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COM

Compatibility of

Commonly Used

Intravenous

Drugs

A

ll

rig

Co

ht

py

s

rig ed.

re

ht

se

rv

20

11

Re

M

pr

cM

od

uc

ah in w

tio

on

T

n

he number of available IV

Pu

bl

is

ho

hi

ng

le

or

G

ro

in

up

pa

un ou

rt

w

le

ith

ss

ot

to be administered concurrently.

he

tp

rw

er

is

m

e

is

no

si

on

te

d.

is

pr

oh

These factors contribute to the escalating complex- medication is combined or added to an IV fluid. It is

ib

ity of IV drug administration and have resulted in an important to recognize that compatibility is not just

ite

ever-increasing number of possible incompatibilities. a function of the drugs themselves, but also can be

d.

The potential for serious and life-threatening adverse dependent on a variety of factors including the concen-

drug events exists when incompatible medications are tration, temperature, storage vehicle, infusion solution,

infused together. Therefore, it is important to verify drug order of mixing, and administration technique. Compat-

compatibility prior to coadministration. A clear and con- ibility differences even have been reported for different

cise compatibility chart can be a useful tool in helping to brands of the same drug.

deliver safe, high-quality IV therapy to patients. Three types of incompatibilities are commonly dis-

A chance of incompatibility exists whenever any cussed: physical, chemical, and therapeutic. Physical

Text continues on page 6

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G P H A R M AC Y P R AC T I C E N E WS • S E P T E M B E R 2 0 1 1

1

Table. Compatibility of Selected IV Drugs (continued)

Ampicillin-sulbactam

Dextrose 5% in water

Calcium gluconate

Diphenhydramine

Dexamethasone

Esomeprazole

Anidulafungin

Azithromycin

Ciprofloxacin

Caspofungin

Amiodarone

Dobutamine

Clindamycin

Fluconazole

Epinephrine

Ceftazidime

Bumetanide

Daptomycin

Doxycycline

Ceftizoxime

Eptifibatide

Furosemide

Ceftriaxone

Argatroban

Cefotaxime

Gentamicin

Famotidine

Doripenem

Ceftaroline

Aztreonam

Enalaprilat

Bivalirudin

Dopamine

Ampicillin

Diazepam

Cefepime

Diltiazem

Cefazolin

Acyclovir

Amikacin

Cefoxitin

Fentanyl

Esmolol

A

Acyclovir C N C I C C N I C C C N C I C C C C C C I C I C C I N N I I C C C I I I N C C C C N

ll

Amikacin C C N N C N I C C C C C C H C C C C C C C C C C C I C C C C C C C C C C N C C C C C

rig

Co

Amiodarone N C N I C I N N I C C C N N N N C I C C C C C N N N C N C C C C N C N C N C C C N C

ht

py

Ampicillin C N N N C N N N C N N I N N N N N N I N N S C N I I N I I I N I N N C N N N N I S I

s

Ampicillin-sulbactam I N I N C N N N C N N I N C I I N N N N I N C N A I N N I N N I N N C N N N N N N N

rig ed.

re

Anidulafungin C C C C C C C C C C C C C C C C N C C C C C N C C I C C C C C C C C C C N C C C C C

ht

se

Argatroban C N I N N C N N C N N N N N N N N N N N N N C N C N C C C C N N N N C N N N C N C N

rv

Azithromycin N I N N N C N I C N N N N N I N C I N I I I C N C N N C N N C N N N C N N I I N I I

20

Aztreonam I C N N N C N I C C C C C C C C N C C C C C C C C I C N C C N C C C C C N C C C C C

C C I C C C C C C C C I C C C C N C C C C C C C C I C C N C N C C C C C N C C C C C

11

Bivalirudin

Re

Bumetanide C C C N N C N N C C C C C C C C C C C C N C C C C I C C N C C C C C C C N C C C C C

M

pr

Calcium gluconate C C C N N C N N C C C C C C C C C C C I A C C I C I C C N C C C C C C C N C C N C C

