Nutrition 411: The Diabetic Foot Ulcer — Can Diet

Make a Difference?

Thursday, 11/07/13 | 10820 reads

1 8 0 419

Issue Number:
Volume 59 - Issue 11 - November 2013 ISSN 1943-2720

Login toDownload PDF version

Liz Friedrich, MPH, RD, CSG, LDN; and Nancy Collins, PhD, RD, LD/N, FAPWCA

The statistics are shocking: 25.8 million Americans, or 8.3% of the population of the US, has
been diagnosed with diabetes.1 Among the complications of the disease are diabetic foot ulcers
(DFUs), which affect as many as 20% of patients with diabetes during their lifetime.2 DFUs can
significantly impair a patient’s quality of life, require prolonged hospitalization, involve infection
and gangrene, and may ultimately result in amputation.
The National Pressure Ulcer Advisory Panel (NPUAP) has established evidence-based nutrition
recommendations for the prevention and treatment of pressure ulcers. These guidelines focus on
increasing micro- and macronutrients to promote wound healing.3 Unfortunately, no such
guidelines exist for treating DFUs, and it is unclear if recommendations for pressure ulcers can
be extrapolated to DFUs. However, it appears that nutrition does play an important role. A poor
diet can result in altered immune function, malnutrition, and poor glycemic control, all of which
are risk factors for poor healing.4,5 Achieving and maintaining a healthy body weight can help
maximize wound healing because glycemic control can be negatively affected by
obesity.6 Healthcare professionals (HCPs) should encourage patients with DFUs to consume a
healthy diet that contains nutrient-dense foods. A registered dietitian (RD) skilled in medical
nutrition therapy for diabetes can assess, treat, and monitor patients with DFUs to help them
meet their complex nutritional needs.

Immune Function and Malnutrition

Compromised immune function is one factor associated with nonhealing wounds; it affects
wound healing in a number of ways.4 Protein-energy malnutrition is associated with impaired
immunocompetence, including depressed cell-mediated immunity and phagocyte
dysfunction.7 Malnutrition also makes a person more susceptible to infection.8 Infection, whether
systemic or localized in a DFU, can have an impact on wound healing because of the stress it
places on the body. A diet that provides adequate protein, calories, vitamins, and minerals can
help maximize immune function.
Nutrient deficiencies can affect the complex process of wound healing in a multitude of
ways.9Malnutrition and/or nutrient deficiencies can impair collagen synthesis, prolong
inflammation, decrease phagocytosis (causing dysfunction of B and T cells), and decrease the
mechanical strength of the skin.4Many patients with chronic skin ulcers have altered nutritional
status; in one study, malnutrition was identified in 62% of persons with a DFU and was a
predictor of poor outcome.10 To maximize pressure ulcer healing and meet nutritional needs, the
NPUAP recommends 30 to 35 calories per kilogram of body weight per day, 1.25 to 1.5 g of
protein per kilogram body weight per day, and enough vitamins and minerals in the daily diet to
meet the Dietary Reference Intakes for vitamins and minerals.3 Micronutrients involved in wound
healing include vitamin A, vitamin C, magnesium, copper, and zinc.9 Supplements of these or
other nutrients may be recommended if a deficiency is confirmed or suspected.3 The NPUAP
guidelines may be a useful starting point for treatment of the DFU but may need to be adjusted,
especially in the presence of impaired kidney function or poor glycemic control.

Glycemic Control
High blood glucose can lead to defective white blood cell function and render a DFU susceptible
to infection.2,11 High blood glucose also can affect the production of inflammatory molecules,
interfere with collagen synthesis, and change cellular morphology.5 In a recent study at Johns
Hopkins, elevated A1c was significantly associated with a poor wound healing rate.12 Food
choices, including the timing and carbohydrate content of meals and snacks, can impact
glycemic control. Any form of carbohydrate when eaten in excess (including whole grains and not
just simple sugars) can affect blood sugars, so portion control of all carbohydrates is important.
Choosing whole grain breads and cereals instead of refined grains will provide added fiber,
vitamins, and minerals. HCPs can encourage patients to use portions that are outlined by
ChooseMyPlate, the US Department of Agriculture (USDA) food guide available
at www.choosemyplate.gov/food-groups/. Medical nutrition therapy should include helping
patients choose appropriate carbohydrate portions and balance food with oral medication and
insulin to help optimize glycemic control.

