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Stem Cells
Stem cells
retain the ability to renew themselves through
mitotic cell division
can differentiate into adverse range of
specialized cells types (plasticity)
unspecialized cells
Embryonic stem cells are isolated from the inner cell mass
of the blastocyst. The embryos are excess ones produced
from in vitro fertilisation, but the practice is still controversial
because it does destroy the embryo, which could have
been implanted to create a baby.
• The stem cells and niche may induce each other during
development and reciprocally signal to maintain each
other during adulthood.
Several factors are important to regulate stem cell
characteristics within the niche:
Immune rejection
Immunosupressive drugs
Nuclear transfer
Using adult stem cells
Contamination
Fabrication
Hirschsprung Disease
Manajemen
dekompresi (rectal tube dan NGT)
stabilitas cairan, elektrolit, asam basa dan temperatur
keseimbangan nutrisi
kolostomi
operasi definitif
Patofisiologi
Normal : Sel neuroenterik bermigrasi dari krista neuralis
dari oral ke anal; sampai esofagus minggu V, midgut
minggu VII, colon distal minggu XII
HSCR
ENS Origins and Development
GDNF
EDN3
GDNF and EDN3
GDNF
addition
enhance
migration
Key Elements of Stem Cells Therapy for HSCR