cM

od

Caspofungin N C C I I C N N C I C C I I I I I I C I C I C I N I C C C C C C I C N C N C C C I C

uc

ah in w

Cefazolin C C N N N C N N C C C C I N I C N C C C N C C C C I C I I I N I C C C C N N C C C N

tio

I H N N C C N N C C C C I N N N N N N N I C C C C I I I N N N N I N C N N I N C C N

on

Cefepime

Cefotaxime C C N N I C N I C C C C I I N C N I I C N C C C C I C I N C N C C C C C N C C N C N

n

Pu

Cefoxitin C C N N I C N N C C C C I C N C N C I C N C C C C I C I I C N I C C C C N N C C C C

bl

Ceftaroline C C C N N N N C N N C C I N N N N N N N C C N C C I C C N C C N C N N N C C C C C C

is

Ceftazidime C C I N N C N I C C C C I C N I C N C C C C C C C I C I N C N I C C C C N C C N C N

ho

hi

Ceftizoxime C C C I N C N N C C C C C C N I I N C C N C C C C I C C N C N I C C C C N N C C C C

ng

le

Ceftriaxone C C C N N C N I C C C I I C N C C N C C N I C C C I C I I C N C C C C C N N C N C N

or

Ciprofloxacin I C C N I C N I C C N A C N I N N C C N N I C I C N C C C C C N N N C N N N N C I C

ro

in

Clindamycin C C C S N C N I C C C C I C C C C C C C I I C C C I C C N C N C C C C C N C C N C C

up

Daptomycin I C C C C N C C C C C C C C C C C N C C C C C C I C C C C C C C C C C C N C C C C C

pa

Dexamethasone C C N N N C N N C C C I I C C C C C C C C I C C C I C I I C C I C C C I N C C C C I

un ou

rt

D5W C C N I A C C C C C C C N C C C C C C C C C C I C N C C C C C C C C C C C C C C C C

w

le

Diazepam I I N I I I N N I I I I I I I I I I I I I N I C I N I I N I I I I I I I N I N I I I

ith

ss

Diltiazem N C C N N C C N C C C C C C I C C C C C C C C C C C I C C C C C C C C C N C C C I C

ot

Diphenhydramine N C N I N C C C N C C C C I I I I C I C I C C C I C I C C C C C C C C C N C C C I C

he

tp

Dobutamine I C C I I C C N C N N N C I N N I N N N I C N C I C N C C C C C C C C C N C C C I C

rw

Dopamine I C C I N C C N C C C C C I N C C C C C C C C C C C I C C C C C C C N C N C C C N C

er

Doripenem C C C N N C N C N N C C C N N N N C N N N C N C C C I C C C C N C N N C C C C C C C

is

m

Doxycycline C C C I I C N N C C C C C I N C I N I I C N C C I C I C C C C N C C C C N C C C I C

is

no

si

Enalaprilat C C N N N C N N C C C C I C I C C C C C C N C C C C I C C C C C C C C C N C C C C C

on

te

Epinephrine I C C N N C N N C C C C C C N C C N C C C N C C C C I C C C C N C C C C N C C C C C

d.

Eptifibatide I C N C C C C C C C C C N C C C C N C C C C C C C C I C C C N N C C C C N C C C I C

is

Esmolol I C C N N C N N C C C C C C N C C N C C C N C C I C I C C C C C C C C C N C C C I C

pr

Esomeprazole N N N N N N N N N N N N N N N N N C N N N N N N N C N N N N N C N N N N N N N N N N

oh

Famotidine C C C N N C N I C C C C C N I C N C C N N N C C C C I C C C C C C C C C C N C C N C

ib

Fentanyl C C C N N C C I C C C C C C N C C C C C C N C C C C N C C C C C C C C C C N C C C C

ite

a

Protect from light. b Testing was performed with ethylenediaminetetra-acetic acid (EDTA)-free formulation.

d.

KEY

A = Physically compatible for at least 2 hours H = Physically compatible for at least 1 hour

C = Physically compatible I = Incompatible

D = Physically compatible in dextrose 5% in water N = Information on compatibility is not available or not adequate

E = Physically compatible for at least 5 minutes R = Physically compatible for 24 hours under refrigeration

G = Physically compatible in glass bottle only S = Physically compatible in 0.9% sodium chloride

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

2

Methylprednisolone sod. Succ.

Hydrocortisone Sod. Succ.

