FACULTY OF ENGINEERING TECHNOLOGY

Technical Report

Subject/Code: BTP1613 Introduction to Pharmaceutical Science Date:7/3/18

Section: 1A
Module title: Uniformity of weight of tablets and capsules Groups Member:
1. Goh Yi Ling (TD17024)
Learning Outcome: 2.Cham Pa A/P Ai Wong (TD17010)
3. Nurul Syamira Muhd Anuar (TD17017)
4. Mahmud Zuhdi Bin Mohamad Poze
(TD17020)
Objectives:
1. To determine the uniformity of weight of tablets and capsules.
2. To ensure the consistency of dosage unit.

Apparatus/Material:
-Micro balance
-Weighing boat
-Tablets dosage form
-Capsule dosage form

Procedure:
1. 20 capsules are selected at random.
2. One capsule was weighed. The capsule was opened and the contents are removed as completely as possible. The
emptied shells are weighed. The net weight of its contents are determined, that is by subtracting the weight of shells
from the weight of the intact capsule.
3. The procedure are repeated with another 19 capsules.
4. For tablets dosage, 20 tablets are weighed.
5. The average weight was determined from the sum of individual’s net weight.
6. The percentage of deviation from the average net weight for each capsules are determined.
7. The deviation of individual weight from the average weight should not exceed the limits given below.
Average weight of tablet (mg) Percentage Difference Number of tablet
<130 10 Maximum 2
130-324 7.5 Maximum 2
>324 5 Maximum 2
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Technical Report

Result:
(𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑖𝑛𝑑𝑖𝑣𝑖𝑑𝑢𝑎𝑙 𝑡𝑎𝑏𝑙𝑒𝑡 − 𝑎𝑣𝑒𝑟𝑎𝑔𝑒 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑡𝑎𝑏𝑙𝑒𝑡)
𝑝𝑒𝑟𝑐𝑒𝑛𝑡𝑎𝑔𝑒 𝑜𝑓 𝑑𝑒𝑣𝑖𝑎𝑡𝑖𝑜𝑛 = × 100%
𝑎𝑣𝑒𝑟𝑎𝑔𝑒 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑡𝑎𝑏𝑙𝑒𝑡

For capsules:

Capsules Weight (mg) Percentage of deviation (%)

1 100.6 -1.9493
2 101.2 -1.3645
3 104.9 2.2417
4 103.3 0.6823
5 104.9 2.2417
6 100.7 -1.8519
7 100.0 -2.5341
8 96.7 -5.7505
9 103.1 0.4873
10 103.8 1.1696
11 101.8 -0.7797
12 101.8 -0.7797
13 102.5 -0.0975
14 103.2 0.5848
15 104.6 1.9493
16 104.6 1.9493
17 103.6 0.9747
18 103.0 0.3899
19 104.8 2.1442
20 102.8 0.1949
Total 205.2
Average 102.6

𝑇𝑜𝑡𝑎𝑙 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 20 𝑐𝑎𝑝𝑠𝑢𝑙𝑒𝑠 205.2𝑚𝑔

𝐴𝑣𝑒𝑟𝑎𝑔𝑒 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑐𝑎𝑝𝑠𝑢𝑙𝑒 = = = 10.26𝑚𝑔
20 20
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Technical Report

For tablets:

Tablets Weight (mg) Percentage of deviation (%)

1 606.5 2.0872
2 596.8 0.4545
3 585.7 -1.4139
4 600.6 1.0941
5 596.0 0.3198
6 581.7 -2.0872
7 597.2 0.5218
8 601.8 1.2961
9 589.2 -0.8248
10 590.5 -0.6060
11 586.5 -1.2792
12 596.1 0.3366
13 596.9 0.4713
14 587.9 -1.0436
15 594.4 0.0505
16 594.8 0.1178
17 594.3 0.0337
18 594.8 0.1178
19 594.4 0.0505
20 595.0 0.1515
Total 11881.1
Average 594.1

𝑇𝑜𝑡𝑎𝑙 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 20 𝑡𝑎𝑏𝑙𝑒𝑡𝑠 11881.1𝑚𝑔

𝐴𝑣𝑒𝑟𝑎𝑔𝑒 𝑤𝑒𝑖𝑔ℎ𝑡 𝑜𝑓 𝑡𝑎𝑏𝑙𝑒𝑡 = = = 594.1𝑚𝑔
20 20

Discussion:
Based on the result, the capsules used have an average weight of 102.6 mg which is under the category of ‘less
than 130 mg’.

Average weight of tablet (mg) Percentage Difference Number of tablet

<130 10 Maximum 2
All the 20 tablets that have been carried out did not exceed the limit of ± 10.0% and therefore, they are considered
to pass the test.

For tablets, since our average weight is 594.1 mg, the deviation of individual net weight should not exceed the
limits given below:
Average weight of tablet (mg) Percentage Difference Number of tablet
>324 5 Maximum 2
From the results, all our capsules are having a deviation of ± 5%, which means that all capsules have uniform
weights. , so all the capsules pass the test .This may indicate the uniformity of the capsules production.
 FACULTY OF ENGINEERING TECHNOLOGY
Technical Report

Test of uniformity of weight (mass) is carried out to tablets and capsules to ensure accurate and consistent dosage
form to be administered by patients. This is necessary to ensure that patients take a precise pharmaceutical dose.

Conclusion & Recommendation:

Date Submit: Checked by:

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