any suggestions?
********************************************************************************Fro
m news@nntp-server.caltech.edu Fri Sep 15 16:39:28 1995
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Re: Periodic table
Date: Fri, 15 Sep 95 20:39:05 GMT
Organization: Caltech (Environmental Engineering Science)
>
>I am looking for a periodic table of the most abundent isotopes for our mass
>spec lab. My contact with Kratos proved unsuccessful. If anyone knows
>where I may find one please let me know.
>
It is amazing how un-helpful a remarkable number of companies are!
http://www.cchem.berkeley.edu/Table/web-elements-oldhome.html
-Peter Green
********************************************************************************Fro
m news@serval.net.wsu.edu Fri Sep 15 22:21:15 1995
From: knaack@wsu.edu (Charles Knaack)
Subject: Searching for Sciex
Date: Sat, 16 Sep 1995 03:24:44 GMT
Organization: W.S.U. Geology Dept.
Pardon the bandwidth, but I'm looking for somebody at Sciex or Perkin
Elmer that I can ask some questions about an ELAN 250 ICP/MS. We have
been having problems with excessive background counts. It seems to be
worse at higher incident plasma energies. The background count rate seems
to be very sensitive to the movement of the ribbon cables the mass-spec
bin and the power supply chassis. I suspect that somehow RF energy is
interfering with the pulse processing electronics, but I'm not quite sure
whereto look. Any help would be greatly appreciated.
Thanks,
Charles Knaack
Geoanalytical Lab
Washington State Univ.
(509) 335-1626
knaack@wsu.edu
--
Charles Knaack
Geoanalytical Laboratory
Geology Department
Washington State University
Pullman, WA 99164
(509)335-1626
knaack@wsu.edu
********************************************************************************Fro
m root@newsbf02.news.aol.com Sun Sep 17 14:01:30 1995
From: sismspec@aol.com (Sismspec)
Subject: New Mass Spec Web Site now on line
Date: 17 Sep 1995 14:01:15 -0400
Organization: America Online, Inc. (1-800-827-6364)
Scientific Instrument Services WEB site is now available. The address is:
http://www.sisweb.com
Reference materials Include the calibration peaks and spectra for the
common mass spec calibration compounds such as FC43 and PFK, an article on
mass spec sensitivity and mass spec tips.
We have tried something new - putting our full application notes on the
internet. They include full text and color charts and tables of data. We
would appreciate any feedback of the value of putting complete reference
articles on line for easy retrieval.
Input from the mass spec community for the various sections such as
employment, wanted/ for sale, ms groups, meetings and laboratory
facilities is requested. Suggestions as to other resources to be included
are appreciated.
Most of the sections describing our product line are still under
construction, but we decided to announce our pages because most of the
resource materials are finished.
John J. Manura
Scientific Instrument Services
Supplies and Services for Mass Spectrometers, Gas Chromatographs and
related Scientific Instruments
SIS Home Page: http://www.sisweb.com
E-Mail: sismspec@aol.com
Phone: (908) 788-5550
FAX: (908) 806-6631
********************************************************************************Fro
m becknerc@kelso.pprd.abbott.com Mon Sep 18 15:28:42 1995
From: becknerc@kelso.pprd.abbott.com (Carl Beckner)
Subject: Re: Looking for Finnigan MAT on the net
Date: 18 Sep 1995 14:26:30 -0500
Organization: Abbott Laboratories
In article <43jqd6$g52@acmex.gatech.edu>,
Dr. Gavin E. Black <geblack@cbdcom.apgea.army.mil> wrote:
>I've done the Infoseeking, the crawling, and even the begging (at K.Murray's
>Web page), but I STILL have not found a net site for Finnigan MAT. Anyone
>have any suggestions?
>
>Gavin E. Black, Ph.D.
>U.S. Army - ERDEC
>Aberdeen Proving Ground, MD 21010-5423
>
>
Finnigan does not have a WWW or ftp site if that is what you are
looking for. However, many of the software developers do have
internet e-mail addresses and do read these news groups.
Carl
********************************************************************************Fro
m news@sciex.com Mon Sep 18 17:56:22 1995
From: greg@sciex.com (Greg King)
Subject: Re: Searching for Sciex
Date: Mon, 18 Sep 1995 17:55:27 -0400
Organization: SCIEX
> Pardon the bandwidth, but I'm looking for somebody at Sciex or Perkin
> Elmer that I can ask some questions about an ELAN 250 ICP/MS.
I write software for the organic side of the company but I'll see if I
can pass your request along to the appropriate person.
Greg
--
Greg King
SCIEX
71 Four Valley Drive
Concord, Ontario, Canada
(905) 660-9006 ext 201
greg@sciex.com
********************************************************************************Fro
m news@hustle.rahul.net Mon Sep 18 22:05:28 1995
From: Jim Shofstahl <jhs@rahul.net>
Subject: Finnigan MAT on the Internet
Date: 19 Sep 1995 02:05:09 GMT
Organization: a2i network
For the past couple of years Finnigan has been using e-mail through a UUCP
connection. Well that connection is in the process of being upgraded. Within
the near future, Finnigan will have access to the Internet and will offer more
services, such as an ftp site and Web page. The exact content of the Web is
still being discussed as is the extent of ftp abilities presented to customers.
With ICIS 8.2, a new program has been added that will allow customers to e-mail
SPR's (bugs) related to ICIS directly to Finnigan in San Jose. This program
works on both ULTRIX and Digital UNIX (formal DEC OSF/1). We expect to release
ICIS 8.2, ICL 8.3 for XSQ-7000's and ICL 7.5 for XSQ700's during the next few
weeks.
Jim Shofstahl,
Technical Lead on ICIS
jhs@finnigan.com
********************************************************************************Fro
m db32@prism.gatech.edu Tue Sep 19 09:07:11 1995
Subject: GC/MS Problem
Date: 19 Sep 1995 08:28:12 -0400
Organization: America Online, Inc. (1-800-827-6364)
Has anyone experienced a problem with analyzing water samples (via EPA
Method 624) preserved with sodium thiosulfate on a purge and trap GC/MS
system? We have an HP5890 Series II GC with an HP5972A MSD. It is
connected to a Tekmar 3000 purge and trap concentrator with a VOCARB 3000
trap. The column is a J & W DB624 (0.180 mm id) directly connected to the
MSD. The GC inlet is operated in split mode. The problems we encountered
are:
1. Large SO2 peaks early in the total ion chomatogram which swamped
(coeluted) with the EPA 624 gases, thus prohibiting their quantification.
Thanks
Mark Hannay
------- end of forwarded message -------
********************************************************************************Fro
m news@news.cs.brandeis.edu Tue Sep 19 09:39:38 1995
From: tmiller@rose.brandeis.edu (Todd M. Miller)
Subject: Re: Periodic table
Date: 19 Sep 1995 13:38:51 GMT
Organization: Brandeis University
>> I am looking for a periodic table of the most abundent isotopes for our mass
>> spec lab. My contact with Kratos proved unsuccessful. If anyone knows
>> where I may find one please let me know.
>>
There is a large wall chart which was called the "Chart of the Nuclides"
which had on it "Knolls Atomic Power Lab operated by General Electric
Co." and "Naval Reactors, U.S. Department of Energy." Ours was
published in nineteen seventy seven.
********************************************************************************Fro
m ui22273@sunmail.lrz-muenchen.de Tue Sep 19 11:27:08 1995
From: ui22273@sunmail.lrz-muenchen.de
Subject: Re: New mass spectrometry books?
Date: Tue, 19 Sep 1995 17:26:43 +0200 (MET DST)
Sorry, but at the moment my newsreader does not allow me to edit the text
(?), he just posts it right away. So if you please just post the
following for me (thanks):
--
Werner Spahl (ui22273@sun1.lrz-muenchen.de)
"The meaning of my life is to make me crazy!"
********************************************************************************Fro
m news@emory.edu Tue Sep 19 12:33:54 1995
From: "K. Murray" <kmurray@emory.edu>
Subject: Re: Periodic table
Date: 19 Sep 1995 16:32:46 GMT
Organization: Emory University
----------
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
********************************************************************************Fro
m root@newsbf02.news.aol.com Wed Sep 20 05:26:47 1995
From: sismspec@aol.com (Sismspec)
Subject: Re: New mass spectrometry books?
Date: 19 Sep 1995 13:35:25 -0400
Organization: America Online, Inc. (1-800-827-6364)
********************************************************************************Fro
m db32@prism.gatech.edu Wed Sep 20 09:26:25 1995
Subject: Searching: HP 9825A-Comp. for MASS-SPECTROMETER
Date: 20 Sep 1995 08:48:56 GMT
Organization: University Frankfurt/M
A.Dietrich@em.uni-frankfurt.de
********************************************************************************Fro
m news@ftp.univie.ac.at Thu Sep 21 05:43:46 1995
From: folabm@@ftp.univie.ac.at
Subject: Helicobacter Pylori - Breathtest using 13C-Urea
Date: 21 Sep 1995 09:43:34 GMT
Organization: Vienna University, Austria
Fritz Tichy
********************************************************************************Fro
m news@nntp.ucs.ubc.ca Thu Sep 21 15:59:02 1995
From: blades@chem.ubc.ca (Mike Blades)
Subject: 1995 FACSS Conference Program
Date: Thu, 21 Sep 1995 12:59:33 +1000
Organization: UBC
The program is on the Web at:
http://a103.chem.ubc.ca/FACSS_PROGRAM.html
Mike Blades
********************************************************************************Fro
m O_DavidS@msn.com Thu Sep 21 23:02:36 1995
Date: Fri, 22 Sep 95 03:01:53 UT
From: "O. David Sparkman" <O_DavidS@msn.com>
Subject: RE: GC/MS Problem
Try using the direct split interface. HP and Varian both have App notes on
this
Regards;
O. David Sparkman
----------
********************************************************************************Fro
m:
Has anyone
experienced a problem with analyzing water samples (via EPA
Method 624)
preserved with sodium thiosulfate on a purge and trap GC/MS
system? We have
an HP5890 Series II GC with an HP5972A MSD. It is
connected to a Tekmar
3000 purge and trap concentrator with a VOCARB 3000
trap. The column is a J
& W DB624 (0.180 mm id) directly connected to the
MSD. The GC inlet is
operated in split mode. The problems we encountered
are:
1. Large SO2
peaks early in the total ion chomatogram which swamped
(coeluted) with the
EPA 624 gases, thus prohibiting their quantification.
2. Since we stopped
using the sodium thiosulfate, the baseline stability
early in the total ion
chromatogram (1st 3 minutes) has been bad.
Recovery of the EPA 624 gaseous
analytes has also been poor since that
single lot of Na2SO3 samples was
analyzed. A column change, trap change,
and inlet liner change have not
corrected the problem. The mass spectrum
of the baseline early in the TIC
is filled with fragment ions of many
m/z's, with m/z 94 being the most
abundant.
Thanks
Mark Hannay
********************************************************************************Fro
m news@mailbox.uq.oz.au Thu Sep 21 23:28:55 1995
From: Masa Takahashi <masa@mailbox.uq.oz.au>
Subject: (no subject)
Date: 22 Sep 1995 03:28:26 GMT
Organization: University of Queensland
I am just getting into the game of TOF mass spectrometry, and am wondering if there
is
any software out there available for fitting curves to peaks - including partially
overlapping peaks - from mass spectra. If anyone can help, please email me at
russ@sun.mech.uq.oz.au
********************************************************************************Fro
m O_DavidS@msn.com Thu Sep 21 23:02:36 1995
Date: Fri, 22 Sep 95 03:01:53 UT
From: "O. David Sparkman" <O_DavidS@msn.com>
Subject: RE: GC/MS Problem
Try using the direct split interface. HP and Varian both have App notes on
this
Regards;
O. David Sparkman
----------
:Has anyone
:experienced a problem with analyzing water samples (via EPA
:Method 624)
:preserved with sodium thiosulfate on a purge and trap GC/MS
:system? We have
:an HP5890 Series II GC with an HP5972A MSD. It is
:connected to a Tekmar
:3000 purge and trap concentrator with a VOCARB 3000
:trap. The column is a J
:& W DB624 (0.180 mm id) directly connected to the
:MSD. The GC inlet is
:operated in split mode. The problems we encountered
:are:
:
:1. Large SO2
:peaks early in the total ion chomatogram which swamped
:(coeluted) with the
:EPA 624 gases, thus prohibiting their quantification.
:
:2. Since we stopped
:using the sodium thiosulfate, the baseline stability
:early in the total ion
:chromatogram (1st 3 minutes) has been bad.
:Recovery of the EPA 624 gaseous
:analytes has also been poor since that
:single lot of Na2SO3 samples was
:analyzed. A column change, trap change,
:and inlet liner change have not
:corrected the problem. The mass spectrum
:of the baseline early in the TIC
:is filled with fragment ions of many
:m/z's, with m/z 94 being the most
:abundant.
:Thanks
:Mark Hannay
********************************************************************************Fro
m news@usenet.ucs.indiana.edu Fri Sep 22 13:39:18 1995
From: "Margaret P. Ricci" <isotopes@indiana.edu>
Subject: Re: Looking for Finnigan MAT on the net
Date: 22 Sep 1995 17:37:05 GMT
Organization: Indiana University, Bloomington
While it is true that Finnigan MAT has no official net presence yet,
there is a Web page for users of online isotope ratio monitoring systems.
The URL is
http://silver.ucs.indiana.edu/~isotopes/home.html
I am the keeper of the page and also one of the software developers.
Margaret P. Ricci
isotopes@indiana.edu
********************************************************************************Fro
m netnews@ix.netcom.com Sat Sep 23 11:57:57 1995
From: teknvent@ix.netcom.com (Phil Berger )
Subject: New Teknivent Home Page
Date: 23 Sep 1995 15:57:40 GMT
Organization: Netcom
http://www.teknivent.com/teknivent
Originator: glasrud@squeaky.free.org
My name is Scott Glasrud, and I am running for the New Mexico State Senate
during the 1996 elections. One of the reasons I have chosen to run is to combat
the
proposed state and federal regulations of the Internet. As you know, the
Internet
was never designed to be regulated! It was designed to allow communications in
the event of anuclear war or a major catastrophe. I OPPOSE REGULATION, and if
elected
will fight to preserve your constitutional rights. HOWEVER, I NEED YOUR HELP!
I am asking each person who reeives this message to send $5.00 to the
Scott Glasrud Campaign Committee. If we pull together, we CAN protect our first
amendment rights! HELP ME show the politicians the POWER behind this
important NETWORK. Please send contributions to:
Thank you!
********************************************************************************Fro
m news@usenet.ucs.indiana.edu Tue Sep 26 10:10:39 1995
From: wbrubake@ezinfo.ucs.indiana.edu (William Wayne Brubaker)
Subject: Gold capillaries
Date: 26 Sep 1995 14:09:25 GMT
Organization: Indiana University, Bloomington
********************************************************************************Fro
m news@stc06.ctd.ornl.gov Tue Sep 26 19:10:15 1995
From: "Gary J. Van Berkel" <vanberkelgj@ornl.gov>
Subject: Re: Gold capillaries
Date: 26 Sep 1995 22:59:07 GMT
Organization: Lockheed Martin Energy Systems
Goodfellow Corp.
800 Lanccaster Avenue
Berwyn, PA 19312-1780
phone: 1-800-821-2870
fax: 1-800-283-2020
********************************************************************************Fro
m news@sonnet.com Wed Sep 27 01:20:06 1995
From: Leland Palmer <chicasaw@moa.com>
Subject: Re: RE: GC/MS Problem
Date: 27 Sep 1995 05:20:38 GMT
Organization: SONNET Networking - Modesto
********************************************************************************Fro
m news@news.cerf.net Thu Sep 28 04:47:28 1995
From: Nahum <oksi@cerfnet.com>
Subject: (no subject)
Date: 28 Sep 1995 08:46:09 GMT
Organization: Opto-Knowledge Systems, Inc.
TechExpo at URL
http://www.techexpo.com/
has just posted the first entries in its Technology Information Center.
These include a comprehensive compilation of SI Units conversion factors.
The table of conversion factors is designed to be downloaded and easily
imported into a spread-sheet as an ascii file. Tabs are included for
separation between values and labels.
Comments, corrections, as well as suggestions for other data lists would
be appreciated.
Regards,
********************************************************************************Fro
m sam!news@uunet.uu.net Fri Sep 29 11:27:41 1995
From: rleavitt@on.novamann.ca (Randy Leavitt)
Subject: Finnigan GCQ GC/MS Info
Date: Fri, 29 Sep 95 11:32:37 PST
Organization: GfWare
We have recently committed a purchase order for two (2) Finnigan GCQ
EI/CI gas chrmoatograph/mass spectrometers with the GCQ Tandem MS/MS
upgrade. Our application is in the area of forensic doping control in
the race horse. Colleagues in England and France have had good
experience with this equipment in the same application. However, we hear
reports that all is not well in other applications. Has anyone in the
newsgroup had experience with this relatively new system? We have become
a little concerned. Any input would be appreciated.
Thanx.
********************************************************************************Fro
m news@dub-news-svc-2.compuserve.com Fri Sep 29 15:17:35 1995
From: <75530.3472@compuserve.com>
Subject: MS Data System
Date: 29 Sep 1995 19:16:00 GMT
Organization: CompuServe Incorporated
Regards;
David Sparkman
********************************************************************************Fro
m news@dub-news-svc-2.compuserve.com Fri Sep 29 16:33:03 1995
From: Ludwig Gruber <100111.1734@compuserve.com>
Subject: Re: Finnigan MAT on the Internet
Date: 29 Sep 1995 20:32:12 GMT
Organization: UP GbR
Jim Shofstahl <jhs@rahul.net> wrote:
>Dr. Gavin E. Black asked about Finnigan MAT's net presence.
>
>With ICIS 8.2, a new program has been added that will allow customers to e-mail
>SPR's (bugs) related to ICIS directly to Finnigan in San Jose. This program
>works on both ULTRIX and Digital UNIX (formal DEC OSF/1). We expect to release
>ICIS 8.2, ICL 8.3 for XSQ-7000's and ICL 7.5 for XSQ700's during the next few
>weeks.
>
Means this that this service is also accessible for users of the high-res
instruments
Regards
Lou Gruber
Reply to gruber@ilv.fhg.de
********************************************************************************Fro
m news@news-2.csn.net Sat Sep 30 13:53:10 1995
From: rbihler@csn.net (Ron Bihler)
Subject: MS Sample Prep Glassware coated
Date: Sat, 30 Sep 1995 11:07:18
Organization: SuperNet Inc. (303)-296-8202 Denver Colorado
I am posting this message in the hope of getting some feed back for a new
product I am working on.
Ron Bihler
Technical Glass, Inc.