Piperacillin-tazobactam

Penicillin G Potassium

Sodium bicarbonate

Imipenem-cilastatin

Potassium chloride

Magnesium sulfate

Ringer’s, lactated

Prochlorperazine

Morphine sulfate

Hydromorphone

Metoclopramide

Norepinephrine

Insulin, regular

Metronidazole

Phenylephrine

Nitroprussidea

Pantoprazoleb

Palonosetron

Nitroglycerin

Voriconazole

Ondansetron

Levofloxacin

Vancomycin

Vasopressin

Meropenem

Granisetron

Tobramycin

Tigecycline

Lorazepam

Micafungin

Midazolam

Tacrolimus

Phenytoin

TMP-SMX

Labetalol

Linezolid

Propofol

Mannitol

Nafcillin

Heparin

N C C C C C I I C C C C N C N C N I N C C I N I I N C I I I C I C N C C I C C C C C C Acyclovir

ll

C I C C C N C C C C C C N C C C N C C C C C C C C C C C I C C C I C C C C C C I C C C Amikacin

rig

Co

C I N N I C C I C C N N N C N C I C C N C N C N C N C C N I C N N N I N C I C N C C C Amiodarone

ht

py

C S N N N N N C C I N N N N N C N I N I N I N I C C I N I N N I C I I C N C N I N N C Ampicillin

s

C N N C N N N C C I N N N I N C N I N N N N N I C C N N I N N I N R N C N C N I N N C Ampicillin-sulbactam

rig ed.

re

C C C C C C C C C C I C C C C C N C C C C C C C C C N C I C C C N N I C C N C C C C C Anidulafungin

ht

se

N N C C N N N N N C N N N N N N N C C N C C C C N N N C N N N N N C N C N C N N N C N Argatroban

rv

N N N N I N N N N N N N N N N N N N I N N N N C C C N N N I I N N C N C N C I N N C C Azithromycin

20

C C C C N C C C C I C C N C C I N C C N C C C C C I C C I C C I C C C C C C C N N C C Aztreonam

C C C C C C C C C C C C C C C C N C C C C C C C C N N C I C C I N N C C C C C C I C C

11

Bivalirudin

Re

C C C C C C C C C C C C N C C C C N C C C C C C C C C C I C C N C C C C C C C I C C C Bumetanide

M

pr

C C N C N C C C C C N C N I C C C C C C C C C C C C C C I C C N C C I C C C C I C C C Calcium gluconate

cM

od

C I C C C C C C C N C C C I C N N C C I C I C C C N N C I I C C N N I C C C C I C C C Caspofungin

uc

ah in w

C C C N C C N I C C N C N C C C N C C C C C C C C N C C I N C I C C C C C C N I N C C Cefazolin

tio

C C C C C H N C C C I I N C I C N I N N N N N I C I N N I C C I N N C C I C N C N C I

on

Cefepime

C C C C C C I N C C C C N I C C N C C C C C C C C I C C I N C I C C I C C C C I N C C Cefotaxime

n

Pu

C C C C C I I I C C C C N I C C N C C C C C C C C C C C I N C I C C I C C C C I N C C Cefoxitin

bl

C C C C N C I C N C N C N C C C N C C N N N C C N C N N N N C N C C C C N N C C N C C Ceftaroline

is

C C C C C C C C C C C C N C C C N I C C C I C N C N C C I N C I N C C C C C C I N C C Ceftazidime

ho

hi

C C C C C C C C C C C C N C C C N C C C C C C C C C C C I N C I C C C C C C C I N C C Ceftizoxime

ng

le

C C C C I C I C N C I C N C C C N C C C C C C N C C C C I N C I C I C C C C I I N C C Ceftriaxone

or

C I I C N N N N C C I N N I C C N C N N N N C C C I N N I I C N I C I C C C C N N C C Ciprofloxacin

ro

in

C C C C C C N C C C C C N C C C N N C C C C C C C N C C I C C I C C C C C C N I C C C Clindamycin

up

C C C C I C C C C C C C C C C I N C C C I C C C C I N C I C C C N C C C C C C C I C C Daptomycin

pa

C C C N C C I C C C I C C C C C N I C C C C C C C I C C I C C I C C C C C C I I N C C Dexamethasone

un ou

rt

C N C C N C C C C N C N I N C N C C C C G C C C C C C C I C C N C C C C N C C N C N C D5W

w

le

I I I N I I I I I N I I I I I I N I N N I I I N I I I I I C I I I I I N I I I I I I I Diazepam

ith

ss

C N N C C N C C C C C C C N C C I C C N C C C C C I C C I I C C N N N C C C C C C C C Diltiazem

ot

C N N C C I C C C C C C C I C C N C C N C I C C C I C C I C C C C C I C C C C I C C C Diphenhydramine

