Tinea versicolor

Tinea versicolor is a condition characterized by a skin eruption on the trunk

Tinea versicolor
and proximal extremities.[1] The majority of tinea versicolor is caused by the
fungus Malassezia globosa, although Malassezia furfur is responsible for a Synonyms Dermatomycosis
small number of cases.[2][3] These yeasts are normally found on the human skin furfuracea,[1] pityriasis
and become troublesome only under certain circumstances, such as a warm and versicolor,[1] tinea flava,[1]
humid environment, although the exact conditions that cause initiation of the lota
disease process are poorly understood.[2][4]

The condition pityriasis versicolor was first identified in 1846.[5] Versicolor

comes from the Latin, from versāre to turn + color.[6] It is also commonly
[7]
referred to as Peter Elam's disease in many parts of South Asia.

Contents
Signs and symptoms
Specialty Dermatology

Pathophysiology
Diagnosis
Treatment
Epidemiology
References
External links

Signs and symptoms

The symptoms of this condition include:

Occasional fine scaling of the skin producing a very superficial ash-like

scale
Pale, dark tan, or pink in color, with a reddish undertone that can darken
when the patient is overheated, such as in a hot shower or during/after
exercise. Tanning typically makes the affected areas contrast more
starkly with the surrounding skin.[9]
Sharp border[10]
Pityriasis versicolor is more common in hot, humid climates or in those who sweat
heavily, so it may recur each summer.[10]
Pityriasis versicolor commonly
causes hypopigmentation in people
The yeasts can often be seen under the microscope within the lesions and typically
[11] as the round yeasts produce
with dark skin tones.
have a so-called "spaghetti and meatball appearance"
filaments.

In people with dark skin tones, pigmentary changes such as hypopigmentation (loss of color) are common, while in those with lighter
[12]
skin color, hyperpigmentation (increase in skin color) is more common. These discolorations have led to the term "sun fungus".

Pathophysiology
In cases of tinea versicolor caused by the fungus Malassezia furfur,
lightening of the skin occurs due to the fungus's production of azelaic acid,
which has a slight bleaching effect.[13]

Diagnosis
Tinea versicolor may be diagnosed by a potassium hydroxide (KOH)
Pityriasis versicolor in a 27-year-old man
preparation and lesions may fluoresce copper-orange when exposed to and electron micrograph of his skin showing
Wood's lamp.[14] The differential diagnosis for tinea versicolor infection round Malassezia spores (S).[8]
includes:

Progressive macular hypomelanosis

Pityriasis alba
Pityriasis rosea
Seborrheic dermatitis
Erythrasma
Vitiligo
Leprosy
Syphilis
Post-inflammatory hypopigmentation

Treatment
Treatments for tinea versicolor include:

Topical antifungal medications containing selenium sulfide are often

recommended.[14] Ketoconazole (Nizoral ointment and shampoo) is
another treatment. It is normally applied to dry skin and washed of f after
10 minutes, repeated daily for two weeks.Ciclopirox (Ciclopirox Tinea versicolor fluorescence under
olamine) is an alternative treatment to ketoconazole, as it suppresses Wood's lamp
growth of the yeast Malassezia furfur. Initial results show similar efficacy
to ketoconazole with a relative increase in subjective symptom relief due
to its inherent anti-inflammatory properties.[15] Other topical antifungal agents such asclotrimazole, miconazole,
terbinafine, or zinc pyrithione can lessen symptoms in some patients.[16] Additionally, hydrogen peroxide has been
known to lessen symptoms and, on certain occasions, remove the problem, although permanent scarring has
occurred with this treatment in some sufferers. Clotrimazole is also used combined with selenium sulfide.
Oral antifungals including ketoconazole or fluconazole in a single dose, or ketoconazole for seven days, or
itraconazole can be used.[17][18] The single-dose regimens, orpulse therapy regimens, can be made more effective
by having the patient exercise 1–2 hours after the dose, to induce sweating. The sweat is allowed to evaporate, and
showering is delayed for a day, leaving a film of the medication on the skin.[19]

Epidemiology
This skin disease commonly affects adolescents and young adults, especially in warm and humid climates. The yeast is thought to
feed on skin oils (lipids), as well as dead skin cells. Infections are more common in people who have seborrheic dermatitis, dandruff,
and hyperhidrosis.[4]