(303)367-8619
********************************************************************************
******************************************************************************
From: "Harrelson Davis" <HARRELDA@dcsmserver.med.sc.edu>
Organization: School of Medicine
Date: Mon, 2 Oct 1995 16:07:50 EDT
Subject: GCQ
To whom it may concern:
Davis Harrelson
******************************************************************************
From: Christophe Morin <Christophe.Morin@ujf-grenoble.fr>
Subject: High Resolution MS
Date: 3 Oct 1995 11:17:03 GMT
Organization: LEDSS
******************************************************************************
From: "K. Murray" <kmurray@emory.edu>
Subject: STMS FTP Archive
Date: 3 Oct 1995 14:52:11 GMT
Organization: Emory University
The STMS listserver mailings are public and the archive of STMS*.TXT
files can be mirrored by anyone with FTP or WWW page space. The text
files are about 100 kB per month for just over 500 kB so far. The Apple
Macintosh search server is available at
http://www.monash.edu.au/informatics/tr-www.html and runs under the
MacHTTP/Webstar ( http://www.biap.com/ ) WWW server.
-----
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
From: Jim.Carter@bristol.ac.uk (JF. Carter)
Subject: anyone recognise this spectrum?
Date: Wed, 4 Oct 1995 09:31:15 +0100 (BST)
Needless to say the spectra do not library serach. Has anyone out there
seen and/or identified these compounds.
Thanks,
Jim Carter
Environmental and Analytical Section
School of Chemistry
University of Bristol
******************************************************************************
From: Beat Aebi <baebi@irm.unibe.ch>
Subject: Finnigan SSQ7000 Ion Source
Date: 4 Oct 1995 13:33:07 GMT
Organization: University of Berne
Has anybody recently changed from the old 700 to the 7000 system or is
otherwise capable to make a comparision of the two instruments / ion
sources?
******************************************************************************
Date: Thu, 5 Oct 95 16:24:37 -0400
From: callahan@nrlfs1.nrl.navy.mil (John Callahan)
Subject: October 16, 1995 MSDG meeting
Next Meeting:
Monday, October 16, 1995
Location:
Hewlett-Packard Divisional Office, Park Plaza Building, 2101 Gaither Rd,
Rockville, MD
Speaker:
Dr. Vicki Wysocki, Department of Chemistry, Virginia Commonwealth University
Topic:
Recent Progress in Surface-Induced Dissociation: Fundamental Studies and
Applications to Peptide Fragmentation
eot
John H. Callahan
Code 6113/Chemistry Division
Naval Research Laboratory
Washington, D.C. 20375
202-767-0719
FAX 202-404-8119
John.Callahan@nrl.navy.mil
******************************************************************************
From: Kevin Hart <HartKJ@ornl.gov>
Subject: MSDG: ETMSDG Vendor's Night
Date: 5 Oct 1995 21:22:52 GMT
Organization: Oak Ridge National Laboratory
The East Tennessee Mass Spectrometry Group will be holding its annual
Vendor's Night on October 26 at the Riverwatch Restaurant in Oak Ridge,
TN. Members from Oak Ridge National Laboratory and other Lockheed
Martin Energy Systems facilites, U of Tennessee, TVA, Tennessee Eastman
and other East Tennessee companies are expected to attend. Vendor's
will include both instrument manufacturers and suppliers of components
and add-ons. The setting for this meeting promises to be quite
beautiful with the restaurant having a great view of the Clinch River
and near maximum fall color. The meeting will run 3-9pm with a free
continous buffet being served from 4-7pm for ETMSDG members (annual
membership - $5). Any vendors of mass spectrometry instrumentation or
related products and services who have not been contacted by ETMSDG but
wish to attend, please contact me ASAP. Corporate Membership also comes
with our mailing list and the publication of business cards for local
sales/technical reps in our newsletter (8-9/year).
Kevin J. Hart
Secretary, ETMSDG
HartKJ@ornl.gov
(615) 241-5187
ORNL
PO Box 2008, MS 6120
Oak Ridge, TN 37831
******************************************************************************
From: "Andrew N. Eaton" <ar30@dial.pipex.com>
Subject: Thermo Takeover of Fisons Instruments - latest statement
Date: 6 Oct 1995 08:11:33 GMT
Organization: UnipalmPIPEX server (post doesn't reflect views of UnipalmPIPEX)
There is a statement on the status of the takeover of Fisons
Instruments by Thermo in the "What's New" section of the VG
Organic web site. This statement has been authorised by Dr David
Richardson, Managing Director of Fisons Instruments
<A
HREF="http://www.vgorganic.co.uk/">http://www.vgorganic.co.uk/</A>
******************************************************************************
Date: Fri, 06 Oct 1995 11:00:05 +0000 (GMT)
From: koets@dutndo7.tn.tudelft.nl (Erico Koets)
Subject: 22" Magnet(1 Tesla) + supply available free of charge (Repost)
Organization: Delft Univ. of Technology
The (commercial) power supply (0..160 A, 0..90 V), the (home built)
stabilization amplifiers and the motor-generator local power station
(35 kVA) with switch gear are also available.
This system ran at long term field stabilities of better than 1 : 10^7
and
short term stabilities of 1 : 10^11.
E. Koets
Charged Particle Optics Group
Appl. Physics Dept.
Delft Univ. of Technology
the Netherlands
******************************************************************************
Date: 06 Oct 95 09:51:54 EDT
From: David Sparkman <75530.3472@compuserve.com>
Subject: Re: Anyone Reconize this spectrum
Jim;
Can you tell me more about the CI spectrum? Does it show a peak at 301 or 300?
Is there a M+NH3 peak? Where did this sample come from? Can you look at it by
IR? Is it there any chance that the three GC peaks are artifacts of an
injection problem? What is the solvent used to inject the sample into the GC?.
What are some of the low intensity peaks. Remember, amines give very low
intensity molecular ion peaks. Alcohols show no molecular ion peaks and small
M-18 peaks in some cases, and small M-46 peaks. What do the isotope peaks for
the large peaks in the EI spectra tell you. What does the isotope peak for
molecular ion peak in the CI spectrum tell you?
O. David Sparkman
******************************************************************************
Date: 06 Oct 95 09:51:56 EDT
From: David Sparkman <75530.3472@compuserve.com>
Subject: Re: GCQ
Did you test any other instruments. Since you have an EI application, I was
wondering if you looked at the Saturn, MSD (HP 5972) or the Fison's MD 800.
O. David Sparkman
******************************************************************************
From: ngurpra@ibm.net
Subject: What Ion Trap MS are you using?
Date: 6 Oct 1995 16:14:59 GMT
NNTP-Posting-Host: slip153-1.on.ca.ibm.net
******************************************************************************
Date: Fri, 06 Oct 1995 11:16:02 -0800 (PST)
From: "Dr. David Lustig" <David.Lustig@SYNTEX.COM>
Subject: Serious Quantitation Bug in MassLynx
I have reported this bug to Fisons/VG and they have promised a fix in the form
of an "update disk". I have received my disk, but I don't know if they have
been sent to the general user base yet.
The Quantitation bug occurs when the DILUTION FACTOR is not equal to 1. The
DILUTION FACTOR is completely ignored in both the CALCULATED CONCENTRATION and
the % DEVIATION from the known concentration.
This error occurs for QC (quality control) samples and to a lesser extent for
ANALYTE samples. (In ANALYTE samples the CALCULATED CONCENTRATION is correct,
but the % DEVIATION is not, if one had entered a "known" concentration for some
reason). The error is reproducible 100% of the time when the above conditions
are met.
We found the error while trying to validate the software after upgrading to
version 2.1.0, so we did not have any actual results in error. However, I am
very concerned about users who have these erroneous results in reports they are
submitting to the FDA, EPA, etc.
All MassLynx 2.1.0 users should examine their quantitation results for these
errors and should install the Update disk when the receive it.
David Lustig
Roche Bioscience
3401 Hillview Avenue
Palo Alto, CA 94304
USA
david.lustig@syntex.com
415-855-5785
******************************************************************************
From: "Andrew N. Eaton" <ar30@dial.pipex.com>
Subject: Re: Serious Quantitation Bug in MassLynx
Date: 9 Oct 1995 16:34:08 GMT
Organization: UnipalmPIPEX server (post doesn't reflect views of UnipalmPIPEX)
The problem occurs when the DILUTION FACTOR is not equal to 1. The
DILUTION FACTOR is ignored in both the calculated concentration
and the deviation from the known concentration.
I would like to thank Dr. Lustig for bringing this matter to our
attention.
Jeremy Batt
VG Organic
Tudor Road
Altrincham
Cheshire
WA14 5RZ
England
Jeremy.Batt@instruments.fisons.co.uk
+44 161 929 9666
******************************************************************************
From: pesinc@pluto.njcc.com (PES Inc )
Subject: Simion 3D 6.0 Released by David Dahl of INEL
Date: 9 Oct 1995 21:31:05 GMT
Organization: New Jersey Computer Connection, Lawrenceville, NJ
WWW: http://pluto.njcc.com/~pesinc/
Anonymous ftp: ftp.njcc.com/pub/pes/simion3d.exe
******************************************************************************
Date: Tue, 10 Oct 1995 08:17:43 -0400 (EDT)
From: "Dana DeJohn (313)996-7135" <dejohn@aa.wl.com>
Subject: Mich. Mass Spec. Disc.Grp/ANACHEM/SAS meeting
The next meeting of the Michigan Mass Spectrometry Discussion Group will be
held in ***conjunction with the 1995 ANACHEM/SAS Symposium on Thursday
November 2 at the Armenian Community Center, Dearborn, MI.*** It is located
north of Ford Road and just to the west of the Southfield Expressway. The
address is 19310 Ford Road. The schedule includes:
A wine and cheese reception will be held in the Poster area during the
session. Registration is $30.00 for pre-registration ($15.00 student).
Registration at the door will be $5.00 higher. Mail checks made out to
ANACHEM to:
Dennis Schott
c/o Detroit Edison
6100 W. Warren
WSC-H-16
Detroit, MI 48210
or call 313-897-1328. Include name, affiliation, address, phone and
registration as regular or student.
Best Regards,
Dana DeJohn
Parke-Davis Pharmaceutical Research
2800 Plymouth Rd.
Ann Arbor, MI 48105
TEL: 313-996-7135
FAX: 313-998-2716
INTERNET: dejohn@aa.wl.com
******************************************************************************
From: J.Traeger@latrobe.edu.au (John Traeger)
Subject: ANZSMS WWW HomePage
Date: 9 Oct 1995 03:55:35 GMT
Organization: La Trobe University
NNTP-Posting-Host: 131.172.148.1
Xdisclaimer: No attempt was made to authenticate the sender's name.
The Australian and New Zealand Society for Mass Spectrometry now has a
World-Wide Web home page on the Internet. The address is
"http://www.latrobe.edu.au/ANZSMS/ANZSMS.html".
John Traeger
School of Chemistry
La Trobe University
Melbourne
Australia
******************************************************************************
From: gabarret@nickel.ucs.indiana.edu (gregory barrett-wilt)
Subject: Re: Anyone Reconize this spectrum
Date: 11 Oct 1995 13:05:58 GMT
Organization: Indiana University, Bloomington
In article <453e59$ju1@acmey.gatech.edu>,
David Sparkman <75530.3472@compuserve.com> wrote:
>Jim;
>
>Can you tell me more about the CI spectrum? Does it show a peak at 301 or
>300? Is there a M+NH3 peak? Where did this sample come from? Can you look
>at it by IR? Is it there any chance that the three GC peaks are artifacts
>of an injection problem? What is the solvent used to inject the sample
>into the GC?. What are some of the low intensity peaks. Remember, amines
>give very low intensity molecular ion peaks. Alcohols show no molecular
>ion peaks and small M-18 peaks in some cases, and small M-46 peaks. What
>do the isotope peaks for the large peaks in the EI spectra tell you. What
>does the isotope peak for molecular ion peak in the CI spectrum tell you?
>
>O. David Sparkman
>
>
>
|
| | |
| | | |
| | || |
| | | || |
|| || | || |
|| | || | || | |
----------------------------------------------
5 1 1 2
0 0 5 0
0 0 0
I know, a big pain. On the other hand, you could just scan a spectrum,
uuencode it and post it as a jpeg or gif. Then we could decode it and
view it. The only info I can give on the spectrum itself is that 77
could correspond to a phenyl group and 91 to a C7H7 tropylium ion. M/z
55 could be C3H3O (dehydration product of alpha hydroxy ketone?). I'm
not sure about the m/z 113. It would be very helpful to know where this
sample came from, and what solvent it is compatible with. Good luck!
-Greg Barrett-Wilt
******************************************************************************
From: cescript@mtu.edu (Charles Scripter)
Subject: Re: Anyone Reconize this spectrum
Date: 12 Oct 1995 17:26:52 -0400
Organization: Michigan Tech
> |
> | | |
> | | | |
> | | || |
> | | | || |
> || || | || |
> || | || | || | |
> ----------------------------------------------
> 5 1 1 2
> 0 0 5 0
> 0 0 0
Or you could feed it through GNUPLOT, using `set term dumb' and
`set output "spectra.txt" ' to get an ASCII graph.
--
Charles Scripter * cescript@phy.mtu.edu
Dept of Physics, Michigan Tech, Houghton, MI 49931
******************************************************************************
From: madi@biocell.fundp.ac.be (Marc DIEU)
Subject: Desalting primer before electrospray mass spectrometry
Date: 13 Oct 1995 11:29:55 GMT
Organization: FUNDP (Cellular Biochemistry)
Hello,
Is there someone who knows the best method for desalting primer before
electrospray MS. I tried microcon but the recovery was not good.
Thank you by advance
Marc DIEU
Laboratory of Cellular Biochemistry,
Facult#s Universitaires ND de la Paix,
61, rue de Bruxelles,
B-5000 Namur (Belgium).
Fax: ++/32/81/72.41.35.
Email: fredele@biocell.fundp.ac.be.
******************************************************************************
NOTICE:
The previous notice of the ETMSDG Vendor's Night on October 26, 1995
should be disregarded as the restaurant we had scheduled went bankrupt!
No wonder the price they gave us looked so good. The Vendor's Night has
been postponed indefinitely. However, several of our Vendors have
suggested a "slow" period such as February for a new date. We'll post
revised information when we get it.
Kevin J. Hart
Secretary, ETMSDG
******************************************************************************
Date: Wed, 13 Sep 95 21:10:58 -0500
From: "John C. Huffman" <huffman@indiana.edu>
Organization: Indiana University Molecular Structure Center
Subject: Position Open
http://www.iumsc.indiana.edu/chem/massopen.html
=============================================
John C. Huffman Senior Scientist
Indiana University Molecular Structure Center
huffman@indiana.edu
http://www.iumsc.indiana.edu
=============================================
******************************************************************************
From: "Michelle D. Beeson" <mbeeson@emory.edu>
Subject: Atlanta/Athens MSDG
Date: 16 Oct 1995 03:51:52 GMT
Organization: Emory University
The speaker for the evening will be Ben Freiser from Purdue University.
The title of his talk is "Having a Ball with Buckyball, Met-cars and
FTMS." This will be an interesting and exciting talk that everyone will
want to attend.
Anyone who would like to receive information about the AAMSDG meetings
via email should send a message to mbeeson@emory.edu.
Michelle D. Beeson
Microchemical Facility
Winship Cancer Center voice: (404) 778-4589
Emory University fax:
(404) 778-4281
Atlanta, GA 30033 email:
mbeeson@emory.edu
******************************************************************************
Date: Mon, 16 Oct 1995 16:28:38 +0100 (MET)
From: Paul Van Den Broeck <Paul.VanDenBroeck@rug.ac.be>
Subject: triglycerides in MS
******************************************************************************
From: "John C. Huffman" <huffman@indiana.edu>
Subject: (no subject)
Date: 16 Oct 1995 20:20:53 GMT
Organization: Ind. Univ. Molecular Structure Center
http://www.iumsc.indiana.edu/chem/massopen.html
=============================================
John C. Huffman Senior Scientist
Indiana University Molecular Structure Center
huffman@indiana.edu
http://www.iumsc.indiana.edu
=============================================
******************************************************************************
From: A.TREUMANN@dundee.ac.uk (H.J. Treumann Biochemistry ext 4301)
Subject: Re: triglycerides in MS
Date: 17 Oct 1995 11:51:43 +0100
Organization: The University, Dundee, DD1 4HN, Scotland, UK.
Paul,
Good luck,
Achim Treumann
--
Achim Treumann tel. +44-1382-344301
Carbohydrate Research Centre fax +44-1382-322583
Department of Biochemistry
Dundee DD1 4HN, Scotland, UK email a.treumann@dundee.ac.uk
******************************************************************************
From: db32@prism.gatech.edu (David E. Bostwick)
Subject: ASMS Web page
Date: 17 Oct 1995 10:32:10 -0400
Organization: Georgia Institute of Technology
Those of you who get the ASMS newsletter have already seen this, but there
are several readers of the group who aren't in ASMS.
The American Society for Mass Spectrometry now has a Web home page. The
address is
http://www.newmexico.com/~asms
--
David E. Bostwick
Georgia Institute of Technology, Atlanta, GA, 30332
david.bostwick@chemistry.gatech.edu
******************************************************************************
From: phkrh@zeus.bris.ac.uk (K R. Hallam)
Subject: VG Micromass Q4
Organization: University of Bristol, England
Date: Tue, 17 Oct 1995 15:45:14 GMT
Dear All,
Does anyone have a VG Micromass Q4 controller and lead (early style, three M3
screws hold the lead in place on the head unit rather than a threaded knurled
ring) for sale/rent/giving away? We have a head unit, but if you want to get
rid of one of those as well, then the more the merrier.
Thankyou,
--
Dr. Keith R. Hallam University of Bristol, Interface Analysis Centre, Oldbury
House, 121, St. Michael's Hill, Bristol, BS2 8BS, England
Telephone: + 44 (0)117 925 5666 | E-mail: k.r.hallam@bristol.ac.uk
Facsimile: + 44 (0)117 925 5646 | URL: http://zeus.bris.ac.uk/~phkrh/
******************************************************************************
From: hongli@scs.unr.edu (Hong Li)
Subject: Roommate LC/MS Symposium
Date: 17 Oct 1995 21:14:23 GMT
Organization: UCCSN System Computing Services
--
I am looking for someone (M/F) to share a hotel room in the Crystal Sands
Resort, Hilton Head Island, SC during the 12th Montreux LC/MS Symposium
(Nov 1 thru 3). If interested, please Email me @ hongli@scs.unr.edu or
call(702) 784-4126 ASAP.
Me: Hong Li, 25 yr old M, 4th yr biochem grad student in U of Nevada, Reno.
******************************************************************************
From: biohelp@net.bio.net (BIOSCI Administrator)
Subject: VBC'96 - Call for Papers
Date: 17 Oct 1995 18:37:49 -0700
Organization: University Hospital Eppendorf / Hamburg
--------------------------------------------------------------------
Hamburg, Germany
--------------------------------------------------------------------
Scope
Following Georgia Tech, the University of North Carolina, and the Mayo
Institutions, the University of Hamburg will host the 4th conference on
Visualization in Biomedical Computing (VBC'96). Its goal is to enhance and
promote the science of computer based visualization of biomedical
information, especially about the various aspects of the human body. An
interdisciplinary, international group of scientists, engineers, and
clinicians will present and discuss the state of the art concerning
algorithms, the rapidly increasing number of applications, and the
practical problems of system design.