he

tp

C N I C N N C C C C N C C C C C I N C C C N C C C I I C I I C C C C I C C C C I C C C Dobutamine

rw

C C C C C N C C C C C C C C C C C C C C C C C C C N C C I C C C C C N C C C C I C C C Dopamine

er

C C C C N C C C C C C C N C C C C C C N N N C C N C N C N N C N I N C C C C C N C N C Doripenem

is

m

C I I C C C C C C C C C N I C C N C C I C C C C I C I C I I C C C N I C C N C I C C C Doxycycline

is

no

si

C C C C C C C C C C C C C C C C N C C C C C C C C N C C I C C C C N C C C C C N C C C Enalaprilat

on

te

C C C C C N C C C C C C N C C C I C C C C C C C C C C C I C C C C C I C C C C I C C C Epinephrine

d.

C C C C C N C C C C C C C C C C C C C N C N C C C N N C I C C C N N C C N C C C C N N Eptifibatide

is

C N N C C C C C C C C C N N C C C C C N C C C C C I C C N C C C C C C C C C C N C C C Esmolol

pr

N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N C N C I N N N N N N Esomeprazole

oh

C C C C C N C C C C C C N C C C N C C C C C C C C I C C N I C C C C C C C C C I C C C Famotidine

ib

C C C C C C C C C C C C N C C C N C C C C C C C C I C C I C C C C N C C C C C I C C C Fentanyl

ite

d.

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

3

Table. Compatibility of Selected IV Drugs (continued)

Ampicillin-sulbactam

Dextrose 5% in water

Calcium gluconate

Diphenhydramine

Dexamethasone

Esomeprazole

Anidulafungin

Azithromycin

Ciprofloxacin

Caspofungin

Amiodarone

Dobutamine

Clindamycin

Fluconazole

Epinephrine

Ceftazidime

Bumetanide

Daptomycin

Doxycycline

Ceftizoxime

Eptifibatide

Furosemide

Ceftriaxone

Argatroban

Cefotaxime

Gentamicin

Famotidine

Doripenem

Ceftaroline

Aztreonam

Enalaprilat

Bivalirudin

Dopamine

Ampicillin

Diazepam

Cefepime

Diltiazem

Cefazolin

Acyclovir

Amikacin

Cefoxitin

Fentanyl

Esmolol

A

Fluconazole C C C I N C N N C C C N C C C N C C N C N C N C C C I C C C C C C C C C C N C C N C

ll

Furosemide C C N S N C C I C C C C I C C C C C C C C I C C C C I I I I N C I C C I I N N C N N

rig

Co

Gentamicin N C C I N C N I C C C C C N N N C C N C N C C C I C I C C C C C C C C C C N C C C N

ht

py

Granisetron N C C C C C N N C C C C C C C C C C C C C C C C C C I C C C C C C C C C C N C C C C C

s

Heparin C I I S N C N N C C C C I C C C C C C C C I C C C N I N N N C C I C C C N N C C C C I

rig ed.

re

Hydrocortisone C C N N N C C N C C C N C C C C C C C C C I C C C C I N N I C C I C C C N N C C C C N

ht

se

Hydromorphone C C N N C C C N C C C C C N C C C C C C C C C C N C N C C C C C C C C C C N C C C C C

rv

Imipenem-cilastatin C C I N N C N I N C C N C C C C C N C C I N C I C N I C C N C N C C C C C N C C N C C

20

Insulin, regular C N C N N C N N C C C C C C H C I C C C C N C C C C I N I N N C C C N N C N N C C C N

I C C N N C N N C C C C C N N I I I C C I N N C I C I C C C C C C C C C C N C C C N C

11

Labetalol

Re

Levofloxacin I C I C C C N N C C C C C I C N I C C C C N C C C C I C C C C C C C C C C N C C C I C

