HEMOSTAN/ Tranexamic acid

______________________________________________________

Hemostan® [inj]
Biomedis [ United Lab ]

MIMS Class : Haemostatics

Contents
Tranexamic acid
Indications
Listed in dosage.
Dosage
Cap OB-GYNE Menorrhagia/menometrorrhagia 1-1.5 g (12-25 mg/kg body wt) 6-8 hrs
for 3-4 days. Inj General surgeries 0.5-1 g (10-15 mg/kg body wt) IV every 8-12 hrs
immediately after surgery. Orally, 1-1.5 g every 6-8 hrs. Coronary artery bypass surgery
1 g IV bolus before surgery or 30 mg/kg in aspirin treated patients; 200 mg/hr infusion
during surgery. Valvular heart surgery 100 mg/kg body wt IV before surgery. Correction
of congenital heart disease in childn Initial bolus 15 mg/kg body wt IV before & after
surgery. Thoracic aortic surgery 1 g IV before skin incision, 400 mg infusion during
surgery & 500 mg in pump priming. Orthopedic surgery knee replacement/arthroplasty
10 mg/kg body wt IV before surgery repeat after 3 hrs. Total hip replacement/arthroplasty
Initial dose: 10 mg/kg body wt IV bolus repeat after 3 hrs & 1 mg/kg/hr continuous
infusion for 10 hrs after surgery. Scoliosis surgery Initial dose: 10 mg/kg body wt &
infusion of 1 mg/kg/hr. Medical Epistaxis in cases of recurrent bleeding 1 g every 8 hrs
for 7 days. GI hemorrhage 1 g IV every 4 hrs for 3 days; 1.5 g orally every 6 hrs for 4
days. Hereditary angioneurotic edema 1-1.5 g every 8-12 hrs. Dental extraction w/
coagulopathies 10 mg/kg body wt IV before surgery; 25 mg/kg body wt 6-8 hrs for 6-8
days after surgery, orally.
Special Precautions
Not advisable to use for prolonged periods in patients predisposed to thrombosis. Not
recommended for prophylaxis during pregnancy & before delivery.
Adverse Drug Reactions
GI disorders, nausea, vomiting, anorexia, headache may appear, impaired renal
insufficiency, hypotension when IV inj is too rapid.
View ADR Monitoring Website
Drug Interactions
Increased risk of clotting when used w/ estrogen-containing OC.
View more drug interactions with Hemostan
Pregnancy Category (US FDA)
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but
there are no controlled studies in pregnant women or animal-reproduction studies have
shown an adverse effect (other than a decrease in fertility) that was not confirmed in
controlled studies in women in the 1st trimester (and there is no evidence of a risk in later
trimesters).

MIMS Class
Haemostatics
ATC Classification
B02AA02 - Tranexamic acid ; Belongs to the class of amino acid antifibrinolytics. Used
in the treatment of hemorrhage.
Poison Schedule
Rx
Presentation/Packing
Form Packing/Price Photo
Hemostan capsule Hemostan 250 mg x 100's (P1815.2)
Hemostan 500 mg x 100's (P2462.3)

Hemostan injection Hemostan 250 mg/2.5 mL x 5's (P765.5)

Hemostan 500 mg/5 mL x 5's (P914.6)

Mims.com
______________________________________________________

AMINOPHYLLINE/
______________________________________________________

GENERIC NAME: AMINOPHYLLINE - INJECTION (am-in-AWF-uh-lin)

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose
| Notes | Missed Dose | Storage | Medical Alert

USES: Aminophylline opens breathing passages in the lungs. It is used to treat breathing
problems such as asthma, chronic bronchitis and emphysema.

HOW TO USE: Use this medication exactly as prescribed. This drug is given slowly by
vein (IV), diluted in IV fluids as directed. Dosage is based on your condition and
response to therapy as well as drug blood levels. Learn all preparation and administration
instructions in the product package and ask your doctor or pharmacist if you are unclear
on any information. A harmless yellowish discoloration may occur when this drug is
mixed in dextrose. Do not use if the solution contains crystals/particles. Make sure
needles and any medical supplies are stored safely and disposed of properly.