------------------------------------------------------------------------
Topics
------------------------------------------------------------------------
Format
Submission
Papers
Authors are invited to submit five copies of an extended abstract
not shorter than two pages which may include figures. Submission of
full papers is encouraged. The submission must begin with a 50 word
statement about the major results of the work.
Posters
Authors are invited to submit posters under the conditions applying
for papers. They will be included in the proceedings as short papers.
Demonstrations
There will be the possibility of hands-on demonstrations. Please
submit an outline (not exceeding 2000 words), including the hardware
requirements.
Tutorials
Proposals for half-day (four hour) tutorials are invited to any aspect
of visualization in biomedical computing as described in the topics
section. Proposals should include an outline accompanied by a
curriculum vitae.
VBC`94 offered:
3D Imaging in Biomedical Computing, Volume Visualization,
Visualization in the Neurosurgical OR, Modern 3D Microscopy and
Visualization, Multiscale Geometric Image Analysis
------------------------------------------------------------------------
! DEADLINES !
! !
! Paper/Poster Submission : February 1, 1996 !
! !
! Tutorial Submission : February 1, 1996 !
! !
! Notification of Acceptance : April 1, 1996 !
! !
! Full papers : June 15, 1996 !
! !
! Demonstration Proposals : June 1, 1996 !
------------------------------------------------------------------------
Proceedings
Visits
Visits to laboratories in Hamburg will be arranged for the day after the
conference (IMDM, Philips Research, Dept. of Computer Science)
------------------------------------------------------------------------
Location
Previous Conferences
1990
Georgia Institute of Technology, Atlanta, GA
Proceedings: First Conference on Visualization in Biomedical Computing,
IEEE Computer Society Press, 1990
1992
University of North Carolina, Chapel Hill, NC
Proceedings: Visualization in Biomedical Computing II,
Proc. SPIE 1808, 1992
1994
Mayo Foundation, Rochester, MN
Proceedings: Visualization in Biomedical Computing 1994,
Proc. SPIE 2359, 1994
------------------------------------------------------------------------
Conference Committee
Chairman
Program Committee
Coordinators
Supporting Organisations
University of Hamburg
The Institute of Electrical and Electronics Engineers (IEEE)
German Society of Computer Science (GI)
------------------------------------------------------------------------
E-mail: vbc96@uke.uni-hamburg.de
========================================
http://www.uni-hamburg.de/~medizin/vbc96
========================================
---------------------------------------------------------------------------
******************************************************************************
From: "Andrew N. Eaton" <ar30@dial.pipex.com>
Subject: Re: Desalting primer before electrospray mass spectrometry
Date: 18 Oct 1995 08:07:50 GMT
Organization: UnipalmPIPEX server (post doesn't reflect views of UnipalmPIPEX)
******************************************************************************
From: Ian Michael <ian@impub.demon.co.uk>
Subject: European Mass Spectrometry Web Site
Date: Wed, 18 Oct 1995 14:06:34 GMT
Organization: IM Publications
The European Mass Spectrometry Web Site is now up and running. The URL is:
http://www.impub.co.uk
The site contains abstracts of all issues published and of papers in press, a
complete sample issue for free downloading in Adobe Acrobat format, information
for authors on publishing with EMS, links to other sites and
subscription information.
******************************************************************************
From: knewland@herbie.unl.edu (KIRK NEWLAND)
Subject: Re: MALDI
Date: Wed, 18 Oct 1995 13:15:46 -0500 (CDT)
I was wondering if anyone had any information concerning any new recipes for
MALDI-tof matrices. I am working with a large range of peptides and protein
digests. Any information would be greatly appreciated.
BTW, I am hoping to move down to Atlanta this Summer. How is the job
market for mass spec work there?
Kirk Newland
University of Nebraska
******************************************************************************
From: brooks@physics.unc.edu (Steve Brooks)
Subject: Re: triglycerides in MS
Date: Thu, 19 Oct 1995 12:57:31 -0500
Organization: UNC Department Of Physics & Astronomy
> Does annybody know a good article, book, or review on th following topic :
> 'Fragmentation pathways of triglycerides (triacylglycerols) in Mass
> Spectroscopy' ?
I done a bit of lipid mass spec, but haven't done anything with
triacylglycerols. This sounds like something that might best be served by
a triple quad mass spec (especially if you are interested in the
constituent FAs. You might want to check with Dr. Ski Chilton at the
Bowman Gray School of Medicine in Winston-Salem, NC. He has done quite a
bit of relavent work. He is in the Department of Medicine, Section on
Pulmonary and Critical Care. Good luck.
Steve
--
Steve Brooks
PHONE: (919) 968-7977
EMAIL: BROOKS@PHYSICS.UNC.EDU
******************************************************************************
From: "Andrew N. Eaton" <ar30@dial.pipex.com>
Subject: Re: MALDI
Date: 20 Oct 1995 13:00:41 GMT
Organization: UnipalmPIPEX server (post doesn't reflect views of UnipalmPIPEX)
I too have had a lot of questions about MALDI matrices via the VG ORGANIC
web site. As of 16th October 95, we have started an index of MALDI
Matrices to which anyone can post suggestions.
http://www.vgorgani.co.uk/bio/mmatrix1.htm
******************************************************************************
From: Drew Gibson <Drew_Gibson@sandwich.pfizer.com>
Subject: Re: MALDI
Date: 20 Oct 1995 11:38:09 GMT
Organization: Pfizer
I don't use MALDI myself, but just happened to note a reference in our library
yesterday - which may be of interest to you :-
6-aza-2-thiothymine : A matrix for MALDI spectra of oligonucleotides.
Lecchi (or Leechi ?) P, Le, HMT and Pannell, LK
Nucl. Acid Res. 1995 23(7) 1276.
As I say, I'm not a MALDI user, so I hope that this is of use to you.
Cheers,
Drew Gibson,
Pfizer Central Research (Drug Met Mass Spec Group)
Sandwich, England.
******************************************************************************
From: forensic@unix.asb.com (charles salerno)
Subject: copper analysis
Organization: ASB
Date: Fri, 20 Oct 1995 23:24:17 GMT
If anyone has any info how to extract copper from blood please pass it along.
Thank you
C.S.
******************************************************************************
From: forensic@unix.asb.com (charles salerno)
Subject: copper analysis
Organization: ASB
Date: Fri, 20 Oct 1995 23:31:31 GMT
I am looking for a gcms copper analysis and extraction from blood samples.
If you have one, please pass it along.
Thank you
C.S.
******************************************************************************
From: Seng Woon Lim <amoured@u.washington.edu>
Subject: D2O and HDO mass spectra
Date: Sat, 21 Oct 1995 00:27:07 -0700
Organization: University of Washington
hi. i need the help of you guys out there. i am in a process of analysing
my D2O data and unfortunatedly it is somewhat contaminated by H2O.
therefore, i am desperately looking for mass spectra that provides the
fragmentation pattern of D2O and HDO.
i would very much appreciate if anyone can tell me where in the
literature i can look up the relevant data.
David
LSWD
CAFFEINECAFECOFFEECAFETERIACUPCAFFEINECOFFEECAFECAFETERIACOFFEECAFECUPCOFFEECAFE
================================================================================
' amoured@u.washington.edu
' { ' swlim@cheme.washington.edu
} } { Department of Chemical Engineering
{ { } (Water Interface Group)
/""""""""""\ University of Washington
|-==========-|/^^I Benson Hall, BF-10
| ^ ^ |- I Room B-011/B-005
| V | / TEL: (206) 543-5467
| Coffee |/ FAX: (206) 543-3778
\__________/ http://weber.u.washington.edu/~amoured/index.html
================================================================================
******************************************************************************
From: Nahum Gat <nahum@techexpo.com>
Subject: Re: VBC'96 - Call for Papers
Date: 22 Oct 1995 07:54:20 GMT
Organization: TechExpo Corporation
Hi,
You may want to post your conference / workshop/ call for papers
announcement at TechExpo, URL:
http://www.techexpo.com/
Regards,
******************************************************************************
From: lwojcik@intele.net (Leonard Wojcik)
Subject: Re: D2O and HDO mass spectra
Date: Sun, 22 Oct 1995 11:51:01 MST
Organization: WTS
>hi. i need the help of you guys out there. i am in a process of analysing
>my D2O data and unfortunatedly it is somewhat contaminated by H2O.
>therefore, i am desperately looking for mass spectra that provides the
>fragmentation pattern of D2O and HDO.
David ,
Unfortunately mass spec is a very bad technique for dealing with D2O / D2O /
HDO because the stuff exchanges very, very fast. Exchanges happen in inlet
lines, storage bulbs (if you have not equilibrated the surface) and most
definitely in the source. I know of one chap who very painstakingly prepared
dideuterioacetylene from calcium carbide and D2O on a vac rack. When he went
to do his ICR (Ion Cyclotron Resonance) kinetic experiments he got a terible
mix due to the exchange of the acidic hydrogens on the acetylene. So make
sure your deuterium labeling is on a non exchangable site. (By the way things
are even worse if you're doing chemical ionization - everything equilibrates
all over the place if it stays in the source very long)
As for the spectra, there should be lines at 20 and 19 for D2O; 19,18 and 17
for HDO, and of course 18 and 17 for H2O.
******************************************************************************
Date: Sun, 22 Oct 95 14:12 EDT
From: Bill Lillycrop <aurora@user.rose.com>
Subject: Calibration Standard for Neg. Ci
Organization: Rose Media Inc, Toronto, Ontario, Canada
We wish to calibrate out GCMS in Ci-neg. mode down to mass 35. We have
looked at adding CCl4 and Ch2Cl2 to the FC43 to get masses between 35-200,
without much success. Does anyone have any suggestions as to a new
reference compound, or a compound which would be added to FC43 so that we
can get a full range tune from 35 to 700?
******************************************************************************
From: bellini@mnvax.irfmn.mnegri.it
Subject: GC-MS method for Demeton
Date: 19 Oct 1995 08:52:07 GMT
Organization: Istituto MARIO NEGRI
I've some problem for the GC-MS analysis of Demeton-O ethyl and Demeton-O
methyl. Could you help me, please?
Thank you in advance,
Alberto
******************************************************************************
From: palmenj@govonca.gov.on.ca (J-P Palmentier)
Subject: Re: Calibration Standard for Neg. Ci
Date: 23 Oct 1995 15:34:15 GMT
Organization: Government of Ontario
J-P
******************************************************************************
From: palmenj@govonca.gov.on.ca (J-P Palmentier)
Subject: Re: Calibration Standard for Neg. Ci
Date: 23 Oct 1995 15:44:29 GMT
Organization: Government of Ontario
J-P
******************************************************************************
From: krakovej@zgi.com (Jonathan Krakover)
Subject: Re: MALDI
Date: Mon, 23 Oct 1995 16:48:06 -0100
Organization: ZymoGenetics
> I too have had a lot of questions about MALDI matrices via the VG ORGANIC
> web site. As of 16th October 95, we have started an index of MALDI
> Matrices to which anyone can post suggestions.
>
> The list is indexed according to matrix name and contains a description of
> the compound(s) for which it has been tried, some sample prep information
> and the Name, organisation and E-Mail address of the person who submitted
> it. Full instructions for posting suggestions are given on the page
>
> http://www.vgorgani.co.uk/bio/mmatrix1.htm
>
> All contributions are welcome.
>
> Dr Andrew N. Eaton, Marketing Manager, VG ORGANIC
> E-Mail: Andrew.Eaton@instruments.fisons.co.uk
> Tel: ++44 (0)161 929 9666, Fax: ++44 (0)161 941 5242
> Tudor Road, Altrincham, Cheshire WA14 5RZ, United Kingdom
http://www.vgorganic.co.uk/bio/mmatrix1.htm
http://chait-sgi.rockefeller.edu/
Jonathan Krakover
krakovej@zgi.com
ZymoGenetics Inc.
******************************************************************************
From: JR_Laboratories Inc <JR_Laboratories_Inc@mindlink.bc.ca>
Date: Tue, 17 Oct 95 11:36:53 -700
Subject: lc/ms
Dear:gatech.edu
I'd be curious to know how other people using LC/MS have been able
to boost sensitivity, particularly for neutral compounds such as
fat soluble vitamins. I'm running an HP API-electrospray system
on a 5989B mass spectrometer. As yet have only been able to get
decent spectra from concentrations in the mid to high ppb range.
I'm using positive ion mode and can't seem to go any lower.
Unfortunately I don't have CI capabilities.
Any suggestions?
Paul
******************************************************************************
From: "Gary J. Van Berkel" <vanberkelgj@ornl.gov>
Subject: Re: lc/ms
Date: 24 Oct 1995 17:08:33 GMT
Organization: Lockheed Martin Energy Systems
You need an ionic form the analyte in solution for best signal in true
ES-MS (i.e., no gas-phase ionization processes). You should examine the
functional groups on the molecule to determine the best way to form an
ion--e.g., Bronsted or Lewis acid/base chemistry, chemical
electron-transfer, electrochemical electron transfer (using the inherent
electrolytic effect in ES), or possibly derivatization to form an ionic
compound or a compound ionizable by the methods described above.
******************************************************************************
From: rcivi@cts.com (Richard Civitate)
Subject: For Sale: GC/MS/PC System
Date: 24 Oct 1995 22:29:11 GMT
Organization: Scientific Equipment Exchange, Inc.
******************************************************************************
Date: Tue, 24 Oct 1995 16:14:09 -0700
From: WITOLD WINNIK <ASDWXW@wpmail.las.epa.gov>
Subject: Response to Bill Lillycrop, subject: Calibration Standard for Neg. Ci
Response to:
Dear Bill,
I have been using Fomblin (Aldrich 31, 792-6) for NICI/MS tuning with
very good results. This compound is a perfluoropolyether, average M.Wt.
up to 1800 daltons. It calibrates very well from 35 up to almost 2000 m/z.
First, I tried introducing it through the calibration gas inlet system (TSQ
700 instrument), but the compound was not volatile enough. Later I
found out that the best method of introduction of the compound into the
source was simply through the solids probe inlet. Fomblin is basicaly a
pump oil which is characterized by low vapor pressure, so it evaporates
slowly and evenly from the solids probe vial and gives a very good
negative-ion spectrum, a lot better than FC43.
A high resolution NICI spectrum of this compound and a list of peaks was
published by William C. Brumley several years ago.
Good luck!
******************************************************************************
From: Chris Carvalho <c.carvalho@qut.edu.au>
Subject: Announcing QLD RACI Organic Group on the WWW
Date: 25 Oct 1995 07:13:37 GMT
Organization: QUT
http://www.sci.qut.edu.au/chem/orgchem/
******************************************************************************
From: Mario.Furlanut@dpmsc.uniud.it
Subject: levodopa and API III
Date: 25 Oct 95 14:59:51 MET
Organization: University of Udine
We need help in order to prepare a mobile phase to separate levodopa and its
metabolites in plasma using LC/MS SCIEX API III
Thank's
******************************************************************************
From: matuszakk@randb.pprd.abbott.com
Subject: Re: lc/ms
Date: 25 Oct 95 07:03:14 CST
Organization: Abbott Laboratories
Ken M.
******************************************************************************
From: daweil@mmm.com
Subject: MALDI of Polymers
Date: 25 Oct 1995 15:35:36 GMT
Organization: 3M - St. Paul, MN 55144-1000 US
Is there any interest in having a separate listing of MALDI matrices that work well
with Industrial Polymers?
The matrices listed in the VGORGANICS web site are mainly for Biopolymers and not
synthetic polymers.
The advancement of MALDI for polymer characterization could be improved with a free
exchange of sample
preparation and matrices for specific polymer classes.
David Weil
daweil@mmm.com
******************************************************************************
From: WMBONE00@ukcc.uky.edu (Bill Bone)
Subject: Re: Calibration Standard for Neg. Ci
Date: Wed, 25 Oct 95 16:01:52 EDT
Organization: The University of Kentucky
In article <46e2i7$4ni@acmey.gatech.edu>
Bill Lillycrop <aurora@user.rose.com> writes:
>We wish to calibrate out GCMS in Ci-neg. mode down to mass 35. We have
>looked at adding CCl4 and Ch2Cl2 to the FC43 to get masses between 35-200,
>without much success. Does anyone have any suggestions as to a new
>reference compound, or a compound which would be added to FC43 so that we
>can get a full range tune from 35 to 700?
>
>
I've used OH- background at M/z = 17 and F- at M/z = 19 in the past when
I have needed to scan to low masses. It has always worked fine.
Good luck.
Bill
>
******************************************************************************
From: mlynek@chem.wisc.edu (Peter Mlynek)
Subject: Re: D2O and HDO mass spectra
Date: Wed, 25 Oct 1995 20:11:46 -1000
Organization: University of Wisconsin-Madison
******************************************************************************
Date: Thu, 26 Oct 1995 16:15:29 +0000 (GMT)
From: gs_klinger@pnl.gov (George S Klinger)
Subject: Re: copper analysis
Organization: Battelle Pacific Northwest Labs
******************************************************************************
From: mwelch@TRENTU.CA (Somewhere in Bohemia)
Subject: Dating/Radio&Stable Tracers
Organization: Trent University, Peterborough
Date: Fri, 27 Oct 1995 07:20:08 GMT
MJ Welch
Watershed Ecosystems Graduate Studies
c/o Lady Eaton College
Trent University
Peterborough, Ontario
Canada K9J 7B8
Email: MWelch@TrentU.Ca
******************************************************************************
From: "Andrew N. Eaton" <ar30@dial.pipex.com>
Subject: Re: MALDI of Polymers
Date: 27 Oct 1995 09:01:43 GMT
Organization: UnipalmPIPEX server (post doesn't reflect views of UnipalmPIPEX)
http://www.vgorganic.co.uk/bio/mmatrix1.htm
Best Regards,
******************************************************************************
Date: Thu, 26 Oct 1995 23:08:20 -0700
From: coburn@indirect.com (Anne Coburn)
Subject: Re: Position available
OBJECTIVE:
To support and contribute to the efforts of this group as they conceive of
and develop
new approaches in order to obtain structural information about proteins,
peptides, glyco-
proteins, and carbohydrates through the use of state-of-the-art mass
spectrometry.
This is a hands-on research position which will focus on the challenge of
going beyond
conventional methods to obtain information on increasingly limited amounts
of material.
In addition, this person will also act as an in-house liaison between this
group and the
rest of the company.
DUTIES:
- The characterization/purification/mapping of proteins and peptides using
mass spectroscopy.
- Function as liaison between this group and various people and groups
in-house.
- Support and contribute to on-going research projects.
REQUIREMENTS:
- B.S. or M.S. in Chemistry, Biochemistry, or closely related field. (No
Ph.D.'s will be considered)
- Expertise in electrospray LC/MS, LC/MS, and laser desorption ionization
(MALDI) required.