Weight Loss
All overweight or obese individuals who have or are at risk for diabetes should consider weight
loss as part of their treatment plan.6 Studies show that moderate weight loss (5% of body weight)
is associated with decreased insulin resistance, improved measures of glycemic and blood lipid
control, and reduced blood pressure.6 Unfortunately, many patients attempt to lose weight by
restricting calories and/or protein. This practice could result in impaired wound healing because
nutrient needs, particularly calories and protein, are elevated in the presence of a wound.13

Experts don’t know the optimal mix of protein, carbohydrate, and fat in the
diet needed for successful weight loss, but low-carbohydrate diets could have a negative effect
on health. The body needs at least 130 g of carbohydrate per day to provide enough glucose for
normal bodily functioning.6 Low-carb diets can limit other nutrients, including dietary fiber,
vitamins, and minerals. For safe and effective weight loss for persons with a DFU, a moderate
calorie restriction combined with regular physical activity (if feasible) will usually have a positive
effect. Patients can be advised to use the Dietary Guidelines for Americans
(www.health.gov/dietaryguidelines ) (see Table 1) and ChooseMyPlate.gov for guidance on
appropriate food choices and portion sizes to help facilitate weight loss.

Specialized Nutrition Interventions

Oral nutrition supplements. High-protein, high-calorie, nutrient-enriched supplements
(referred to as oral nutrition supplements, or ONS) may be recommended between meals if food
intake doesn’t meet a patient’s needs for wound healing.3 ONS can help meet basic needs for
weight maintenance in patients with chronic disease and/or those who are experiencing
unintended weight loss. They provide additional calories and are a source of carbohydrate and
should be recommended in the overall context of a patient’s eating pattern and medications. The
effect of high-protein ONS on blood sugars and renal function should be evaluated frequently.
Amino acids. Arginine and glutamine are two amino acids that have been studied extensively
for their role in wound healing. In addition, beta-hydroxy-methylbuterate, which is a metabolite of
the amino acid leucine, has been linked with improved wound healing and tissue regrowth.
Results of studies of ONS containing these nutrients are mixed, some showing promising
benefit11,14,15 and others showing little benefit.16 Currently, no evidence-based guidelines are
available for addressing the safe use and appropriate dosage of these supplements.3,9 However,
ONS containing these ingredients are available as an option to promote wound healing and often
are used successfully with patients with chronic wounds.