M

pr

Linezolid C C C C C C N N C C C C C C C C C N C C N C C C C C I C C C C C C C C C C N C C C C C

cM

od

Lorazepam C C C I I C C N I C C C N C C C C C C C C C C C C N N C C C C C C C C C C N C C C C C

uc

ah in w

Magnesium sulfate C C N N N I N N C C C N C N I C C N C C I I C C I C I C C N C C C C C C C N C C C N C

tio

C C N N N C N N C C C C C C I C C C C C C N C C C N I C C C C C C C C C C N C C C C C

on

Mannitol

Meropenem N N N N N C N N N C N N C N N N N N N N N N N C C I I C C C C N N C N C N N N N C C C

n

Pu

Methylprednisolone C C C N I C N N C C C I I C C I I C C C C I C C C N I N I C C C I C C C N N C C C C C

bl

Metoclopramide N C N N N C N N C C C C C C I C C C C C C C C C C C I C C C C C C C C C C N C C C N C

is

Metronidazole C C C C C C N N I C C C N C C C C C C C C C C I C N I C C C C C C C C C C N C C C C C

ho

hi

Micafungin N N I N N N N N N N C C N N N N N N N N N N N N N C N I N I C C N N I C C N N N N C N

ng

le

Midazolam I C C I I C C N C C N C C C I C C C I C C C N C I C I C C N C C C C C C C N C C C I C

or

Morphine sulfate N C C N N C C I C C C C C C N C C C C C C N C C C C N C C C C C C C C C C N C C C N C

ro

in

Nafcillin C C N I N C N N N C C C I C N C C N C C C N C C C C N N N C C N I C C N N N C C C C N

up

Nitroglycerin C C C N N C C N C C C C C C N C C N C C C N C I C G I C C C C N C C C C C N C C C N C

pa

Nitroprussidea I C N I N C C N C C C C I C N C C N I C C N C C C C I C I N C N C C C N C N C C C C C

un ou

rt

Norepinephrine N C C N N C C N C C C C C C N C C C C C C C C C C C I C C C C C C C C C C N C C C N C

w

le

Ondansetron I C N I I C C C C C C C C C I C C C N C N C C C C C N C C C C C C C C C C N C C C I C

ith

ss

Palonosetron I C C C C C N C C C C C C C C C C N C C C C C C C C I C C C C N I C C C C N C C C C C

ot

Pantoprazoleb N C N C C C N C I N C C N N I I C C N C C I N I I C I I I I N C C N C N I N I I I N C

he

tp

Penicillin G C C C I N N N N C N C C N C N C C N C C C N C N C C I C C I C N I C C N C N C C C C C

rw

Phenylephrine I C C N N C C N C C C C C C N C C N C C C N C C C C I C C C C C C C C C C N C C C I C

er

Phenytoin I I N I I I N N I I I I I I I I I N I I I I I I I I I I I I I N I I I I N N N I N I I

is

m

Piperacillan-tazobactam I C I N N C N I C C C C I N C N N N N N N I C C C C C I C I C N I C C C C N I C C C N

is

no

si

Potassium chloride C C C N N C N I C C C C C C C C C C C C C C C C C C I C C C C C C C C C C N C C C C C

on

te

Prochlorperazine I C N I I C N N I I N N C I I I I N I I I N I C I N I C C C C N C C C C C N C C C I C

d.

Propofol C I N C N N N N C N C C N C N C C C N C C I C N C C I N C C C I C C C N C N C C C C I

is

Ringer’s, lactated N C N I R N C C C N C C N C N C C C C C I C C C C C I N C C C N N N C N C C C N C C C

pr

Sodium bicarbonate C C I I N I N N C C C I I C C I I C C C C I C C C C I N I I N C I C I C C N C C C C C

oh

ib

Tacrolimus I C C N N C N N C C C C C C I C C N C C C C C C C N I C C C C C C C C N C I C C C N C

ite

Tigecycline C C I C C N C C C C C C C C C C C N C C C C C C C C I C C C C C N C C C C N C C C C C

d.

Tobramycin C C C N N C N I C C C C C N N C C C C C I C N C I C I C C C C C C C C C C N C C C C C

TMP-SMX C I N I I C N N N C I I I I C I I C I I I N I C I N I C I I I N I N I C N N I I I I I

Vancomycin C C C N N C N N N I C C C N N N N N N N N N C I N C I C C C C C C C C C C N C C C I C

Vasopressin C C C N N C C C C C C C C C C C C C C C C C C C C N I C C C C N C C C N C N C C C N C

Voriconazole C C C C C C N C C C C C C C I C C C C C C C C C C C I C C C C C C C C N C N C C C C C

a

Protect from light. b Testing was performed with ethylenediaminetetra-acetic acid (EDTA)-free formulation.

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

4

Methylprednisolone sod. Succ.

Hydrocortisone Sod. Succ.