Experience in Capillary LC/MS would be an attractive additional skill.
- A minimum of 2 years experience in mass spectroscopy working with and
peptides and proteins.
- Expertise in protein and peptide mapping, characterization and
purification.
- The ability to operated specialized laboratory equipment and computers.
- Some background in the interpretation of mass spectra.
- Strong analytical skills.
- The ability to work independently with minimum supervision.
Fax:520.321.1475
coburn@indirect.com
----------------------------------------------------------------------------
--------------------------------
Anne Coburn
COBURN Scientific Search
4449 Whitman
Tucson, AZ 85711
Ph: 602.881.0084
Fax: 602.321.1475
******************************************************************************
From: "John Bartmess" <BARTMESS@novell.chem.utk.edu>
Organization: Univ. of Tenn. Dept. of Chemistry
Date: Fri, 27 Oct 1995 11:17:59 EST
Subject: MS simulator program?
John
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=-
| John Bartmess | Organic Chem || my opinions, being antithetical |
| Dept. of Chem., U. of Tennessee || to "big time" football, cannot |
| Knoxville TN 37996-1600 || be those of the Univ. of Tennessee|
| (423) 974-6578 Fax: 974-3454 || "Anions are more fun!" |
| jbartmess@utk.edu http://novell.chem.utk.edu/bartmess.htm |
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=--=-
******************************************************************************
From: "Rob O'Brien" <ROB.O'BRIEN@nrc.ca>
Subject: Re: Calibration Standard for Neg. Ci
Date: 27 Oct 1995 15:48:00 GMT
Organization: National Research Council, Canada
I have not tried these mixtures myself. I use the background Chlorine
isotopes at mass 35 and 37 to check the lower mass range.
Note, I have noticed that the relative abundance of ions in FC43 and
PFK can change somewhat at different source pressures, temperatures,
and with different moderator gasses types. Therefore, it is useful
to create a secondary caibration file that reflects this change.
ro@iecems.lan.nrc.ca or robrien@ccs.carleton.ca
regards,
R.O'B
******************************************************************************
From: m.vandeweert@stud.chem.ruu.nl (Weird L. Marcowitz)
Subject: [Q] Mass spectra of indoles, oxyindols
Date: Thu, 26 Oct 1995 09:46:03 +0100
Organization: Academic Compter Centre Utrecht
Hi everyone,
Regards,
Marco
******************************************************************************
From: Kathy Plavcan <plavcak@aa.wl.com>
Subject: Post-Doc Available at Parke-Davis, NJ
Date: 27 Oct 1995 21:39:35 GMT
Organization: Warner-Lambert Parke-Davis Research
******************************************************************************
From: "John Bartmess" <BARTMESS@novell.chem.utk.edu>
Organization: Univ. of Tenn. Dept. of Chemistry
Date: Sat, 28 Oct 1995 14:04:15 EST
Subject: Re: Calibration Standard for Neg. Ci
John
******************************************************************************
From: "John Bartmess" <BARTMESS@novell.chem.utk.edu>
Organization: Univ. of Tenn. Dept. of Chemistry
Date: Sat, 28 Oct 1995 14:06:10 EST
Subject: Remailing Service for STMS - problems
There are now ca. 125 people subscribed. I've been having a
consistent problem, however, with about 5% of new subscribers. The
mailings to these folks are returned to me with an error message,
indicating that either the host/domain or username is not valid.
- There are a few addresses that have *never* been valid hosts, on
many successive mailings.
I realize that mailing subscribers probably *won't* see this post. If you
know of someone attempting to receive the group this way, and having
problems, please pass the following information along to them.
Thanks,
******************************************************************************
From: ahq@mail.utexas.edu (Ah-Q The Horrible)
Subject: {Q}: What's the spectrum of teflon look like?
Date: Sat, 28 Oct 1995 17:45:58 -0600
Organization: UT-Austin, Physics Dept.
Hi, All:
******************************************************************************
From: JOERG.HAU@01.chlsnr.nestrd.ch
Date: Mon, 30 Oct 1995 08:47:53 +0100
Subject: Re: API of neutrals
>I'd be curious to know how other people using LC/MS have been able
>to boost sensitivity, particularly for neutral compounds such as
>fat soluble vitamins. [...]
>Unfortunately I don't have CI capabilities.
Hi Paul,
If you have neutrals and no APCI, you're having a problem. By the nature
of its ionization process, electrospray alone will not give very high
sensitivity on "neutral" (i.e., non-protonable or non-ionic) compounds.
We've had the same problem, e.g. for carotenoids; the only solution we
found was to use APCI.
Good luck,
Joerg
---------------------------------------
Dr. Joerg Hau
Nestl'#e Research Centre
Vers-chez-les-Blanc
Case postale 44
CH-1000 Lausanne 26, Switzerland
******************************************************************************
From: JOERG.HAU@01.chlsnr.nestrd.ch
Date: Mon, 30 Oct 1995 13:59:10 +0100
Subject: For sale
******************************************************************************
Date: Mon, 30 Oct 1995 11:56:00 -0500 (CDT)
From: "Steven P. Cepa 708-937-7539" <CEPA.STEVEN@igate.pprd.abbott.com>
Subject: November meeting
Tuesday, November 14
At the Mirage Restaurant at the Howard Johnson O'Hare
in Schiller Park, IL -- 10249 Irving Park Rd.
Registration is $20
Call 708-245-3403 by Nov. 10 for reservations.
******************************************************************************
From: "Gary J. Van Berkel" <vanberkelgj@ornl.gov>
Subject: Re: API of neutrals
Date: 30 Oct 1995 23:06:53 GMT
Organization: Lockheed Martin Energy Systems
I need help with locating a supplier of Kratos spares for an MS80 mass
spec. An exKratos engineer told me of a supplier which trades under the
name of DSR for Kratos spares. However I've not been able to locate a
contact fax number or address for this company can anyone supply me with a
contact for this company which is run by one Doug Ross(?). Any help will be
most greatfully accepted. Many thanks in advance.
Bruce Clark
Chemistry Dept
University of Canterbury
Private Bag 4800
Christchurch
New Zealand
email:B.Clark@CHEM.CANTERBURY.AC.NZ
******************************************************************************
From: caughran@cr2novl.chem.uga.edu (Joel A. Caughran)
Subject: Carbonyl Compounds
Date: 31 Oct 1995 15:22:45 GMT
Organization: Chemistry Learning Center
Ques. 1: Is there a good solvent mix for HPLC that will allow you
to elute aldehydes, ketones, and other carbonyl compounds? After
elution, the solvent/sample plug will be carried into a mass spectrometer,
so that needs to be taken into account as well. Inorganic buffers or
salts are not an option.
=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-
Joel A Caughran caughran@cr2novl.chem.uga.edu
Chemistry Learning Center caughran@sunchem.chem.uga.edu
Department of Chemistry
University of Georgia Voice (706) 542-1906
Athens, GA 30602 Fax (706) 542-9454
-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=
******************************************************************************
From: news@chaos.kulnet.kuleuven.ac.be
Subject: Re: Help with Kratos spares
Date: 31 Oct 1995 16:07:33 GMT
Organization: K.U.Leuven
>email:B.Clark@CHEM.CANTERBURY.AC.NZ
>
Personally, I don't know the DSR company, but Kratos still has spares for
most of its instruments. Their service is located on :
http://www.kratos.com/spares.html
Are you shure about the name DSR ? I know Kratos used a lot of parts
distributed by RS. I have their address if you need it.
Perhaps it would be more clear if you could tell what you need.
Jef.
******************************************************************************
From: pesinc@pluto.njcc.com (PES Inc )
Subject: Simion 3D Ion optics similation available
Date: 31 Oct 1995 21:13:54 GMT
Organization: New Jersey Computer Connection, Lawrenceville, NJ
WWW: http://pluto.njcc.com/~pesinc/
Anonymous ftp: ftp.njcc.com/pub/pes/simion3d.exe
******************************************************************************
From: yhardgb@chem1.chem.dal.ca (G.B. Yhard)
Subject: APCI of air sensatives
Date: Tue, 31 Oct 1995 22:36:56 GMT
Organization: Chemistry Department, Dalhousie University
******************************************************************************
From: knewland@herbie.unl.edu (KIRK NEWLAND)
Subject: Re: MALDI of Polymers
Date: 1 Nov 1995 10:00:07 GMT
Organization: University of Nebraska--Lincoln
daweil@mmm.com wrote:
: RE: MALDI Matrices
: The matrices listed in the VGORGANICS web site are mainly for Biopolymers
: and not synthetic polymers.
: David Weil
: daweil@mmm.com
I have a friend who is researching that very thing. Could you send me a copy
of the info you have via e-mail?
Kirk Newland
University of Nebraska
knewland@herbie.unl.edu
******************************************************************************
From: "Lorne M. Fell" <g9526457@mcmail.cis.mcmaster.ca>
Subject: Re: MS simulator program?
Date: 1 Nov 1995 17:42:05 GMT
Organization: McMaster University
Sounds like a job for 'Simion' to me. I have not myself used this
package, but essentially it simulates ion trajectories within a
specified geometry (mass spectrometer). Your internet browser should
have a search function....
Lorne
--
IN THE UNIVERSE THE DIFFICULT THINGS ARE DONE AS IF THEY WERE EASY.
-- LAO-TSU
Lorne M. Fell
Department of Chemistry
McMaster University
Hamilton, Ontario, Canada email: g9526457@mcmail.cis.mcmaster.ca
******************************************************************************
From: "John Bartmess" <BARTMESS@novell.chem.utk.edu>
Subject: MS simulator program?
Date: 27 Oct 1995 11:21:54 -0400
Organization: Univ. of Tenn. Dept. of Chemistry
John
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=-
| John Bartmess | Organic Chem || my opinions, being antithetical |
| Dept. of Chem., U. of Tennessee || to "big time" football, cannot |
| Knoxville TN 37996-1600 || be those of the Univ. of Tennessee|
| (423) 974-6578 Fax: 974-3454 || "Anions are more fun!" |
| jbartmess@utk.edu http://novell.chem.utk.edu/bartmess.htm |
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=--=-
---------------------------------106902267317289--
******************************************************************************
From: Rachel Ogorzalek Looo <loo@brcf.med.umich.edu>
Subject: Re: APCI of air sensatives
Date: 1 Nov 1995 20:06:01 GMT
Organization: University of Michigan
******************************************************************************
From: ijames@codon.nih.gov (Carl F. Ijames)
Subject: Re: MALDI
Organization: National Institutes of Health
Date: Thu, 2 Nov 1995 02:25:12 GMT
> I too have had a lot of questions about MALDI matrices via the VG ORGANIC
> web site. As of 16th October 95, we have started an index of MALDI
> Matrices to which anyone can post suggestions.
>
> The list is indexed according to matrix name and contains a description of
> the compound(s) for which it has been tried, some sample prep information
> and the Name, organisation and E-Mail address of the person who submitted
> it. Full instructions for posting suggestions are given on the page
>
> http://www.vgorgani.co.uk/bio/mmatrix1.htm
Regards,
Carl Ijames ijames@codon.nih.gov
******************************************************************************
From: "Michael J. Shifflet" <shiffty@postoffice.ptd.net>
Subject: Re: Carbonyl Compounds
Organization: ProLog - PenTeleData, Inc.
Date: Thu, 2 Nov 1995 02:37:58 GMT
Mike Shifflet
shiffty@ptd.net
******************************************************************************
From: dfettero@ahoynet.com (Dean D. Fetterolf)
Subject: Bear Instruments benchtop QQQ - WWW page
Date: Thu, 02 Nov 1995 03:57:50 GMT
Organization: Capital Area Internet Service info@cais.com 703-448-4470
******************************************************************************
From: rbaker@gas.uug.arizona.edu (RB)
Subject: Cleaning glassware
Date: Wed, 01 Nov 1995 22:52:39 +1000
Organization: The University of Arizona
Hi,
I have a question for you all. I'm going to be measuring low levels of
magnesium ions (in the .1-10 ppb range) and know that I need to have good
standards to do this. I have good, clean water (I think), but need some
help figuring out what glass/plastic ware to use and how to clean it to
get rid of residual ions, minimize leeching of Mg from the bottle, and
minimize ion adhesion to the bottle. If you can let me know what you
recomend using (and maybe even a company that sells such), it would be
appriciated.
Thanks!
Robert Baker
University of Arizona
rbaker@gas.uug.arizona.edu
******************************************************************************
From: mpotter@uoguelph.ca (Miriam D Potter)
Subject: PCB analysis by HRGS/HRMS
Date: 1 Nov 1995 04:23:15 GMT
Organization: University of Guelph
******************************************************************************
From: greg@sciex.com (Greg King)
Subject: Re: APCI of air sensatives
Date: Thu, 02 Nov 1995 13:34:30 -0500
Organization: SCIEX
> Anyone have any experience in the analyzsis of air sensative compounds by
> APCI/ESI, or know of any references to this?
I have no specific experience but I would think that the nitrogen curtain
gas used on our machines (PE-Sciex API-100/300) would purge most of the
air from the source chamber. Especially if nitrogen is also used as the
nebulizer gas. But this is my opinion only.
--
Greg King
SCIEX
71 Four Valley Drive
Concord, Ontario, Canada
(905) 660-9006 ext 201
greg@sciex.com
******************************************************************************
From: kull@leland.stanford.edu (Alan Kull)
Subject: Re: Simion 3D Ion optics similation available
Date: Thu, 02 Nov 1995 15:21:15 -0800
Organization: Stanford University
Thanks,
Alan
--
Alan Kull
High Temperature Gasdynamics Laboratory
Stanford University
Stanford, CA 94305
415-723-4182
kull@leland.stanford.edu
******************************************************************************
From: joestroll@aol.com (Joe Stroll)
Subject: Career Opportunity
Date: 3 Nov 1995 09:55:30 -0500
Organization: America Online, Inc. (1-800-827-6364)
Dear Colleagues:
Many thanks for your continuing assistance and guidance with the
identification of a Research Scientist for one of my clients
He/She should have a Ph.d. and 0-4 years of experiences using a G. C. Mass
Spectrometer. Our Client has already installed a H. P. 5980 so experience
with trouble shooting and methods development with this instrumentation
would be a considerable plus.
The successful candidate would have developed and validated GC/MS, HPLC,
and GC methods to separate, quantify, characterize and identify drugs,
xenobiotics, and metabolites in biological samples such as plasma urine,
tissues and feces.
He/She would have performed and supervised human clinical and animal
non-clinical sample analyses to support Pharmacokinetic studies. He/She
should have strong Mass Spent interpretation skills for structural
elucidation. He/She should have strong problem solving abilities in method
development and in operation, maintenance and trouble shooting of GC/MS
and LC/MS . They should have strong computer skills and be proficient with
software programming and lab automation.
If the successful candidate shows they have the ability to supervise and
train, they would have the opportunity to supervise several Post Does and
could be responsible for several additional ancillary Lab facilities.
I am aware you are well situated and are continuously sly contributing to
your successes. You could, however, be cognizant of a colleague who is not
being recognized for their contributions. I would be much in your debt if
you could refer him/her to me for our confidential
Ray C. Peters
Exec. Vice Pres.
J. Stroll Associates, Inc.
Office-203-227-3688
or FAX 203-222-0180
******************************************************************************
From: G.Spierings@fys.ruu.nl (Geert Spierings)
Subject: Re: {Q}: What's the spectrum of teflon look like?
Date: Fri, 3 Nov 1995 16:30:41 GMT
Organization: Physics and Astronomy, University of Utrecht, The Netherlands
>Hi, All:
Geert.
--
-----------------------------------------------------------------------
Geert Spierings Debye Institute
Princetonplein 5
spiering@fys.ruu.nl 3584 CC Utrecht, NL
-----------------------------------------------------------------------
******************************************************************************
From: matuszakk@randb.pprd.abbott.com
Subject: Re: HP Andi AIA Support
Date: 3 Nov 95 13:40:43 CST
Organization: Abbott Laboratories
I ask again:
What is the point of having input/output into a universal format if the
integrity of the header information is not kept intact?
See below
>
> Using the HP header display commands againist a NON HP
> MS data file (AIA) will almost always display confusing
> information. Thus, the need for AIA Header display
> macro.
>
Make no mistake about it the data has been corrupted in this process.
Clearly the "Aquired" line has been garbled. The "Sample Name",
and "Misc Info" lines have been completely lost. The "Instrument" line
and the "Vial Number" lines have also been changed.
The Finnigan ICIS software for example does a better job at reading the
HP andi_MS file than the HP software does. More of the header is still
intact.
Because of this we will not use this feature of the MSD, I will
not recommend the purchase of any other HP products if this is HP's
philosophy on supporting input and output, and I will let anyone know
who asks what HP means by supporting input/output.
Ken M.
******************************************************************************
From: cato.brede@kjemi.uio.no (Cato Brede)
Subject: GC with plasma MS detection
Date: 4 Nov 1995 01:09:08 GMT
Organization: Uninversity of Oslo
Hello
I'd like to discuss the use of plasma mass spectrometric detection in gas
chromatography. Although inductively coupled plasmas (ICP) have been used
in some works, I want to focus on microwave induced plasma (MIP) which is
most common for GC. Other plasmas may also be discussed.
Some questions:
How large is the need for an element selective detection method following
a GC separation? Any special applications?
Any instrumental problems (lens and focusing, space charge and beem
splitting, etc)?
GC-MIP-MS vs. GC-MIP-AED (atomic emmission detection)
Improved detection limits, increased number of elements pr. scan,
the costs associated with an MSD, etc.
Cato Brede
Dept. of Chemistry
University of Oslo
Norway
******************************************************************************
From: J.Traeger@latrobe.edu.au (John Traeger)
Subject: ANZSMS-15 Abstracts
Date: 6 Nov 1995 04:23:24 GMT
Organization: La Trobe University
The Complete program for the 15th Conference of the Australian and New
Zealand Society for Mass Spectrometry, including abstracts, is now
available
at the ANZSMS WWW homepage
(http://www.latrobe.edu.au/ANZSMS/ANZSMS.html).
John Traeger
School of Chemistry
La Trobe University
Melbourne
Australia
******************************************************************************
From: J.Traeger@latrobe.edu.au (John Traeger)
Subject: Re: Simion 3D Ion optics similation available
Date: 6 Nov 1995 04:26:42 GMT
Organization: La Trobe University
John Traeger
School of Chemistry
La Trobe University
Melbourne
Australia
******************************************************************************
From: "K. Murray" <kmurray@emory.edu>
Subject: Re: Simion 3D Ion optics similation available
Date: 6 Nov 1995 15:13:05 GMT
Organization: Emory University
----------
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
From: "The S. Lab" <ssinghal@julian.uwo.ca>
Subject: Does LC-Ion Trap MS Exist?
Date: 6 Nov 1995 22:31:43 GMT
Organization: The University of Western Ontario
I have heard that Finnigan MAT now builds an Ion Trap MS with an
LC/electrospray ionization interface. Can anyone confirm whether this is
true?