SIDE EFFECTS: Flushing, nausea, vomiting, diarrhea, loss of appetite, irritability,

nervousness, trouble sleeping and increased urination may occur. If these effects persist
or worsen, notify your doctor promptly. Unlikely but report promptly: stomach pain,
coffee-ground vomit, dizziness/fainting, severe mental/mood changes, rapid breathing,
irregular heartbeat (unusually fast or slow), chest pain, muscle twitching, seizures. In the
unlikely event you have an allergic reaction to this drug, seek immediate medical
attention. Symptoms of an allergic reaction include: swelling of the throat, rash, trouble
breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor your medical history, including: any allergies, seizure
disorders, high blood pressure, diabetes, stomach/intestinal ulcer, eye disease (glaucoma),
heart disease, liver or kidney disease, flu symptoms (e.g., high fever), other lung disease,
thyroid disease. Avoid drinking large amounts of beverages containing caffeine (e.g.,
coffee, tea, cola). Smoking may affect this medication. Inform your physician if you are a
smoker. Also consult your physician if you quit smoking. A dosage adjustment may be
necessary. Caution is advised when using this in the elderly, as this group may experience
more drug side effects. Caution is advised when using this in children, as this group may
experience more drug side effects. A preservative (benzyl alcohol) which may be found
in this product or in the liquid used to mix this product (diluent) can infrequently cause
serious problems (sometimes death), if given in large amounts (more than 100 mg/kg
daily) to an infant during the first months of life (neonatal period). The risk is also greater
with low birth weight infants. Symptoms include sudden gasping, low blood pressure, or
a very slow heartbeat. Report these symptoms to the doctor immediately should they
occur. If possible, a preservative-free product should be used when treating neonates.
This medication should be used only when clearly needed during pregnancy. Discuss the
risks and benefits with your doctor. This drug is excreted into breast milk. Consult your
doctor before breast-feeding.

aminophylline-injection (cont.)

DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription

medication you may use, especially: cimetidine, allopurinol, lithium, quinolone
antibiotics (e.g., ciprofloxacin, levofloxacin), macrolide antibiotics (e.g., clarithromycin,
erythromycin), rifamycins (e.g., rifampin), birth control pills, carbamazepine, phenytoin,
barbiturates (e.g., phenobarbital), beta-blockers (e.g., propranolol), "blood thinners" (e.g.,
warfarin), fluvoxamine, mexiletine, moricizine, other "adrenalin- like" drugs (e.g.,
ephedrine), digoxin, pentoxifylline, tacrine, dipyridamole injection, methotrexate,
disulfiram, thiabendazole, zileuton, flu vaccine or ticlopidine, St John's wort. Do not start
or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or

emergency room immediately. US residents can call the US national poison hotline at 1-
800-222-1222. Canadian residents should call their local poison control center directly.
Symptoms of overdose may include fast or irregular heartbeat, nausea or vomiting,
unusual nervousness or restlessness, agitation, irritability, headache, and seizures.

NOTES: Do not share this medication with others. Laboratory and/or medical tests will
be performed to monitor for side effects or response to treatment.
MISSED DOSE: If you miss a dose, contact your doctor or pharmacist promptly to
establish a new dosing schedule.

STORAGE: Store the vials at room temperature between 59 and 86 degrees F (15 to 30
degrees C) away from light. Do not freeze. Do not use after the expiration date. The drug
mixed in IV fluids should be used within 48 hours.

MEDICAL ALERT: Your condition can cause complications in a medical emergency.

For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-
1507 (Canada).

http://www.medicinenet.com/aminophylline-injection/page2.htm

______________________________________________________

D50/50
______________________________________________________

D50, the half maximal inhibitory dose, represents the dose of light or ionising radiation
that is required for 50% inactivation of a tumor cell population. It can also, in parallel
fashion, represent the dose of a drug or toxin necessary to kill 50% of a cellular
population.

D50 also is a solution of 50% dextrose in water, also written D50W or for 50% dextrose
in normal saline, D50NS.