Yaqin Si Peking University

Yaqin Si
Mobile: +86-188-1053-3112 Email: siyaqin@pku.edu.cn

Research Interests
Precision Medicine, Modelling Study, Screening Strategies, Risk Prediction, Causal Inference, Health Economics

Educational Background
09/2016-now Health Science Center, Peking University Beijing, China
 Master of Science in Epidemiology and Biostatistics, School of Public Health, GPA: 3.7 / 4.0
 Dissertation: Effectiveness of Different Screening Strategies for Primary Prevention of Cardiovascular Diseases in a Rural
Chinese Population
 Major Courses: Linear Regression, Generalized Linear Models, Multivariate Statistical Analysis, Genetic Epidemiology,
Integration and Application of Medical Evidence, Analytical Tools in Epidemiology Research
07/2016 School of Public Health, Fudan University Shanghai, China
 Summer School (A-): Advanced Statistical Methods in Public Health. Syllabus: Data Visualization and Inference in R,
Bayesian Inference, Multilevel Model, Variable Selection (Classification Tree, LASSO Regression) and Validation, Spline
09/2011-07/2016 Health Science Center, Peking University Beijing, China
 Bachelor of Medicine in Preventive Medicine, School of Public Health, GPA: 3.7 / 4.0
 Major Courses: Advanced Mathematics (I & II) , Biostatistics, Epidemiology, Introduction to Computation, Medical
Genetics, Biology, Biochemistry, Neurology, Medical Imageology, Internal Medicine, Clinical Practice
09/2013-07/2016 National School of Development, Peking University Beijing, China
 Bachelor of Economics, Dual Degree, GPA：3.4 / 4.0
 Major Courses: Linear Algebra, Probability and Statistics, Econometrics, Principle of Economics, Macroeconomics,
Microeconomics, Options Futures and Derivatives Pricing, Behavioral Economics

Research Experiences
Department of Epidemiology and Biostatistics, School of Public Health, Peking University
07/2016-03/2018, A prospective cohort study on non-communicable diseases in Rural Northern Chinese Communities.
Advisor: Prof. Pei Gao (peigao@bjmu.edu.cn) Prof. Yonghua Hu (yhhu@bjmu.edu.cn)
Part 1 Field study
 Participated in this field study as an investigator, conducted a survey based on paper-free questionnaires, which covered
information about demographics, nutrition, anthropometrics, disease history, and medication.
 Examined Pulse Wave Velocity, body fat and carotid ultrasound (as assistant), tested blood glucose and HbA1c.
Part 2 Effectiveness of Different Screening Strategies for Primary Prevention of Cardiovascular Diseases in a Rural Chinese
Population
 Set Markov Status of cardiovascular diseases (CVD) according to natural history of diseases from alive without CVD to
death of any causes, obtained status transition probability from publications and administrative databases.
 Used China-PAR Cardiovascular Diseases Risk Prediction Model and the strategy recommended by Chinese Guideline for
prevention of cardiovascular diseases to stratify people into different risk strata. Modeled the effect of screening and treating
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high risk population in different scenarios compared with no screening. Evaluated health impact of each screening strategy
with Number Need to Treat, Number Need to Screen, Life Year Gained and Quality Adjusted Life Year.
 Conduct probabilistic sensitivity analysis concerning uncertainty of all parameters.
9/2016-now, Focusing on the CHinese Electronic health Records Research in Yinzhou(CHERRY) study
Advisor: Prof. Pei Gao (peigao@bjmu.edu.cn)
Part 1 Data preprocessing and management: CVD risk factors, diagnosis and death certification. (Team Leader)
 Extracted variables with SQL in Rhive, formatted data with R packages (dplyr, tidyr and lubridate).
 Described baseline characteristics (age, urban/rural, education, BMI, smoking, alcohol) by sex and overall CVD events/death
in the protocol paper.
Part 2 CVD incidence and all-cause mortality (Team Leader)
 Linked epidemiological surveillance data, chronic diseases management data and inpatient Electronic Medical Records data
to identify first-ever cardiovascular events and deaths. Identified permanent residents in Electronic Health Records database
as total population.
 Analyzed incidence rate of CVD (combine stroke and MI, around 250/100,000 person-years) and all-cause mortality (around
700/100,000 person-years) in people older than 40 years old from 2010 to 2016, and standardized according to 2010 Chinese
population census. Used Chi-square test to examine differences between sex and age subgroups.
 Tested trend with linear regression. Beta coefficient showed stroke, MI and death were stable.
Part 3 Multimorbidity and Risk of Mortality in China
 Identified exposure and outcome: number of multimorbidity and time to death, multimorbidity was defined as suffering from
≥2 of the following disorders: Cancer, CVD, Diabetes and Hypertension.
 Calculated prevalence of one (16.16%), two (4.11%), three (0.36%) disorders, and hazard ratios (HR, 1.17, 1.78, 2.97) for
death compared to people with none of these conditions.
10/2016-02/2017, Efficacy of statin for Primary Prevention in East Asian Adults: A Systematic Review and Meta-Analysis.
(Team Leader)
 Clarified the research question, set inclusion and exclusion criteria in terms of PICOTS (Population, Intervention, Control,
Outcomes, Time, Setting and Study Design), designed searching strategies and scanned retrieved titles and abstracts from
online databases (PUBMED, EMBASE and Cochrane Central Register of Controlled Trials)
 Assessed the quality and risk of bias for included articles, used Cochrane Collaboration’s tool for Assessing Risk of Bias
for Randomized Clinical Trials, and Newcastle-Ottawa Scale for cohort studies.
 Synthesized data from qualified articles with random-effect model in Stata 14. Used I-square to measure heterogeneity,
Egger’s test to measure publication bias.
 Concluded that using statin could reduce 27% risk of major cardiovascular diseases in East Asia adults for CVD primary
prevention, Relative Risk 0.73, (95% CI: 0.62, 0.83), no significant heterogeneity (I2=0.0%, P=0.536)
Department of Health Service Management, School of Public Health, Peking University
Advisor: Prof. Li Yang (lyang@bjmu.edu.cn)
12/2015-02/2016, Factors Influencing Patient Referral between Teaching Hospitals and Community Clinics
 Designed Open Ended Interview Program and interviewed officers in Xicheng Health Bureau, patients and doctors in
hospitals, recorded the interview with participants’ permission, coded with MAXQDA software, and synthesized the results.
Yaqin Si Peking University