Thanks,
Rod DeKoter
mailto://dekoter@julian.uwo.ca
The S. Lab.
The University of Western Ontario
London, Ontario
Canada N6A 5C1
******************************************************************************
From: "Gary J. Van Berkel" <vanberkelgj@ornl.gov>
Subject: Re: Does LC-Ion Trap MS Exist?
Date: 7 Nov 1995 00:42:47 GMT
Organization: Lockheed Martin Energy Systems
Yes, it is called the LCQ
******************************************************************************
From: "Jo, kyuBong" <jokbong@saitgw.sait.samsung.co.kr>
Subject: [Q] Can GC/MS analyze H2 and O2 Quantitatively ?
Date: Tue, 07 Nov 1995 05:34:01 -0800
Organization: Samsung Advanced Institute of Technology
******************************************************************************
From: bart.devreese@rug.ac.be (bdevrees)
Subject: Re: Does LC-Ion Trap MS Exist?
Date: 7 Nov 1995 09:24:30 GMT
Organization: university gent
Dear Rod,
It's true that Finnigan has an LC-ESI ion trap MS. It's called the LCQ
(they have similarly a GCQ for GC-MS). It's brought recently on the
market, but I suggest you try to find out the Canadian representatives.
I'm afraid that Finnigan has not a web page yet.
Bart Devreese
Bart.devreese@rug.ac.be
University ofGent, belgium
> I have heard that Finnigan MAT now builds an Ion Trap MS with an
> LC/electrospray ionization interface. Can anyone confirm whether this is
> true?
>
> Also, does Finnigan MAT have a www page?
>
> Thanks,
>
> Rod DeKoter
>
> mailto://dekoter@julian.uwo.ca
> The S. Lab.
> The University of Western Ontario
> London, Ontario
> Canada N6A 5C1
******************************************************************************
From: Marcus Macht <macht@eurybia.rz.uni-konstanz.de>
Subject: Re^2: MALDI
Date: 7 Nov 1995 10:25:45 GMT
Organization: Universitaet Konstanz
The adress is :
http://www.vgorganic.co.uk/
Marcus Macht
******************************************************************************
Date: Tue, 7 Nov 1995 11:11:30 -0500
From: John Callahan <callahan@ccsalpha2.nrl.navy.mil>
Subject: November 13, 1995 Washington Baltimore MSDG meeting
eot
John H. Callahan
Code 6113/Chemistry Division
Naval Research Laboratory
Washington, D.C. 20375
202-767-0719, FAX 202-404-8119
John.Callahan@nrl.navy.mil
******************************************************************************
From: Kevin Hart <HartKJ@ornl.gov>
Subject: ETMSDG November meeting
Date: 7 Nov 1995 18:51:48 GMT
Organization: Oak Ridge National Laboratory
The next meeting of the ETMSDG will be held on Thursday, November 16th,
at the Sagebrush Steakhouse on Illinois Avenue in Oak Ridge. The
speaker for this meeting will be Subi Chandra of Cornell University.
Dr. Chandra will present a talk entitled "SIMS Imaging of Ionic and
Molecular Transport at Subcellular Resolution". The meeting will begin
at 6:00pm and dinner will begin at 6:30pm. As usual, the speaker will
begin his presentation after dinner at about 7:30pm. The menu for the
dinner will be: 8 oz. ribeye @$10.95, grilled chicken @ $8.95, shrimp&
rice @$11.95 and grilled chicken salad @ $6.95. Complimentary coffee
will be served and a 15% gratuity will be added to the checks.
Reminder- ETMSDG subsidizes graduate and undergraduate attendees.
Kevin J. Hart
Secretary, ETMSDG
******************************************************************************
From: Kevin Hart <HartKJ@ornl.gov>
Subject: Postdoc/Graduate Student Appointment
Date: 7 Nov 1995 18:57:22 GMT
Organization: Oak Ridge National Laboratory
******************************************************************************
From: kmj526@chollian.dacom.co.kr (Sunho Kim)
Subject: ESI & MALDI system
Date: 8 Nov 1995 13:39:20 -0500
Organization: KORNET (Korea Telecom)
In fact, I'am a NMR analysist, so I don't have any good idea in mass
analysis.
******************************************************************************
From: knewland@herbie.unl.edu (KIRK NEWLAND)
Subject: Desalt a protein digest
Date: 8 Nov 1995 21:43:31 GMT
Organization: University of Nebraska--Lincoln
Thanks,
Kirk Newland
knewland@herbie.unl.edu
University of Nebraska
Mass-Spec lab
******************************************************************************
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Re: [Q] Can GC/MS analyze H2 and O2 Quantitatively ?
Date: Wed, 8 Nov 95 22:26:10 GMT
Organization: Caltech (Environmental Engineering Science)
I think either MS or TCD will work. However, many MS's on GC's may
not go down to a mass of 2. (Ours only go to 10, for example.) TCD
simply requires a carrier gas with a different enough thermal
conductivity for your analytes and their concentration. I would
think He should be good.
>I think the first problem is Collecting Sample.
Gas sampling valves are commonly put on GC's. These pass a fixed
volume of gas to the inlet.
******************************************************************************
From: jbartmess@utk.edu (John Bartmess)
Subject: Re: [Q] Can GC/MS analyze H2 and O2 Quantitatively ?
Date: Thu, 9 Nov 1995 13:57:14 GMT
Organization: Are You Kidding?
>I think either MS or TCD will work. However, many MS's on GC's may
>not go down to a mass of 2. (Ours only go to 10, for example.) TCD
>simply requires a carrier gas with a different enough thermal
>conductivity for your analytes and their concentration. I would
>think He should be good.
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=-
| John Bartmess | Organic Chem! || my opinions, being antithetical |
| Dept. of Chem., U. of Tennessee || to "big time" football, cannot |
| Knoxville TN 37996-1600 || be those of the Univ. of Tennessee|
| (423) 974-6578 Fax: 974-3454 || "Anions are more fun!" |
| jbartmess@utk.edu http://novell.chem.utk.edu/bartmess.htm |
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=--=-
******************************************************************************
From: Chris Ashwell <ashwell@mgrp.bgsm.wfu.edu>
Subject: ESI-MS of membrane proteins
Date: 9 Nov 1995 15:46:38 GMT
Organization: Wake Forest University
Does anyone have any ideas or comments that might help us in determining
the mass of membrane/hydrophobic proteins in the 20-40kDa range, we have
had consistently inconsistent results. We have had good results and no
results from identical samples. We have been careful to remove
detergent and as many contamanants as possible by reverse phase HPLC.
Any ideas about solvents? We have been using 50% Acetonitrile/Water, 1%
Formic acid. Is chloroform a good idea? Any information would be much
appreciated... thanks
Chris Ashwell
Bowman Gray School of Medicine
Wake Forest University
Departmant of Biochemistry
Medical Center Blvd.
Winston-Salem, NC 27157
(910) 716-0454
******************************************************************************
From: "Gary J. Van Berkel" <vanberkelgj@ornl.gov>
Subject: Re: ESI-MS of membrane proteins
Date: 9 Nov 1995 17:44:18 GMT
Organization: Lockheed Martin Energy Systems
I've seen several abstracts at recent ASMS meetings dealing with such
compounds, and at least one paper published in a mass spec. journal, but
I can't give you a reference. However, a viable solution to your problem
would be to go with a mix of ACN/methylene chloride or chloroform. This
solvent system should dissolve the protein and still spray well.
******************************************************************************
From: dabell@gpu.srv.ualberta.ca (Darcy Abell)
Subject: MALDI of poly-lysine
Date: Thu, 09 Nov 1995 23:50:52 GMT
Organization: University of Alberta
******************************************************************************
From: roberts@ucunix.san.uc.edu (Michael A. Roberts)
Subject: Re: Desalt a protein digest
Date: 10 Nov 1995 00:09:09 GMT
Organization: University of Cincinnati
In article <47rhre$144@acmex.gatech.edu>,
KIRK NEWLAND <knewland@herbie.unl.edu> wrote:
>I am looking for a procedure to desalt a protein digest in prep for a
>MALDI-tof experiment. Any suggestions?
>
>Presently, I am washing protein pellet in 70% ethanol with little effect.
Why not suspend the pellet and dialyze against some suitable solvent,
ie. distilled water?
BTW, the word "presently" means "soon", as in, "The plane will be
arriving presently." :-)
Hope I helped in both matters. If you cannot pursue the dialysis option,
check out any recent issue of Journal of Protein Science for a method
that might suit your needs.
Cheers,
--
Michael Roberts | "The greatest pleasure I know is to do a
roberts@ucunix.san.uc.edu | good action by stealth, and to have it
| found out by accident."
Speaking only for myself. | -Charles Lamb
******************************************************************************
From: m.vandeweert@chemail.chem.ruu.nl (Weird L. Marcowitz)
Subject: Re: Desalt a protein digest
Date: Fri, 10 Nov 1995 09:12:48 +0100
Organization: Academic Compter Centre Utrecht
You might try to filter the salt off. There are many different centrifuge
filters which can be placed in a eppendorf centrifuge. You can call Amicon
at 1-800-343-1397 for information.
Another possibility is a chromatographic separation using volatile buffers
like NH4AC.
Confucius
******************************************************************************
In article <47ta56$9s3@acmey.gatech.edu>,
Chris Ashwell <ashwell@mgrp.bgsm.wfu.edu> wrote:
>
>Does anyone have any ideas or comments that might help us in determining
>the mass of membrane/hydrophobic proteins in the 20-40kDa range, we have
>had consistently inconsistent results. We have had good results and no
>results from identical samples. We have been careful to remove
>detergent and as many contamanants as possible by reverse phase HPLC.
>Any ideas about solvents? We have been using 50% Acetonitrile/Water, 1%
>Formic acid. Is chloroform a good idea? Any information would be much
>appreciated... thanks
>
Hi Chris!
Andreas
******************************************************************************
From: madi@biocell.fundp.ac.be (Marc DIEU)
Subject: Re: ESI-MS of membrane proteins
Date: Fri, 10 Nov 1995 15:44:10 -0600
Organization: F.U.N.D.P - Cellular Biochemistry
> Does anyone have any ideas or comments that might help us in determining
> the mass of membrane/hydrophobic proteins in the 20-40kDa range, we have
> had consistently inconsistent results. We have had good results and no
> results from identical samples. We have been careful to remove
> detergent and as many contamanants as possible by reverse phase HPLC.
> Any ideas about solvents? We have been using 50% Acetonitrile/Water, 1%
> Formic acid. Is chloroform a good idea? Any information would be much
> appreciated... thanks
>
> Chris Ashwell
> Bowman Gray School of Medicine
> Wake Forest University
> Departmant of Biochemistry
> Medical Center Blvd.
> Winston-Salem, NC 27157
> (910) 716-0454
--
Marc DIEU
Laboratory of Cellular Biochemistry,
Facultis Universitaires ND de la Paix,
61, rue de Bruxelles,
B-5000 Namur (Belgium).
Fax: ++/32/81/72.41.35.
Email: madi@biocell.fundp.ac.be
******************************************************************************
From: <100024.660@compuserve.com>
Subject: Finnigan LC/Ion Trap
Date: 10 Nov 1995 16:24:13 GMT
Organization: CompuServe Incorporated
Per-Anders Samuelsson
Finnigan MAT AB
Sweden
******************************************************************************
From: palmenj@govonca.gov.on.ca (J-P Palmentier)
Subject: Re: Does LC-Ion Trap MS Exist?
Date: 10 Nov 1995 17:44:40 GMT
Organization: Government of Ontario
The LCQ is a new benchtop mass spectrometer for LC/MS, LC/MS/MS and
LC/MS^n. The system consists of an API source, for either ESI or APCI,
coupled to a high performance ion trap mass spectrometer. The API source
allows direct coupling of HPLC or HPCE systems at 1 uL/min to over 1
mL/min flow rates. The mass range is 30-2000 m/z and this can be scanned
at over 3 scans/sec at unit mass resolution across the entire mass range.
Sensitivity in full scan mode is at least an order of magnitude better
than typical quadrupole systems in MS/MS mode. In addition, the system
may be scanned at higher mass resolution over a narrow mass range.
You could contact Ian Jardine at Finnigan MAT, 355 River Oaks parkway,
San Jose, CA 95134.
He just gave a talk on Wednesday (Nov 8th) at MOEE LSB in Toronto on this
subject.
J-P
******************************************************************************
Date: Fri, 10 Nov 1995 20:13:34 +0000 (GMT)
From: ddxdd@IMAP1.ASU.EDU
Subject: Re: MALDI of poly-lysine
Organization: daves not here
i am not sure the above conditions will work with the conjugates
you have, but they are worth a try.
-dave dogruel
arizona state university
dept. of chemistry and biochemistry
biological mass spectrometry laboratory
******************************************************************************
Date: Fri, 10 Nov 1995 20:30:16 +0000 (GMT)
From: ddxdd@IMAP1.ASU.EDU
Subject: Re: Desalt a protein digest
Organization: daves not here
: Why not suspend the pellet and dialyze against some suitable solvent,
: ie. distilled water?
| |
| |
| | | |
| | .. | |
| | .. | | . = ion exhange beads
| |||||| | ||| = filter
| |||||| |
| | | |
| \ / |
| || |
| || |
\ `' /
\ /
\/
-dave dogruel
arizona state university
dept. of chemistry and biochemistry
biological mass spectrometry laboratory
******************************************************************************
From: pggreen@cco.caltech.edu (Peter G. Green)
Subject: Re: Does LC-Ion Trap MS Exist?
Date: Thu, 9 Nov 95 17:27:26 GMT
Organization: Caltech (Environmental Engineering Science)
>I have heard that Finnigan MAT now builds an Ion Trap MS with an
>LC/electrospray ionization interface. Can anyone confirm whether this is
>true?
>
I got their brochure introducing the new 'LCQ' just a few weeks ago.
US phone # 408-433-4800
******************************************************************************
From: James Speakman <Jim.Speakman@instruments.fisons.co.uk>
Subject: Connection trouble
Date: Tue, 14 Nov 1995 14:47:28 -0800
******************************************************************************
From: @chemistry.gatech.edu, Frank_Hollis-1%notes@sb.com (Triple Quadrophenic)
Subject: Re: Does LC-Ion Trap MS Exist?
Date: 14 Nov 1995 14:58:22 GMT
Organization: SB
The GCQ is, indeed, available right now. The LCQ is a different
matter. As far as I know it's not available for general purchase
yet.
Frank J Hollis_________________________________________
Mass Spec. | |
SB Pharm | The Sinclair C5 of the |
Welwyn | Information Superhighway |
Herts. UK. |_______________________________________|
01438 782551 All opinions my own (So I'm told)
Frank_Hollis-1%notes@sb.com or Hollis_F%frgen.dnet@sb.com
******************************************************************************
From: <Unknown> (Ilse Vandecandelaere)
Subject: question on HPLC-MS
Date: 15 Nov 1995 14:39:47 GMT
Organization: Katholieke Universiteit Leuven
Hello,
Thanks,
Ilse
ddxdd@IMAP1.ASU.EDU wrote:
> we shot some samples of poly-lysine two weeks ago and had no
>problem on our linear machine. sample concentrations were approximately
>0.1 mg/mL and were added 1:1 with saturated DHB matrix on the probe
>tips. approx. 0.5 uL of saturated NaCl solution was added to enhance
>polymer ionization. laser wavelength was 355 nm, and we were looking
>at positive ions with 30 kV extraction.
******************************************************************************
From: Michael Glocker <glocker@eurybia.rz.uni-konstanz.de>
Subject: Re: MALDI of poly-lysine
Date: 15 Nov 1995 16:13:46 GMT
Organization: I DID NOT CONFIGURE MY ORGANIZATION IN MY NEWSREADER
Dear Dave,
I read your note concerning the poly-lys maldi. We would also like to try your
method for a poly-lys of approx. 20 kDa. What was the MW of your poly-lys? Do
you have any experience with heterogeneity of the poly-lys and signal response?
Sincerely, Michael
******************************************************************************
From: tgamble@TRENTU.CA (TANYA- THE STRESS CASE)
Subject: SiEt4
Organization: Trent University, Peterborough
Date: Wed, 15 Nov 1995 19:37:56 GMT
In the article by Louris et al. in Anal. Chem. 59(13) 1987, the energy transferred
to tetraethylsilane during CAD was discussed. The experiments were performe on the
Finnigan MAT model 700 ion trap detector. The article failed to mention the
ionization
energy that they used. Does anyone know the energy that they used?
Thanks in advance,
Tanya
******************************************************************************
From: ocean1@phoenix.net (ocean1)
Subject: Re: [Q] Can GC/MS analyze H2 and O2 Quantitatively ?
Date: Wed, 15 Nov 1995 23:12:58 GMT
Organization: Phoenix Data Systems
>I think either MS or TCD will work. However, many MS's on GC's may
>not go down to a mass of 2. (Ours only go to 10, for example.) TCD
>simply requires a carrier gas with a different enough thermal
>conductivity for your analytes and their concentration. I would
>think He should be good.
>Gas sampling valves are commonly put on GC's. These pass a fixed
>volume of gas to the inlet.
******************************************************************************
From: tgamble@TRENTU.CA (TANYA- THE STRESS CASE)
Subject: SiEt4
Organization: Trent University, Peterborough
Date: Wed, 15 Nov 1995 21:05:34 GMT
Thanks in advance
Tanya
******************************************************************************
From: Nahum Gat <oksi@cerfnet.com>
Subject: TechExpo New Classification Schedule for Industry, Science, Engineering,
and Technology.
Date: Wed, 15 Nov 1995 22:48:56 -0800
Organization: CERFnet
Thanks,
******************************************************************************
From: john@wd1v.MV.COM (John Seney)
Subject: Digital Scope.FAQ - How to Get
Organization: MV Communications, Inc.
Date: Thu, 16 Nov 1995 10:38:41 GMT
\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\
:::::::::::::::::::::::::::::::::::::
::Date/Time | O O ::
:: /\ | ::
:: / \ | O O ::
:: / \ /\ | ::
::__/ \ / \ /`| O O ::
:: \ / \/ | ::
:: \ / | O O ::
::1.5 GHz BW \/ 10 GS/s |________::
::________________________|A B C D ::
:: rise 1.5 ns | x x x ::
:: fall 4.9 ns | x x x ::
::_________________________________::
::(*) (*) (*) (*) (*) (*) ::
:::::::::::::::::::::::::::::::::::::
::: :::
Dear Technologist(s):
This Digital Storage Scope.FAQ file contains many (but not all) of your
answers to the more "Frequently Asked Questions" re: Digital Storage
Oscilloscopes (DSOs).
If you want the next version of this file sent to you automatically, send an
EMAIL where the subject field contains the text "subscribe scope.faq".
\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\
KEY ISSUES REVIEWED IN THIS FAQ (in order of appearance)
* ARCHIVAL & MEMORY (How fast, how deep, and can I get more?)