Practice Points
Nutrition is a critical component of the healing of DFUs, particularly as it relates to immune
function, malnutrition, glycemic control, and weight loss and weight maintenance.
Recommendations for a healthful eating pattern (following the Dietary Guidelines for Americans
and ChooseMyPlate) should be individualized based on protein, calorie and carbohydrate needs,
blood sugars, and weight. Nutrition assessment and intervention by a RD can help patients with
a DFU maximize their nutritional status to promote wound healing.
Long-term randomized trials of individual nutrients and clinically relevant endpoints are needed
to show the benefits of nutritional supplementation and dietary interventions. Until they are
available, the best evidence suggests the importance of screening every patient for malnutrition,
estimating caloric needs, and monitoring dietary intake of essential nutrients to ensure those
needs are met.17
Ms. Friedrich is President, Friedrich Nutrition Consulting, and Associate Director,
Nutrition411.com. Dr. Collins is a registered dietitian based in Las Vegas, NV, and founder and
executive director of Nutrition411.com. For the past 23 years, she has served as a consultant to
healthcare institutions and as a medico-legal expert to law firms involved in healthcare litigation.
Correspondence may be sent to Dr. Collins at NCtheRD@aol.com or Ms. Friedrich
at ekf@carolina.rr.com.
References:
1. Centers for Disease Control and Prevention. National diabetes fact sheet: national estimates
and general information on diabetes and prediabetes in the United States, 2011. Atlanta, GA:
U.S. Department of Health and Human Services, Centers for Disease Control and Prevention,
2011. Available at: www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf. Accessed June 21, 2013.
2. Pham HI, Rich J, Veves A. Wound healing in diabetic foot ulceration: a review and
commentary. WOUNDS. 2000;12(4):79–81.
3. National Pressure Ulcer Advisory Panel and European Pressure Ulcer Advisory
Panel. Prevention and treatment of pressure ulcers: clinical practice guideline. Washington, DC:
National Pressure Ulcer Advisory Panel;2009.
4. Academy of Nutrition and Dietetics Nutrition Care Manual. Available
at: www.nutritioncaremanual.org. Accessed June 21, 2013.
5. Tsourdi E, Barthel A, Rietzsch H, Reichel A, Bornstein SR. Current aspects in the
pathophysiology and treatment of chronic wounds in diabetes mellitus. Available
at: www.hindawi.com/journals/bmri/2013/385641/. Accessed June 10, 2013.
6. Standards of Medical Care in Diabetes 2012. Diabetes Care. 2013:36(1 supp1):S11–S66.
7. Litchford MD. Clinical: biochemical assessment. In: Mahan LK, Escott-Stump S, Raymond JL
(ed). Krause’s Food and the Nutrition Care Process, 13th ed. St. Louis, MO: Elsevier
Saunders;2012:198.
8. Katona P, Katona-Apte J. The interaction between nutrition and infection. Clin Infect Dis.
2008:46(10).0:1582–1588.
9. Stechmiller JK. Understanding the role of nutrition and wound healing. Nutr Clin Pract.
2010;25(1):61–68.
10. Zhang S, Tang Z, Fang P, Qian HJ.0, Xu L, Ning G. Nutritional status deteriorates as the
severity of diabetic foot ulcers increases and independently associates with prognosis. Exp Ther
Med. 2013;5(10):215–222.
11. Tatti P, Barber A. The use of a specialized nutritional supplement for diabetic foot ulcers
reduces the use of antibiotics. J Endocrinol Metab. 2012;2(1):26–31.
12. Christman AL, Selvin E, Margolis DJ, Lazarus GS, Garza LA. Hemoglobin A1c is a predictor
of healing rate in diabetic wounds. J Invest Dermatol. 2011:131(10):2121–2127.
13. Demling RH Nutrition, anabolism, and the wound healing process: an overview. Eplasty.
Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC2642618/. Accessed June 21, 2013.
14. Sipahi S, Gungor O, Gunduz M, Cici M, Demirci MC, Tamer A. The effect of oral
supplementation with a combination of beta-hydrozy-beta-methylbutyrate, arginine and glutamine
on wound healing; a retrospective analysis of diabetic haemodialysis patients. BMC Nephrol.
Available at: www.ncbi.nlm.nih.gov/pmc/articles/PMC3598478/pdf/1471-2369-14-8.pdf.
Accessed June 12, 2013.
15. van Anholt RD, Sobotka L, Meijer EP, Heyman H, Groen HW, Topinkova E, et al. Specific
nutrition support accelerates pressure ulcer healing and reduces wound care intensity in
malnourished patients. Nutrition. 2010;29(9):867–872.
16. Bauer JD, Isenring E, Waterhouse M. The effectiveness of a specialized oral nutrition
supplement on outcomes in patients with chronic wounds: a pragmatic randomized study. J Hum
Nutr Diet. 2013;26(5):452–458.
17. Little MO. Nutrition and skin ulcers. Curr Opin Clin Nutri Metabol Care. 2013:16(1):39-49. 18.
Dietary Guidelines for Americans 2010. Available at: www.health.gov/dietaryguidelines.
Accessed June 24, 2013.