Training Experience
11/2015-Present School of Public Health, Peking University Beijing, China
 Reviewed literatures, Attended Journal Club weekly--oral reports and comments
 Attended scientific conferences, Communicated with other researchers
06/2015-09/2015 Center of Disease Control Intern Public Health Doctor Shenzhen, China
 Investigated cases of infectious diseases, food poisoning, and chronic diseases, Sampled and cultivated bacteria
02/2014-02/2015 Beijing Shijitan Hospital Medical Intern Beijing China
 Communicated with patients, tracked medical history, conducted physical examination and lab testing (Blood Glucose,
Arterial Blood Gas), observed and assisted surgery, interpreted laboratory and imaging results
07/2013-09-2013 National Key Laboratory of Epidemiology, Peking University Beijing China
 Trained for field study in data collection from questionnaires and blood tests, Practiced DNA extraction.

Publications
 [Effectiveness of Different Screening Strategies for Primary Prevention of Cardiovascular Diseases in a Rural Chinese
Population. Journal of Peking University(Health Sciences), 2018, accepted, First Author]
 [Incidence rate and risk factors of chronic kidney disease in population with diabetes: a big data analysis from the CHinese
Electronic health Records Research in Yinzhou (CHERRY) Study. Journal of Peking University(Health Sciences), 2018,
accepted, Fifth Author]
 Incidence of Cardiovascular Diseases and All-cause Mortality: Cardiovascular Outcomes from The CHinese Electronic
health Records Research in Yinzhou (CHERRY) Study, 2018, in preparation, First Author
 Multimorbidity and Risk of Mortality in China: Results From the CHinese Electronic health Records Research in Yinzhou
(CHERRY) Study, Circulation. 2017;135: AP166, Fifth Author. http://circ.ahajournals.org/content/135/Suppl_1/AP166
 Lin H, Tang X, Shen P, Zhang D, Wu J, Zhang J, Lu P, Si Y, Gao P. Using big data to improve cardiovascular care and
outcomes in China: a protocol for the CHinese Electronic health Records Research in Yinzhou (CHERRY) Study. BMJ open
2018;8:e019698.

Extracurriculum Experience
2011-2012 Private Tutor
 Tutored two high school students on Math, Chemistry and Physics during summer holidays
2012-2013 School of Public Health, Peking University vice-President of the Student Union
 Promoted health knowledge about HIV/AIDS and environmental pollution in communities.
2012-2015 Health Education and Survey
 Interviewed administrative officers, doctors and patients to learn about their degree of satisfaction of New Rural Cooperative
Medical Scheme insurance in Jincheng, China
 Conveyed health education on knowledge and attitudes towards HIV/AIDS among high school students in Jincheng, China
 Presented health education of Helicobacter Pylori and Dental Health in local communities and schools of migrant children
2011-2014 Peking University Third Hospital and Beijing Red Cross Blood Center Volunteer (part-time)
 Accommodated to hospital environment and work processes, prepared for internship
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 Patient / Blood donor registration: demographics and blood pressure.

Skills
 Software: Proficiency in R, Stata, SPSS, PASS, TreeAge, C-survey, Familiar with SAS
 Language: TOFEL (Speaking 23, Writing 27, Reading 22, listenting 28)
GRE (Verbal 154, Quantitative 170, Writing 3.0)