Saba Omer

Question #1

a. Yes drug will diffuse across the cell membrane at physiologic pH. Since drug’s pka is 8.5 and it’s a
weak base in that case physiologic PH of the body 7.2 will help drug to diffuse across the cell
membrane.
According to Henderson–Hasselbalch equation: For weak base, more basic the pH results in
more unionized drug.
b. Un-ionized drugs are lipid soluble because they are not charged and does not make large
complexes.
c. Being a lipid soluble drug, drug will enter in hepatic circulation may also enter the bile and be
excreted into the duodenum and small intestines. Depending on the chemical properties of the
drug, it may then be re-absorbed from the small intestine and recirculate throughout the body
(enterohepatic recycling). If it will not re-absorbed will pass through the large intestines and be
excreted in the feces.
d. Being a lipid soluble drug it is likely that drug penetrate sanctuaries.
e. The most common feature of p- glycoprotein substrate is, hydrophobicity and lipophilic nature.
This drug due to its lipophilic nature can be a substrate for p-glycoprotein.

Question #2

a. Half life
T1/2= Vd/Cl x0.7
210/225 x0.7 =0.653/Hr
b. Cmax
c. IV to PO conversion

Question #3

In class discussion

Question #4

In class

Question #5

Considering drug have a short half-life, this drug is likely to be time dependent.

Question #6 rep

Question #7 rep
 Saba Omer

Question #8

MIC range MIC 50 MIC

Least susceptible 90
Escherichia coli <0.03-128 1 16
Because MIC of
Klebsiella pneumoniae <0.03-128 2 32
the drug is the
Pseudomonas aeruginosa 8->256 8 >256
highest among all Rhodococcus equi 0.06->256 2 32
for this organism Pasteurella multocida <0.03-1 0.03 0.06
Staphylococcus aureus 0.5-256 8 16
Staphylococcus (pseud)intermedius 0.125-128 4 16 Most
Streptococcus equi <0.03-64 1 8 susceptible
because MIC
of the drug is
the lowest for
this organism