Piperacillin-tazobactam

Penicillin G Potassium

Sodium bicarbonate

Imipenem-cilastatin

Potassium chloride

Magnesium sulfate

Ringer’s, lactated

Prochlorperazine

Morphine sulfate

Hydromorphone

Metoclopramide

Norepinephrine

Insulin, regular

Metronidazole

Phenylephrine

Nitroprussidea

Pantoprazoleb

Palonosetron

Nitroglycerin

Voriconazole

Ondansetron

Levofloxacin

Vancomycin

Vasopressin

Meropenem

Granisetron

Tobramycin

Tigecycline

Lorazepam

Micafungin

Midazolam

Tacrolimus

Phenytoin

TMP-SMX

Labetalol

Linezolid

Propofol

Mannitol

Nafcillin

Heparin

C C C C N C C C C C C C C C C C N C C C C C C C C I C C N C C C C C C C C C C I C C C Fluconazole

ll

C C C C C C N I C C N C C C N C C I N C N C N I C N C I I C C I C C C C N C C I I N C Furosemide

rig

Co

C I N C C N C C C C C C C C C C N C C N C C C C C C C C I N C C I C C C C C C I C C C Gentamicin

ht

py

C C C C C C C C C C C C C C C N C C C C C C N N C N C I C C C C N C C C C C C C C C Granisetron

s

C N N C C N I C C C C C N C C C C N C C C C C C C C C I C C N C N C C C C I E I C C Heparin

rig ed.

re

C N C C C I C C C N C N N C C N N C N C C C C C N C C I C C N C C C C C C N I N C C Hydrocortisone

ht

se

C N C C C C C C C C C C C C C C C C C C C C C C N C C I C C N C C I C C C C C C C N Hydromorphone

rv

C C C C C C C C I C I N C C C N N C C C N C C I C C C I N N I C I I R C C C I C C C Imipenem-cilastatin

20

C C C C C I N C C C C C C C C I N N N C C N N C N C I I I C I C G C N C C N I C N C Insulin, regular

C N I C C I C C C C C N C C C I C C N C C C C C I N C I I C C C C N C C C C N C C C

11

Labetalol

Re

C I C C C N C C N N C N C C C N C C N I I N C C I N C I I C I I N C C C C C C C C C Levofloxacin

M

pr

C C C C C C C C C C C C C C C N C C C C C C C C I N C I C C C N C C C C C C N C C C Linezolid

cM

od

C C C C I C C N C C C C C C C C C C C C C C I C I N C I C C N C N C N C C C C C C C Lorazepam

uc

ah in w

C C N C C C C C C C C C I C C C C C C C C C C C N C C I C C C C C C C C C C N C C C Magnesium sulfate

tio

C C C C I C C C C C C I C C C N C C C C C C C C N C C I C C C C N C N C C C I C C C

on

Mannitol

C C N C N C N N C C C I N C C N N C N N N C N C N N N N N N N N I I R C C N N C C C Meropenem

n

Pu

C N N C C C C C C C I C N C C N N C N C C C N N I C C I C N C I N C C C N C I C C C Methylprednisolone

bl

C C C C C C C C C C C C C C C N C C C C C C C C N C C I C C C I C C C C C C I C C C Metoclopramide

is

C C C C C C C C C C C C C C C N C C C C C C C C I N C I C C C N N C N C C C C C C C Metronidazole

ho

hi

N C N C N I I N N C C N N N N N I I N C C C I N N N C I N C N N C N C C N N N N C N Micafungin

ng

le

C C N C N N C C C C C C N N C C I C N C C C C C I C C I I C I N N I C C C C I C C C Midazolam

or

C N C C C N C C C C C C C C C C I C C C C C C C N C C I C C C N C N C C C C N C C C Morphine sulfate

ro

in

C C N C C N N N C C C C N N C C N N C C C C C I C C C I N C C C C C C C C N I N C C Nafcillin

up

C C C C C C C I C C C C N C C C C C C C C C C C N C C I C C C C G C G C C C I C C C Nitroglycerin

pa

C C C C N C C I C C C C N C C C C C C C C C C C N C C I C C I C C C C C C C I C C I Nitroprussidea

un ou

rt

C C C C C N C N C C C C C C C C C C C C C C C C N C C I C C C C C I C C C C I C C C Norepinephrine

w

le

N C C C C N C C C I C C N N C C I C C C C C C N I C C I C C C C C I C C C C I C C C Ondansetron

ith

ss

N C C C I C C C C C C C C N C C N C C I C C C N I N C I C C C C N C C C C C C C C C Palonosetron