References
1. Rapini, Ronald P; Bolognia, Jean L.; Jorizzo, Joseph L (2007).Dermatology: 2-Volume Set. St Louis: Mosby.
pp. Chapter 76. ISBN 1-4160-2999-0.
2. Morishita N; Sei Y. (December 2006). "Microreview of pityriasis versicolor andMalassezia species". Mycopathologia.
162 (6): 373–76. doi:10.1007/s11046-006-0081-2(https://doi.org/10.1007%2Fs11046-006-0081-2) .
 3. Prohic A; Ozegovic L. (January 2007). M " alassezia species isolated from lesional and non-lesional skin in patients
with pityriasis versicolor".Mycoses. 50 (1): 58–63. doi:10.1111/j.1439-0507.2006.01310.x(https://doi.org/10.1111%2
Fj.1439-0507.2006.01310.x). PMID 17302750 (https://www.ncbi.nlm.nih.gov/pubmed/17302750).
4. Weedon, D. (2002). Skin pathology (2nd ed.). Churchill Livingstone.ISBN 0-443-07069-5.
5. Inamadar AC, Palit A (2003)."The genus Malassezia and human disease" (http://www.ijdvl.com/text.asp?2003/69/4/
265/4990). Indian J Dermatol Venereol Leprol. 69 (4): 265–70. PMID 17642908 (https://www.ncbi.nlm.nih.gov/pubme
d/17642908).
6. "versicolor" (http://dictionary.reference.com/browse/versicolor). Collins English Dictionary — Complete & Unabridged
10th Edition. HarperCollins Publishers. Retrieved March 2, 2013.
7. Kaushik A, Pinto HP, Bhat RM, Sukumar D, Srinath MK (2014)."A study of the prevalence and precipitating factors
of pruritus in pityriasis versicolor"(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030364). Indian Dermatology
Online Journal. 5 (2): 223–224. doi:10.4103/2229-5178.131141(https://doi.org/10.4103%2F2229-5178.131141) .
PMC 4030364 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030364) . PMID 24860771 (https://www.ncbi.nlm.ni
h.gov/pubmed/24860771).
8. Ran Yuping (2016). "Observation of Fungi, Bacteria, and Parasites in Clinical Skin Samples Using Scanning Electron
Microscopy". In Janecek, Milos; Kral, Robert.Modern Electron Microscopy in Physical and Life Sciences
. InTech.
doi:10.5772/61850 (https://doi.org/10.5772%2F61850). ISBN 978-953-51-2252-4.
9. "What to Avoid While Treating Tinea Versicolor" (https://web.archive.org/web/20130727011050/http://tineaversicolor
.
us:80/whattoavoid.html). Archived from the original (http://tineaversicolor.us/whattoavoid.html) on 2013-07-27.
Retrieved 2013-01-05.
10. Pityriasis versicolor | DermNet New Zealand(http://www.dermnetnz.org/fungal/pityriasis-versicolor.html).
Dermnetnz.org. Retrieved on 2016-10-14.
11. "Adolescent Health Curriculum - Medical Problems - Dermatology - Papulosquamous Lesions (B4)"
(http://www.usc.
edu/student-affairs/Health_Center/adolhealth/content/b4derm4.html). Retrieved 2008-12-10.
12. "Tioconazole (Topical Route) - MayoClinic.com"(http://www.mayoclinic.com/health/drug-information/DR601345).
Retrieved 2008-12-10.
13. Vary JC Jr (November 2015). "Selected Disorders of Skin Appendages-Acne, Alopecia, Hyperhidrosis".The Medical
Clinics of North America. 99 (6): 1195–1211. doi:10.1016/j.mcna.2015.07.003(https://doi.org/10.1016%2Fj.mcna.20
15.07.003). PMID 26476248 (https://www.ncbi.nlm.nih.gov/pubmed/26476248).
14. Likness, LP (June 2011). "Common dermatologic infections in athletes and return-to-play guidelines".
The Journal of
the American Osteopathic Association. 111 (6): 373–379. PMID 21771922 (https://www.ncbi.nlm.nih.gov/pubmed/21
771922).
15. Ratnavel RC, Squire RA, Boorman GC (2007). "Clinical efficacies of shampoos containing ciclopirox olamine (1.5%)
and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis".J Dermatolog Treat. 18 (2): 88–96.
doi:10.1080/16537150601092944(https://doi.org/10.1080%2F16537150601092944) . PMID 17520465 (https://www.
ncbi.nlm.nih.gov/pubmed/17520465).
16. Faergemann, Jan (2000). "Management of Seborrheic Dermatitis and Pityriasisersicolor".
V Am. J. Clin. Dermatol.1
(2): 75–80. doi:10.2165/00128071-200001020-00001(https://doi.org/10.2165%2F00128071-200001020-00001) .
PMID 11702314 (https://www.ncbi.nlm.nih.gov/pubmed/11702314).
17. Faergemann J, Gupta AK, Al Mofadi A, Abanami A, Shareaah AA, Marynissen G (January 2002). "Efficacy of
itraconazole in the prophylactic treatment of pityriasis (tinea) versicolor"
(http://archderm.ama-assn.org/cgi/pmidlook
up?view=long&pmid=11790169). Arch Dermatol. 138 (1): 69–73. doi:10.1001/archderm.138.1.69(https://doi.org/10.
1001%2Farchderm.138.1.69). PMID 11790169 (https://www.ncbi.nlm.nih.gov/pubmed/11790169).
18. Mohanty J, Sethi J, Sharma MK (2001)."Efficacy of itraconazole in the treatment of tinea versicolor" (http://www.ijdvl.
com/article.asp?issn=0378-6323;year=2001;volume=67;issue=5;spage=240;epage=241;aulast=Mohanty) . Indian J
Dermatol Venereol Leprol. 67 (5): 240–1. PMID 17664760 (https://www.ncbi.nlm.nih.gov/pubmed/17664760).
19. Ketoconazole (http://www.fpnotebook.com/ID/Pharm/Ktcnzl.htm). Fpnotebook.com. Retrieved on 2016-10-14.

External links
Classification ICD-10: V·T·D
B36.0 · ICD-9-CM:
Media related to Tinea versicolor at Wikimedia Commons
111.0 · MeSH:
 D014010 ·
DiseasesDB:
10071
External MedlinePlus:
resources 001465 ·
eMedicine:
derm/423

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inea_versicolor&oldid=830560699"

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