* DEMOS & PURCHASING (How can I see and get the DSO I really need?)
Best regards,
******************************************************************************
From: v.d.drift@ams.chem.ruu.nl (Koen van der Drift)
Subject: Postdoc wanted in Utrecht, The Netherlands
Date: Thu, 16 Nov 1995 13:58:13 +0100
Organization: Utrecht University
Fax: +31-30-2518219.
E-mail: j.thomas-oates@ams.chem.ruu.nl
******************************************************************************
From: v.d.drift@ams.chem.ruu.nl (Koen van der Drift)
Subject: Postdoc available in Utrecht, The Netherlands
Date: Thu, 16 Nov 1995 15:10:40 +0100
Organization: Utrecht University
Fax: +31-30-2518219.
E-mail j.thomas-oates@ams.chem.ruu.nl
******************************************************************************
From: v.d.drift@ams.chem.ruu.nl (Koen van der Drift)
Subject: Postdoc available in Utrecht, The Netherlands
Date: Thu, 16 Nov 1995 15:36:21 +0100
Organization: Utrecht University
Fax: +31-30-2518219.
E-mail j.thomas-oates@ams.chem.ruu.nl
******************************************************************************
From: "Gary J. Van Berkel" <vanberkelgj@ornl.gov>
Subject: Re: SiEt4
Date: 17 Nov 1995 16:22:41 GMT
Organization: Lockheed Martin Energy Systems
Given the way in which electrons are injected into the trap their energy
is not easily controlled. The energies are affected by the frequency and
amplitude of the rf applied to the ring electrode. However, I believe
some work out of Rick Yost's group showed an average energy around 50 eV.
******************************************************************************
Date: Fri, 17 Nov 1995 10:37:18 -0600
From: Kerry Peru <peruk@nhrisv.nhrc.sk.doe.ca>
Subject: Trio 1000 quantitation problems
******************************************************************************
From: Richard Civitate <rcivi@cts.com>
Subject: Great New Source for Used Scientific Equipment
Date: 17 Nov 1995 20:12:12 GMT
Organization: Scientific Equipment Exchange, Inc.
Scientific Equipment Exchange, Inc. announces its new WWW site at:
http://www.cts.com/browse/rcivi If you are considering a purchase,
or have equipment for sale, you shouldn't pass up this site! Visit it
now! Then make it a Bookmark. See you there.
******************************************************************************
From: forensic@unix.asb.com (charles salerno)
Subject: Hewlett Packard GC/MS wanted!!
Organization: ASB
Date: Sat, 18 Nov 1995 00:25:34 GMT
Looking for a Hewlett Packard GC/MS. If you have a GC/MS that you are willing
to part with please email me.
Thank you,
Charles Salerno
Forensic Associates
forensic@unix.asb.com
******************************************************************************
Date: Mon, 20 Nov 1995 12:16:52 MET
From: PETER KOFEL <KOFEL@ioc.unibe.ch>
Cc: KOFEL@ioc.unibe.ch
Subject: Postdoctoral Position
******************************************************************************
Date: Mon, 20 Nov 1995 19:38:39 +0000 (GMT)
From: ddxdd@IMAP1.ASU.EDU
Subject: maldi of poly-lys
Organization: daves not here
>I read your note concerning the poly-lys maldi. We would also like to try
>your method for a poly-lys of approx. 20 kDa. What was the MW of your
>poly-lys? Do you have any experience with heterogeneity of the poly-lys
>and signal response?
the poly-lysine we were working with was only 3-4 kDa, with a
distribution extending from ~3100 to ~4300 Da. for a sample with higher
MW, i would try the 2,5-DHB matrix first. if that matrix did not give
decent signal, trans-3-indoleacrylic acid or HABA might work. as i
previously mentioned, sometimes it works (for us) to add a bit of
sodium or cesium salt to aid ionization of the polymer. some polymers
require a slightly higher laser fluence before the onset of good
signal.
we have not tried to shoot a heterogenous mixture of poly-lys
with another compound. i have been able to get decent signal of a
synthetic polymer/protein mixture using the DHB matrix, however.
good luck.
dave dogruel
arizona state university
dept. of chemistry and biochemistry
biological mass spectrometry laboratory
******************************************************************************
From: forensic@unix.asb.com (charles salerno)
Subject: Kewaunee Fume Hoods For Sale
Organization: ASB
Date: Mon, 20 Nov 1995 23:36:18 GMT
Please contact
Charles Salerno
Forensic Associates
Email forensic@unix.asb.com
http://www.asb.com/com/forensic/home.html
******************************************************************************
From: louris@netcom.com (John N. Louris)
Subject: Re: SiEt4
Organization: Teledyne Electronic Technologies
Date: Tue, 21 Nov 1995 20:06:04 GMT
The paper described a new instrument that was built using the electronic
components from an ITD 700, additional electronic components, a modified
trap assembly, and a new vacuum system. The ionization circuit was not
modified and the method of ionization was the same as in the ITD 700:
Electrons were produced outside of the trapping volume and were injected
into the trap with about twelve volts of energy. (The end electrodes
are at ground and the filament is at minus twelve volts.)
John Louris
******************************************************************************
Date: Tue, 21 Nov 1995 22:26:08 -0300 (GRNLNDST)
From: "Ivan P. de Arruda Campos" <ipdacamp@usp.br>
Subject: Re: Re: Does LC-Ion Trap MS Exist?
In-Reply-To: <76EFCC661C@novell.chem.utk.edu>
******************************************************************************
From: pocasip@ix.netcom.com (David Mintzer )
Subject: Calibration
Date: 22 Nov 1995 00:46:24 GMT
Organization: Netcom
Greetings,
David Mintzer
dmintzer@ix.netcom.com
******************************************************************************
Date: Tue, 21 Nov 1995 22:26:08 -0300 (GRNLNDST)
From: "Ivan P. de Arruda Campos" <ipdacamp@usp.br>
Subject: Re: Re: Does LC-Ion Trap MS Exist?
In-Reply-To: <76EFCC661C@novell.chem.utk.edu>
******************************************************************************
Date: Wed, 22 Nov 95 10:23:27 -0500
From: Chip Cody <cody@titian.jeol.com>
Subject: Submission to STMS: Followup to calibration question
>Greetings,
>I wonder what kind of effort is necessary to really tune the MS for
>calibration. I may have some sexy tips to bring to the party.
>David Mintzer
>dmintzer@ix.netcom.com
------------------
You probably will need to be more specific about what kind of calibration
you have in mind. There are several things that can be calibrated:
4. Peak shape and ion source tuning. The mass spectrometer parameters
(ion source voltages, lens potentials, and also excitation
and detection conditions in
trapped-ion methods) all have to be adjusted to give good sensitivity and
good peak shapes for a standard reference compound at some specified
resolution value.
Chip Cody
JEOL USA, Inc.
******************************************************************************
From: boneyr.psych.som.ohsu@ohsu.EDU (Rick Boney)
Subject: mass spec vs electric guitar
Date: Wed, 22 Nov 1995 17:11:16 GMT
Organization: OHSU
******************************************************************************
From: boneyr.psych.som.ohsu@ohsu.EDU (Rick Boney)
Subject: joke
Date: Wed, 22 Nov 1995 21:18:26 GMT
Organization: OHSU
******************************************************************************
From: u3725283@netserv.chula.ac.th (Chuenchit Bussai)
Subject: THEORY
Date: 23 Nov 1995 09:09:26 GMT
Organization: Chulalongkorn University
Hello,everybody.I 've learned about mass spec,nmr and ir.But,
I 've learn only in theory.Then I think it 's interesting.
I wonder if you can suggest me about using in fact.That 's
really nice....
>
>
THANKS============================================================>
******************************************************************************
From: JOERG.HAU@01.chlsnr.nestrd.ch
Date: Thu, 23 Nov 1995 08:26:24 +0100
Subject: Data systems for sector field MS
***
Kratos Analytical
Barton Dock Road
Urmston, Manchester M31 2LD
England
***
Mass Spectrometry Systems Ltd.
Unit 2A, Mountheath Industrial Park
George Street, Prestwich, Manchester M25 8WB
England
***
Shrader Laboratories
3814 Vinewood Ave., Detroit, MI 48208
USA
Phone 001 313 894-4440
Fax 001 313 894-4489
e-mail sacli@mail.msen.com
***
Joerg
---------------------------------------------------------------
Dr. Joerg Hau
Nestl'#e Research Centre
Vers-chez-les-Blanc
Case postale 44
CH-1000 Lausanne 26
Switzerland
******************************************************************************
From: James Speakman <Jim.Speakman@instruments.fisons.co.uk>
Subject: Mass spec tuning
Date: Thu, 23 Nov 1995 12:01:21 -0800
******************************************************************************
From: "John C. Huffman" <huffman@indiana.edu>
Subject: Mass Spectroscopy Opening (2nd listing)
Date: 23 Nov 1995 19:13:37 GMT
Organization: Indiana University Molecular Structure Center
******************************************************************************
From: Mike Head <aa04@dial.pipex.com>
Subject: interLAB WWW Update
Date: 24 Nov 1995 18:38:31 GMT
Organization: The Virtual Networking Company Limited
http://www.interlab.co.uk/
STOP PRESS: there are only a few days left on the Anachem Special Offer
and Welcome to Millipore who joined interLAB today!
Regards
******************************************************************************
From: glassgreen@aol.com (GLASSGREEN)
Subject: Finnigan MAT 95 Users
Date: 25 Nov 1995 12:31:26 -0500
Organization: America Online, Inc. (1-800-827-6364)
******************************************************************************
From: news@chaos.kulnet.kuleuven.ac.be
Subject: Data files standard
Date: 27 Nov 1995 09:57:02 GMT
Organization: K.U.Leuven
Doe anyone know if there is a standard for mass spectrometric data files
and where details about it can be found ?
Jef.
--
Jef.Rozenski@Rega.KULeuven.ac.be
Rega Institute for Medical Research
K.U.Leuven
Minderbroedersstraat 10
B-3000 Leuven
Belgium
******************************************************************************
From: abbottsd@esvx19.es.dupont.com
Subject: have a 320 accel power supply to donate
Organization: DuPont (Opinions are those of the writer only)
Date: Mon, 27 Nov 1995 15:25:32 GMT
I have an acceleration potential power supply for a Dupont 320 scanning gcms for
which I would like to find a new home-- a school or institute etc.. This unit takes
low level inputs and puts out high voltage moderate current for use in the voltage
scannin
g gcms. It could be useful in a number of applications outside the mass spec one.
******************************************************************************
From: scurlock@sunchem.chem.uga.edu (Christopher Scurlock)
Subject: H + KOH(ion) binding energy
Date: 27 Nov 1995 17:24:55 GMT
Organization: Department of Chemistry, University of Georgia, Athens
Can anyone send me a good starting reference to find the above, that is
the delta H part from:
Thanks,
Chris
******************************************************************************
Date: Tue, 28 Nov 1995 13:02:48 +0100
From: marc@eawag.ch (Marc Suter)
Subject: Answer to Ilse Vandecandelaere
The easiest way to approach your problem is to collect some HPLC fractions
and do a flow injection, using an electrospray interface. Unless you have
access to a LC-MS instrument that runs routinely, flow injection is easier
than trying to find similar HPLC conditions on a microbore or capillary
column (down-scale).
90% aqueous should be ok, if you have a nebulizer option.
We have been looking at small carboxylic acids that way, using 100% 20 mM
sulfate buffer. This work was done on an AutoSpec instrument, using the
newer VG ESI interface.
It should also be possible to detect your intact La-complex. We have had no
problem analyzing Fe-EDTA complexes and even transformation products thereof.
You also would have to check your sample in positive ion mode, because
depending on the oxidation state of your metal and the number of cations
attached to the complex or its components, it is possible that signal
intensities are better for positive ions.
Also, be sure to tune your instrument and interface (especially the so
called skimmer-nozzle voltage) so that you do see acetate and other small
anions.
_______________________________________________________________
Marc J.-F. Suter, Ph.D. e-mail: suter@eawag.ch
Swiss Federal Institute for Environmental Science & Technology
Chemistry Dept. / 35
phone: +41-1-823-5479 / 5091 fax: +41-1-823-5028
_______________________________________________________________
******************************************************************************
From: forensic@unix.asb.com (charles salerno)
Subject: Kewaunee Fume Hoods For Sale
Organization: ASB
Date: Wed, 29 Nov 1995 00:46:49 GMT
Contact
C. Salerno
email forensic@unix.asb.com
******************************************************************************
From: JOERG.HAU@01.chlsnr.nestrd.ch
Date: Wed, 29 Nov 1995 11:19:54 +0100
Subject: Finnigan LCQ
A similar question was posed recently at the annual meeting of the SGMS
(Swiss MS society). The Finnigan representative said that the LCQ is
actually being sold (i.e. it IS available for purchase), and the first
instruments shall be delivered around December/January.
Joerg Hau
Joerg.Hau@chlsnr.NestRD.ch
******************************************************************************
From: ron@sciex.com (Ron Bonner)
Subject: Re: Data files standard
Date: Wed, 29 Nov 1995 07:53:00 -0400
Organization: Sciex
> Doe anyone know if there is a standard for mass spectrometric data files
> and where details about it can be found ?
>
>
> Jef.
Jef:
There *Is* a standard for the transfer of MS (profile or centroid) and SIM
data between different vendors data systems, and most manufacturers have
implemented bi-directional translators.
The format is known as 'andi/MS' and was developed under the auspices of
the ASMS and later the AIA. Details can be found by anonymous ftp from
'ftp.pe-nelson.com' where you will find a directory 'andi-MS'
Regards
Ron
--
Ron Bonner, Sciex, 905 881 4646
******************************************************************************
From: Richard Civitate <rcivi@cts.com>
Subject: New Source for Used Scientific Instruments
Date: 30 Nov 1995 19:48:38 GMT
Organization: Scientific Equipment Exchange, Inc.
Scientific Equipment Exchange, Inc. announces its new WWW site at:
http://www.sci-equip-ex.com. If you are considering a purchase, or
have equipment for sale, you shouldn't pass up this site! Visit it now!
Then make it a Bookmark. See you there.
******************************************************************************
From: cato.brede@kjemi.uio.no (Cato Brede)
Subject: Re: Data files standard
Date: 1 Dec 1995 11:39:24 GMT
Organization: Universitet i Oslo
Cato Brede
******************************************************************************
Date: Fri, 01 Dec 95 15:22:53 0500
From: Catherine stacey <ccs@bruker.com>
Organization: Bruker Instuments Inc.
Subject: Bruker Product Announcements
Also see our product ads on the back cover of JASMS each month.
******************************************************************************
From: "Mark E. Hemling" <Mark_E_Hemling@sbphrd.com>
Subject: (no subject)
Date: 1 Dec 1995 21:43:14 GMT
Organization: SmithKline Beecham
Free to a good home; taker(s) to arrange and pay for removal and
transport:
Contact:
Steven A. Carr
610-270-6650
E-mail: Steven_A_Carr@SBPHRD.COM
******************************************************************************
From: ui22273@sunmail.lrz-muenchen.de
Subject: FAB-HR?
Date: Sat, 2 Dec 1995 16:51:42 +0100
Organization: Leibniz-Rechenzentrum, Muenchen (Germany)
Hi everybody,
http://wwwchem.uwimona.edu.jm:1104/software/jcampdx.html
P.S
At the time of writing this I was unable to FTP to the Pe.nelson.com site
as directed.
regards,
Rob O'Brien
Ro@iecems.lan.nrc.ca
robrien@ccs.carleton.ca
******************************************************************************
From: @chemistry.gatech.edu, Frank_Hollis-1%notes@sb.com (Triple Quadrophenic)
Subject: Re: Finnigan LCQ
Date: 4 Dec 1995 09:00:29 GMT
Organization: SB
Frank J Hollis_________________________________________
Mass Spec. | |
SB Pharm | The Sinclair C5 of the |
Welwyn | Information Superhighway |
Herts. UK. |_______________________________________|
01438 782551 All opinions my own (So I'm told)
Frank_Hollis-1%notes@sb.com or Hollis_F%frgen.dnet@sb.com
******************************************************************************
From: "Mark E. Hemling" <Mark_E_Hemling@sbphrd.com>
Subject: MS to Good Home
Date: 4 Dec 1995 13:04:11 GMT
Organization: SmithKline Beecham
Free to a good home; taker(s) to arrange and pay for removal and
transport:
Contact:
Steven A. Carr
King of Prussia, PA USA
610-270-6650
E-mail: Steven_A_Carr@SBPHRD.COM
******************************************************************************
From: "K. Murray" <kmurray@emory.edu>
Subject: Re: Data files standard
Date: 4 Dec 1995 16:12:51 GMT
Organization: Emory University
http://www.dejanews.com/forms/dnq.html
Kermit K. Murray
mailto:kmurray@emory.edu
http://tswww.cc.emory.edu/~kmurray/
******************************************************************************
Date: Mon, 4 Dec 1995 12:39:13 -0500
From: John Callahan <callahan@ccsalpha2.nrl.navy.mil>
Subject: December 11, 1995 MSDG meeting
Next Meeting:
Monday, December 11, 1995, 7:30 pm
Location:
Hewlett-Packard Divisional Office, Park Plaza Building, 2101 Gaither Rd,
Rockville, MD
Speaker:
Professor James A. Laramee, Agricultural Chemistry and Life Sciences, Oregon
State University
Topic:
Tunable Energy (0.03-60 eV) Electron Capture Negative Ion Mass Spectrometry
Further details can be obtained at our World Wide Web Home Page
(http://chem1.nrl.navy.mil/analytical/msdg), including abstract, directions
and list of upcoming meetings and dates.
eot
John H. Callahan
Code 6113/Chemistry Division
Naval Research Laboratory
Washington, D.C. 20375
202-767-0719, FAX 202-404-8119
John.Callahan@nrl.navy.mil
******************************************************************************
From: dabell@gpu.srv.ualberta.ca (Darcy Abell)
Subject: MALDI with large poly-lysine -Help!
Date: Mon, 04 Dec 1995 21:18:34 GMT
Organization: University of Alberta
If anyone has had success with this or something similar, please pass
along some advice. I have tried a number of matrixes and
concentrations. I am currently using an HP instrument.
******************************************************************************
From: JOERG.HAU@01.chlsnr.nestrd.ch
Date: Tue, 5 Dec 1995 14:43:27 +0100
Subject: Data Systems for Sector MS
(This is a re-mailing of a message that I sent some time ago. Sorry for
those who receive the 4 kB twice ... As John Bartmess pointed out in the
mailing of Dec 4th, it may be that the first message did get "lost".)