ot

C C N N C N I I I I N N N I N I N I N C N N N I I N C I N C I N C N C N C N N N C I Pantoprazoleb

he

tp

N C C C C C N N N N C C N C C N N C C C C C C C N N C I N C C N C N N C N C I N C N Penicillin G

rw

C C C C C I C C C C C C N C C C C C C C C C C C C C C I C C C N C C C C C C I C C C Phenylephrine

er

I I I I I I I I I I I I N I I I I I I I I I I I I I I I I I I I I I I I I I I I I I Phenytoin

is

m

C C C C N I I I C C C C N C C C N I C N C C C C C N N C I C I N C C C C C I C N C C Piperacillin-tazobactam

is

no

si

C C C C N C C C C C C C N N C C C C C C C C C C C C C C I C C C C C C C C C I C C C Potassium chloride

on

te

C N N N I I C I C N C C N C C C N I C C C I C C C I C C I I C C C N N C C C I C C N Prochlorperazine

d.

C C C C C C C I N C C C N I I N N N N C C C C C C N N N I N C C C C N N N I N N N N Propofol

is

N N C C I G C N C N C N I N C N C N C C G C C C N C C C I C C C C N N N C C N C N N Ringer’s, lactated

pr

C C C I I C N C C C C C I C C C N I N C C C I I C N N C I C C N C N C C C C I N C C Sodium bicarbonate

oh

ib

C C C C C C C C C C C C C C C C C C C C C C C C C N C C I C C C N N C N C C N C C C Tacrolimus

ite

C C C C C C C C C C C C C N C C N C C C C C C C C C N C I C C C N C C N C C C C C N Tigecycline

d.

C I N C C N C C C C C C N C C C N C C N C C C C C N C C I I C C I C C C C C I C C C Tobramycin

C E I C I I N C N C N I N I I C N I N I I I I I C N I I I C I I N N I N N C I I N C TMP-SMX

C I N C C C C C C C C C C C C C N C C N C C C C C N N C I N C C N C N C C C C I C C Vancomycin

C C C C C N C C C C C C C C C C C C C C C C C C C C C C I C C C N N C N C C C N C C Vasopressin

C C C N C C C C C C C C C C C C N C C C C I C C C I N C I C C N N N C C C N C C C C Voriconazole

I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

5

Text continued from page 1 help clinicians minimize their occurrence. Continuing

incompatibilities are the most easily detected and are research adding to the existing body of knowledge on

evidenced by visible changes, such as particulate for- IV compatibilities is vital.

mation, haze, precipitation, color change, and gas evo-

lution. Chemical incompatibilities are those that result Suggested Reading

in decomposition of a drug. Loss of potency of greater

than 10% over the defined testing period is considered Bertsche T, Mayer Y, Stahl R, Hoppe-Tichy T, Encke J, Haefeli WE.

Prevention of intravenous drug incompatibilities in an intensive care

chemical incompatibility. Most chemical incompat- unit. Am J Health Syst Pharm. 2008;65(19):1834-1840.

ibilities can be detected only with a suitable analytic

method. Therapeutic incompatibilities in which a drug Canann D, Tyler LS, Barker B, Condie C. Visual compatibility of IV

medications routinely used in bone marrow transplant recipients.

combination results in undesirable antagonistic or syn- Am J Health Syst Pharm. 2009;66(8):727-729.

A

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most compatibility references. Condie CK, Tyler LS, Barker B, Canann DM. Visual compatibility of

rig

Co

The purpose of this chart is to provide data in an

ht

py

s

rig ed.

information can be accessed quickly and conveniently. Data on file. Wyeth Pharmaceuticals.

re

ht

se

the type of incompatibility or compatibility is not spec-

rv

ified in this chart. A designation of “compatible” indi-

20

cates that the combination evaluated appears to be Nemec K, Kopelent-Frank H, Greif R. Standardization of infusion solu-

11

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M

pr

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od

of compatibility. All conditions that may affect com- Trissel LA, ed. Handbook on Injectable Drugs. 16th ed. Bethesda, MD:

American Society of Health-System Pharmacists; 2011.

patibility cannot be included in such a format and it

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ah in w

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arise, but it is hoped that the information provided may Dr. Cayo reports no relevant conflicts of interest.

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I N D E P E N D E N T LY D E V E L O P E D B Y M C M A H O N P U B L I S H I N G

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