***
***
Kratos Analytical
Barton Dock Road
Urmston, Manchester M31 2LD
England
***
***
Shrader Laboratories
3814 Vinewood Ave., Detroit, MI 48208
USA
Phone 001 313 894-4440
Fax 001 313 894-4489
e-mail sacli@mail.msen.com
***
Joerg
---------------------------------------------------------------
Dr. Joerg Hau
Nestl'#e Research Centre
Vers-chez-les-Blanc
Case postale 44
CH-1000 Lausanne 26
Switzerland
******************************************************************************
From: boneyr.psych.som.ohsu@ohsu.EDU (Rick Boney)
Subject: melatonin LC/MS anyone?
Date: Tue, 5 Dec 1995 19:59:57 GMT
Organization: OHSU
Keywords: melatonin, LC/MS
Does anyone out there know where I can find a LC/MS assay for the quantitation
of melatonin? ( boneyr@ohsu.edu)
******************************************************************************
From: john@wd1v.MV.COM (John Seney)
Subject: Digital Scope.FAQ WWW Site
Organization: MV Communications, Inc.
Date: Wed, 6 Dec 1995 10:12:42 GMT
FYI: The latest version of Digital Scope.FAQ <300> is on my WWW Home Page.
******************************************************************************
From: jeolbxl@pophost.eunet.be (JEOL Brussel)
Subject: data systems for sector Hi-res sector field MS
Date: 6 Dec 1995 14:21:05 GMT
Organization: JEOL (Europe) BV
Just to inform that BENELUX, Germany and Switzerland the Shrader system is
represented by
JEOL (Europe) BV
IKAROSLAAN 7A
B-1930 ZAVENTEM
BELGIUM
Yours sinceely
Dr.R.C.Hertsens
General Manager
******************************************************************************
Date: Wed, 06 Dec 95 09:46:37 -0500
From: Chip Cody <cody@titian.jeol.com>
Subject: Re: FAB-HR?
Orig-To: ui22273@sunmail.lrz-muenchen.de
Subject: Re: FAB-HR?
>Hi everybody,
Dear Werner,
http://www.jeol.com
along with FAB matrix spectra and other reference masses. PEG is generally a
very good reference standard for use with NBA as a matrix. You will often see
cation adducts (M+Na or M+K) as well as the protonated species. The cations
are omnipresent, and probably come from solvents stored in glass, etc. You may
see dehydrated species, particularly at low mass. However, I'm not sure about
the strange mass differences that you report. There may be impurities
present.
The mmu difference required to confirm a sample depends a lot on the molecular
weight and other information available to you about the sample (isotope
ratios, other chemical information, sample history). The higher the
mass, the less you can trust the mass measurement to PROVE a composition.
However, an accurate mass measurement is always a valuable piece of
confirming evidence, and a check against errors in interpretation. For
what it's worth, there's an essay on interpreting exact masses on our
website. Good luck!
Chip Cody
Applications Manager
Mass Spectrometry
JEOL USA, Inc.
******************************************************************************
From: bruce_f@nelson.planet.org.nz (Bruce Fraser)
Subject: Ion traps vs quadrupoles
Date: Wed, 06 Dec 1995 21:40:14 +1200
Organization: PlaNet Community Networking (Canterbury, New Zealand)
Can anyone help me? I am evaluating ion traps (specifically the Saturn
4) vs quadrupole GC-MS systems and the following issues have come up
It seems clear that the Saturn is quite a bit more sensitive than the
quads however I have have been told...
* The performance of the ion trap goes down markedly when the source
gets contaminated. Ion traps are reputedly much more sensitive to this
than quadrupole systems
* They still give non classical spectra => problems when using
commercial libraries such as NIST/EPA/NIH to search. Also less robust
in litigation situations
* The ion trap has trouble coping with the amounts of water
introduced into the system when doing Purge and Trap sampling.
Regards
Bruce Fraser
19 Ngatiawa St, Nelson
New Zealand
ph: +64 3 545 6016
fax: +64 3 545 7017
Email: bruce_f@nelson.planet.co.nz
******************************************************************************
From: Andrew La rouche <alarou@umr.edu>
Subject: labeled standards-need help
Date: 6 Dec 1995 17:42:44 GMT
Organization: University of Missouri-Rolla
******************************************************************************
From: Bob Hendry <Bob.Hendry@gtri.gatech.edu>
Subject: Re: Ion traps vs quadrupoles
Date: 6 Dec 1995 22:57:15 GMT
Organization: Georgia Tech Research Institute
We have a Saturn which during the first 3 months of doing air monitoring
did not need to be cleaned and performance was wonderful. Although when
doing injections of a sludge like matter the traped needed to be cleaned
every week to keep performance acceptable. But the cleaning of the trap
is very simple compared to the quads in our lab. Our lab has several
quads and one Saturn, but the Saturn does most of the work because of its
sensitivity and flexablity.
>
>* They still give non classical spectra => problems when using
>commercial libraries such as NIST/EPA/NIH to search. Also less robust
>in litigation situations
I have run into some problems with library matching, the correct compound
not in the first three hits, but the correct hit is usally inthe top ten.
>
>* Spectrum varies with the amount of the component present =>
>problems with quantitation. Also quantitation of a small peak
>chromatographically partly (or not) resolved from an adjacent large
>peak is not good.
>
The spectrum variation I have seen is when the trap is overloaded with
the compound of interest. I have not had problems with the software
quanitation of a peak from coeluting peaks.
>* The ion trap has trouble coping with the amounts of water
>introduced into the system when doing Purge and Trap sampling.
>
I have not done Purge and Trap on the Saturn, but have had problems with
water in air monitoring with the VTAT injector (none that could not be
solved).
Overall I love the job the Saturn ion trap has done in our lab.
--
Bob Hendry
Georgia Tech Research Institute
Atlanta, Ga 30332-0820
Phone 404-894-3825 FAX 404-853-0113
Internet bob.hendry@gtri.gatech.edu
******************************************************************************
From: Vladimir Patoprsty <chempaty@savba.savba.sk>
Subject: EI spectrum of Solanidine
Date: Thu, 7 Dec 1995 11:59:53 +0100 (MET)
Cc: chempaty@savba.savba.sk (Vladimir Patoprsty)
Hi!
Could anyone send me EI spectrum of Solanidine - a steroid alkaloid?
Thank you,
Vld.
******************************************************************************
From: jwindak@umich.edu (Jim Windak)
Subject: Re: FAB-HR?
Followup-To: sci.techniques.mass-spec
Date: 7 Dec 1995 12:35:26 GMT
Organization: University of Michigan
The main peaks in the PEG spectrum are the protonated oligimers of PEG.
They are of the general form (C2.H4.O)nH3O+ , and they differ by 44 amu
(the mass of the repeat unit C2.H4.O). I've also observed smaller
intensity peaks due to sodium or potassium adducts of the PEG oligimers.
These are of the form (C2.H4.O)H2O.Na+ and (C2.H4.O)H2O.K+ .
I've never observed peaks that differ by 13 amu, but the 6 amu difference
which you observe might possibly be explained by the presence of lithium
ion. At times I've observed lithium ion adducts of the form
(C2.H4.O)H2O.Li+ . These would differ by 6 amu from the corresponding
protonated oligimers. (Subtract 7 amu for Li and add 1 amu for the proton).
Jim Windak
University of Michigan
Chemistry Dept.
jwindak@umich.edu
******************************************************************************
From: Michelle Beeson <mbeeson@emory.edu>
Subject: Jan. Meeting of Atlanta-Athens MSDG
Date: 7 Dec 1995 19:10:49 GMT
Organization: Emory University, Microchemical Facility
---------------------------------------------------------------
----- Atlanta-Athens Mass Spectrometry Discussion Group -----
---------------------------------------------------------------
December 7, 1995
Our next meeting will be 7:00PM Tuesday, January 23, 1996. The meeting
will be at Emory University in room 316 of the Chemistry building. A map
of the campus is available on the WWW at
"http://tswww.cc.emory.edu/~kmurray/aamsdg.html".
The speaker for the evening will be Dr. Jim Perkle from the CDC. The
title of his talk is "Applications of Mass Spectrometry in Environmental
Health." This will be an opportunity to learn how mass spectrometric
techniques are applied to health and environmental problems.
Sincerely,
Michelle D. Beeson
Microchemical Facility
Winship Cancer Center voice: (404) 778-4589
Emory University fax: (404) 778-4281
Atlanta, GA 30033 email: mbeeson@emory.edu
******************************************************************************
Subject: Re: labeled standards-need help
Date: 7 Dec 1995 20:05:16 GMT
Organization: Uni Ulm
From: News Owner <news@oracle.rz.uni-ulm.de>
best regards
-karlheinz
------------------------------------------------------------------------
Karlheinz Hauff
University of Ulm; Dept. of Analytical and Environmental Chemistry
e-mail: karlheinz.hauff@chemie.uni-ulm.de
------------------------------------------------------------------------
******************************************************************************
From: Karl Martin Syring <syring@pollux.edv.agrar.tu-muenchen.de>
Subject: Varian V70 D turbo pump
Date: Sun, 10 Dec 1995 17:18:47 +0100
Organization: Munich University of Technology
Does anyone know, where I can get a Varian V70 D turbo pump
*very* quickly?
Thanks
--
Karl M. Syring
Institute of Plant Nutrition
Munich University of Technology
D-85350 Freising
Germany
******************************************************************************
From: Gordon Buckley <buckg@homead.dnet.co.uk>
Subject: Multi-charge ions?
Date: 11 Dec 1995 00:09:20 GMT
Organization: none
Andy Buckley
******************************************************************************
From: belmans@schs.uia.ac.be (Francois.Belmans)
Subject: MS-lab equipment for sale
Organization: U.I.A. University of Antwerp
Date: Mon, 11 Dec 1995 11:15:01 GMT
The apparatus , a JEOL 01 BM2, has completely refurnished electronics and vacuum
sections (new rotary, turbo and ion pumps and pressure gauges). The recently
computerized photometer was build up from a ZEIS GII photometer.
The renovation of the vacuum section of the SSMS mounted up to about 40 000 US
dollars
and the installation of the renewed photometer to about $80 000.
Different lab-accessories for a laboratory confronted with trace analyses of solids
are also available: balans, mixer, diamond-saw, vertical laminar flow bench, photo
enlarger, sandblasting box, back-lit work-bench, glove box with gas flux, He-leak
detector, ...
A quick response, regarding the complete or part of the sale, will be welcome.
Best regards
J. Allegre.
Rhone-Poulenc S.A.
Centre Recherches Aubervilliers
52, rue de la Haie Coq
93308 - Aubervilliers CEDEX
France
tel.: + 33 1 49 37 62 62
fax.: + 33 1 49 37 61 00
or e-mail me:
Francois
------------------------------------------------------------------------------
- Francois Belmans Francois.Belmans@uia.ua.ac.be -
- Dept. of Chemistry B2.30 Tel.:+32.38.20.23.46 -
- University of Antwerp Fax.:+32.38.20.23.76 -
- Universiteitsplein 1, B-2610 Wilrijk o 0 -
- Belgium | Windows '95 < Mac '84 -
---------------------------------------------------\_/------------------------
Try this <A HREF="http://www.uia.ua.ac.be/u/belmans/index.html">WWW</A>
------------------------------------------------------------------------------
******************************************************************************
Date: Mon, 11 Dec 1995 07:58:43 +0100
From: marc@eawag.ch (Marc Suter)
Subject: Answer to Ilse Vandecandelaere
The easiest way to approach your problem is to collect some HPLC fractions
and do a flow injection, using an electrospray interface. Unless you have
access to a LC-MS instrument that runs routinely, flow injection is easier
than trying to find similar HPLC conditions on a microbore or capillary
column (down-scale).
90% aqueous should be ok, if you have a nebulizer option.
We have been looking at small carboxylic acids that way, using 100% 20 mM
sulfate buffer. This work was done on an AutoSpec instrument, using the
newer VG ESI interface.
It should also be possible to detect your intact La-complex. We have had no
problem analyzing Fe-EDTA complexes and even transformation products thereof.
You also would have to check your sample in positive ion mode, because
depending on the oxidation state of your metal and the number of cations
attached to the complex or its components, it is possible that signal
intensities are better for positive ions.
Also, be sure to tune your instrument and interface (especially the so
called skimmer-nozzle voltage) so that you do see acetate and other small
anions.
_______________________________________________________________
Marc J.-F. Suter, Ph.D. e-mail: suter@eawag.ch
Swiss Federal Institute for Environmental Science & Technology
Chemistry Dept. / 35
phone: +41-1-823-5479 / 5091 fax: +41-1-823-5028
_______________________________________________________________
******************************************************************************
From: Marcus Macht <macht@chclu.chemie.uni-konstanz.de>
Subject: Re: Multi-charge ions?
Date: 11 Dec 1995 17:52:57 GMT
Organization: Universitaet Konstanz
Hello Andy !
Marcus Macht
Faculty of Chemistry
University of Konstanz
******************************************************************************
From: hwebb@rain.org (Hugh Webb)
Subject: Re: Multi-charge ions?
Date: 11 Dec 1995 19:13:29 GMT
Organization: RAIN Public Access Internet (805) 967-RAIN
Hugh Webb
******************************************************************************
From: "Andrew N. Eaton" <ar30@dial.pipex.com>
Subject: (no subject)
Date: 12 Dec 1995 08:59:38 GMT
Organization: VG ORGANIC
--
Dr Andrew N. Eaton, Marketing Manager, VG ORGANIC
Tudor Road, Altrincham, Cheshire WA14 5RZ, United Kingdom
Tel: +44 (0)161 929 9666 Fax: +44 (0)161 941 5242
Email: Andrew.Eaton@instruments.fisons.co.uk or 100446.3561@compuserve.com
******************************************************************************
From: @chemistry.gatech.edu, Frank_Hollis-1%notes@sb.com (Triple Quadrophenic)
Subject: Re: Multi-charge ions?
Date: 12 Dec 1995 10:37:52 GMT
Organization: SB
Frank J Hollis________Frank_Hollis-1@sbphrd.com________
Mass Spec. | |
SB Pharm | The Sinclair C5 of the |
Welwyn | Information Superhighway |
Herts. UK. |_______________________________________|
01438 782551 All opinions my own (So I'm told)
******************************************************************************
From: Hagen@gold.ucr.edu (Jeffrey Hagen)
Subject: Re: Multi-charge ions?
Date: 12 Dec 1995 15:40:23 GMT
Organization: University of California, Riverside
******************************************************************************
From: chris stoneking <chris@aql.eas.gatech.edu>
Subject: Re: Ion traps vs quadrupoles
Date: Tue, 12 Dec 1995 12:02:54 -0800
Organization: Georgia Institute of Technology
What Bob doesn't mention is that most of the compounds he is hunting for
are easily identifiable, i.e. they have very distinct spectra. I believe
Bob is in a fairly typical analytical setup and his comments are valid.
Now, if you want to know about problems, lets talk about the Saturn's software.
It sucks. Big time. They wrote the software focusing on the EPA guidelines for
air toxics and such. Because of that there are some major wholes in the abilities
of the software. Furthermore, whoever wrote it wasn't a chromatographer and
probably wouldn't know one if it snuck up on him and bit him on the ass.
These comments, by the way, go equally for Finnigan's Magnum software, which is
virtually identical to the Saturn.
I know of someone else who did have / is having auto-CI induced by water in the
sample. He has a Varian Saturn with one of their VTAT systems on top. (I don't
recomend that baby either)
It comes down to what you are going to use it for. If you have a straight forward
analytical lab setting where you either know ahead of time what you are looking for
or are willing to live with the library matches, you probably won't have any
problems
with the Saturn. If you are in a research field where you will eventually have to
figure out for yourself what that odd peak is because you are certain protein
fragments
don't show up in process water from settling pond #4, then you might think twice
about the ion trap systems.
******************************************************************************
From: Wayne Shanks <Aleph@wam.umd.edu>
Subject: Re: Multi-charge ions?
Date: 12 Dec 1995 18:13:59 GMT
Organization: Space Physics University of Marylend
What you need is an energy per charge separator. This is done by deflecting the
ion between two concentric cylindrical metal plates=
charged to some voltage v1 and v2. like the magnetic sepparator the ion is
deflected. Unlike the magnetic sepparator the deflecti=
on is only a function of the energy per charge. So put one of these electro static
E/Q analizers on the front end of your magnetic =
regidity sepparator and you are in business.
Wayne Shanks
******************************************************************************
From: Soeren Deininger <sd1@eurybia.rz.uni-konstanz.de>
Subject: Posttranslational modifications ?
Date: 13 Dec 1995 11:23:13 GMT
Organization: I DID NOT CONFIGURE MY ORGANIZATION IN MY NEWSREADER
Hello,
Thanks
Soeren Deininger
******************************************************************************
Date: Wed, 13 Dec 1995 16:22:50 -0500
From: cphinney@ENH.NIST.GOV (Curtis Phinney)
Subject: Field portable GC/MS
Sincerely,
Curtis S. Phinney
National Institute of Standards and Technology
222/B208
Gaithersburg, MD 20899-0001
Fax (301) 977-0685
Voice (301) 975-3141
******************************************************************************
From: Karen Jonscher <krj@u.washington.edu>
Subject: Re: Posttranslational modifications ?
Date: 14 Dec 1995 01:12:12 GMT
Organization: UW
Try http://www.medstv.unimelb.edu.au/WWWDOCS/SVIMRDocs/Mass
I think there might be something after the Mass part, but I couldn't see it. Hope
this helps.
Karen
******************************************************************************
Date: Thu, 14 Dec 1995 07:08:10 +0000 (GMT)
From: ddxdd@IMAP1.ASU.EDU
Subject: Re: Posttranslational modifications ?
Organization: daves not here
: Thanks
: Soeren Deininger
-d^2
******************************************************************************
From: Jeff Corkern <74030.52@CompuServe.COM>
Subject: Re: Ion traps vs quadrupoles
Date: 15 Dec 1995 02:05:02 GMT
Organization: 74030.52@compuserve.com
--
Jeff Corkern
******************************************************************************
From: spban@eskimo.com (banerian)
Subject: FT-MS basic reference
Organization: Eskimo North
Date: Fri, 15 Dec 1995 03:44:02 GMT
TIA
--
--
stef banerian
spban@eskimo.com
banerian@scn.org
******************************************************************************
From: srlnjxa@lhn.gns.cri.nz
Subject: Thermal Ionisation mass spectrometry
Date: Fri, 15 Dec 95 16:55:37 +1200
Organization: Institute of Geological and Nuclear Sciences
I would be curious to know which software you feel is best for MS. I think all
that is left is
HP and VG. I've seen both of those, and I agree with your general assessment on
the Finnigan and
Varian S/W. VG has done some neat things, and I think HP has some newer software
that I haven't
seen.
> It comes down to what you are going to use it for. If you have a straight
> forward analytical lab setting where you either know ahead of time what
> you are looking for or are willing to live with the library matches, you
> probably won't have any problems with the Saturn. If you are in a
> research field where you will eventually have to figure out for yourself
> what that odd peak is because you are certain protein fragments don't show
> up in process water from settling pond #4, then you might think twice
> about the ion trap systems.
How would you compare a Saturn to a HP MSD in a routine setting (know what you are
looking for)?
--
_________________________________________________________________________
******************************************************************************
From: Fred Schwarzer <fred1330@mailszrz.zrz.tu-berlin.de>
Subject: Long Filename Support for MS-Chemstation
Date: 15 Dec 1995 07:43:05 GMT
Organization: Institute of Food Chemistry / TU Berlin
--
Fred Schwarzer
Institute of Food Chemistry / TU Berlin
see also
http://stanpc1.lb.tu-berlin.de/lc/fred.htm
******************************************************************************
From: bfuchu@chbs.ciba.com (Fuchslueger Ulf)
Subject: Finnigan GCQ
Organization: CIBA-GEIGY AG
Date: Fri, 15 Dec 1995 13:56:21 GMT
But then, the second surprise: when trying to start a series with this
configuration the system stopped irregularily beween the injections with
a data-file error (unable to open "next data filename").
The reason: the time base of the GCQ and the data system is different,
resulting sometimes (very often) in an attempt of the data system to
open the next file before the old one was closed, which leads to the
error above.
The consequence: if you intend to use your GCQ with any other GC than the
original one (which is highly recommended) you will not be able to run
your analysis automatically.
----------------------------------------------------------------------------
Fuchslueger Ulf Polymer Analytics CIBA - GEIGY AG Switzerland
E-Mail: bfuchu@chbs.ciba.com
FAX: +41-61-6967227
----------------------------------------------------------------------------
******************************************************************************
From: "John Bartmess" <BARTMESS@novell.chem.utk.edu>
Organization: Univ. of Tenn. Dept. of Chemistry
Date: Fri, 15 Dec 1995 11:19:05 EST
Subject: Re: FT-MS basic reference
John Bartmess
Cc; to spban.
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=-
| John Bartmess | Organic Chem || my opinions, being antithetical |
| Dept. of Chem., U. of Tennessee || to "big time" football, cannot |
| Knoxville TN 37996-1600 || be those of the Univ. of Tennessee|
| (423) 974-6578 Fax: 974-3454 || "Anions are more fun!" |
| jbartmess@utk.edu http://novell.chem.utk.edu/bartmess.htm |
--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=--=-=--=--=--=--=--=--=--=-
******************************************************************************
From: mikemcd@axionet.com (Mike McDonell)
Subject: Re: Ion traps vs quadrupoles
Date: Fri, 15 Dec 95 23:56:06 PST
Organization: Axion internet
After filling the trap, the ion source is gated off, and you are
left with only ions and the bath gas in the trapping volume
>________________________________________________________________________
_
>
> Bob MacPherson Laboratory Equipment Exchange
> http://www.magic.mb.ca/~econolab Your Internet Magazine for Used
> econolab@magic.mb.ca Scientific Equipment
> four star rated by the mckinley
>________________________________________________________________________
_
>
>
******************************************************************************
From: mrheadmstr@aol.com (MrHeadmstr)
Subject: Re: Finnigan LCQ
Date: 16 Dec 1995 12:23:53 -0500
Organization: America Online, Inc. (1-800-827-6364)
I am being visited by the regional Finnigan SE later this week, and I'll
ask him about a definite date on the LCQ. I'll post it here.
******************************************************************************
From: mrheadmstr@aol.com (MrHeadmstr)
Subject: Re: Ion traps vs quadrupoles
Date: 16 Dec 1995 12:25:53 -0500
Organization: America Online, Inc. (1-800-827-6364)
>Can anyone help me? I am evaluating ion traps (specifically the Saturn
>4) vs quadrupole GC-MS systems and the following issues have come up
I recently purchased a system and went thru the same Q/A process as you
are doing now, and wound up buying a Finnigan GCQ. Here's some of what
went into my decision making process. (And this is a former HP field
service guy talking!)
1) Mass Range. The GCQ ranges from 10-1000amu. The HP MSD is up to 650.
OK for standard EPA work, not good for work with more variety.
2) Capability. The GCQ offers EI+, EI-, CI+ and CI-. The Saturn also
offers CI but it is a $20K option!
3) Data System. The GCQ is written in C++ to run on WindowsNT, a full 32
bit OS with a good reputation for stability. It came with a Gateway2000
P5-75, with 1.3GB hard drive, 16MB RAM, a Quad speed CD-ROM.
4) Library. Either NIST or Wiley on CD-ROM.
5) GC flexibility. Can get it with either the new Finnigan GC or the HP
5990.
6) EPC. Comes with the HP electronic pressure control standard.
Split/Splitless capillary is standard also.
7) MS/MS. THE reason why people buy an ion trap instead of quadropole,
isn't it?
8) Price. I paid $72,000 for mine with capillary, EPC, MS/MS, EI/CI/NCI,
NIST library. I couldn't get the vacuum interlock (a STRONGLY recommended
>$6000 option) due to budget constraints. For the same price, I could
have a HP MSD without any options, or a Saturn without CI/NCI (and with an
unsat software system). IMO, right now, the GCQ offers WAY more bang for
the buck than any other GC/MS on the market.
Good Luck. Wishing I could come visit your beautiful country someday!
******************************************************************************
From: mrheadmstr@aol.com (MrHeadmstr)
Subject: Re: Multi-charge ions?
Date: 16 Dec 1995 12:27:29 -0500
Organization: America Online, Inc. (1-800-827-6364)
Don't you mean to "charge 1+ ions of mass 1/2m"? The MS sees the mass to
charge ratio, m/z.
MrH
******************************************************************************
From: freonfran@aol.com (Freon Fran)
Subject: Anyone familiar w/ Perkin Elmer Q-Mass 910
Date: 16 Dec 1995 17:40:32 -0500
Organization: America Online, Inc. (1-800-827-6364)
I am Looking for folks who use or have used Perkin Elmer 910 Benchtop Mass
Spec. Our Lab has just aquired one and I am currently being trained for
using it. Actually, it's more accurate to say that I am training myself.
I have GC experience, but have never worked with a mass spec. I would
like to have a few sources that I could turn to for advise once in a while
if I hit a glitch. Can anyone out there help?
******************************************************************************
Date: 17 Dec 95 15:35:20 EST
From: David Sparkman <75530.3472@compuserve.com>
Subject: Re Ion Traps
I have to comment on the recent questions regarding quadrupole ion trap mass
spectrometers. An ion trap GC/MS requires a more experienced operator than a
transmission quad. When working with unknowns, strange results are possible due
to ion-molecule reactions that may take place between odd-electron ion fragments
produced by polar analytes and the analyte molecules. On of the best examples
of this is with 2-octanone. The mass spectrum obtained using an ion trap can
have one predominate peak at m/z 129 (M+1). This is because the odd-electron
ion with an m/z value of 58 is a very good proton donor and will protonate the
2-octanone molecules present in the trap as the m/z 58 ions are formed and
stored.
All of the rest of ions normally formed are present, but their abundance pales
by comparison to the M+1 ions that are formed. The presence of peaks
representing the M+1 ion can be avoided by not storing ions below a value that
will exclude the fragment at m/z 58. However, you can still see the presence of
this important odd-electron ion peak in the spectrum you obtain.
The ion trap does not take all the data for a single spectrum in a single scan.
For those instruments where ions are formed in the trap, the scan is divided
into four different segments. A separate ionization takes place to produce ions
to be analyzed in each segment, However, all the ions form m/z 20 to m/z 650
are formed AND STORED during each ionization. If you want to avoid the presence
of protonated molecules in spectra of polar compounds, set the RF to store all
ions between m/z 20 and m/z 650 in the first scan segment. This is the default
storage voltage, and will allow the detection of all ions present between m/z 20
and 99. This segment is used to record data on ions between m/z 20 and 99. Set
the storage voltage for the other three scan segments to store only ions between
m/z 90 and m/z 650. Most of the odd-electron ions that are very good
protonating agents formed by the rearrangement fragmentation are below m/z 100.
This will reduce the sensitivity in these segments and may require an adjustment
to the ionization time. Use a mixture of ketones and methyl esters of fatty
acids to set the conditions that will give "classical" spectra. Then use these
conditions for the analysis of your unknowns. The overall sensitivity of the
ion trap will be reduced, but it is still as sensitive as or more so than a
transmission quadrupole.
With the ion trap, you will have the advantages of low pressure CI and MS/MS to
get even more qualitative information.
You should try to avoid the presence of water in trap during the time some
analytes are being looked at. With respect to EPA purge and trap, a lot has
been written on this, and EPA accepts the data you can obtain from the trap.
Regards;
David Sparkman
******************************************************************************
From: i.hemmingsen@gns.cri.nz (Ian Hemmingsen)
Subject: Ion Beam Instability
Date: Sun, 17 Dec 1995 21:59:46 GMT
Organization: Victoria University of Wellington, New Zealand.
To All Thermal Ionisation Mass Spectrometer Users.
I tried to post this article before, but the news reader I was using
was too archaic.
Has anyone out there got any suggestions as to why my ion beams are so
unstable? I'd be really appreciative of any help on this. My email
address is;
j.aggarwal@gns.cri.nz
Thanks
Jug
******************************************************************************
From: nonsuch@netcom.com (David Mcnerney)
Subject: Re: Ion traps vs quadrupoles
Organization: NETCOM On-line Communication Services (408 261-4700 guest)
Date: Mon, 18 Dec 1995 06:15:25 GMT
I have been using a Saturn ion trap GC/MS for the past two years, mostly
to analyze extracts of environmental samples for semivolatile compounds,
but also with purge and trap. The company I work for owns two Saturns.
I'll atttempt to answer your questions... keep in mind that I have no
experience with other types of mass specs such as the HP MSD, etc.
I'm sure that spectra produced by the Saturn do not always match
classical EI spectra very well, because of the way the Saturn uses scan
segments to mimic the tuning of other mass specs. Nevertheless, for many
compounds I am able to get a very good match to the NIST library. I don't
usually have to identify unknowns, so I haven't looked into this problem
too much.
For some compounds, under some circumstances, the Saturn ion trap will
produce concentration-dependent spectra. I have observed this with the
phthalate esters in particular. I think that there are ways to minimize
the problem, however.
The ion trap is extremely sensitive, but its sensitivity varies inversely
to the level of chemical background. If two compounds coelute and the
amount of one is extremely large while the amount of another is very
small, the EICP peak for the small compound may be affected. This has to
do with the way that the Saturn varies the time that it opens its
electron gate (ionization time) in order to maintain an optimum number of
ions in the trap. If you are only interested in the small peak, there are
ways to reject the ions generated by the other compound so as to enhance
your sensitivity and accuracy of quantitation. Your Varian salesperson will
no doubt be happy to explain those, since they cost extra.
WRT to the idea that the ion trap is adversely affected by the water in a
purge and trap system - I have never heard of this before. It is true
that the ion trap is extremely sensitive to the air/water background and
care must be taken to keep that background as low as possible, but we
used a purge and trap system with one of our Saturns for months with
excellent results. I always assumed that the trap in the purge & trap
didn't hold on to the water vapor from the purge.
Dave
******************************************************************************
Date: Mon, 18 Dec 95 12:51:41 -0500
From: Chip Cody <cody@titian.jeol.com>
Subject: Re: Posttranslational modifications ?
http://www.jeol.com/ms/amino_acids.html
Robert B. Cody
Applications Manager
Mass Spectrometry
JEOL USA, Inc.
******************************************************************************
From: proana@hacom.nl (Bert Tammenga)
Subject: ICP-MS in Environmental applications ??
Organization: Pro Analyse
Date: Tue, 19 Dec 1995 09:42:08 GMT
Hello,
Bert Tammenga
******************************************************************************
From: pedrom <PEDROM@dq.ua.pt>
Subject: Re: Posttranslational modifications ?
Date: 19 Dec 1995 17:03:34 GMT
Organization: Aveiro University
try
http://chait-sgi.rockefeller.edu/MSDB-html/ms.home.html
Pedro Domingues
******************************************************************************
From: chris stoneking <chris@aql.eas.gatech.edu>
Subject: Re: Ion traps vs quadrupoles
Date: 19 Dec 1995 17:48:06 GMT
Organization: Georgia Institute of Technology
We do ambient air, looking for ozone precursors and the like. A lot
of the time, this means packing up my equipment and taking it out to
the field with me. Last summer I spent 8 weeks in a cow pasture
outside of Nashville, TN. There are no routine settings for us. I
tend to think that side by side in a lab, the Saturn (or Finnigan)
systems will be more sensitive and just as well behaved as HP's stuff.
And the innards of the ion trap are easier to clean that any quadrapole!
Chris Stoneking
chris@aql.eas.gatech.edu
******************************************************************************
Date: Tue, 19 Dec 1995 19:57:54 +0000 (GMT)
From: DAVID.DOGRUEL@ASU.Edu (dave)
Subject: post-translational modifcations
Organization: dave's not here
the URL for the list of protein post-translational modifcations (DeltaMass)
is:
http://www.medstv.unimelb.edu.au/WWWDOCS/SVIMRDocs/MassSpec/deltamassV2.html
-d^2
******************************************************************************
From: Mike Head <wwwadmin@www.interlab.co.uk>
Subject: interLAB WWW Update
Date: 19 Dec 1995 21:43:56 GMT
Organization: Virtual Networking Company Ltd
http://www.interlab.co.uk/interlab
The New Products from the Press area has expanded with more current product
offerings from across the industry.
The Discussion Group area has proved popular for Visitors to request help and
information but we need more feedback from you with answers and suggestions.
Remember that all e-mails are routed through interLAB, so there will be no
direct access to you from any information posted.
Best regards
Mike Head
interLAB Web Master
******************************************************************************
From: Juergen Lipinski <Sofia@igz.fta-berlin.de>
Subject: MS-Data-System for Finnigan 4500 searched
Date: 20 Dec 1995 09:45:03 GMT
Organization: SOFIA GmbH
Dear MS users,
we are looking for an unexpensive way to replace our Incos data system by
a PC based solution. Does anybody knows a way that is not so expensive
like the masscom data system or the technivent system (vector 2) or does
anybody intend to cell as a used system.
Great thanks for help
Juergen Lipinski
******************************************************************************
From: chelber@goodnet.com (Carl A. Helber)
Subject: FERRAN SCIENTIFIC
Date: 20 Dec 1995 14:29:11 GMT
Organization: GoodNet, Inc.
Does anyone out there have any experience using the Ferran
Scientific Micropole RGA equipment?
******************************************************************************
From: "Gregory G. Dolnikowski" <dolnikows_ms@hnrc.tufts.edu>
Subject: Re: Field portable GC/MS
Date: Wed, 20 Dec 1995 14:53:51 -0800
Organization: Tufts University
Viking Instruments
12007 Sunrise Valley Drive
Reston, VA 22091
>
> we are looking for an unexpensive way to replace our Incos data system by
> a PC based solution. Does anybody knows a way that is not so expensive
> like the masscom data system or the technivent system (vector 2) or does
> anybody intend to cell as a used system.
>
******************************************************************************
Date: Tue, 20 Dec 1994 14:23:12 -0500
From: Daniel Ouellet <ouelletd@EM.AGR.CA>
Subject: System controller needed
So, I am looking for a "VG Isotech es-1044 idu system controller" part
number 3601816.
Could I and Where should I send this message for announcement to the
mass-spectrometer group?
Yours faithfully,
Daniel Ouellet
Dairy and Swine Research
and Development Centre
Agriculture and Agri-Food Canada
P.O. Box 90 - 2000, route 108 East
Lennoxville, QC
Canada
J1M 1Z3
Telephone: (819) 565-9171; (819) 565-9174 voice mail #209
Fax: (819) 564-5507
E-mail: OUELLETD@EM.AGR.CA
******************************************************************************
Date: Tue, 20 Dec 1994 14:23:12 -0500
From: Daniel Ouellet <ouelletd@EM.AGR.CA>
Subject: System controller needed
So, I am looking for a "VG Isotech es-1044 idu system controller" part
number 3601816.
Yours faithfully,
Daniel Ouellet
Dairy and Swine Research
and Development Centre
Agriculture and Agri-Food Canada
P.O. Box 90 - 2000, route 108 East
Lennoxville, QC
Canada
J1M 1Z3
Telephone: (819) 565-9171; (819) 565-9174 voice mail #209
Fax: (819) 564-5507
E-mail: OUELLETD@EM.AGR.CA
******************************************************************************
From: one_good@solution.nl (Michiel F.E. van Reenen)
Subject: LC Packings on the Web.
Date: Thu, 21 Dec 95 15:41:53 GMT
Organization: One Good Solution WWW Publishers
F.Y.I.
--
New at http://www.solution.nl/lcpackings/
--
LC Packings
--
LC Packings has a world-wide leadership position in Micro HPLC and
ancillary Micro- and Nanoseperation techniques.
On these pages you will find company and product information,
a list of dealers and E-mail forms to request additional
information with. You will also find a 'What's New with
LC Packings'-section.
---------------------------------------------------------------------
Michiel F.E. van Reenen |"Love and war are what work's about."
+31 (0)23 532 8418 |
reenen@solution.nl |"Do things - if you don't, they will
http://www.solution.nl/~reenen/| be done."
New on our site:
W. van Kiel (IT Advisor) at http://www.solution.nl/kiel/
LC Packings (Capillary LCs) at http://www.solution.nl/lcpackings/
---------------------------------------------------------------------
******************************************************************************
From: Jeff Corkern <74030.52@CompuServe.COM>
Subject: Re: Field portable GC/MS
Date: 22 Dec 1995 06:01:44 GMT
Organization: 74030.52@compuserve.com
--
Jeff Corkern
******************************************************************************
From: cdelumpa@best.com
Subject: Surface Science Laboratories New Web Site
Date: Fri, 22 Dec 1995 17:55:28 GMT
Organization: Best Internet Communications
http://www.surface-science.com
The SSL web site includes an overview of the various surface, organic
and inorganic/imaging analytical techniques employed by the company to
help solve high-tech materials problems.
Also featured at the site are specific applications overviews for the
magnetic media, semiconductor, biomedical device and ultra-pure
delivery systems industries. Future additions to this site will
include downloadable technical articles on high-tech problem-solving,
and problem-solving discussion/chat rooms.
###
******************************************************************************
From: cdelumpa@best.com
Subject: Surface Science Laboratories New Web Site
Date: Fri, 22 Dec 1995 18:00:21 GMT
Organization: Best Internet Communications
http://www.surface-science.com
The SSL web site includes an overview of the various surface, organic
and inorganic/imaging analytical techniques employed by the company to
help solve high-tech materials problems.
Also featured at the site are specific applications overviews for the
magnetic media, semiconductor, biomedical device and ultra-pure
delivery systems industries. Future additions to this site will
include downloadable technical articles on high-tech problem-solving,
and problem-solving discussion/chat rooms.
###
******************************************************************************
From: chmleehk@leonis.nus.sg (Lee Hian Kee)
Subject: VG 7035 and MSS upgrade
Date: 27 Dec 1995 01:29:09 GMT
Organization: National University of Singapore
Hi!
Regards,
HK Lee
chmleehk@nus.sg
chmleehk@leonis.nus.sg